Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-09-12

AUTHORS

Yoshiko Atsuta, Junichi Sugita, Hirohisa Nakamae, Yumiko Maruyama, Ken Ishiyama, Souichi Shiratori, Takahiro Fukuda, Mio Kurata, Naoki Shingai, Yukiyasu Ozawa, Masayoshi Masuko, Koji Nagafuji, Satoru Takada, Shinichi Kako, Yoshinobu Kanda, Junya Kanda, Tatsuo Ichinohe, Takanori Teshima

ABSTRACT

We retrospectively compared outcomes of unrelated donor bone marrow transplant (UBMT) and HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haploPBSCT) using the Japanese registry data. Recipients of first HCT for acute leukemia and myelodysplastic syndromes between 2012 and 2015 were included. The analyzed subjects comprised UBMT recipients with 8/8 matched HLA alleles (n = 1470), 7/8 matched alleles (n = 859), 6/8 matched alleles (n = 186), and recipients of PTCy-haploPBSCT (n = 133). In multivariate analyses with 8/8 matched UBMT as the reference, PTCy-haploPBSCT showed similar overall mortality, decreased risk of non-relapse mortality (NRM), increased risk of relapse, and decreased risk of grade II–IV acute graft-versus-host disease (GVHD) and chronic GVHD. Adjusted probabilities for 8/8 matched UBMT, PTCy-haploPBSCT, and 7/8 and 6/8 matched UBMT groups at 2 years post-transplant were 61%, 60%, 58%, and 52% for overall survival, 23%, 28%, 21%, and 19% for relapse, and 20%, 7%, 24%, and 33% for NRM. PTCy-haploPBSCT was associated with remarkably low NRM, contributing to survival outcomes that were comparable to 8/8 matched UBMT. The higher relapse rate in the PTCy-haploPBSCT group might be associated with the higher proportion of high-risk patients. PTCy-haploPBSCT may be a viable alternative when HLA-matched related donors are not available. More... »

PAGES

1-7

Journal

TITLE

Bone Marrow Transplantation

ISSUE

N/A

VOLUME

N/A

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-022-01822-3

DOI

http://dx.doi.org/10.1038/s41409-022-01822-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150926658

