Long-term results of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia: a retrospective analysis of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03-20

AUTHORS

Masamitsu Yanada, Takahiro Fukuda, Masatsugu Tanaka, Shuichi Ota, Takashi Toya, Takehiko Mori, Naoyuki Uchida, Yukiyasu Ozawa, Hirohisa Nakamae, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano

ABSTRACT

The long-term outcomes of allogeneic hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC) remain inconclusive. To address this issue, we conducted a nationwide registry-based study of patients with acute myeloid leukemia (AML) age 50 years or older who underwent allogeneic HCT in complete remission using RIC (n = 284) or myeloablative conditioning (MAC, n = 190) between 2002 and 2007. The median follow-up period for surviving patients was 10.1 years for RIC recipients and 10.4 years for MAC recipients. The 10-year probabilities of overall survival, relapse, and non-relapse mortality were 36.4%, 30.0%, and 35.7% for RIC recipients, and 39.8%, 26.3%, and 35.5% for MAC recipients, respectively. Multivariate analysis revealed that the conditioning intensity did not affect overall mortality (P = 0.184), relapse (P = 0.904), or non-relapse mortality (P = 0.387). For the 218 patients qualifying for propensity score-matched pairing (109 pairs), RIC was found to be associated with similar survival (P = 0.095) and relapse (P = 0.467), and significantly lower non-relapse mortality (P = 0.046) compared with MAC. Our results confirm the long-term efficacy of RIC allogeneic HCT for older patients with AML and mitigate concerns over an increase in late relapse. More... »

PAGES

2008-2016

References to SciGraph publications

  • 2015-11-07. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data) in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2006-11-23. HLA-identical sibling allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning compared to autologous peripheral blood stem cell transplantation for elderly patients with de novo acute myeloid leukemia in LEUKEMIA
  • 2011-03-28. Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS in BONE MARROW TRANSPLANTATION
  • 2018-08-14. Patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: trends in survival during the past two decades in BONE MARROW TRANSPLANTATION
  • 2014-05-20. Prediction of non-relapse mortality in recipients of reduced intensity conditioning allogeneic stem cell transplantation with AML in first complete remission in LEUKEMIA
  • 2012-05-22. Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation in LEUKEMIA
  • 2005-09-29. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT) in LEUKEMIA
  • 2012-04-16. Impact of cytogenetics risk on outcome after reduced intensity conditioning allo-SCT from an HLA-identical sibling for patients with AML in first CR: a report from the acute leukemia working party of EBMT in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Comparison of conditioning regimens of various intensities for allogeneic hematopoietic SCT using HLA-identical sibling donors in AML and MDS with <10% BM blasts: a report from EBMT in BONE MARROW TRANSPLANTATION
  • 2019-05-08. Unit selection for umbilical cord blood transplantation for adults with acute myeloid leukemia in complete remission: a Japanese experience in BONE MARROW TRANSPLANTATION
  • 2015-06-01. Conditioning intensity in middle-aged patients with AML in first CR: no advantage for myeloablative regimens irrespective of the risk group–an observational analysis by the Acute Leukemia Working Party of the EBMT in BONE MARROW TRANSPLANTATION
  • 2014-11-07. A comparative assessment of the curative potential of reduced intensity allografts in acute myeloid leukaemia in LEUKEMIA
  • 2014-09-12. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia during first complete remission: a clinical perspective in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2017-01-23. Reduced-intensity conditioning allogeneic hematopoietic cell transplantation for younger patients with acute myeloid leukemia: a registry-based study in BONE MARROW TRANSPLANTATION
  • 2016-11-12. Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia in ANNALS OF HEMATOLOGY
  • 2016-11-08. Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7

    DOI

    http://dx.doi.org/10.1038/s41409-020-0868-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125759940

