Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Benjamin Goeppert, Stephanie Roessler, Marcus Renner, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Elena Czink, Bruno Köhler, Christoph Springfeld, Jan Pfeiffenberger, Christian Rupp, Karl Heinz Weiss, Peter Schirmacher, Magnus von Knebel Doeberitz, Matthias Kloor

ABSTRACT

BACKGROUND: A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarcinoma (CCA) has been conflicting. METHODS: We employed a cohort comprising 308 Western-world, non-liver fluke-associated CCAs (159 intrahepatic, 106 perihilar, and 43 distal). We analysed the mononucleotide microsatellite instability marker panel consisting of BAT25, BAT26, and CAT25 and detected MSI-H in 4/308 CCAs (1.3%). RESULTS: Patients affected by MSI-H CCA had mostly an atypical histomorphology (p = 0.004), showed a longer overall survival, although having a high tumour stage, and were of younger age. Correlation analysis of microsatellite instability status with tumour-infiltrating immune cells, MHC I, and PD-L1 expression in the same cholangiocarcinoma cohort showed higher numbers of CD8 + T cells, FOXP3 + regulatory T cells, CD20 + B cells and high or at least moderate MHC I expression levels in MSI-H CCAs. CONCLUSIONS: Even though the overall number of MSI-H CCAs is low, the dismal prognosis of the disease and the therapeutic option of immune checkpoint blockade in the respective patients justify MSI testing of cholangiocarcinoma, particularly in younger patients showing an atypical histomorphology. More... »

PAGES

109-114

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0199-2

DOI

http://dx.doi.org/10.1038/s41416-018-0199-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107912892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30377340


