Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03-16

AUTHORS

Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

ABSTRACT

A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant. More... »

PAGES

1399-1409

Journal

TITLE

Bone Marrow Transplantation

ISSUE

7

VOLUME

55

Author Affiliations

  • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan
  • Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan
  • Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Okayama, Japan
  • Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan
  • Department of Hematology and Oncology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan
  • Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
  • Department of Hematology, Gifu University Graduate School of Medicine, Gifu, Japan
  • Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
  • Department of Hematology and Oncology, Shimane Prefectural Central Hospital, Izumo, Japan
  • Department of Hematology and Oncology, Tokai University Hospital, Isehara, Japan
  • Department of Hematology, Sapporo Medical University Hospital, Sapporo, Japan
  • Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
  • Department of Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Department of Hematology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Division of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan
  • Department of Hematology, Miyagi Cancer Center, Natori, Japan
  • Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
  • Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan
  • Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-0859-8

    DOI

    http://dx.doi.org/10.1038/s41409-020-0859-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125674046

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32203259


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