Pathological mechanisms and therapeutic outlooks for arthrofibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-26

AUTHORS

Kayley M. Usher, Sipin Zhu, Georgios Mavropalias, John A. Carrino, Jinmin Zhao, Jiake Xu

ABSTRACT

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract pouches, bursae and tendons, cause pain and prevent a normal range of joint motion, with devastating consequences for patient quality of life. Arthrofibrosis affects people of all ages, with published rates varying. The risk factors and best management strategies are largely unknown due to a poor understanding of the pathology and lack of diagnostic biomarkers. However, current research into the pathogenesis of fibrosis in organs now informs the understanding of arthrofibrosis. The process begins when stress signals stimulate immune cells. The resulting cascade of cytokines and mediators drives fibroblasts to differentiate into myofibroblasts, which secrete fibrillar collagens and transforming growth factor-β (TGF-β). Positive feedback networks then dysregulate processes that normally terminate healing processes. We propose two subtypes of arthrofibrosis occur: active arthrofibrosis and residual arthrofibrosis. In the latter the fibrogenic processes have resolved but the joint remains stiff. The best therapeutic approach for each subtype may differ significantly. Treatment typically involves surgery, however, a pharmacological approach to correct dysregulated cell signalling could be more effective. Recent research shows that myofibroblasts are capable of reversing differentiation, and understanding the mechanisms of pathogenesis and resolution will be essential for the development of cell-based treatments. Therapies with significant promise are currently available, with more in development, including those that inhibit TGF-β signalling and epigenetic modifications. This review focuses on pathogenesis of sterile arthrofibrosis and therapeutic treatments. More... »

