Comparable survival outcomes with haploidentical stem cell transplantation and cord blood transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-08-20

AUTHORS

Junichi Sugita, Yoshiko Atsuta, Hirohisa Nakamae, Yumiko Maruyama, Ken Ishiyama, Souichi Shiratori, Takahiro Fukuda, Mio Kurata, Naoki Shingai, Yukiyasu Ozawa, Masayoshi Masuko, Koji Nagafuji, Naoyuki Uchida, Masatsugu Tanaka, Makoto Onizuka, Junya Kanda, Takafumi Kimura, Tatsuo Ichinohe, Takanori Teshima

ABSTRACT

HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) and umbilical cord blood transplantation (UCBT) are alternative to HLA-matched stem cell transplantation. We conducted a matched-pair analysis of PTCy-haplo and UCBT using the Japanese registry data. We identified 136 patients aged between 16 and 69 years who received PTCy-haplo as their first transplantation for acute leukemia or myelodysplastic syndromes. Control group included 408 UCBT recipients selected to match the PTCy-haplo group. Overall and relapse-free survival probabilities at 2 years were comparable between the PTCy-haplo and UCBT groups: 55% vs. 53% for overall survival (p = 0.46), and 47% vs. 48% for relapse-free survival (p = 0.79), respectively. The cumulative incidence of relapse was significantly higher (43% vs. 29%, respectively, p = 0.006), while the cumulative incidence of non-relapse mortality (NRM) was significantly lower (9% vs. 23%, respectively, p < 0.001) in the PTCy-haplo group. The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) was lower in the PTCy-haplo group compared to the UCBT group (29% vs. 41%, respectively, p = 0.016), while those of grade III-IV acute GVHD and chronic GVHD were not statistically different between the two groups. Our results suggest that both PTCy-haplo and UCBT are viable alternatives to HLA-matched stem cell transplantation. More... »

PAGES

1681-1688

References to SciGraph publications

Journal

TITLE

Bone Marrow Transplantation

ISSUE

11

VOLUME

57

Author Affiliations

  • Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
  • Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
  • Hematology, Osaka City University Hospital, Osaka, Japan
  • Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
  • Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan
  • Department of Hematopoietic Cell Therapy, Niigata University Medical and Dental Hospital, Niigata, Japan
  • Division of Hematology and Oncology, Department of Medicine, Kurume University Hospital, Kurume, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-022-01770-y

    DOI

    http://dx.doi.org/10.1038/s41409-022-01770-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1150378138

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35987912


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