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goeppert", 
        "givenName": "Benjamin", 
        "id": "sg:person.01063463072.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063463072.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roessler", 
        "givenName": "Stephanie", 
        "id": "sg:person.01022653512.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022653512.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renner", 
        "givenName": "Marcus", 
        "id": "sg:person.01177455056.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177455056.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singer", 
        "givenName": "Stephan", 
        "id": "sg:person.01127447200.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127447200.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Liver Cancer Center Heidelberg (LCCH), Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mehrabi", 
        "givenName": "Arianeb", 
        "id": "sg:person.0732434166.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732434166.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Diagnostic and Interventional Radiology, Thoraxklinik at University Hospital of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogel", 
        "givenName": "Monika Nadja", 
        "id": "sg:person.0751540326.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751540326.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pathil", 
        "givenName": "Anita", 
        "id": "sg:person.0712507177.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712507177.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, Department of Medical Oncology, University Hospital Heidelberg, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Czink", 
        "givenName": "Elena", 
        "id": "sg:person.01362637217.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362637217.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, Department of Medical Oncology, University Hospital Heidelberg, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00f6hler", 
        "givenName": "Bruno", 
        "id": "sg:person.01331373405.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331373405.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, Department of Medical Oncology, University Hospital Heidelberg, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Springfeld", 
        "givenName": "Christoph", 
        "id": "sg:person.0735442654.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735442654.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeiffenberger", 
        "givenName": "Jan", 
        "id": "sg:person.01232370337.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232370337.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rupp", 
        "givenName": "Christian", 
        "id": "sg:person.0675271554.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675271554.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weiss", 
        "givenName": "Karl Heinz", 
        "id": "sg:person.01024626273.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024626273.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany", 
            "Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirmacher", 
        "givenName": "Peter", 
        "id": "sg:person.01072556301.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Knebel Doeberitz", 
        "givenName": "Magnus", 
        "id": "sg:person.01337272037.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337272037.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kloor", 
        "givenName": "Matthias", 
        "id": "sg:person.01204274004.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204274004.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2014.59.7591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000554003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000656763", 
          "https://doi.org/10.1038/bjc.2015.337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.11380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000697802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015240642", 
          "https://doi.org/10.1038/nm.4191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015240642", 
          "https://doi.org/10.1038/nm.4191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.20146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019389718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.20146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019389718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65436-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021519853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2011.326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025167349", 
          "https://doi.org/10.1038/jid.2011.326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033114418", 
          "https://doi.org/10.1038/bjc.2013.610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00052-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034361405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200311000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036054483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200311000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036054483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040279504", 
          "https://doi.org/10.1038/ng.3375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(03)00133-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041335426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(03)00133-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041335426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2016.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042192730", 
          "https://doi.org/10.1038/nrgastro.2016.51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-011-9449-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045654236", 
          "https://doi.org/10.1007/s10689-011-9449-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047946992", 
          "https://doi.org/10.1038/nrc3239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048130718", 
          "https://doi.org/10.1038/ng.2806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048130718", 
          "https://doi.org/10.1038/ng.2806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2016.02.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049973998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1500596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053017729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/cco.2016.10.04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068832482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.20.4.1043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083941942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086121715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/mcs.a001974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086128505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-17-0368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090391922"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01", 
    "datePublishedReg": "2019-01-01", 
    "description": "BACKGROUND: A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarcinoma (CCA) has been conflicting.\nMETHODS: We employed a cohort comprising 308 Western-world, non-liver fluke-associated CCAs (159 intrahepatic, 106 perihilar, and 43 distal). We analysed the mononucleotide microsatellite instability marker panel consisting of BAT25, BAT26, and CAT25 and detected MSI-H in 4/308 CCAs (1.3%).\nRESULTS: Patients affected by MSI-H CCA had mostly an atypical histomorphology (p\u2009=\u20090.004), showed a longer overall survival, although having a high tumour stage, and were of younger age. Correlation analysis of microsatellite instability status with tumour-infiltrating immune cells, MHC I, and PD-L1 expression in the same cholangiocarcinoma cohort showed higher numbers of CD8\u2009+\u2009T cells, FOXP3\u2009+\u2009regulatory T cells, CD20\u2009+\u2009B cells and high or at least moderate MHC I expression levels in MSI-H CCAs.\nCONCLUSIONS: Even though the overall number of MSI-H CCAs is low, the dismal prognosis of the disease and the therapeutic option of immune checkpoint blockade in the respective patients justify MSI testing of cholangiocarcinoma, particularly in younger patients showing an atypical histomorphology.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41416-018-0199-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "120"