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32203266


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Aichi Cancer Center, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Aichi Cancer Center, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yanada", 
            "givenName": "Masamitsu", 
            "id": "sg:person.01024604275.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "Takahiro", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kanagawa Cancer Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Kanagawa Cancer Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Masatsugu", 
            "id": "sg:person.01171141246.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sapporo Hokuyu Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415262.6", 
              "name": [
                "Sapporo Hokuyu Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ota", 
            "givenName": "Shuichi", 
            "id": "sg:person.011176077202.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toya", 
            "givenName": "Takashi", 
            "id": "sg:person.01116427675.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116427675.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Takehiko", 
            "id": "sg:person.015512754302.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchida", 
            "givenName": "Naoyuki", 
            "id": "sg:person.01243564276.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japanese Red Cross Nagoya First Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414932.9", 
              "name": [
                "Japanese Red Cross Nagoya First Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ozawa", 
            "givenName": "Yukiyasu", 
            "id": "sg:person.01165712107.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Graduate School of Medicine, Osaka City University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261445.0", 
              "name": [
                "Graduate School of Medicine, Osaka City University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamae", 
            "givenName": "Hirohisa", 
            "id": "sg:person.01014223462.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.0617055140.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.257022.0", 
              "name": [
                "Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichinohe", 
            "givenName": "Tatsuo", 
            "id": "sg:person.0623252373.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nagoya University Graduate School of Medicine, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
                "Nagoya University Graduate School of Medicine, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsuta", 
            "givenName": "Yoshiko", 
            "id": "sg:person.01146754030.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yano", 
            "givenName": "Shingo", 
            "id": "sg:person.01265010246.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12185-015-1894-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036307316", 
              "https://doi.org/10.1007/s12185-015-1894-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052594326", 
              "https://doi.org/10.1038/bmt.2011.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049155895", 
              "https://doi.org/10.1038/sj.leu.2404461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020254406", 
              "https://doi.org/10.1038/leu.2014.164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41409-018-0301-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106149902", 
              "https://doi.org/10.1038/s41409-018-0301-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045367684", 
              "https://doi.org/10.1038/leu.2014.319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013678032", 
              "https://doi.org/10.1038/bmt.2015.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-016-2872-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050065713", 
              "https://doi.org/10.1007/s00277-016-2872-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-014-1657-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031936200", 
              "https://doi.org/10.1007/s12185-014-1657-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010249774", 
              "https://doi.org/10.1038/bmt.2012.55"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001127017", 
              "https://doi.org/10.1038/leu.2012.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023301181", 
              "https://doi.org/10.1038/sj.leu.2403967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41409-019-0539-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113958970", 
              "https://doi.org/10.1038/s41409-019-0539-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005426871", 
              "https://doi.org/10.1038/bmt.2012.236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2016.358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074201971", 
              "https://doi.org/10.1038/bmt.2016.358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13045-016-0347-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008861458", 
              "https://doi.org/10.1186/s13045-016-0347-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-03-20", 