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36097040


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan", 
            "Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01146754030.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugita", 
        "givenName": "Junichi", 
        "id": "sg:person.01154070542.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154070542.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Osaka City University Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.470114.7", 
          "name": [
            "Hematology, Osaka City University Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "Hirohisa", 
        "id": "sg:person.01014223462.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412814.a", 
          "name": [
            "Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maruyama", 
        "givenName": "Yumiko", 
        "id": "sg:person.010321122573.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321122573.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412002.5", 
          "name": [
            "Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishiyama", 
        "givenName": "Ken", 
        "id": "sg:person.01203713705.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203713705.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shiratori", 
        "givenName": "Souichi", 
        "id": "sg:person.0653535643.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuda", 
        "givenName": "Takahiro", 
        "id": "sg:person.016452523632.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan", 
          "id": "http://www.grid.ac/institutes/grid.511247.4", 
          "name": [
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurata", 
        "givenName": "Mio", 
        "id": "sg:person.01317204426.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317204426.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shingai", 
        "givenName": "Naoki", 
        "id": "sg:person.0642033705.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642033705.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Yukiyasu", 
        "id": "sg:person.01165712107.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematopoietic Cell Therapy, Niigata University Medical and Dental Hospital, Niigata, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412181.f", 
          "name": [
            "Department of Hematopoietic Cell Therapy, Niigata University Medical and Dental Hospital, Niigata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masuko", 
        "givenName": "Masayoshi", 
        "id": "sg:person.01274407522.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274407522.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology and Oncology, Department of Medicine, Kurume University Hospital, Kurume, Japan", 
          "id": "http://www.grid.ac/institutes/grid.470127.7", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, Kurume University Hospital, Kurume, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagafuji", 
        "givenName": "Koji", 
        "id": "sg:person.01236323766.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236323766.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416616.2", 
          "name": [
            "Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Satoru", 
        "id": "sg:person.0624156521.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624156521.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415020.2", 
          "name": [
            "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kako", 
        "givenName": "Shinichi", 
        "id": "sg:person.0675760325.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Jichi Medical University, Shimotsuke, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Hematology, Jichi Medical University, Shimotsuke, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanda", 
        "givenName": "Yoshinobu", 
        "id": "sg:person.0617055140.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanda", 
        "givenName": "Junya", 
        "id": "sg:person.01100640630.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichinohe", 
        "givenName": "Tatsuo", 
        "id": "sg:person.0623252373.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teshima", 
        "givenName": "Takanori", 
        "id": "sg:person.0777004671.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777004671.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12185-015-1894-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036307316", 
          "https://doi.org/10.1007/s12185-015-1894-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41409-020-01065-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1131125476", 
          "https://doi.org/10.1038/s41409-020-01065-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1532/ijh97.06239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054504897", 
          "https://doi.org/10.1532/ijh97.06239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41409-018-0279-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106020930", 
          "https://doi.org/10.1038/s41409-018-0279-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2015.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005138628", 
          "https://doi.org/10.1038/nrclinonc.2015.128"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-09-12", 
    "datePublishedReg": "2022-09-12", 
