Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-09

AUTHORS

N. O. Elander, K. Aughton, P. Ghaneh, J. P. Neoptolemos, D. H. Palmer, T. F. Cox, F. Campbell, E. Costello, C. M. Halloran, J. R. Mackey, A. G. Scarfe, J. W. Valle, A. C. McDonald, R. Carter, N. C. Tebbutt, D. Goldstein, J. Shannon, C. Dervenis, B. Glimelius, M. Deakin, R. M. Charnley, A. Anthoney, M. M. Lerch, J. Mayerle, A. Oláh, M. W. Büchler, W. Greenhalf, for the European Study Group for Pancreatic Cancer

ABSTRACT

BackgroundDeoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma.MethodsImmunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups.ResultsNeither log-rank testing on dichotomised strata or Cox proportional hazard regression showed any relationship of DCTD or RRM1 expression levels to survival overall or by treatment group.ConclusionsExpression of either DCTD or RRM1 was not prognostic or predictive in patients with pancreatic adenocarcinoma who had had post-operative chemotherapy with either gemcitabine or 5-fluorouracil with folinic acid. More... »

PAGES

1084-1088

Journal

TITLE

British Journal of Cancer

ISSUE

8

VOLUME

118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0005-1

DOI

http://dx.doi.org/10.1038/s41416-018-0005-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101398151

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29523831


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