Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Fotios Loupakis, Herbert I. Hurwitz, Leonard Saltz, Dirk Arnold, Axel Grothey, Quynh Lan Nguyen, Stuart Osborne, Jonathan Talbot, Stefanie Srock, Heinz-Josef Lenz

ABSTRACT

BACKGROUND: Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. METHODS: Patients with sidedness information from two randomised phase III studies of bevacizumab + chemotherapy (CT) vs CT as 1L mCRC treatment were analysed retrospectively. RESULTS: Sidedness was determined in 1590 (27% right and 73% left) of 2214 patients. Progression-free survival was improved with bevacizumab + CT vs CT in right-sided (HR = 0.75; 95% CI 0.61, 0.93; p = 0.008) and left-sided (HR = 0.76; 95% CI 0.67, 0.86; p < 0.001) mCRC (pooled analysis). Similarly, overall survival was numerically improved with bevacizumab + CT vs CT in right-sided mCRC (HR = 0.82; 95% CI 0.65, 1.03; p = 0.085), and significantly improved in left-sided mCRC (HR = 0.85; 95% CI 0.74, 0.98; p = 0.028). CONCLUSIONS: This analysis indicates that the effect of bevacizumab is independent of tumour location in mCRC. More... »

PAGES

1451-1455

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0304-6

DOI

http://dx.doi.org/10.1038/s41416-018-0304-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110155321

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30487637


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