    "description": "We retrospectively compared outcomes of unrelated donor bone marrow transplant (UBMT) and HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haploPBSCT) using the Japanese registry data. Recipients of first HCT for acute leukemia and myelodysplastic syndromes between 2012 and 2015 were included. The analyzed subjects comprised UBMT recipients with 8/8 matched HLA alleles (n\u2009=\u20091470), 7/8 matched alleles (n\u2009=\u2009859), 6/8 matched alleles (n\u2009=\u2009186), and recipients of PTCy-haploPBSCT (n\u2009=\u2009133). In multivariate analyses with 8/8 matched UBMT as the reference, PTCy-haploPBSCT showed similar overall mortality, decreased risk of non-relapse mortality (NRM), increased risk of relapse, and decreased risk of grade II\u2013IV acute graft-versus-host disease (GVHD) and chronic GVHD. Adjusted probabilities for 8/8 matched UBMT, PTCy-haploPBSCT, and 7/8 and 6/8 matched UBMT groups at 2 years post-transplant were 61%, 60%, 58%, and 52% for overall survival, 23%, 28%, 21%, and 19% for relapse, and 20%, 7%, 24%, and 33% for NRM. PTCy-haploPBSCT was associated with remarkably low NRM, contributing to survival outcomes that were comparable to 8/8 matched UBMT. The higher relapse rate in the PTCy-haploPBSCT group might be associated with the higher proportion of high-risk patients. PTCy-haploPBSCT may be a viable alternative when HLA-matched related donors are not available.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41409-022-01822-3", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "unrelated donor bone marrow transplant", 
      "non-relapse mortality", 
      "stem cell transplantation", 
      "survival outcomes", 
      "cell transplantation", 
      "HLA-haploidentical peripheral blood stem cell transplantation", 
      "peripheral blood stem cell transplantation", 
      "lower non-relapse mortality", 
      "haploidentical stem cell transplantation", 
      "blood stem cell transplantation", 
      "donor bone marrow transplant", 
      "unrelated bone marrow transplantation", 
      "post-transplant cyclophosphamide", 
      "Japanese registry data", 
      "comparable survival outcomes", 
      "high-risk patients", 
      "bone marrow transplantation", 
      "bone marrow transplant", 
      "risk of relapse", 
      "high relapse rate", 
      "similar overall mortality", 
      "first HCT", 
      "acute graft", 
      "chronic GVHD", 
      "host disease", 
      "overall survival", 
      "overall mortality", 
      "relapse rate", 
      "related donors", 
      "marrow transplantation", 
      "marrow transplant", 
      "myelodysplastic syndrome", 
      "acute leukemia", 
      "grade II", 
      "registry data", 
      "HLA alleles", 
      "multivariate analysis", 
      "transplantation", 
      "recipients", 
      "relapse", 
      "outcomes", 
      "mortality", 
      "risk", 
      "higher proportion", 
      "GVHD", 
      "cyclophosphamide", 
      "alleles", 
      "patients", 
      "transplant", 
      "group", 
      "HLA", 
      "syndrome", 
      "graft", 
      "leukemia", 
      "disease", 
      "Hct", 
      "survival", 
      "subjects", 
      "viable alternative", 
      "years", 
      "proportion", 
      "donors", 
      "rate", 
      "data", 
      "alternative", 
      "analysis", 
      "reference", 
      "probability"
    ], 
    "name": "Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation", 
    "pagination": "1-7", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1150926658"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41409-022-01822-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "36097040"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41409-022-01822-3", 
      "https://app.dimensions.ai/details/publication/pub.1150926658"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_942.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41409-022-01822-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-022-01822-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-022-01822-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-022-01822-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-022-01822-3'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      96 URIs      83 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41409-022-01822-3 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N219c17672942463f8d50cbea741fe369
4 schema:citation sg:pub.10.1007/s12185-015-1894-x
5 sg:pub.10.1038/nrclinonc.2015.128
6 sg:pub.10.1038/s41409-018-0279-1
7 sg:pub.10.1038/s41409-020-01065-0
8 sg:pub.10.1532/ijh97.06239
9 schema:datePublished 2022-09-12
10 schema:datePublishedReg 2022-09-12
11 schema:description We retrospectively compared outcomes of unrelated donor bone marrow transplant (UBMT) and HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide (PTCy-haploPBSCT) using the Japanese registry data. Recipients of first HCT for acute leukemia and myelodysplastic syndromes between 2012 and 2015 were included. The analyzed subjects comprised UBMT recipients with 8/8 matched HLA alleles (n = 1470), 7/8 matched alleles (n = 859), 6/8 matched alleles (n = 186), and recipients of PTCy-haploPBSCT (n = 133). In multivariate analyses with 8/8 matched UBMT as the reference, PTCy-haploPBSCT showed similar overall mortality, decreased risk of non-relapse mortality (NRM), increased risk of relapse, and decreased risk of grade II–IV acute graft-versus-host disease (GVHD) and chronic GVHD. Adjusted probabilities for 8/8 matched UBMT, PTCy-haploPBSCT, and 7/8 and 6/8 matched UBMT groups at 2 years post-transplant were 61%, 60%, 58%, and 52% for overall survival, 23%, 28%, 21%, and 19% for relapse, and 20%, 7%, 24%, and 33% for NRM. PTCy-haploPBSCT was associated with remarkably low NRM, contributing to survival outcomes that were comparable to 8/8 matched UBMT. The higher relapse rate in the PTCy-haploPBSCT group might be associated with the higher proportion of high-risk patients. PTCy-haploPBSCT may be a viable alternative when HLA-matched related donors are not available.
12 schema:genre article
13 schema:isAccessibleForFree false
14 schema:isPartOf sg:journal.1096890
15 schema:keywords GVHD
16 HLA
17 HLA alleles
18 HLA-haploidentical peripheral blood stem cell transplantation
19 Hct
20 Japanese registry data
21 acute graft
22 acute leukemia
23 alleles
24 alternative
25 analysis
26 blood stem cell transplantation
27 bone marrow transplant
28 bone marrow transplantation
29 cell transplantation
30 chronic GVHD
31 comparable survival outcomes
32 cyclophosphamide
33 data
34 disease
35 donor bone marrow transplant
36 donors
37 first HCT
38 grade II
39 graft
40 group
41 haploidentical stem cell transplantation
42 high relapse rate
43 high-risk patients
44 higher proportion
45 host disease
46 leukemia
47 lower non-relapse mortality