        "datePublishedReg": "2020-03-20", 
        "description": "The long-term outcomes of allogeneic hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC) remain inconclusive. To address this issue, we conducted a nationwide registry-based study of patients with acute myeloid leukemia (AML) age 50 years or older who underwent allogeneic HCT in complete remission using RIC (n\u2009=\u2009284) or myeloablative conditioning (MAC, n\u2009=\u2009190) between 2002 and 2007. The median follow-up period for surviving patients was 10.1 years for RIC recipients and 10.4 years for MAC recipients. The 10-year probabilities of overall survival, relapse, and non-relapse mortality were 36.4%, 30.0%, and 35.7% for RIC recipients, and 39.8%, 26.3%, and 35.5% for MAC recipients, respectively. Multivariate analysis revealed that the conditioning intensity did not affect overall mortality (P\u2009=\u20090.184), relapse (P\u2009=\u20090.904), or non-relapse mortality (P\u2009=\u20090.387). For the 218 patients qualifying for propensity score-matched pairing (109 pairs), RIC was found to be associated with similar survival (P\u2009=\u20090.095) and relapse (P\u2009=\u20090.467), and significantly lower non-relapse mortality (P\u2009=\u20090.046) compared with MAC. Our results confirm the long-term efficacy of RIC allogeneic HCT for older patients with AML and mitigate concerns over an increase in late relapse.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41409-020-0868-7", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8421209", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9338482", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "55"
          }
        ], 
        "keywords": [
          "allogeneic hematopoietic cell transplantation", 
          "hematopoietic cell transplantation", 
          "reduced-intensity conditioning", 
          "non-relapse mortality", 
          "RIC recipients", 
          "MAC recipients", 
          "older patients", 
          "cell transplantation", 
          "reduced-intensity conditioning allogeneic hematopoietic cell transplantation", 
          "RIC allogeneic HCT", 
          "nationwide registry-based study", 
          "lower non-relapse mortality", 
          "registry-based study", 
          "long-term outcomes", 
          "age 50 years", 
          "long-term efficacy", 
          "long-term results", 
          "acute myeloid leukemia", 
          "median follow", 
          "complete remission", 
          "myeloablative conditioning", 
          "overall survival", 
          "overall mortality", 
          "late relapse", 
          "conditioning intensity", 
          "myeloid leukemia", 
          "retrospective analysis", 
          "similar survival", 
          "patients", 
          "multivariate analysis", 
          "mortality", 
          "recipients", 
          "relapse", 
          "transplantation", 
          "follow", 
          "survival", 
          "years", 
          "remission", 
          "AML", 
          "leukemia", 
          "efficacy", 
          "outcomes", 
          "conditioning", 
          "period", 
          "study", 
          "increase", 
          "analysis", 
          "results", 
          "concern", 
          "data", 
          "MAC", 
          "intensity", 
          "probability", 
          "issues", 
          "pairing"
        ], 
        "name": "Long-term results of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia: a retrospective analysis of 10-year follow-up data", 
        "pagination": "2008-2016", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1125759940"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41409-020-0868-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32203266"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41409-020-0868-7", 
          "https://app.dimensions.ai/details/publication/pub.1125759940"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_839.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41409-020-0868-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0868-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    333 TRIPLES      21 PREDICATES      103 URIs      79 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41409-020-0868-7 schema:about N06109b9069134b8a9ed52ec4b9248655
    2 N311171d2b6bc4f0aab0421504b1d0172
    3 N613a37e9c10148c3b105106f31ec736d
    4 N6c4992433b264e88acccce4c420cff84
    5 Nca714dd013fc4e3fb088e0cfa08079ae
    6 Ncaf312305d5f4985b13fb02bd534f489
    7 Nd04261ce5b554b6ca8d66aeec63d5355
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N12fadfb5b37a48749179060292419d69
    11 schema:citation sg:pub.10.1007/s00277-016-2872-y
    12 sg:pub.10.1007/s12185-014-1657-0
    13 sg:pub.10.1007/s12185-015-1894-x
    14 sg:pub.10.1038/bmt.2011.69
    15 sg:pub.10.1038/bmt.2012.236
    16 sg:pub.10.1038/bmt.2012.55
    17 sg:pub.10.1038/bmt.2015.121
    18 sg:pub.10.1038/bmt.2016.358
    19 sg:pub.10.1038/leu.2012.135
    20 sg:pub.10.1038/leu.2014.164
    21 sg:pub.10.1038/leu.2014.319
    22 sg:pub.10.1038/s41409-018-0301-7
    23 sg:pub.10.1038/s41409-019-0539-8
    24 sg:pub.10.1038/sj.leu.2403967
    25 sg:pub.10.1038/sj.leu.2404461
    26 sg:pub.10.1186/s13045-016-0347-1
    27 schema:datePublished 2020-03-20
    28 schema:datePublishedReg 2020-03-20
