Impact of HLA disparity on the risk of overall mortality in patients with grade II–IV acute GVHD on behalf of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-09-03

AUTHORS

Shigeo Fuji, Akitoshi Hakoda, Junya Kanda, Makoto Murata, Seitaro Terakura, Yoshihiro Inamoto, Naoyuki Uchida, Takashi Toya, Tetsuya Eto, Hirohisa Nakamae, Kazuhiro Ikegame, Masatsugu Tanaka, Toshiro Kawakita, Tadakazu Kondo, Toshihiro Miyamoto, Takahiro Fukuda, Tatsuo Ichinohe, Takafumi Kimura, Yoshiko Atsuta, Ayumi Shintani, Satoko Morishima

ABSTRACT

Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Stem cell source or HLA disparity may exert a significant impact on the overall survival (OS) after the development of aGVHD. In order to clarify this point, we performed a retrospective analysis using a database of the Japan Society for HCT. We analyzed the clinical outcomes of 10,035 patients who developed grade II–IV aGVHD. The median age of the patients was 48 years. The probability of 2-year OS after the onset of grade II–IV aGVHD in the study cohort was 54.1%. The multivariate analysis showed that the HLA ≥2-loci mismatched related donor and HLA 1-locus mismatched unrelated donor were significantly associated with an inferior OS after grade II–IV aGVHD. In a subgroup analysis, peripheral blood stem cells and HLA disparity were associated with an inferior OS in patients who received related or unrelated HCT. Thus, the clinical outcome after grade II–IV aGVHD significantly varied as per the combination of the presence of HLA disparity and stem cell source. Further research using other databases is necessary to confirm our findings. More... »

PAGES

2990-2996

Journal

TITLE

Bone Marrow Transplantation

ISSUE

12

VOLUME

56

Author Affiliations

  • Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
  • Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Department of Hematology, Kyoto University Hospital, Kyoto, Japan
  • Department of Hematology, Nagoya University Hospital, Nagoya, Aichi, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Osaka City University Hospital, Osaka, Japan
  • Department of Hematology, Hyogo College of Medicine Hospital, Hyogo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Hematology, Oncology & Cardiovascular medicine, Kyushu University Hospital, Fukuoka, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-021-01443-2

    DOI

    http://dx.doi.org/10.1038/s41409-021-01443-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140864407

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34480119


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