48 marrow transplant
49 marrow transplantation
50 mortality
51 multivariate analysis
52 myelodysplastic syndrome
53 non-relapse mortality
54 outcomes
55 overall mortality
56 overall survival
57 patients
58 peripheral blood stem cell transplantation
59 post-transplant cyclophosphamide
60 probability
61 proportion
62 rate
63 recipients
64 reference
65 registry data
66 relapse
67 relapse rate
68 related donors
69 risk
70 risk of relapse
71 similar overall mortality
72 stem cell transplantation
73 subjects
74 survival
75 survival outcomes
76 syndrome
77 transplant
78 transplantation
79 unrelated bone marrow transplantation
80 unrelated donor bone marrow transplant
81 viable alternative
82 years
83 schema:name Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation
84 schema:pagination 1-7
85 schema:productId N769be045df114ce69277aaa9429baec9
86 Ne48d4bdbd0a041d4a7e4b8f6b9913de6
87 Nfe92f2c0851e475a9c92743b24a3e825
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1150926658
89 https://doi.org/10.1038/s41409-022-01822-3
90 schema:sdDatePublished 2022-12-01T06:44
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N7934d5c76dfe4fa0a2b42591ec7df42e
93 schema:url https://doi.org/10.1038/s41409-022-01822-3
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N219c17672942463f8d50cbea741fe369 rdf:first sg:person.01146754030.08
98 rdf:rest Nd876adbf326042778686c202534a67e7
99 N2b142506c46b40e28db64ae1916cc06d rdf:first sg:person.016452523632.46
100 rdf:rest Nbf7083f433b04e9d893772bde35b8e21
101 N55e4913c457640ada65a0f45149212ec rdf:first sg:person.01236323766.31
102 rdf:rest N8cc380f13c054dcab4939d0e518f2543
103 N660af3fb871147e8807581f3f2bc5aa1 rdf:first sg:person.01014223462.98
104 rdf:rest N6bbfac2c23104335a432961759817180
105 N6b6c6c680bff406d813a5ec5ef11deb5 rdf:first sg:person.01100640630.10
106 rdf:rest Naadfc2dde52644208994694d3dfa34b1
107 N6bbfac2c23104335a432961759817180 rdf:first sg:person.010321122573.82
108 rdf:rest Nb7c55d3a90674be5b89071e477492eee
109 N702b59204ce94280b5f6e07676acf42b rdf:first sg:person.01165712107.72
110 rdf:rest N76e1191e34c649ba8a590ec56ba79624
111 N769be045df114ce69277aaa9429baec9 schema:name doi
112 schema:value 10.1038/s41409-022-01822-3
113 rdf:type schema:PropertyValue
114 N76e1191e34c649ba8a590ec56ba79624 rdf:first sg:person.01274407522.85
115 rdf:rest N55e4913c457640ada65a0f45149212ec
116 N78609c9bb8b540e9ad20451d65b4af7b rdf:first sg:person.0642033705.29
117 rdf:rest N702b59204ce94280b5f6e07676acf42b
118 N7934d5c76dfe4fa0a2b42591ec7df42e schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N7a55e366193c42959397d25b19fd4d7f rdf:first sg:person.0675760325.07
121 rdf:rest Nb277ff262df94014a5607658855c46a1
122 N8cc380f13c054dcab4939d0e518f2543 rdf:first sg:person.0624156521.99
123 rdf:rest N7a55e366193c42959397d25b19fd4d7f
124 N9a4dcb2889174968af41a11dd49e656f rdf:first sg:person.0653535643.01
125 rdf:rest N2b142506c46b40e28db64ae1916cc06d
126 Naadfc2dde52644208994694d3dfa34b1 rdf:first sg:person.0623252373.33
127 rdf:rest Nb37826e2bb8e4908967a1c4ef0100496
128 Nb277ff262df94014a5607658855c46a1 rdf:first sg:person.0617055140.49
129 rdf:rest N6b6c6c680bff406d813a5ec5ef11deb5
130 Nb37826e2bb8e4908967a1c4ef0100496 rdf:first sg:person.0777004671.06
131 rdf:rest rdf:nil
132 Nb7c55d3a90674be5b89071e477492eee rdf:first sg:person.01203713705.56
133 rdf:rest N9a4dcb2889174968af41a11dd49e656f
134 Nbf7083f433b04e9d893772bde35b8e21 rdf:first sg:person.01317204426.94
135 rdf:rest N78609c9bb8b540e9ad20451d65b4af7b
136 Nd876adbf326042778686c202534a67e7 rdf:first sg:person.01154070542.38
137 rdf:rest N660af3fb871147e8807581f3f2bc5aa1
138 Ne48d4bdbd0a041d4a7e4b8f6b9913de6 schema:name pubmed_id
139 schema:value 36097040
140 rdf:type schema:PropertyValue
141 Nfe92f2c0851e475a9c92743b24a3e825 schema:name dimensions_id
142 schema:value pub.1150926658
143 rdf:type schema:PropertyValue
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
148 schema:name Cardiorespiratory Medicine and Haematology
149 rdf:type schema:DefinedTerm
150 sg:journal.1096890 schema:issn 0268-3369
151 1476-5365
152 schema:name Bone Marrow Transplantation
153 schema:publisher Springer Nature
154 rdf:type schema:Periodical
155 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.470114.7
156 schema:familyName Nakamae
157 schema:givenName Hirohisa
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
159 rdf:type schema:Person
160 sg:person.010321122573.82 schema:affiliation grid-institutes:grid.412814.a
161 schema:familyName Maruyama
162 schema:givenName Yumiko
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321122573.82
164 rdf:type schema:Person
165 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.258799.8
166 schema:familyName Kanda
167 schema:givenName Junya
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
169 rdf:type schema:Person
170 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.411234.1
171 schema:familyName Atsuta
172 schema:givenName Yoshiko
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
174 rdf:type schema:Person
175 sg:person.01154070542.38 schema:affiliation grid-institutes:grid.412167.7
176 schema:familyName Sugita
177 schema:givenName Junichi
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154070542.38
179 rdf:type schema:Person
180 sg:person.01165712107.72 schema:affiliation grid-institutes:None
181 schema:familyName Ozawa
182 schema:givenName Yukiyasu
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72
184 rdf:type schema:Person
185 sg:person.01203713705.56 schema:affiliation grid-institutes:grid.412002.5
186 schema:familyName Ishiyama
187 schema:givenName Ken
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203713705.56
189 rdf:type schema:Person
190 sg:person.01236323766.31 schema:affiliation grid-institutes:grid.470127.7
191 schema:familyName Nagafuji
192 schema:givenName Koji
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236323766.31
194 rdf:type schema:Person
195 sg:person.01274407522.85 schema:affiliation grid-institutes:grid.412181.f
196 schema:familyName Masuko
197 schema:givenName Masayoshi
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274407522.85
199 rdf:type schema:Person
