Reduced-intensity stem cell transplantation for acute myeloid leukemia with fludarabine-based conditioning with intravenous busulfan versus melphalan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03-12

AUTHORS

Takuya Yamashita, Akiyoshi Takami, Naoyuki Uchida, Takahiro Fukuda, Tetsuya Eto, Souichi Shiratori, Shuichi Ota, Takashi Akasaka, Shigesaburo Miyakoshi, Tadakazu Kondo, Michihiro Hidaka, Junya Kanda, Yoshiko Atsuta, Shingo Yano

ABSTRACT

Reduced-intensity conditioning (RIC) has been facilitating allogeneic hematopoietic cell transplantation (allo-HCT) for patients originally considered ineligible for HCT with myeloablative conditioning. Fludarabine (Flu) with reduced doses of busulfan (Bu) (Flu + Bu) and Flu with reduced doses of melphalan (Mel) (Flu + Mel) are widely used RIC regimens for acute myeloid leukemia (AML). A nationwide retrospective study comparing clinical outcomes of adult patients with AML receiving first allo-HCT after RIC between 2001 and 2010 was performed. Cumulative incidences of relapse were not significantly different among the Flu + ivBu-based (FBiv), Flu + poBu-based (FBpo), and Flu + Mel-based (FM) groups (p = 0.29). Non-relapse mortality (NRM) was significantly lower in patients receiving FBiv compared with FBpo (p = 0.003) and FM (p < 0.001). On multivariate analysis, there was no significant difference in overall survival, but FM was associated with a significantly lower risk of relapse (hazard ratio (HR) = 0.65, 95% confidence interval (CI): 0.50–0.85, p = 0.002), higher NRM (HR = 1.60, 95% CI: 1.10–2.33, p = 0.013) and better leukemia-free survival (HR = 0.77, 95% CI: 0.63–0.95, p = 0.015) compared with FBiv. These results suggest that Flu + Mel has a more intense disease control potential and Flu + ivBu is less toxic than the other. Both RIC regimens provide similar survival outcomes and are effective and useful regimens for patients with AML who received allo-HCT. More... »

PAGES

1955-1965

References to SciGraph publications

  • 2000-05-01. Allogeneic stem cell transplantation (BMT) for AML and MDS following i.v. busulfan and cyclophosphamide (i.v. BuCy) in BONE MARROW TRANSPLANTATION
  • 2006-07-27. Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning in LEUKEMIA
  • 2007-08-27. Reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation with fludarabine and melphalan is associated with durable disease control in myelodysplastic syndrome in BONE MARROW TRANSPLANTATION
  • 2011-08-29. Intravenous compared with oral busulfan as preparation for allogeneic hematopoietic progenitor cell transplantation for AML and MDS in BONE MARROW TRANSPLANTATION
  • 2007-08-09. Comparison between two fludarabine-based reduced-intensity conditioning regimens before allogeneic hematopoietic stem-cell transplantation: fludarabine/melphalan is associated with higher incidence of acute graft-versus-host disease and non-relapse mortality and lower incidence of relapse than fludarabine/busulfan in LEUKEMIA
  • 2007-10-01. Unification of Hematopoietic Stem Cell Transplantation Registries in Japan and Establishment of the TRUMP System in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2008-11-17. Busulfex (i.v. BU) and CY regimen before SCT: Japanese-targeted phase II pharmacokinetics combined study in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2007-04-01. Unrelated-Donor Bone Marrow Transplantation with a Conditioning Regimen Including Fludarabine, Busulfan, and 4 Gy Total Body Irradiation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2001-10-01. A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome in BONE MARROW TRANSPLANTATION
  • 2017-05-15. Conditioning regimens for allogeneic hematopoietic stem cell transplants in acute myeloid leukemia in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    10

    VOLUME

    55

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-0856-y

    DOI

    http://dx.doi.org/10.1038/s41409-020-0856-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125556029