      }
    ], 
    "name": "Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma", 
    "pagination": "109-114", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "32b9e118bd22d2b2de2a696a20fb9cf55181c5d56ca7326f914d3dcd7c13168f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30377340"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41416-018-0199-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107912892"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41416-018-0199-2", 
      "https://app.dimensions.ai/details/publication/pub.1107912892"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000353_0000000353/records_45345_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41416-018-0199-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0199-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0199-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0199-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0199-2'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41416-018-0199-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N4e4bddc3029346f5aaad3985b001859a
4 schema:citation sg:pub.10.1007/s10689-011-9449-7
5 sg:pub.10.1038/bjc.2013.610
6 sg:pub.10.1038/bjc.2015.337
7 sg:pub.10.1038/jid.2011.326
8 sg:pub.10.1038/ng.2806
9 sg:pub.10.1038/ng.3375
10 sg:pub.10.1038/nm.4191
11 sg:pub.10.1038/nrc3239
12 sg:pub.10.1038/nrgastro.2016.51
13 https://doi.org/10.1002/ijc.11380
14 https://doi.org/10.1002/mc.20146
15 https://doi.org/10.1016/j.ccell.2017.05.009
16 https://doi.org/10.1016/j.immuni.2016.02.025
17 https://doi.org/10.1016/s0002-9440(10)65436-3
18 https://doi.org/10.1016/s0165-4608(03)00133-x
19 https://doi.org/10.1016/s0304-3835(02)00052-6
20 https://doi.org/10.1056/nejmoa1500596
21 https://doi.org/10.1097/00000478-200311000-00002
22 https://doi.org/10.1101/mcs.a001974
23 https://doi.org/10.1126/science.aan6733
24 https://doi.org/10.1158/0008-5472.can-04-4146
25 https://doi.org/10.1158/2159-8290.cd-17-0368
26 https://doi.org/10.1200/jco.2002.20.4.1043
27 https://doi.org/10.1200/jco.2014.59.7591
28 https://doi.org/10.21037/cco.2016.10.04
29 schema:datePublished 2019-01
30 schema:datePublishedReg 2019-01-01
31 schema:description BACKGROUND: A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarcinoma (CCA) has been conflicting. METHODS: We employed a cohort comprising 308 Western-world, non-liver fluke-associated CCAs (159 intrahepatic, 106 perihilar, and 43 distal). We analysed the mononucleotide microsatellite instability marker panel consisting of BAT25, BAT26, and CAT25 and detected MSI-H in 4/308 CCAs (1.3%). RESULTS: Patients affected by MSI-H CCA had mostly an atypical histomorphology (p = 0.004), showed a longer overall survival, although having a high tumour stage, and were of younger age. Correlation analysis of microsatellite instability status with tumour-infiltrating immune cells, MHC I, and PD-L1 expression in the same cholangiocarcinoma cohort showed higher numbers of CD8 + T cells, FOXP3 + regulatory T cells, CD20 + B cells and high or at least moderate MHC I expression levels in MSI-H CCAs. CONCLUSIONS: Even though the overall number of MSI-H CCAs is low, the dismal prognosis of the disease and the therapeutic option of immune checkpoint blockade in the respective patients justify MSI testing of cholangiocarcinoma, particularly in younger patients showing an atypical histomorphology.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N03af3a08b444440cabf222389e7e7ff8
36 N46fe346066c648299a5cfcc03fa26931
37 sg:journal.1017082
38 schema:name Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma
39 schema:pagination 109-114
40 schema:productId N2aba3b2ffc244786a311a1771fb719bd
41 N34ab5e6a90404a049fa69076a700a416
42 Na24d58686bed4dacb521ca79624b2e2e
43 Nb7a5a260b24c4da391231c8eaf076aaa
44 Ncde3de747892463d94b8b555bdb4485e
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107912892
46 https://doi.org/10.1038/s41416-018-0199-2
47 schema:sdDatePublished 2019-04-11T11:10
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N6fd3a65469154769842a65763ee3a5db
50 schema:url https://www.nature.com/articles/s41416-018-0199-2
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N03af3a08b444440cabf222389e7e7ff8 schema:issueNumber 1
55 rdf:type schema:PublicationIssue
56 N098d7828b0c04b87b664f7d762569a29 rdf:first sg:person.01072556301.62
57 rdf:rest Nc89cfe358c974098a15f0ea749eb8862
58 N13565c98613b4f2aafa90c89dece6c8e rdf:first sg:person.01204274004.37
59 rdf:rest rdf:nil
60 N1c2d167f5b0642a287e42b77cd61f074 rdf:first sg:person.0712507177.21
61 rdf:rest Na343adf19a6f49eabce704b360423848
62 N2aba3b2ffc244786a311a1771fb719bd schema:name dimensions_id
63 schema:value pub.1107912892
64 rdf:type schema:PropertyValue
65 N34ab5e6a90404a049fa69076a700a416 schema:name nlm_unique_id
66 schema:value 0370635
67 rdf:type schema:PropertyValue
68 N46fe346066c648299a5cfcc03fa26931 schema:volumeNumber 120
69 rdf:type schema:PublicationVolume
70 N4e4bddc3029346f5aaad3985b001859a rdf:first sg:person.01063463072.90
71 rdf:rest N9c2d414624f34d0d9bc06e8d9ab27504
72 N5c913ad2072a47e987a52a1b414b09a9 rdf:first sg:person.01127447200.72
73 rdf:rest Ncc59434a92934635a3cfb44635ba94bc
74 N6fd3a65469154769842a65763ee3a5db schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N7977f85e85164e5088e405adca0676dc rdf:first sg:person.01177455056.76
77 rdf:rest N5c913ad2072a47e987a52a1b414b09a9
78 N942d601c46cd4fd9ab2eac692be8e2c1 rdf:first sg:person.01024626273.16
79 rdf:rest N098d7828b0c04b87b664f7d762569a29
80 N947c3a18bb5b42e18dc3dcf24cb110fe rdf:first sg:person.01331373405.19
81 rdf:rest Nb3f04b6d4c734355a9a21ac383e04fcf
82 N9c2d414624f34d0d9bc06e8d9ab27504 rdf:first sg:person.01022653512.47
83 rdf:rest N7977f85e85164e5088e405adca0676dc
84 Na24d58686bed4dacb521ca79624b2e2e schema:name pubmed_id
85 schema:value 30377340
86 rdf:type schema:PropertyValue
87 Na343adf19a6f49eabce704b360423848 rdf:first sg:person.01362637217.80
88 rdf:rest N947c3a18bb5b42e18dc3dcf24cb110fe
89 Nb3f04b6d4c734355a9a21ac383e04fcf rdf:first sg:person.0735442654.05
90 rdf:rest Nbec8abdc7fdb4d65b8a31e4885bf844e
91 Nb7a5a260b24c4da391231c8eaf076aaa schema:name doi
92 schema:value 10.1038/s41416-018-0199-2
93 rdf:type schema:PropertyValue
94 Nbec8abdc7fdb4d65b8a31e4885bf844e rdf:first sg:person.01232370337.74
95 rdf:rest Nd5bdcb06fdb6404aacb316073e8e6016
96 Nc89cfe358c974098a15f0ea749eb8862 rdf:first sg:person.01337272037.40
97 rdf:rest N13565c98613b4f2aafa90c89dece6c8e
98 Ncc59434a92934635a3cfb44635ba94bc rdf:first sg:person.0732434166.83
99 rdf:rest Nd348facb47484e7ea8a17968ddb5d711
100 Ncde3de747892463d94b8b555bdb4485e schema:name readcube_id
101 schema:value 32b9e118bd22d2b2de2a696a20fb9cf55181c5d56ca7326f914d3dcd7c13168f
102 rdf:type schema:PropertyValue
103 Nd348facb47484e7ea8a17968ddb5d711 rdf:first sg:person.0751540326.01
104 rdf:rest N1c2d167f5b0642a287e42b77cd61f074
105 Nd5bdcb06fdb6404aacb316073e8e6016 rdf:first sg:person.0675271554.36
106 rdf:rest N942d601c46cd4fd9ab2eac692be8e2c1
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
111 schema:name Oncology and Carcinogenesis
112 rdf:type schema:DefinedTerm
113 sg:journal.1017082 schema:issn 0007-0920
114 1532-1827
115 schema:name British Journal of Cancer
116 rdf:type schema:Periodical
117 sg:person.01022653512.47 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
