Impact of conditioning intensity and regimen on transplant outcomes in patients with adult T-cell leukemia-lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-31

AUTHORS

Yoshitaka Inoue, Nobuaki Nakano, Shigeo Fuji, Tetsuya Eto, Toshiro Kawakita, Youko Suehiro, Toshihiro Miyamoto, Yasushi Sawayama, Naoyuki Uchida, Tadakazu Kondo, Junya Kanda, Yoshiko Atsuta, Takahiro Fukuda, Makoto Yoshimitsu, Koji Kato

ABSTRACT

In allogeneic hematopoietic cell transplantation (allo-HCT) for adult T-cell leukemia-lymphoma (ATL), the optimal conditioning regimens have not yet been determined. We conducted a Japanese nationwide, retrospective study to investigate this issue. This study included 914 ATL patients who underwent allo-HCT between 1995 and 2015. In patients aged 55 years or younger, there was no statistically significant difference between reduced-intensity conditioning (RIC) regimens and myeloablative conditioning (MAC) regimens regarding risk of relapse (vs. RIC group: MAC group, hazard ratio (HR) 0.76, P = 0.071), non-relapse mortality (vs. RIC group: MAC group, HR 1.38, P = 0.115), or overall mortality (vs. RIC group: MAC group, HR 1.17, P = 0.255). Among RIC regimens, fludarabine plus melphalan-based (Flu/Mel) regimens were associated with a lower risk of relapse (Flu/Mel140 group, HR 0.59, P < 0.001; Flu/Mel80 group, HR 0.79, P = 0.021) than the Flu plus busulfan-based regimen (Flu/Bu2 group). Meanwhile, Flu/Mel140 group had a significantly higher risk of non-relapse mortality (vs. Flu/Bu2 group: HR 1.53, P = 0.025). In conclusion, it is acceptable to select a RIC regimen for younger patients. Moreover, it might be beneficial to select a Flu/Mel-based regimen for patients at high risk of relapse. More... »

PAGES

2964-2974

References to SciGraph publications

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  • 2007-10-01. Unification of Hematopoietic Stem Cell Transplantation Registries in Japan and Establishment of the TRUMP System in INTERNATIONAL JOURNAL OF HEMATOLOGY
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  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    12

    VOLUME

    56

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-021-01445-0

    DOI

    http://dx.doi.org/10.1038/s41409-021-01445-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140747007

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34462567


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