    29 schema:description The long-term outcomes of allogeneic hematopoietic cell transplantation (HCT) with reduced-intensity conditioning (RIC) remain inconclusive. To address this issue, we conducted a nationwide registry-based study of patients with acute myeloid leukemia (AML) age 50 years or older who underwent allogeneic HCT in complete remission using RIC (n = 284) or myeloablative conditioning (MAC, n = 190) between 2002 and 2007. The median follow-up period for surviving patients was 10.1 years for RIC recipients and 10.4 years for MAC recipients. The 10-year probabilities of overall survival, relapse, and non-relapse mortality were 36.4%, 30.0%, and 35.7% for RIC recipients, and 39.8%, 26.3%, and 35.5% for MAC recipients, respectively. Multivariate analysis revealed that the conditioning intensity did not affect overall mortality (P = 0.184), relapse (P = 0.904), or non-relapse mortality (P = 0.387). For the 218 patients qualifying for propensity score-matched pairing (109 pairs), RIC was found to be associated with similar survival (P = 0.095) and relapse (P = 0.467), and significantly lower non-relapse mortality (P = 0.046) compared with MAC. Our results confirm the long-term efficacy of RIC allogeneic HCT for older patients with AML and mitigate concerns over an increase in late relapse.
    30 schema:genre article
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N7a7cf03eddbc407db1f7813e753a4100
    33 Nb84c165b84934860a520286a2c1d50ce
    34 sg:journal.1096890
    35 schema:keywords AML
    36 MAC
    37 MAC recipients
    38 RIC allogeneic HCT
    39 RIC recipients
    40 acute myeloid leukemia
    41 age 50 years
    42 allogeneic hematopoietic cell transplantation
    43 analysis
    44 cell transplantation
    45 complete remission
    46 concern
    47 conditioning
    48 conditioning intensity
    49 data
    50 efficacy
    51 follow
    52 hematopoietic cell transplantation
    53 increase
    54 intensity
    55 issues
    56 late relapse
    57 leukemia
    58 long-term efficacy
    59 long-term outcomes
    60 long-term results
    61 lower non-relapse mortality
    62 median follow
    63 mortality
    64 multivariate analysis
    65 myeloablative conditioning
    66 myeloid leukemia
    67 nationwide registry-based study
    68 non-relapse mortality
    69 older patients
    70 outcomes
    71 overall mortality
    72 overall survival
    73 pairing
    74 patients
    75 period
    76 probability
    77 recipients
    78 reduced-intensity conditioning
    79 reduced-intensity conditioning allogeneic hematopoietic cell transplantation
    80 registry-based study
    81 relapse
    82 remission
    83 results
    84 retrospective analysis
    85 similar survival
    86 study
    87 survival
    88 transplantation
    89 years
    90 schema:name Long-term results of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia: a retrospective analysis of 10-year follow-up data
    91 schema:pagination 2008-2016
    92 schema:productId N14faa95ba13247b1b101ee8e0a458bab
    93 Ne13c466b6ffc45ed8e114f504fac4e54
    94 Ne2f7e0a5876346478329c86f067bedbe
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125759940
    96 https://doi.org/10.1038/s41409-020-0868-7
    97 schema:sdDatePublished 2022-08-04T17:08
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N9b34338ac66c4d15b8b0737a115d37ad
    100 schema:url https://doi.org/10.1038/s41409-020-0868-7
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N02c88448ccb64bce8707a8d9cba24d20 rdf:first sg:person.0623252373.33
    105 rdf:rest N561f98a3b45e42e8a20c16edb53882c0
    106 N06109b9069134b8a9ed52ec4b9248655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Middle Aged
    108 rdf:type schema:DefinedTerm
    109 N12fadfb5b37a48749179060292419d69 rdf:first sg:person.01024604275.66
    110 rdf:rest N52b59d4a3aa64f0683cda6931dd96700
    111 N14faa95ba13247b1b101ee8e0a458bab schema:name doi
    112 schema:value 10.1038/s41409-020-0868-7
    113 rdf:type schema:PropertyValue
    114 N1a521b9e077446fb847880f9d7c1b238 rdf:first sg:person.01171141246.33
    115 rdf:rest N3ba6d3cc31c244d5b7af0fc4f2c9720a
    116 N1c7a8161a7124b64a1fa7448e80ec51d rdf:first sg:person.01116427675.42
    117 rdf:rest N59567bce3d564c62baa101b9ceda5f82
    118 N2d930d84c9444bd48a66946482cb1b86 rdf:first sg:person.01014223462.98
    119 rdf:rest Nb519670282d34233baedc164177ad6d9
    120 N311171d2b6bc4f0aab0421504b1d0172 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Leukemia, Myeloid, Acute
    122 rdf:type schema:DefinedTerm
    123 N3ba6d3cc31c244d5b7af0fc4f2c9720a rdf:first sg:person.011176077202.18
    124 rdf:rest N1c7a8161a7124b64a1fa7448e80ec51d
    125 N52b59d4a3aa64f0683cda6931dd96700 rdf:first sg:person.016452523632.46
    126 rdf:rest N1a521b9e077446fb847880f9d7c1b238
    127 N561f98a3b45e42e8a20c16edb53882c0 rdf:first sg:person.01146754030.08
    128 rdf:rest N7706ae3a161044f482a75d9a4d2daf96
    129 N59567bce3d564c62baa101b9ceda5f82 rdf:first sg:person.015512754302.32
    130 rdf:rest Nb7ba55af0e8f437a8f8d79a2f3b23f85
    131 N613a37e9c10148c3b105106f31ec736d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Hematopoietic Stem Cell Transplantation
    133 rdf:type schema:DefinedTerm
    134 N6c4992433b264e88acccce4c420cff84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 N7706ae3a161044f482a75d9a4d2daf96 rdf:first sg:person.01265010246.42