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32203256


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Busulfan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft vs Host Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melphalan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vidarabine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology, St. Luke\u2019s International Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.430395.8", 
              "name": [
                "Department of Hematology, St. Luke\u2019s International Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamashita", 
            "givenName": "Takuya", 
            "id": "sg:person.01276656114.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656114.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Internal Medicine, Aichi Medical University Hospital, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.510308.f", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, Aichi Medical University Hospital, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takami", 
            "givenName": "Akiyoshi", 
            "id": "sg:person.0577702220.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchida", 
            "givenName": "Naoyuki", 
            "id": "sg:person.01243564276.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "Takahiro", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413617.6", 
              "name": [
                "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eto", 
            "givenName": "Tetsuya", 
            "id": "sg:person.0720274373.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412167.7", 
              "name": [
                "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiratori", 
            "givenName": "Souichi", 
            "id": "sg:person.0653535643.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415262.6", 
              "name": [
                "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ota", 
            "givenName": "Shuichi", 
            "id": "sg:person.011176077202.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Tenri Hospital, Tenri, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416952.d", 
              "name": [
                "Department of Hematology, Tenri Hospital, Tenri, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akasaka", 
            "givenName": "Takashi", 
            "id": "sg:person.0647415353.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647415353.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417092.9", 
              "name": [
                "Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyakoshi", 
            "givenName": "Shigesaburo", 
            "id": "sg:person.01137533644.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137533644.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kyoto University Hospital, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411217.0", 
              "name": [
                "Department of Hematology, Kyoto University Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kondo", 
            "givenName": "Tadakazu", 
            "id": "sg:person.0666225507.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415538.e", 
              "name": [
                "Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hidaka", 
            "givenName": "Michihiro", 
            "id": "sg:person.01071077443.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071077443.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Junya", 
            "id": "sg:person.01100640630.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
                "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsuta", 
            "givenName": "Yoshiko", 
            "id": "sg:person.01146754030.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Department of Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yano", 
            "givenName": "Shingo", 
            "id": "sg:person.01265010246.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1703215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044695461", 
              "https://doi.org/10.1038/sj.bmt.1703215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2017.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085413197", 
              "https://doi.org/10.1038/bmt.2017.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038554232", 
              "https://doi.org/10.1038/sj.leu.2404335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052335578", 
              "https://doi.org/10.1038/sj.leu.2404886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.06239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054504897", 
              "https://doi.org/10.1532/ijh97.06239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051994531", 
              "https://doi.org/10.1038/sj.bmt.1705801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044929323", 
              "https://doi.org/10.1038/bmt.2011.167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1702351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023445788", 
              "https://doi.org/10.1038/sj.bmt.1702351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2008.372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026589975", 
              "https://doi.org/10.1038/bmt.2008.372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.06199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040472130", 
              "https://doi.org/10.1532/ijh97.06199"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-03-12", 
        "datePublishedReg": "2020-03-12", 
