Disease-specific impact of anti-thymocyte globulin in allogeneic hematopoietic cell transplantation: a nationwide retrospective study on behalf of the JSTCT, transplant ... View Full Text


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Article Info

DATE

2022-01-17

AUTHORS

Shigeo Fuji, Tsuneaki Hirakawa, Kuniko Takano, Noriko Doki, Masashi Sawa, Yoshinobu Kanda, Naoyuki Uchida, Takahide Ara, Toshihiro Miyamoto, Tetsuya Eto, Ken-ichi Matsuoka, Toshiro Kawakita, Yukiyasu Ozawa, Yuta Katayama, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Hideki Nakasone

ABSTRACT

The disease-specific impact of anti-thymocyte globulin (ATG) in allogeneic hematopoietic cell transplantation (allo-HCT) has not been determined. We retrospectively assessed the impact of ATG in allo-HCT using nationwide registry data from the Japan Society for Transplantation and Cellular Therapy. We included patients who received their first allo-HCT between 2007 and 2018 for acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or malignant lymphoma (ML). In total, 8747 patients were included: 7635 patients did not receive ATG and 1112 patients received ATG as GVHD prophylaxis. The median follow-up period of surviving patients was 1457 days. There was no significant impact of pretransplant ATG on the OS or NRM rates in patients with ALL, AML, or ML. In patients with MDS, the probability of 3-year OS was 53.3% in the non-ATG group and 64.2% in the ATG group (P = 0.001). The cumulative incidence rates of relapse and NRM at 3 years were 14.2% and 30.3% (95% CI 27.2–33.3%), respectively, in the non-ATG group and 17.1% and 18.1% in the ATG group (P = 0.15 and P < 0.001). The same finding was observed in a propensity-score matched cohort. Our study suggests that the clinical benefit of ATG could vary among hematological diseases. More... »

PAGES

479-486

Journal

TITLE

Bone Marrow Transplantation

ISSUE

3

VOLUME

57

Author Affiliations

  • Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
  • Department of Hematology and Oncology, St. Marianna University School of Medicine, Kanagawa, Japan
  • Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology and Oncology, Anjo Kosei Hospital, Aichi, Japan
  • Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Hokkaido University Hospital, Hokkaido, Japan
  • Hematology, Oncology & Cardiovascular medicine, Kyushu University Hospital, Fukuoka, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Aichi, Japan
  • Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Kanagawa, Japan
  • Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
  • Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Aichi, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-022-01569-x

    DOI

    http://dx.doi.org/10.1038/s41409-022-01569-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1144714955

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35039621


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