Ontology type: schema:ScholarlyArticle
2020-03-20
AUTHORSMasamitsu Yanada, Takahiro Fukuda, Masatsugu Tanaka, Shuichi Ota, Takashi Toya, Takehiko Mori, Naoyuki Uchida, Yukiyasu Ozawa, Hirohisa Nakamae, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano
ABSTRACTThe long-term outcomes of allogeneic hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC) remain inconclusive. To address this issue, we conducted a nationwide registry-based study of patients with acute myeloid leukemia (AML) age 50 years or older who underwent allogeneic HCT in complete remission using RIC (n = 284) or myeloablative conditioning (MAC, n = 190) between 2002 and 2007. The median follow-up period for surviving patients was 10.1 years for RIC recipients and 10.4 years for MAC recipients. The 10-year probabilities of overall survival, relapse, and non-relapse mortality were 36.4%, 30.0%, and 35.7% for RIC recipients, and 39.8%, 26.3%, and 35.5% for MAC recipients, respectively. Multivariate analysis revealed that the conditioning intensity did not affect overall mortality (P = 0.184), relapse (P = 0.904), or non-relapse mortality (P = 0.387). For the 218 patients qualifying for propensity score-matched pairing (109 pairs), RIC was found to be associated with similar survival (P = 0.095) and relapse (P = 0.467), and significantly lower non-relapse mortality (P = 0.046) compared with MAC. Our results confirm the long-term efficacy of RIC allogeneic HCT for older patients with AML and mitigate concerns over an increase in late relapse. More... »
PAGES2008-2016
http://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7
DOIhttp://dx.doi.org/10.1038/s41409-020-0868-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1125759940
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32203266
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Conditioning",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Aichi Cancer Center, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.410800.d",
"name": [
"Aichi Cancer Center, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Yanada",
"givenName": "Masamitsu",
"id": "sg:person.01024604275.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cancer Center Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.272242.3",
"name": [
"National Cancer Center Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Fukuda",
"givenName": "Takahiro",
"id": "sg:person.016452523632.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kanagawa Cancer Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.414944.8",
"name": [
"Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Masatsugu",
"id": "sg:person.01171141246.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sapporo Hokuyu Hospital, Sapporo, Japan",
"id": "http://www.grid.ac/institutes/grid.415262.6",
"name": [
"Sapporo Hokuyu Hospital, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Ota",
"givenName": "Shuichi",
"id": "sg:person.011176077202.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.415479.a",
"name": [
"Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Toya",
"givenName": "Takashi",
"id": "sg:person.01116427675.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116427675.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Keio University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26091.3c",
"name": [
"Keio University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Mori",
"givenName": "Takehiko",
"id": "sg:person.015512754302.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Toranomon Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410813.f",
"name": [
"Toranomon Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Uchida",
"givenName": "Naoyuki",
"id": "sg:person.01243564276.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japanese Red Cross Nagoya First Hospital, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.414932.9",
"name": [
"Japanese Red Cross Nagoya First Hospital, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Ozawa",
"givenName": "Yukiyasu",
"id": "sg:person.01165712107.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate School of Medicine, Osaka City University, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Graduate School of Medicine, Osaka City University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Nakamae",
"givenName": "Hirohisa",
"id": "sg:person.01014223462.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jichi Medical University, Shimotsuke, Japan",
"id": "http://www.grid.ac/institutes/grid.410804.9",
"name": [
"Jichi Medical University, Shimotsuke, Japan"
],
"type": "Organization"
},
"familyName": "Kanda",
"givenName": "Yoshinobu",
"id": "sg:person.0617055140.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan",
"id": "http://www.grid.ac/institutes/grid.257022.0",
"name": [
"Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ichinohe",
"givenName": "Tatsuo",
"id": "sg:person.0623252373.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University Graduate School of Medicine, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan",
"Nagoya University Graduate School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Atsuta",
"givenName": "Yoshiko",
"id": "sg:person.01146754030.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Jikei University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"The Jikei University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yano",
"givenName": "Shingo",
"id": "sg:person.01265010246.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s12185-015-1894-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036307316",
"https://doi.org/10.1007/s12185-015-1894-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2011.69",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052594326",
"https://doi.org/10.1038/bmt.2011.69"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404461",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049155895",
