Early metabolic response in sequential FDG-PET/CT under cetuximab is a predictive marker for clinical response in first-line metastatic colorectal cancer ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Anne Katrin Berger, Stephan Lücke, Ulrich Abel, Georg Martin Haag, Carsten Grüllich, Annika Stange, Mareike Dietrich, Leonidas Apostolidis, Angelika Freitag, Claudia Trierweiler, Carl von Gall, Jennifer Ose, Frederik Giesel, Tim Frederik Weber, Florian Lordick, Uwe Haberkorn, Dirk Jäger

ABSTRACT

BACKGROUND: To assess the predictive value of early metabolic response (ΔSUV) after short-term treatment with first-line cetuximab in patients (pts) with RAS-wt metastatic colorectal cancer (mCRC). METHODS: In this prospective phase II study, RAS-wt mCRC pts received a single-agent cetuximab run-in therapy of 2 weeks. ΔSUV was assessed with FDG-PET/CT on days 0 and 14. Early clinical response (ECR) was evaluated with CT on day 56 after treatment with FOLFIRI-cetuximab. Primary endpoint was the predictive significance of ΔSUV for ECR. Secondary endpoints were PFS (progression free survival), OS and the influence of ΔSUV on survival. RESULTS: Forty pts were enroled and 33 pts were evaluable for the primary endpoint. The CT response rate was 57.6%. For responders, ΔSUV was significantly higher (p = 0.0092). A significant association of ΔSUV with ECR was found (p = 0.02). Median PFS was 11.7 months and median OS was 33.5 months with a 1-year survival rate of 87.9%. ΔSUV was found to significantly impact the hazard for OS (p = 0.045). CONCLUSIONS: We demonstrate that cetuximab induces metabolic responses in mCRC pts. The study endpoint was met with the ΔSUV discriminating between responders and non-responders. However, these data should be validated in larger patient cohorts. More... »

PAGES

170-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0152-4

DOI

http://dx.doi.org/10.1038/s41416-018-0152-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105223955

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29961759


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    "description": "BACKGROUND: To assess the predictive value of early metabolic response (\u0394SUV) after short-term treatment with first-line cetuximab in patients (pts) with RAS-wt metastatic colorectal cancer (mCRC).\nMETHODS: In this prospective phase II study, RAS-wt mCRC pts received a single-agent cetuximab run-in therapy of 2 weeks. \u0394SUV was assessed with FDG-PET/CT on days 0 and 14. Early clinical response (ECR) was evaluated with CT on day 56 after treatment with FOLFIRI-cetuximab. Primary endpoint was the predictive significance of \u0394SUV for ECR. Secondary endpoints were PFS (progression free survival), OS and the influence of \u0394SUV on survival.\nRESULTS: Forty pts were enroled and 33 pts were evaluable for the primary endpoint. The CT response rate was 57.6%. For responders, \u0394SUV was significantly higher (p\u2009=\u20090.0092). A significant association of \u0394SUV with ECR was found (p\u2009=\u20090.02). Median PFS was 11.7 months and median OS was 33.5 months with a 1-year survival rate of 87.9%. \u0394SUV was found to significantly impact the hazard for OS (p\u2009=\u20090.045).\nCONCLUSIONS: We demonstrate that cetuximab induces metabolic responses in mCRC pts. The study endpoint was met with the \u0394SUV discriminating between responders and non-responders. However, these data should be validated in larger patient cohorts.", 
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0152-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0152-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0152-4'


 

This table displays all metadata directly associated to this object as RDF triples.

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31 schema:description BACKGROUND: To assess the predictive value of early metabolic response (ΔSUV) after short-term treatment with first-line cetuximab in patients (pts) with RAS-wt metastatic colorectal cancer (mCRC). METHODS: In this prospective phase II study, RAS-wt mCRC pts received a single-agent cetuximab run-in therapy of 2 weeks. ΔSUV was assessed with FDG-PET/CT on days 0 and 14. Early clinical response (ECR) was evaluated with CT on day 56 after treatment with FOLFIRI-cetuximab. Primary endpoint was the predictive significance of ΔSUV for ECR. Secondary endpoints were PFS (progression free survival), OS and the influence of ΔSUV on survival. RESULTS: Forty pts were enroled and 33 pts were evaluable for the primary endpoint. The CT response rate was 57.6%. For responders, ΔSUV was significantly higher (p = 0.0092). A significant association of ΔSUV with ECR was found (p = 0.02). Median PFS was 11.7 months and median OS was 33.5 months with a 1-year survival rate of 87.9%. ΔSUV was found to significantly impact the hazard for OS (p = 0.045). CONCLUSIONS: We demonstrate that cetuximab induces metabolic responses in mCRC pts. The study endpoint was met with the ΔSUV discriminating between responders and non-responders. However, these data should be validated in larger patient cohorts.
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