    138 rdf:rest rdf:nil
    139 N7a7cf03eddbc407db1f7813e753a4100 schema:issueNumber 10
    140 rdf:type schema:PublicationIssue
    141 N9b34338ac66c4d15b8b0737a115d37ad schema:name Springer Nature - SN SciGraph project
    142 rdf:type schema:Organization
    143 Naabb95779b384326a4f82f8290cc870b rdf:first sg:person.01165712107.72
    144 rdf:rest N2d930d84c9444bd48a66946482cb1b86
    145 Nb519670282d34233baedc164177ad6d9 rdf:first sg:person.0617055140.49
    146 rdf:rest N02c88448ccb64bce8707a8d9cba24d20
    147 Nb7ba55af0e8f437a8f8d79a2f3b23f85 rdf:first sg:person.01243564276.76
    148 rdf:rest Naabb95779b384326a4f82f8290cc870b
    149 Nb84c165b84934860a520286a2c1d50ce schema:volumeNumber 55
    150 rdf:type schema:PublicationVolume
    151 Nca714dd013fc4e3fb088e0cfa08079ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Retrospective Studies
    153 rdf:type schema:DefinedTerm
    154 Ncaf312305d5f4985b13fb02bd534f489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Transplantation Conditioning
    156 rdf:type schema:DefinedTerm
    157 Nd04261ce5b554b6ca8d66aeec63d5355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Follow-Up Studies
    159 rdf:type schema:DefinedTerm
    160 Ne13c466b6ffc45ed8e114f504fac4e54 schema:name dimensions_id
    161 schema:value pub.1125759940
    162 rdf:type schema:PropertyValue
    163 Ne2f7e0a5876346478329c86f067bedbe schema:name pubmed_id
    164 schema:value 32203266
    165 rdf:type schema:PropertyValue
    166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Medical and Health Sciences
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Oncology and Carcinogenesis
    171 rdf:type schema:DefinedTerm
    172 sg:grant.8421209 http://pending.schema.org/fundedItem sg:pub.10.1038/s41409-020-0868-7
    173 rdf:type schema:MonetaryGrant
    174 sg:grant.9338482 http://pending.schema.org/fundedItem sg:pub.10.1038/s41409-020-0868-7
    175 rdf:type schema:MonetaryGrant
    176 sg:journal.1096890 schema:issn 0268-3369
    177 1476-5365
    178 schema:name Bone Marrow Transplantation
    179 schema:publisher Springer Nature
    180 rdf:type schema:Periodical
    181 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.261445.0
    182 schema:familyName Nakamae
    183 schema:givenName Hirohisa
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
    185 rdf:type schema:Person
    186 sg:person.01024604275.66 schema:affiliation grid-institutes:grid.410800.d
    187 schema:familyName Yanada
    188 schema:givenName Masamitsu
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66
    190 rdf:type schema:Person
    191 sg:person.01116427675.42 schema:affiliation grid-institutes:grid.415479.a
    192 schema:familyName Toya
    193 schema:givenName Takashi
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116427675.42
    195 rdf:type schema:Person
    196 sg:person.011176077202.18 schema:affiliation grid-institutes:grid.415262.6
    197 schema:familyName Ota
    198 schema:givenName Shuichi
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18
    200 rdf:type schema:Person
    201 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
    202 schema:familyName Atsuta
    203 schema:givenName Yoshiko
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
    205 rdf:type schema:Person
    206 sg:person.01165712107.72 schema:affiliation grid-institutes:grid.414932.9
    207 schema:familyName Ozawa
    208 schema:givenName Yukiyasu
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72
    210 rdf:type schema:Person
    211 sg:person.01171141246.33 schema:affiliation grid-institutes:grid.414944.8
    212 schema:familyName Tanaka
    213 schema:givenName Masatsugu
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33
    215 rdf:type schema:Person
    216 sg:person.01243564276.76 schema:affiliation grid-institutes:grid.410813.f
    217 schema:familyName Uchida
    218 schema:givenName Naoyuki
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76
    220 rdf:type schema:Person
    221 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
    222 schema:familyName Yano
    223 schema:givenName Shingo
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
    225 rdf:type schema:Person
    226 sg:person.015512754302.32 schema:affiliation grid-institutes:grid.26091.3c
    227 schema:familyName Mori
    228 schema:givenName Takehiko
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32
    230 rdf:type schema:Person
    231 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    232 schema:familyName Fukuda
    233 schema:givenName Takahiro
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    235 rdf:type schema:Person
    236 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.410804.9
    237 schema:familyName Kanda
    238 schema:givenName Yoshinobu
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
    240 rdf:type schema:Person
    241 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
    242 schema:familyName Ichinohe
    243 schema:givenName Tatsuo
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
    245 rdf:type schema:Person
    246 sg:pub.10.1007/s00277-016-2872-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050065713
    247 https://doi.org/10.1007/s00277-016-2872-y
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s12185-014-1657-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031936200
