Altered effect of killer immunoglobulin-like receptor–ligand mismatch by graft versus host disease prophylaxis in cord blood transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-09-24

AUTHORS

Hisayuki Yokoyama, Masahiro Hirayama, Yoshiyuki Takahashi, Naoyuki Uchida, Masatsugu Tanaka, Makoto Onizuka, Yukiyasu Ozawa, Daishi Onai, Yuna Katsuoka, Atsushi Wake, Masashi Sawa, Hikaru Kobayashi, Yumiko Maruyama, Kazutaka Ozeki, Takafumi Kimura, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Seitaro Terakura, Satoko Morishima

ABSTRACT

The role of killer immunoglobulin-like receptor–ligand mismatch (KIR–ligand mismatch) between donors and recipients undergoing cord blood transplantation (CBT) is controversial. If each immunosuppressant differently affects natural killer (NK) cell function, the effect of KIR–ligand mismatch may be altered depending on the type of graft versus host disease (GVHD) prophylaxis. To verify this hypothesis, the difference in the effect of KIR–ligand mismatch was retrospectively assessed between patients who received CBT for acute leukemia, myelodysplastic syndrome, or chronic myeloid leukemia, as well as GVHD prophylaxis comprising tacrolimus plus methotrexate (MTX) or mycophenolate mofetil (MMF). In the MMF group (n = 1363), KIR–ligand mismatch augmented the incidence of non-relapse mortality (NRM; hazard ratio [HR], 1.40; P = 0.008), which worsened overall survival (OS; HR, 1.30, P = 0.0077). In the analysis of each KIR–ligand mismatch type, HLA-C2 mismatch had a favorable effect on relapse incidence (HR, 0.56; P = 0.0043) and OS (HR, 0.72; P = 0.037) only in the MTX group. In the MMF group, HLA-A3/A11 mismatch worsened NRM (HR, 1.93; P < 0.001) and OS (HR, 1.48; P = 0.014). These results imply that the effects of KIR–ligand mismatch differ with the type of GVHD prophylaxis and that assessing the KIR–ligand mismatch status is important for CBT. More... »

PAGES

3059-3067

References to SciGraph publications

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  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    12

    VOLUME

    56

    Author Affiliations

  • Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
  • Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
  • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Kajigaya, Japan
  • Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
  • Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan
  • Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
  • Department of Hematology and Oncology, Konan Kosei Hospital, Konan, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-021-01469-6

    DOI

    http://dx.doi.org/10.1038/s41409-021-01469-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141361524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34561558


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