Prognostic factors in salvage transplantation for graft failure following allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-04-29

AUTHORS

Kaito Harada, Shun-ichi Kimura, Shigeo Fuji, Yuho Najima, Kimikazu Yakushijin, Naoyuki Uchida, Makoto Onizuka, Kazuhiro Ikegame, Shingo Yano, Naoki Shingai, Ken-ichi Matsuoka, Yasushi Onishi, Masashi Sawa, Satoru Takada, Toshiro Kawakita, Takahiro Fukuda, Junya Kanda, Yoshiko Atsuta, Hideaki Nakasone

ABSTRACT

Although graft failure (GF) is a fatal complication after allogeneic stem cell transplantation (SCT), no mortality risk assessments after salvage SCT have been reported. We developed a comprehensive prognostic scoring system consisting of patient and comorbidity factors with 470 patients as a training cohort out of 940; these patients underwent salvage SCT for GF. The multivariate analysis demonstrated that older age, poorer performance status, a continuation of antimicrobial treatment, and severe organ dysfunction were independently associated with worse overall survival (OS) and non-relapse mortality (NRM). Based on each factor’s hazard ratio, weighted scores of 1–3 were assigned to these factors. Using the summed scores (0–8), a prognostic scoring system successfully stratified outcomes after salvage SCT in the cohort. For patients in the low (0–2, n = 122), intermediate (3–4, n = 209), and high score (5–8, n = 110) groups, the 1-year OS was 62.8%, 40.8%, and 14.2%, respectively (P < 0.001), whereas the 1-year NRM was 24.1%, 43.9%, and 72.7%, respectively (P < 0.001). The prognostic value of the scoring system was confirmed in the validation cohort (n = 470). Our scoring system is useful for predicting survival after salvage SCT. More... »

PAGES

2183-2193

References to SciGraph publications

  • 2012-12-10. Graft failure in the modern era of allogeneic hematopoietic SCT in BONE MARROW TRANSPLANTATION
  • 2019-10-07. Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant Complications Working Group of Japan Society for Hematopoietic Cell Transplantation in BONE MARROW TRANSPLANTATION
  • 2015-11-20. Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2015-03-16. Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies in LEUKEMIA
  • 2015-11-07. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data) in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2020-08-20. Comparison of immunosuppressant regimens in salvage cord blood transplantation for graft failure after allogeneic hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2013-03-25. Salvage allogeneic hematopoietic SCT for primary graft failure in children in BONE MARROW TRANSPLANTATION
  • 2016-02-08. Risk factors and outcome of graft failure after HLA matched and mismatched unrelated donor hematopoietic stem cell transplantation: a study on behalf of SFGM-TC and SFHI in BONE MARROW TRANSPLANTATION
  • 2006-02-27. Severe regimen-related toxicity of second transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2020-02-12. Comparison of the outcomes after haploidentical and cord blood salvage transplantations for graft failure following allogeneic hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    9

    VOLUME

    56

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-021-01310-0

    DOI

    http://dx.doi.org/10.1038/s41409-021-01310-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1137602838

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33927346


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