Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Giuseppe Gullo, Naomi Walsh, David Fennelly, Reetesh Bose, Janice Walshe, Dimitrios Tryfonopoulos, Kate O’Mahony, Lisa Hammond, Nuno Silva, Deirdre McDonnell, Josephine Ballot, Cecily Quinn, Enda W. McDermott, Denis Evoy, Ruth Prichard, James Geraghty, John Amstrong, John Crown

ABSTRACT

BACKGROUND: The optimal timing of (neo)adjuvant trastuzumab initiation with respect to chemotherapy and surgery remains undefined. METHODS: Retrospective analysis of a large institutional database of HER2-positive patients who received anti-HER2 therapy. We included all Stage I to III patients treated with trastuzumab with a minimum follow up of 3 years. The date of first breast biopsy was recorded as initial diagnosis. RESULTS: A total of 506 patients [adjuvant: 386 (76%)-neo-adjuvant: 120 (24%)] were included. The median time-to-first-trastuzumab (TFT) from diagnosis was 12 weeks (range 1.9-122.3). Median follow-up is 73.3 months (range 1.4-176.3). TFT was significantly shorter in the neo-adjuvant than in the adjuvant cohort (median: 4.4 vs. 14 weeks, p < 0.00001). Despite the neo-adjuvant cohort having significantly more node-positive patients (75 vs. 53%, p < 0.0001), DFS rate (neo-adjuvant: 12.5 vs. adjuvant: 18%, p = 0.094) was numerically superior in neo-adjuvant patients. A TFT ≤ 12 weeks was associated with significantly superior DFS and OS over TFT > 12 weeks. Early concomitant regimens were associated with superior DFS over delayed-concomitant and sequential regimens. CONCLUSIONS: Initiating trastuzumab more than 12 weeks from diagnosis has a negative impact on clinical outcome. Neo-adjuvant anti-HER2 therapy could be the optimal strategy to treat early stage HER2-positive breast cancer. More... »

PAGES

374-380

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0114-x

DOI

http://dx.doi.org/10.1038/s41416-018-0114-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104018608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29773838


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College Dublin", 
          "id": "https://www.grid.ac/institutes/grid.7886.1", 
          "name": [
            "Department of Medical Oncology, St Vincent\u2019s University Hospital, Dublin, Ireland", 
            "School of Medicine, University College Dublin (UCD), Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gullo", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01223342332.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223342332.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dublin City University", 
          "id": "https://www.grid.ac/institutes/grid.15596.3e", 
          "name": [
            "National Institute for Cellular Biotechnology, Dublin City University (DCU), Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walsh", 
        "givenName": "Naomi", 
        "id": "sg:person.01271372626.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271372626.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Medical Oncology, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fennelly", 
        "givenName": "David", 
        "id": "sg:person.01112225310.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112225310.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Medical Oncology, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bose", 
        "givenName": "Reetesh", 
        "id": "sg:person.07457762507.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07457762507.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Medical Oncology, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walshe", 
        "givenName": "Janice", 
        "id": "sg:person.01061741661.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061741661.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Agios Savvas Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tryfonopoulos", 
        "givenName": "Dimitrios", 
        "id": "sg:person.0731162517.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731162517.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Aseptic Unit-Pharmacy Department, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Mahony", 
        "givenName": "Kate", 
        "id": "sg:person.07517721517.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07517721517.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Aseptic Unit-Pharmacy Department, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hammond", 
        "givenName": "Lisa", 
        "id": "sg:person.011112662517.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011112662517.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Aseptic Unit-Pharmacy Department, St Vincent\u2019s Private Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Nuno", 
        "id": "sg:person.010315302117.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315302117.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Cancer Clinical Research Trust, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDonnell", 
        "givenName": "Deirdre", 
        "id": "sg:person.011176263127.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176263127.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Cancer Clinical Research Trust, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ballot", 
        "givenName": "Josephine", 
        "id": "sg:person.01327776543.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327776543.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Pathology, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quinn", 