"https://doi.org/10.1038/sj.leu.2404461"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020254406",
"https://doi.org/10.1038/leu.2014.164"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-018-0301-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106149902",
"https://doi.org/10.1038/s41409-018-0301-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.319",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045367684",
"https://doi.org/10.1038/leu.2014.319"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2015.121",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013678032",
"https://doi.org/10.1038/bmt.2015.121"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-016-2872-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050065713",
"https://doi.org/10.1007/s00277-016-2872-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-014-1657-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031936200",
"https://doi.org/10.1007/s12185-014-1657-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.55",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010249774",
"https://doi.org/10.1038/bmt.2012.55"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2012.135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001127017",
"https://doi.org/10.1038/leu.2012.135"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023301181",
"https://doi.org/10.1038/sj.leu.2403967"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-019-0539-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113958970",
"https://doi.org/10.1038/s41409-019-0539-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005426871",
"https://doi.org/10.1038/bmt.2012.236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2016.358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074201971",
"https://doi.org/10.1038/bmt.2016.358"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13045-016-0347-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008861458",
"https://doi.org/10.1186/s13045-016-0347-1"
],
"type": "CreativeWork"
}
],
"datePublished": "2020-03-20",
"datePublishedReg": "2020-03-20",
"description": "The long-term outcomes of allogeneic hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC) remain inconclusive. To address this issue, we conducted a nationwide registry-based study of patients with acute myeloid leukemia (AML) age 50 years or older who underwent allogeneic HCT in complete remission using RIC (n\u2009=\u2009284) or myeloablative conditioning (MAC, n\u2009=\u2009190) between 2002 and 2007. The median follow-up period for surviving patients was 10.1 years for RIC recipients and 10.4 years for MAC recipients. The 10-year probabilities of overall survival, relapse, and non-relapse mortality were 36.4%, 30.0%, and 35.7% for RIC recipients, and 39.8%, 26.3%, and 35.5% for MAC recipients, respectively. Multivariate analysis revealed that the conditioning intensity did not affect overall mortality (P\u2009=\u20090.184), relapse (P\u2009=\u20090.904), or non-relapse mortality (P\u2009=\u20090.387). For the 218 patients qualifying for propensity score-matched pairing (109 pairs), RIC was found to be associated with similar survival (P\u2009=\u20090.095) and relapse (P\u2009=\u20090.467), and significantly lower non-relapse mortality (P\u2009=\u20090.046) compared with MAC. Our results confirm the long-term efficacy of RIC allogeneic HCT for older patients with AML and mitigate concerns over an increase in late relapse.",
"genre": "article",
"id": "sg:pub.10.1038/s41409-020-0868-7",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.8421209",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9338482",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1096890",
"issn": [
"0268-3369",
"1476-5365"
],
"name": "Bone Marrow Transplantation",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "10",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "55"
}
],
"keywords": [
"allogeneic hematopoietic cell transplantation",
"hematopoietic cell transplantation",
"reduced-intensity conditioning",
"non-relapse mortality",
"RIC recipients",
"MAC recipients",
"older patients",
"cell transplantation",
"reduced-intensity conditioning allogeneic hematopoietic cell transplantation",
"RIC allogeneic HCT",
"nationwide registry-based study",
"lower non-relapse mortality",
"registry-based study",
"long-term outcomes",
"age 50 years",
"long-term efficacy",
"long-term results",
"acute myeloid leukemia",
"median follow",
"complete remission",
"myeloablative conditioning",
"overall survival",
"overall mortality",
"late relapse",
"conditioning intensity",
"myeloid leukemia",
"retrospective analysis",
"similar survival",
"patients",
"multivariate analysis",
"mortality",
"recipients",
"relapse",
"transplantation",
"follow",
"survival",
"years",
"remission",
"AML",
"leukemia",
"efficacy",
"outcomes",
"conditioning",
"period",
"study",
"increase",
"analysis",
"results",
"concern",
"data",
"MAC",
"intensity",
"probability",
"issues",
"pairing"
],
"name": "Long-term results of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia: a retrospective analysis of 10-year follow-up data",
"pagination": "2008-2016",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1125759940"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41409-020-0868-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"32203266"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41409-020-0868-7",
"https://app.dimensions.ai/details/publication/pub.1125759940"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_839.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41409-020-0868-7"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'
This table displays all metadata directly associated to this object as RDF triples.
333 TRIPLES
21 PREDICATES
103 URIs
79 LITERALS
14 BLANK NODES