200 sg:person.01317204426.94 schema:affiliation grid-institutes:grid.511247.4
201 schema:familyName Kurata
202 schema:givenName Mio
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317204426.94
204 rdf:type schema:Person
205 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
206 schema:familyName Fukuda
207 schema:givenName Takahiro
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
209 rdf:type schema:Person
210 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.410804.9
211 schema:familyName Kanda
212 schema:givenName Yoshinobu
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
214 rdf:type schema:Person
215 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
216 schema:familyName Ichinohe
217 schema:givenName Tatsuo
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
219 rdf:type schema:Person
220 sg:person.0624156521.99 schema:affiliation grid-institutes:grid.416616.2
221 schema:familyName Takada
222 schema:givenName Satoru
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624156521.99
224 rdf:type schema:Person
225 sg:person.0642033705.29 schema:affiliation grid-institutes:grid.415479.a
226 schema:familyName Shingai
227 schema:givenName Naoki
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642033705.29
229 rdf:type schema:Person
230 sg:person.0653535643.01 schema:affiliation grid-institutes:grid.412167.7
231 schema:familyName Shiratori
232 schema:givenName Souichi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01
234 rdf:type schema:Person
235 sg:person.0675760325.07 schema:affiliation grid-institutes:grid.415020.2
236 schema:familyName Kako
237 schema:givenName Shinichi
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07
239 rdf:type schema:Person
240 sg:person.0777004671.06 schema:affiliation grid-institutes:grid.412167.7
241 schema:familyName Teshima
242 schema:givenName Takanori
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777004671.06
244 rdf:type schema:Person
245 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
246 https://doi.org/10.1007/s12185-015-1894-x
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nrclinonc.2015.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005138628
249 https://doi.org/10.1038/nrclinonc.2015.128
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/s41409-018-0279-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106020930
252 https://doi.org/10.1038/s41409-018-0279-1
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/s41409-020-01065-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131125476
255 https://doi.org/10.1038/s41409-020-01065-0
256 rdf:type schema:CreativeWork
257 sg:pub.10.1532/ijh97.06239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054504897
258 https://doi.org/10.1532/ijh97.06239
259 rdf:type schema:CreativeWork
260 grid-institutes:None schema:alternateName Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan
261 schema:name Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan
262 rdf:type schema:Organization
263 grid-institutes:grid.257022.0 schema:alternateName Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
264 schema:name Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
265 rdf:type schema:Organization
266 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
267 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
268 rdf:type schema:Organization
269 grid-institutes:grid.272242.3 schema:alternateName Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
270 schema:name Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
271 rdf:type schema:Organization
272 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology, Jichi Medical University, Shimotsuke, Japan
273 schema:name Division of Hematology, Jichi Medical University, Shimotsuke, Japan
274 rdf:type schema:Organization
275 grid-institutes:grid.411234.1 schema:alternateName Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
276 schema:name Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
277 Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
278 rdf:type schema:Organization
279 grid-institutes:grid.412002.5 schema:alternateName Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
280 schema:name Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
281 rdf:type schema:Organization
282 grid-institutes:grid.412167.7 schema:alternateName Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
283 schema:name Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
284 rdf:type schema:Organization
285 grid-institutes:grid.412181.f schema:alternateName Department of Hematopoietic Cell Therapy, Niigata University Medical and Dental Hospital, Niigata, Japan
286 schema:name Department of Hematopoietic Cell Therapy, Niigata University Medical and Dental Hospital, Niigata, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.412814.a schema:alternateName Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
289 schema:name Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
290 rdf:type schema:Organization
291 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
292 schema:name Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
293 rdf:type schema:Organization
294 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
295 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
296 rdf:type schema:Organization
297 grid-institutes:grid.416616.2 schema:alternateName Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
298 schema:name Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
299 rdf:type schema:Organization
300 grid-institutes:grid.470114.7 schema:alternateName Hematology, Osaka City University Hospital, Osaka, Japan
301 schema:name Hematology, Osaka City University Hospital, Osaka, Japan
302 rdf:type schema:Organization
303 grid-institutes:grid.470127.7 schema:alternateName Division of Hematology and Oncology, Department of Medicine, Kurume University Hospital, Kurume, Japan
304 schema:name Division of Hematology and Oncology, Department of Medicine, Kurume University Hospital, Kurume, Japan
305 rdf:type schema:Organization
306 grid-institutes:grid.511247.4 schema:alternateName Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
307 schema:name Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...