        "givenName": "Cecily", 
        "id": "sg:person.014506351152.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014506351152.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Surgery, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDermott", 
        "givenName": "Enda W.", 
        "id": "sg:person.01231037062.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231037062.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Surgery, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evoy", 
        "givenName": "Denis", 
        "id": "sg:person.0714465260.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714465260.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Surgery, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prichard", 
        "givenName": "Ruth", 
        "id": "sg:person.01130110642.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130110642.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Surgery, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geraghty", 
        "givenName": "James", 
        "id": "sg:person.01215015156.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215015156.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Luke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477842.a", 
          "name": [
            "Department of Radiation Oncology, St Luke\u2019s Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amstrong", 
        "givenName": "John", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Vincent's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412751.4", 
          "name": [
            "Department of Medical Oncology, St Vincent\u2019s University Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crown", 
        "givenName": "John", 
        "id": "sg:person.01060164243.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060164243.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10549-016-3790-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009476877", 
          "https://doi.org/10.1007/s10549-016-3790-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3790-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009476877", 
          "https://doi.org/10.1007/s10549-016-3790-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)00163-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018821239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027173498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.0946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028123038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0910383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028192490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.62.1797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028580445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030384850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.4577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036202282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)61964-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038345999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.49.7693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041678017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa053028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043831613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61847-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043834514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/2162402x.2015.1100790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058420648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081983002", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1703643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085866538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(17)30717-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092667029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(17)30777-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099644234"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08", 
    "datePublishedReg": "2018-08-01", 
    "description": "BACKGROUND: The optimal timing of (neo)adjuvant trastuzumab initiation with respect to chemotherapy and surgery remains undefined.\nMETHODS: Retrospective analysis of a large institutional database of HER2-positive patients who received anti-HER2 therapy. We included all Stage I to III patients treated with trastuzumab with a minimum follow up of 3 years. The date of first breast biopsy was recorded as initial diagnosis.\nRESULTS: A total of 506 patients [adjuvant: 386 (76%)-neo-adjuvant: 120 (24%)] were included. The median time-to-first-trastuzumab (TFT) from diagnosis was 12 weeks (range 1.9-122.3). Median follow-up is 73.3 months (range 1.4-176.3). TFT was significantly shorter in the neo-adjuvant than in the adjuvant cohort (median: 4.4 vs. 14 weeks, p\u2009<\u20090.00001). Despite the neo-adjuvant cohort having significantly more node-positive patients (75 vs. 53%, p\u2009<\u20090.0001), DFS rate (neo-adjuvant: 12.5 vs. adjuvant: 18%, p\u2009=\u20090.094) was numerically superior in neo-adjuvant patients. A TFT\u2009\u2264\u200912 weeks was associated with significantly superior DFS and OS over TFT\u2009>\u200912 weeks. Early concomitant regimens were associated with superior DFS over delayed-concomitant and sequential regimens.\nCONCLUSIONS: Initiating trastuzumab more than 12 weeks from diagnosis has a negative impact on clinical outcome. Neo-adjuvant anti-HER2 therapy could be the optimal strategy to treat early stage HER2-positive breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41416-018-0114-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "119"
