Impact of in vivo T-cell depletion in patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplant: a registry study ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-02-26

AUTHORS

Edouard Forcade, Sylvie Chevret, Jürgen Finke, Gerhard Ehninger, Francis Ayuk, Dietrich Beelen, Linda Koster, Arnold Ganser, Liisa Volin, Henrik Sengeloev, Mauricette Michallet, Johanna Tischer, Pavel Jindra, Maria Jesús Pascual Cascon, Yener Koc, Mutlu Arat, Agnieszka Tomaszewska, Patrick Hayden, Theo de Witte, Ibrahim Yakoub-Agha, Nicolaus Kröger, Marie Robin

ABSTRACT

While in vivo T-cell depletion (TCD) is widely used, its benefit in patients with MDS still remains a matter of debate. This study evaluates the impact of TCD on outcomes, and compares ATG and alemtuzumab, in patients with MDS. 1284 patients from the EBMT registry were included in this study with 470 patients in the no-TCD group and 814 in the TCD group (alemtuzumab N = 168; ATG N = 646). At 6 months, aGVHD III-IV cumulative incidences (CI) for no-TCD, ATG or alemtuzumab groups were 13% vs 14% vs 11% (ns), respectively. At 5 years, CI of chronic GVHD were 64% vs 52% vs 51% (p < 0.00017); and CI of relapse was 23% vs 25% vs 39% (p < 0.0001) for no TCD, ATG and alemtuzumab respectively; OS was 47% vs 46% vs 34% (p = 0.009) respectively; and GRFS was 21% vs 28% and 20% (p = 0.045) respectively. In multivariable analysis, ATG improved GRFS, and alemtuzumab decreased OS. Both ATG and alemtuzumab decreased risk of chronic GVHD, but the increased risk of relapse with alemtuzumab is associated with a poor GRFS and suggest to not use alemtuzumab in the setting of allo-SCT for high risk disease. More... »

PAGES

768-774

Journal

TITLE

Bone Marrow Transplantation

ISSUE

5

VOLUME

57

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-022-01620-x

DOI

http://dx.doi.org/10.1038/s41409-022-01620-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1145866740

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35220412


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376 grid-institutes:grid.475435.4 schema:alternateName Rigshospitalet, Copenhagen, Denmark
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379 grid-institutes:grid.476306.0 schema:alternateName EBMT Data Office, Leiden, The Netherlands
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382 grid-institutes:grid.503367.4 schema:alternateName CHU de Lille, université de Lille, LIRIC, Inserm U995, 59000, Lille, France
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386 schema:name Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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