Cord blood index predicts engraftment and early non-relapse mortality in adult patients with single-unit cord blood transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-07-15

AUTHORS

Gaku Kondo, Fumihiko Ishimaru, Takaaki Konuma, Satoshi Takahashi, Yoshiko Atsuta, Atsuko Ogawa, Mutsuko Minemoto, Koichi Kashiwase, Fumihiro Azuma, Miyuki Ito, Keiichi Isoyama, Takeshi Kobayashi, Kazuteru Ohashi, Fumiaki Nakajima, Kiyoshi Hiruma, Shigeyoshi Makino, Hideo Mugishima, Noriko Namba, Hirokazu Tsuno, Tadashi Nagai, Kazuo Muroi, Kazunori Nakajima

ABSTRACT

How to select optimal cord blood (CB) remains an important clinical question. We developed and validated an index of CB engraftment, the cord blood index (CBI), which uses three weighted variables representing cell doses and HLA mismatches. We modeled the neutrophil engraftment time with competing events by random survival forests for competing risks as a function of the predictors: total nucleated cells, CD34, colony-forming units for granulocytes/macrophages, and the number of HLA mismatches at the antigen and allele levels. The CBI defined three groups that had different neutrophil engraftment rates at day 30 (High, 83.7% [95% CI, 79.2–88.1%]; Intermediate, 77.0% [95% CI, 73.7–80.2%]; Low, 68.4% [95% CI, 63.6–73.2%]), platelet engraftment rates at day 60 (High, 70.4% [95% CI, 64.9–75.9%]; Intermediate, 62.3% [95% CI, 58.5–66.0%]; Low, 49.3% [95% CI, 44.2–54.5%]), and non-relapse mortality at day 100 (High, 14.1% [95% CI, 9.9–18.3%]; Intermediate, 16.4% [95% CI, 13.5–19.3%]; Low, 21.3% [95% CI, 17.1–25.5%]). This novel approach is clinically beneficial and can be adopted immediately because it uses easily obtained pre-freeze data of CB. More... »

PAGES

2771-2778

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-021-01406-7

DOI

http://dx.doi.org/10.1038/s41409-021-01406-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139692718

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34267354


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This table displays all metadata directly associated to this object as RDF triples.

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18 schema:description How to select optimal cord blood (CB) remains an important clinical question. We developed and validated an index of CB engraftment, the cord blood index (CBI), which uses three weighted variables representing cell doses and HLA mismatches. We modeled the neutrophil engraftment time with competing events by random survival forests for competing risks as a function of the predictors: total nucleated cells, CD34, colony-forming units for granulocytes/macrophages, and the number of HLA mismatches at the antigen and allele levels. The CBI defined three groups that had different neutrophil engraftment rates at day 30 (High, 83.7% [95% CI, 79.2–88.1%]; Intermediate, 77.0% [95% CI, 73.7–80.2%]; Low, 68.4% [95% CI, 63.6–73.2%]), platelet engraftment rates at day 60 (High, 70.4% [95% CI, 64.9–75.9%]; Intermediate, 62.3% [95% CI, 58.5–66.0%]; Low, 49.3% [95% CI, 44.2–54.5%]), and non-relapse mortality at day 100 (High, 14.1% [95% CI, 9.9–18.3%]; Intermediate, 16.4% [95% CI, 13.5–19.3%]; Low, 21.3% [95% CI, 17.1–25.5%]). This novel approach is clinically beneficial and can be adopted immediately because it uses easily obtained pre-freeze data of CB.
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