      }
    ], 
    "name": "Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the \u201cone thousand HER2 patients\u201d project", 
    "pagination": "374-380", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c281547657abea9cbb87857346b1af3b138de21906f9f91b87bb1355bed73619"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29773838"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41416-018-0114-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104018608"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41416-018-0114-x", 
      "https://app.dimensions.ai/details/publication/pub.1104018608"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41416-018-0114-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0114-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0114-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0114-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0114-x'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      48 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41416-018-0114-x schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N0ced01f41bc04625bc30dad49ea2fcad
4 schema:citation sg:pub.10.1007/s10549-016-3790-3
5 https://app.dimensions.ai/details/publication/pub.1081983002
6 https://doi.org/10.1016/s0140-6736(09)61964-4
7 https://doi.org/10.1016/s0140-6736(11)61847-3
8 https://doi.org/10.1016/s1470-2045(16)00163-7
9 https://doi.org/10.1016/s1470-2045(17)30717-9
10 https://doi.org/10.1016/s1470-2045(17)30777-5
11 https://doi.org/10.1056/nejmoa052122
12 https://doi.org/10.1056/nejmoa052306
13 https://doi.org/10.1056/nejmoa053028
14 https://doi.org/10.1056/nejmoa0910383
15 https://doi.org/10.1056/nejmoa1703643
16 https://doi.org/10.1080/2162402x.2015.1100790
17 https://doi.org/10.1093/annonc/mdr484
18 https://doi.org/10.1093/jnci/djh131
19 https://doi.org/10.1200/jco.2008.21.4577
20 https://doi.org/10.1200/jco.2009.23.0946
21 https://doi.org/10.1200/jco.2013.49.7693
22 https://doi.org/10.1200/jco.2015.62.1797
23 schema:datePublished 2018-08
24 schema:datePublishedReg 2018-08-01
25 schema:description BACKGROUND: The optimal timing of (neo)adjuvant trastuzumab initiation with respect to chemotherapy and surgery remains undefined. METHODS: Retrospective analysis of a large institutional database of HER2-positive patients who received anti-HER2 therapy. We included all Stage I to III patients treated with trastuzumab with a minimum follow up of 3 years. The date of first breast biopsy was recorded as initial diagnosis. RESULTS: A total of 506 patients [adjuvant: 386 (76%)-neo-adjuvant: 120 (24%)] were included. The median time-to-first-trastuzumab (TFT) from diagnosis was 12 weeks (range 1.9-122.3). Median follow-up is 73.3 months (range 1.4-176.3). TFT was significantly shorter in the neo-adjuvant than in the adjuvant cohort (median: 4.4 vs. 14 weeks, p < 0.00001). Despite the neo-adjuvant cohort having significantly more node-positive patients (75 vs. 53%, p < 0.0001), DFS rate (neo-adjuvant: 12.5 vs. adjuvant: 18%, p = 0.094) was numerically superior in neo-adjuvant patients. A TFT ≤ 12 weeks was associated with significantly superior DFS and OS over TFT > 12 weeks. Early concomitant regimens were associated with superior DFS over delayed-concomitant and sequential regimens. CONCLUSIONS: Initiating trastuzumab more than 12 weeks from diagnosis has a negative impact on clinical outcome. Neo-adjuvant anti-HER2 therapy could be the optimal strategy to treat early stage HER2-positive breast cancer.
26 schema:genre research_article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N5b61158c6f0646e4981232210cfc5b11
30 N6e9aad8fc2234627946d2195f5efd2d3
31 sg:journal.1017082
32 schema:name Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project
33 schema:pagination 374-380
34 schema:productId N2a52dfd3fdd9458dabe14357419a44af
35 N3472cd4be7554f2c92c9deb59a3e26cc
36 N7b1faec9350141b6b87386f4c191a984
37 N8dd9497137ab480c99b5e445d9ce5fd8
38 Neb1f2cc318ee4f2d9f4a611e5a92c25a
39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104018608
40 https://doi.org/10.1038/s41416-018-0114-x
41 schema:sdDatePublished 2019-04-11T02:23
42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
43 schema:sdPublisher Ncea7423788e64e07b67ac1102f6c10e5
44 schema:url https://www.nature.com/articles/s41416-018-0114-x
45 sgo:license sg:explorer/license/
46 sgo:sdDataset articles
47 rdf:type schema:ScholarlyArticle
48 N0ced01f41bc04625bc30dad49ea2fcad rdf:first sg:person.01223342332.02
49 rdf:rest N184f3f2723ab46e596af613be21e3210
50 N0d9c0046747e4e3e83cda6372b94d23c rdf:first sg:person.014506351152.82
51 rdf:rest N890248321599422ca98219cab0e1c28e
52 N184f3f2723ab46e596af613be21e3210 rdf:first sg:person.01271372626.88
53 rdf:rest N34959528070e4200b364268ae334ba70
54 N254fbbca971f4689af9a308b222d2c38 rdf:first sg:person.07517721517.95
55 rdf:rest Nc4167e1eb20c448eb0ba4cec3381541b
56 N2a52dfd3fdd9458dabe14357419a44af schema:name pubmed_id
57 schema:value 29773838
58 rdf:type schema:PropertyValue
59 N3472cd4be7554f2c92c9deb59a3e26cc schema:name dimensions_id
60 schema:value pub.1104018608