PAGES

9

References to SciGraph publications

  • 2013-12-24. An emerging player in knee osteoarthritis: the infrapatellar fat pad in ARTHRITIS RESEARCH & THERAPY
  • 2015-06-20. Alterations in Hoffa’s fat pad induced by an inflammatory response following idealized anterior cruciate ligament surgery in INFLAMMATION RESEARCH
  • 2011-08-12. Arthrofibrosis after TKA - Influence factors on the absolute flexion and gain in flexion after manipulation under anaesthesia in BMC MUSCULOSKELETAL DISORDERS
  • 2016-06-10. Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition in SCIENTIFIC REPORTS
  • 1999-06. Inducible cyclooxygenase may have anti-inflammatory properties in NATURE MEDICINE
  • 2003-01. Alternative activation of macrophages in NATURE REVIEWS IMMUNOLOGY
  • 2017-07-14. NF-κB signaling in inflammation in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • 2016-04-25. TGF-β: the master regulator of fibrosis in NATURE REVIEWS NEPHROLOGY
  • 2017-02-23. In situ click chemistry generation of cyclooxygenase-2 inhibitors in NATURE COMMUNICATIONS
  • 2016-02-17. Predominance of synovial sensory nerve fibers in arthrofibrosis following total knee arthroplasty compared to osteoarthritis of the knee in JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
  • 2010-04-11. Influenza virus activates inflammasomes through intracellular M2 channel in NATURE IMMUNOLOGY
  • 2017-07-19. Regulation of inflammation by microbiota interactions with the host in NATURE IMMUNOLOGY
  • 2014-05-27. TGF-β signaling and the development of osteoarthritis in BONE RESEARCH
  • 2015-11-10. Fibrosis is a common outcome following total knee arthroplasty in SCIENTIFIC REPORTS
  • 2007-02-20. TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells in COMPARATIVE HEPATOLOGY
  • 2016-08-22. Sex differences in immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2017-11-13. IL-11 is a crucial determinant of cardiovascular fibrosis in NATURE
  • 2017-07-26. The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways in NATURE COMMUNICATIONS
  • 2007-07-24. A giant extrasynovial osteochondroma in the infrapatellar fat pad: end stage Hoffa’s disease in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2012-01. Evaluation and Treatment of Disorders of the Infrapatellar Fat Pad in SPORTS MEDICINE
  • 2015-02-09. Stretching Fibroblasts Remodels Fibronectin and Alters Cancer Cell Migration in SCIENTIFIC REPORTS
  • 2018-01-31. Transforming growth factor-β in stem cells and tissue homeostasis in BONE RESEARCH
  • 2017-01-16. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states in NATURE MEDICINE
  • 2017-07-19. Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome in NATURE IMMUNOLOGY
  • 2015-09-04. Dissecting fibrosis: therapeutic insights from the small-molecule toolbox in NATURE REVIEWS DRUG DISCOVERY
  • 2007-12-08. The Treatment with Antibody of TNF-α Reduces the Inflammation, Necrosis and Fibrosis in the Non-alcoholic Steatohepatitis Induced by Methionine- and Choline-deficient Diet in INFLAMMATION
  • 2013-05-19. Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis in NATURE MEDICINE
  • 2017-03-04. Arthrofibrosis after ACL reconstruction is best treated in a step-wise approach with early recognition and intervention: a systematic review in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2015-08-08. Protective Effect of Infliximab, a Tumor Necrosis Factor-Alfa Inhibitor, on Bleomycin-Induced Lung Fibrosis in Rats in INFLAMMATION
  • 2001-07. Lipid mediator class switching during acute inflammation: signals in resolution in NATURE IMMUNOLOGY
  • 2018-01-30. mTOR signaling in skeletal development and disease in BONE RESEARCH
  • 2013-01-02. HDAC inhibitors in experimental liver and kidney fibrosis in FIBROGENESIS & TISSUE REPAIR
  • 2012-07-06. Mechanisms of fibrosis: therapeutic translation for fibrotic disease in NATURE MEDICINE
  • 2004-08. Fibrotic disease and the TH1/TH2 paradigm in NATURE REVIEWS IMMUNOLOGY
  • 2014-05-28. NLRP3 inflammasome activation is required for fibrosis development in NAFLD in JOURNAL OF MOLECULAR MEDICINE
  • 2007-06. Resolvin E1 and protectin D1 activate inflammation-resolution programmes in NATURE
  • 2016-07-27. Epithelial-mesenchymal transition in tissue repair and fibrosis in CELL AND TISSUE RESEARCH
  • 2004-09-18. α-Smooth muscle actin containing contractile fibroblastic cells in human knee arthrofibrosis tissue in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2015-07-28. Human xylosyltransferases – mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy in SCIENTIFIC REPORTS
  • 2011-01-09. Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis in NATURE GENETICS
  • 2015-09-26. Procedural intervention for arthrofibrosis after ACL reconstruction: trends over two decades in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2016-03-04. Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis in RESPIRATORY RESEARCH
  • 2010-08-09. Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo in LABORATORY INVESTIGATION
  • 2009-01-30. Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells in FIBROGENESIS & TISSUE REPAIR
  • 2009-12-15. Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis _ state of the art in FIBROGENESIS & TISSUE REPAIR
  • 2015-09-30. TNFα in Liver Fibrosis in CURRENT PATHOBIOLOGY REPORTS
  • 2013-09-05. Posttraumatic elbow contractures: targeting neuroinflammatory fibrogenic mechanisms in JOURNAL OF ORTHOPAEDIC SCIENCE
  • 2010-09-01. Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty in FIBROGENESIS & TISSUE REPAIR
  • 2016-03-01. Current research on pharmacologic and regenerative therapies for osteoarthritis in BONE RESEARCH
  • 2005-08. Regulation of immune responses by L-arginine metabolism in NATURE REVIEWS IMMUNOLOGY
  • 2012-06-28. Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor β signaling in MODERN RHEUMATOLOGY
  • 2002-05. Myofibroblasts and mechano-regulation of connective tissue remodelling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1990-03. Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis in NATURE
  • 2009-07-07. Stiffness in total knee arthroplasty in JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
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    http://scigraph.springernature.com/pub.10.1038/s41413-019-0047-x

    DOI

    http://dx.doi.org/10.1038/s41413-019-0047-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112988268

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30937213


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