Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-05-15

AUTHORS

Yoshimitsu Shimomura, Masahiko Hara, Takaaki Konuma, Hidehiro Itonaga, Noriko Doki, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Jun Aoki, Jun Kato, Yasushi Onishi, Satoshi Takahashi, Kentaro Fukushima, Hirohisa Nakamae, Toshiro Kawakita, Junji Tanaka, Takahiro Fukuda, Yoshiko Atsuta, Takayuki Ishikawa, Ken Ishiyama

ABSTRACT

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological data and identify prognostic factors for AYA patients with MDS undergoing allogeneic HSCT. Here, 645 patients were selected from patients enrolled in a multicenter prospective registry for HSCT from 2000 to 2015. The primary endpoint was 3-year overall survival (OS). Survival rates were estimated using the Kaplan–Meier method. Prognostic factors were identified using the multivariable Cox proportional hazards model. The 3-year OS was 71.2% (95% confidence interval [CI]: 67.4–74.6%). In multivariable analysis, active disease status (adjusted hazard ratio: 1.54, 95% CI: 1.09–2.18, p = 0.016), poor cytogenetic risk (1.62, 1.12–2.36, p = 0.011), poor performance status (2.01, 1.13–3.56, p = 0.016), human leukocyte antigen (HLA)-matched unrelated donors (2.23, 1.39–3.59, p < 0.001), HLA-mismatched unrelated donors (2.16, 1.09–4.28, p = 0.027), and cord blood transplantation (2.44, 1.43–4.17, p = 0.001) were significantly associated with poor 3-year OS. In conclusion, in AYA patients with MDS the 3-year OS following allogeneic HSCT was 71.2%. Active disease status, poor cytogenetic risk, poor performance status, and donor sources other than related donors were associated with poor 3-year OS. More... »

PAGES

2510-2517

Journal

TITLE

Bone Marrow Transplantation

ISSUE

10

VOLUME

56

Author Affiliations

  • Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
  • Center for Community-Based Healthcare Research and Education, Shimane University, Shimane, Japan
  • Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Toranomon Hospital, Tokyo, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Division of Hematology and department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology, Tohoku University Hospital, Miyagi, Japan
  • Division of Molecular Therapy, the Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
  • Department of Hematology, Graduate School of Medicine Osaka City University, Osaka, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-021-01324-8

    DOI

    http://dx.doi.org/10.1038/s41409-021-01324-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138087141

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33993196


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    351 grid-institutes:grid.414932.9 schema:alternateName Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
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    357 grid-institutes:grid.415538.e schema:alternateName Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
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