61 rdf:type schema:PropertyValue
62 N34959528070e4200b364268ae334ba70 rdf:first sg:person.01112225310.09
63 rdf:rest N597687c0450e421b8db71f7ae46222ab
64 N3728204de32a435ca079b9cb67dab90c rdf:first sg:person.01130110642.77
65 rdf:rest N4777b87a223a465dbc1c404f69cd2de9
66 N4777b87a223a465dbc1c404f69cd2de9 rdf:first sg:person.01215015156.37
67 rdf:rest N8d580cb8ece6475aad84c7796898b3b1
68 N5405fc9af98b4bf88e6f2a46fa4b2148 rdf:first sg:person.01061741661.54
69 rdf:rest Ndc80b117868e4d72a6353b93ba25095f
70 N597687c0450e421b8db71f7ae46222ab rdf:first sg:person.07457762507.78
71 rdf:rest N5405fc9af98b4bf88e6f2a46fa4b2148
72 N5b61158c6f0646e4981232210cfc5b11 schema:issueNumber 3
73 rdf:type schema:PublicationIssue
74 N6e9aad8fc2234627946d2195f5efd2d3 schema:volumeNumber 119
75 rdf:type schema:PublicationVolume
76 N7b1faec9350141b6b87386f4c191a984 schema:name nlm_unique_id
77 schema:value 0370635
78 rdf:type schema:PropertyValue
79 N890248321599422ca98219cab0e1c28e rdf:first sg:person.01231037062.25
80 rdf:rest Nc327aef0a73b4fb0b8923274ffe6ffd9
81 N8a2caef833fb49a79b1c5d11d787eb6f schema:name Department of Medical Oncology, Agios Savvas Hospital, Athens, Greece
82 rdf:type schema:Organization
83 N8d580cb8ece6475aad84c7796898b3b1 rdf:first Nf14d6ff8749e4faa98105e71c5accc4f
84 rdf:rest Ne1c86058fa234937b679068190e66142
85 N8dd9497137ab480c99b5e445d9ce5fd8 schema:name doi
86 schema:value 10.1038/s41416-018-0114-x
87 rdf:type schema:PropertyValue
88 Nc327aef0a73b4fb0b8923274ffe6ffd9 rdf:first sg:person.0714465260.92
89 rdf:rest N3728204de32a435ca079b9cb67dab90c
90 Nc4167e1eb20c448eb0ba4cec3381541b rdf:first sg:person.011112662517.91
91 rdf:rest Nfccefb24e65548d699104f1723efec7d
92 Ncea7423788e64e07b67ac1102f6c10e5 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 Ndc2cbddc57f348faa82b3500398db147 rdf:first sg:person.01327776543.82
95 rdf:rest N0d9c0046747e4e3e83cda6372b94d23c
96 Ndc80b117868e4d72a6353b93ba25095f rdf:first sg:person.0731162517.77
97 rdf:rest N254fbbca971f4689af9a308b222d2c38
98 Ndd7f346663ab47f683f6b060e0d895d0 schema:name Aseptic Unit-Pharmacy Department, St Vincent’s Private Hospital, Dublin, Ireland
99 rdf:type schema:Organization
100 Ne1c86058fa234937b679068190e66142 rdf:first sg:person.01060164243.98
101 rdf:rest rdf:nil
102 Neb1f2cc318ee4f2d9f4a611e5a92c25a schema:name readcube_id
103 schema:value c281547657abea9cbb87857346b1af3b138de21906f9f91b87bb1355bed73619
104 rdf:type schema:PropertyValue
105 Nf106748d412b41b19789dbd47d36fb2d rdf:first sg:person.011176263127.23
106 rdf:rest Ndc2cbddc57f348faa82b3500398db147
107 Nf14d6ff8749e4faa98105e71c5accc4f schema:affiliation https://www.grid.ac/institutes/grid.477842.a
108 schema:familyName Amstrong
109 schema:givenName John
110 rdf:type schema:Person
111 Nfccefb24e65548d699104f1723efec7d rdf:first sg:person.010315302117.31
112 rdf:rest Nf106748d412b41b19789dbd47d36fb2d
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
117 schema:name Oncology and Carcinogenesis
118 rdf:type schema:DefinedTerm
119 sg:journal.1017082 schema:issn 0007-0920
120 1532-1827
121 schema:name British Journal of Cancer
122 rdf:type schema:Periodical
123 sg:person.010315302117.31 schema:affiliation Ndd7f346663ab47f683f6b060e0d895d0
124 schema:familyName Silva
125 schema:givenName Nuno
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010315302117.31
127 rdf:type schema:Person
128 sg:person.01060164243.98 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
129 schema:familyName Crown
130 schema:givenName John
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060164243.98
132 rdf:type schema:Person
133 sg:person.01061741661.54 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
134 schema:familyName Walshe
135 schema:givenName Janice
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061741661.54
137 rdf:type schema:Person
138 sg:person.011112662517.91 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
139 schema:familyName Hammond
140 schema:givenName Lisa
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011112662517.91
142 rdf:type schema:Person
143 sg:person.01112225310.09 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
144 schema:familyName Fennelly
145 schema:givenName David
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112225310.09
147 rdf:type schema:Person
148 sg:person.011176263127.23 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
149 schema:familyName McDonnell
150 schema:givenName Deirdre
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176263127.23
152 rdf:type schema:Person
153 sg:person.01130110642.77 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
154 schema:familyName Prichard
155 schema:givenName Ruth
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130110642.77
157 rdf:type schema:Person
158 sg:person.01215015156.37 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
159 schema:familyName Geraghty
160 schema:givenName James
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215015156.37
162 rdf:type schema:Person
163 sg:person.01223342332.02 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
164 schema:familyName Gullo
165 schema:givenName Giuseppe
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223342332.02
167 rdf:type schema:Person
168 sg:person.01231037062.25 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
169 schema:familyName McDermott
170 schema:givenName Enda W.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231037062.25
