Allogeneic hematopoietic cell transplantation in patients with therapy-related myeloid neoplasm after breast cancer: a study of the Chronic Malignancies Working ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-04-22

AUTHORS

Mitja Nabergoj, Katya Mauff, Dietrich Beelen, Arnold Ganser, Nicolaus Kröger, Friedrich Stölzel, Jürgen Finke, Jakob Passweg, Jan Cornelissen, Natalie Schub, Joan Hendrik Veelken, Yves Beguin, Keith Wilson, Tsila Zuckerman, Mathilde Hunault-Berger, Bruno Lioure, Rocio Parody Porras, Pascal Turlure, Tessa Kerre, Linda Koster, Patrick J. Hayden, Francesco Onida, Christof Scheid, Yves Chalandon, Marie Robin, Ibrahim Yakoub-Agha

ABSTRACT

We performed a registry study on therapy-related myeloid neoplasm (t-MN), both therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant (allo-HCT). Of 252 identified female patients (median age 57 years), 77% were transplanted for t-AML and 23% for t-MDS, with a median time from breast cancer diagnosis to the diagnosis of tMN and subsequent allo-HCT of 3.7 and 4.6 years, respectively. At transplant, 191 patients were in remission for breast cancer, while 4 were not (57 missing). T-MN was in a complete remission at the time of transplant in 67% of patients. 2-year overall survival, relapse free-survival, relapse incidence and non-relapse mortality were 50%, 45%, 33%, and 22%, respectively. Multivariable analysis revealed that if the t-MN was not in CR pre-transplant, this was associated with lower OS, RFS, and a higher relapse incidence. Seventeen cases of breast cancer recurrence were recorded after a median of 2.4 years post-transplant, and relapse of primary breast cancer accounted for 7% of deaths. This study indicates that allo-HCT for t-MN following treatment for breast cancer shows encouraging transplant outcomes. The incidence of breast cancer relapse post-transplant remains a cause for concern. More... »

PAGES

1072-1078

Journal

TITLE

Bone Marrow Transplantation

ISSUE

7

VOLUME

57

Author Affiliations

  • Hematology Service, Institut Central des Hôpitaux (ICH), Hôpital du Valais, Sion, Switzerland
  • EBMT Statistical Unit, Leiden, the Netherlands
  • Department of Bone Marrow Transplantation, Universitätsklinikum Essen, Essen, Germany
  • Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
  • University Hospital Eppendorf, Hamburg, Germany
  • Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany
  • Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany
  • University Hospital, Basel, Switzerland
  • Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands
  • Division for Stem Cell Transplantation and Immunotherapy, University Hospital of Schleswig-Holstein, Kiel, Germany
  • Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands
  • Department of Hematology, CHU and University of Liège, Liège, Belgium
  • Department of Hematology, University Hospital of Wales, Heath Park, Cardiff, Wales, UK
  • Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
  • CHRU Angers, Angers, France
  • Department of Hematology, ICANS, Strasbourg, France
  • Deparment of Clinical Hematalogy, ICO-Hospital Duran i Reynals, Barcelona, Spain
  • Service d’Hématologie Clinique et Thérapie Cellulaire, Centre Hospitalier Universitaire, Limoges, France
  • Department of Hematology, Ghent University Hospital, Ghent, Belgium
  • EBMT Date Office, Leiden, the Netherlands
  • Department of Hematology, Trinity College Dublin, St. James’s Hospital, Dublin, Ireland
  • Hematology-BMT Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico—University of Milan, Milan, Italy
  • University Hospital Koeln, Cologne, Germany
  • Division of Hematology, Hôpitaux Universitaires de Genève and Faculty of Medicine, University of Geneva, Geneva, Switzerland
  • Hôpital Saint-Louis, APHP, Université Paris 7, Paris, France
  • CHU de Lille, Univ Lille, INSERM U1286, INFINITE, 59000, Lille, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-022-01686-7

    DOI

    http://dx.doi.org/10.1038/s41409-022-01686-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147315179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35459878


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