    250 https://doi.org/10.1007/s12185-014-1657-0
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
    253 https://doi.org/10.1007/s12185-015-1894-x
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/bmt.2011.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052594326
    256 https://doi.org/10.1038/bmt.2011.69
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/bmt.2012.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005426871
    259 https://doi.org/10.1038/bmt.2012.236
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/bmt.2012.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010249774
    262 https://doi.org/10.1038/bmt.2012.55
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/bmt.2015.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013678032
    265 https://doi.org/10.1038/bmt.2015.121
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/bmt.2016.358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074201971
    268 https://doi.org/10.1038/bmt.2016.358
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/leu.2012.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001127017
    271 https://doi.org/10.1038/leu.2012.135
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/leu.2014.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020254406
    274 https://doi.org/10.1038/leu.2014.164
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/leu.2014.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045367684
    277 https://doi.org/10.1038/leu.2014.319
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/s41409-018-0301-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106149902
    280 https://doi.org/10.1038/s41409-018-0301-7
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/s41409-019-0539-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113958970
    283 https://doi.org/10.1038/s41409-019-0539-8
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/sj.leu.2403967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023301181
    286 https://doi.org/10.1038/sj.leu.2403967
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/sj.leu.2404461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049155895
    289 https://doi.org/10.1038/sj.leu.2404461
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1186/s13045-016-0347-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008861458
    292 https://doi.org/10.1186/s13045-016-0347-1
    293 rdf:type schema:CreativeWork
    294 grid-institutes:grid.257022.0 schema:alternateName Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    295 schema:name Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    296 rdf:type schema:Organization
    297 grid-institutes:grid.26091.3c schema:alternateName Keio University School of Medicine, Tokyo, Japan
    298 schema:name Keio University School of Medicine, Tokyo, Japan
    299 rdf:type schema:Organization
    300 grid-institutes:grid.261445.0 schema:alternateName Graduate School of Medicine, Osaka City University, Osaka, Japan
    301 schema:name Graduate School of Medicine, Osaka City University, Osaka, Japan
    302 rdf:type schema:Organization
    303 grid-institutes:grid.272242.3 schema:alternateName National Cancer Center Hospital, Tokyo, Japan
    304 schema:name National Cancer Center Hospital, Tokyo, Japan
    305 rdf:type schema:Organization
    306 grid-institutes:grid.27476.30 schema:alternateName Nagoya University Graduate School of Medicine, Nagoya, Japan
    307 schema:name Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    308 Nagoya University Graduate School of Medicine, Nagoya, Japan
    309 rdf:type schema:Organization
    310 grid-institutes:grid.410800.d schema:alternateName Aichi Cancer Center, Nagoya, Japan
    311 schema:name Aichi Cancer Center, Nagoya, Japan
    312 rdf:type schema:Organization
    313 grid-institutes:grid.410804.9 schema:alternateName Jichi Medical University, Shimotsuke, Japan
    314 schema:name Jichi Medical University, Shimotsuke, Japan
    315 rdf:type schema:Organization
    316 grid-institutes:grid.410813.f schema:alternateName Toranomon Hospital, Tokyo, Japan
    317 schema:name Toranomon Hospital, Tokyo, Japan
    318 rdf:type schema:Organization
    319 grid-institutes:grid.411898.d schema:alternateName The Jikei University School of Medicine, Tokyo, Japan
    320 schema:name The Jikei University School of Medicine, Tokyo, Japan
    321 rdf:type schema:Organization
    322 grid-institutes:grid.414932.9 schema:alternateName Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    323 schema:name Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    324 rdf:type schema:Organization
    325 grid-institutes:grid.414944.8 schema:alternateName Kanagawa Cancer Center, Yokohama, Japan
    326 schema:name Kanagawa Cancer Center, Yokohama, Japan
    327 rdf:type schema:Organization
    328 grid-institutes:grid.415262.6 schema:alternateName Sapporo Hokuyu Hospital, Sapporo, Japan
    329 schema:name Sapporo Hokuyu Hospital, Sapporo, Japan
    330 rdf:type schema:Organization
    331 grid-institutes:grid.415479.a schema:alternateName Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    332 schema:name Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    333 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...