118 schema:familyName Roessler
119 schema:givenName Stephanie
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022653512.47
121 rdf:type schema:Person
122 sg:person.01024626273.16 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
123 schema:familyName Weiss
124 schema:givenName Karl Heinz
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024626273.16
126 rdf:type schema:Person
127 sg:person.01063463072.90 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
128 schema:familyName Goeppert
129 schema:givenName Benjamin
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063463072.90
131 rdf:type schema:Person
132 sg:person.01072556301.62 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
133 schema:familyName Schirmacher
134 schema:givenName Peter
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62
136 rdf:type schema:Person
137 sg:person.01127447200.72 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
138 schema:familyName Singer
139 schema:givenName Stephan
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127447200.72
141 rdf:type schema:Person
142 sg:person.01177455056.76 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
143 schema:familyName Renner
144 schema:givenName Marcus
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177455056.76
146 rdf:type schema:Person
147 sg:person.01204274004.37 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
148 schema:familyName Kloor
149 schema:givenName Matthias
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204274004.37
151 rdf:type schema:Person
152 sg:person.01232370337.74 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
153 schema:familyName Pfeiffenberger
154 schema:givenName Jan
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232370337.74
156 rdf:type schema:Person
157 sg:person.01331373405.19 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
158 schema:familyName Köhler
159 schema:givenName Bruno
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331373405.19
161 rdf:type schema:Person
162 sg:person.01337272037.40 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
163 schema:familyName von Knebel Doeberitz
164 schema:givenName Magnus
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337272037.40
166 rdf:type schema:Person
167 sg:person.01362637217.80 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
168 schema:familyName Czink
169 schema:givenName Elena
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362637217.80
171 rdf:type schema:Person
172 sg:person.0675271554.36 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
173 schema:familyName Rupp
174 schema:givenName Christian
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675271554.36
176 rdf:type schema:Person
177 sg:person.0712507177.21 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
178 schema:familyName Pathil
179 schema:givenName Anita
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712507177.21
181 rdf:type schema:Person
182 sg:person.0732434166.83 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
183 schema:familyName Mehrabi
184 schema:givenName Arianeb
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732434166.83
186 rdf:type schema:Person
187 sg:person.0735442654.05 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
188 schema:familyName Springfeld
189 schema:givenName Christoph
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735442654.05
191 rdf:type schema:Person
192 sg:person.0751540326.01 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
193 schema:familyName Vogel
194 schema:givenName Monika Nadja
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751540326.01
196 rdf:type schema:Person
197 sg:pub.10.1007/s10689-011-9449-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045654236
198 https://doi.org/10.1007/s10689-011-9449-7
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/bjc.2013.610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033114418
201 https://doi.org/10.1038/bjc.2013.610
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/bjc.2015.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000656763
204 https://doi.org/10.1038/bjc.2015.337
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/jid.2011.326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025167349
207 https://doi.org/10.1038/jid.2011.326
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/ng.2806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048130718
210 https://doi.org/10.1038/ng.2806
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/ng.3375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040279504
213 https://doi.org/10.1038/ng.3375
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nm.4191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015240642
216 https://doi.org/10.1038/nm.4191
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nrc3239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047946992
219 https://doi.org/10.1038/nrc3239
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nrgastro.2016.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042192730
222 https://doi.org/10.1038/nrgastro.2016.51
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/ijc.11380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000697802
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/mc.20146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019389718
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.ccell.2017.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086121715
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.immuni.2016.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049973998
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0002-9440(10)65436-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021519853
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0165-4608(03)00133-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041335426
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0304-3835(02)00052-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034361405
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1056/nejmoa1500596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053017729
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/00000478-200311000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036054483
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1101/mcs.a001974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086128505
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.aan6733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942187
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1158/0008-5472.can-04-4146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050476862
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1158/2159-8290.cd-17-0368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090391922
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1200/jco.2002.20.4.1043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083941942
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1200/jco.2014.59.7591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000554003
253 rdf:type schema:CreativeWork
254 https://doi.org/10.21037/cco.2016.10.04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068832482
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
257 schema:name Department of General Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
258 Department of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
259 Diagnostic and Interventional Radiology, Thoraxklinik at University Hospital of Heidelberg, Heidelberg, Germany
260 Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany
261 Liver Cancer Center Heidelberg (LCCH), Heidelberg, Germany
262 National Center for Tumor Diseases, Department of Medical Oncology, University Hospital Heidelberg, Heidelberg, Germany
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
265 schema:name Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...