172 rdf:type schema:Person
173 sg:person.01271372626.88 schema:affiliation https://www.grid.ac/institutes/grid.15596.3e
174 schema:familyName Walsh
175 schema:givenName Naomi
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271372626.88
177 rdf:type schema:Person
178 sg:person.01327776543.82 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
179 schema:familyName Ballot
180 schema:givenName Josephine
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327776543.82
182 rdf:type schema:Person
183 sg:person.014506351152.82 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
184 schema:familyName Quinn
185 schema:givenName Cecily
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014506351152.82
187 rdf:type schema:Person
188 sg:person.0714465260.92 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
189 schema:familyName Evoy
190 schema:givenName Denis
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714465260.92
192 rdf:type schema:Person
193 sg:person.0731162517.77 schema:affiliation N8a2caef833fb49a79b1c5d11d787eb6f
194 schema:familyName Tryfonopoulos
195 schema:givenName Dimitrios
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731162517.77
197 rdf:type schema:Person
198 sg:person.07457762507.78 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
199 schema:familyName Bose
200 schema:givenName Reetesh
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07457762507.78
202 rdf:type schema:Person
203 sg:person.07517721517.95 schema:affiliation https://www.grid.ac/institutes/grid.412751.4
204 schema:familyName O’Mahony
205 schema:givenName Kate
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07517721517.95
207 rdf:type schema:Person
208 sg:pub.10.1007/s10549-016-3790-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009476877
209 https://doi.org/10.1007/s10549-016-3790-3
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1081983002 schema:CreativeWork
212 https://doi.org/10.1016/s0140-6736(09)61964-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038345999
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(11)61847-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043834514
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s1470-2045(16)00163-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018821239
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s1470-2045(17)30717-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092667029
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s1470-2045(17)30777-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099644234
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1056/nejmoa052122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035589584
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1056/nejmoa052306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014794593
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1056/nejmoa053028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043831613
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1056/nejmoa0910383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028192490
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1056/nejmoa1703643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085866538
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1080/2162402x.2015.1100790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058420648
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/annonc/mdr484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030384850
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/jnci/djh131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027173498
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1200/jco.2008.21.4577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036202282
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1200/jco.2009.23.0946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028123038
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1200/jco.2013.49.7693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041678017
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1200/jco.2015.62.1797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028580445
245 rdf:type schema:CreativeWork
246 https://www.grid.ac/institutes/grid.15596.3e schema:alternateName Dublin City University
247 schema:name National Institute for Cellular Biotechnology, Dublin City University (DCU), Dublin, Ireland
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.412751.4 schema:alternateName St. Vincent's University Hospital
250 schema:name Aseptic Unit-Pharmacy Department, St Vincent’s University Hospital, Dublin, Ireland
251 Cancer Clinical Research Trust, St Vincent’s University Hospital, Dublin, Ireland
252 Department of Medical Oncology, St Vincent’s University Hospital, Dublin, Ireland
253 Department of Pathology, St Vincent’s University Hospital, Dublin, Ireland
254 Department of Surgery, St Vincent’s University Hospital, Dublin, Ireland
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.477842.a schema:alternateName St. Luke's Hospital
257 schema:name Department of Radiation Oncology, St Luke’s Hospital, Dublin, Ireland
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.7886.1 schema:alternateName University College Dublin
260 schema:name Department of Medical Oncology, St Vincent’s University Hospital, Dublin, Ireland
261 School of Medicine, University College Dublin (UCD), Dublin, Ireland
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...