        "description": "Reduced-intensity conditioning (RIC) has been facilitating allogeneic hematopoietic cell transplantation (allo-HCT) for patients originally considered ineligible for HCT with myeloablative conditioning. Fludarabine (Flu) with reduced doses of busulfan (Bu) (Flu\u2009+\u2009Bu) and Flu with reduced doses of melphalan (Mel) (Flu\u2009+\u2009Mel) are widely used RIC regimens for acute myeloid leukemia (AML). A nationwide retrospective study comparing clinical outcomes of adult patients with AML receiving first allo-HCT after RIC between 2001 and 2010 was performed. Cumulative incidences of relapse were not significantly different among the Flu\u2009+\u2009ivBu-based (FBiv), Flu\u2009+\u2009poBu-based (FBpo), and Flu\u2009+\u2009Mel-based (FM) groups (p\u2009=\u20090.29). Non-relapse mortality (NRM) was significantly lower in patients receiving FBiv compared with FBpo (p\u2009=\u20090.003) and FM (p\u2009<\u20090.001). On multivariate analysis, there was no significant difference in overall survival, but FM was associated with a significantly lower risk of relapse (hazard ratio (HR)\u2009=\u20090.65, 95% confidence interval (CI): 0.50\u20130.85, p\u2009=\u20090.002), higher NRM (HR\u2009=\u20091.60, 95% CI: 1.10\u20132.33, p\u2009=\u20090.013) and better leukemia-free survival (HR\u2009=\u20090.77, 95% CI: 0.63\u20130.95, p\u2009=\u20090.015) compared with FBiv. These results suggest that Flu\u2009+\u2009Mel has a more intense disease control potential and Flu\u2009+\u2009ivBu is less toxic than the other. Both RIC regimens provide similar survival outcomes and are effective and useful regimens for patients with AML who received allo-HCT.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41409-020-0856-y", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7535173", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "55"
          }
        ], 
        "keywords": [
          "acute myeloid leukemia", 
          "non-relapse mortality", 
          "reduced-intensity conditioning", 
          "allo-HCT", 
          "RIC regimens", 
          "cell transplantation", 
          "myeloid leukemia", 
          "reduced-intensity stem cell transplantation", 
          "reduced doses", 
          "higher non-relapse mortality", 
          "better leukemia-free survival", 
          "allogeneic hematopoietic cell transplantation", 
          "first allo-HCT", 
          "nationwide retrospective study", 
          "leukemia-free survival", 
          "similar survival outcomes", 
          "hematopoietic cell transplantation", 
          "stem cell transplantation", 
          "useful regimens", 
          "myeloablative conditioning", 
          "adult patients", 
          "cumulative incidence", 
          "overall survival", 
          "intravenous busulfan", 
          "clinical outcomes", 
          "retrospective study", 
          "survival outcomes", 
          "lower risk", 
          "patients", 
          "multivariate analysis", 
          "regimens", 
          "flu", 
          "ivBu", 
          "fludarabine", 
          "busulfan", 
          "relapse", 
          "significant differences", 
          "transplantation", 
          "melphalan", 
          "leukemia", 
          "doses", 
          "survival", 
          "outcomes", 
          "mortality", 
          "incidence", 
          "disease control potential", 
          "conditioning", 
          "risk", 
          "group", 
          "Mel", 
          "differences", 
          "study", 
          "potential", 
          "analysis", 
          "results", 
          "control potential", 
          "FM"
        ], 
        "name": "Reduced-intensity stem cell transplantation for acute myeloid leukemia with fludarabine-based conditioning with intravenous busulfan versus melphalan", 
        "pagination": "1955-1965", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1125556029"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41409-020-0856-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32203256"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41409-020-0856-y", 
          "https://app.dimensions.ai/details/publication/pub.1125556029"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:09", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_860.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41409-020-0856-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0856-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0856-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0856-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0856-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    335 TRIPLES      21 PREDICATES      103 URIs      84 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41409-020-0856-y schema:about N5b36bbfb92d142d6b5b4a431dfe4aeb8
    2 N70c28681515b4d6e8b682f52749722df
    3 N81faedcd3ee54a47a0e928fcdb23cfa8
    4 N86d139d20991479592aa21182b87def2
    5 N87b28bdf22df480fbb60de933bfeb3c4
    6 N9cf2434dc2814e55aa26db71a7fb78cb
    7 Na4f3916d6cea406d907ba5c6dae87724
    8 Nbd2b3c45a5554172a4827bf9a6e0e002
    9 Nc5697957568147ecb29bc7abc5d85f4a
    10 Ne6ef7f203cac4ed9b16e899d7e817060
    11 anzsrc-for:11
    12 anzsrc-for:1102
    13 schema:author N882320be0cbb4507bc8b8a9cf3cae07a
    14 schema:citation sg:pub.10.1038/bmt.2008.372
    15 sg:pub.10.1038/bmt.2011.167
    16 sg:pub.10.1038/bmt.2012.244
    17 sg:pub.10.1038/bmt.2017.83
    18 sg:pub.10.1038/sj.bmt.1702351
    19 sg:pub.10.1038/sj.bmt.1703215
    20 sg:pub.10.1038/sj.bmt.1705801
    21 sg:pub.10.1038/sj.leu.2404335
    22 sg:pub.10.1038/sj.leu.2404886
    23 sg:pub.10.1532/ijh97.06199
    24 sg:pub.10.1532/ijh97.06239
    25 schema:datePublished 2020-03-12
    26 schema:datePublishedReg 2020-03-12
    27 schema:description Reduced-intensity conditioning (RIC) has been facilitating allogeneic hematopoietic cell transplantation (allo-HCT) for patients originally considered ineligible for HCT with myeloablative conditioning. Fludarabine (Flu) with reduced doses of busulfan (Bu) (Flu + Bu) and Flu with reduced doses of melphalan (Mel) (Flu + Mel) are widely used RIC regimens for acute myeloid leukemia (AML). A nationwide retrospective study comparing clinical outcomes of adult patients with AML receiving first allo-HCT after RIC between 2001 and 2010 was performed. Cumulative incidences of relapse were not significantly different among the Flu + ivBu-based (FBiv), Flu + poBu-based (FBpo), and Flu + Mel-based (FM) groups (p = 0.29). Non-relapse mortality (NRM) was significantly lower in patients receiving FBiv compared with FBpo (p = 0.003) and FM (p < 0.001). On multivariate analysis, there was no significant difference in overall survival, but FM was associated with a significantly lower risk of relapse (hazard ratio (HR) = 0.65, 95% confidence interval (CI): 0.50–0.85, p = 0.002), higher NRM (HR = 1.60, 95% CI: 1.10–2.33, p = 0.013) and better leukemia-free survival (HR = 0.77, 95% CI: 0.63–0.95, p = 0.015) compared with FBiv. These results suggest that Flu + Mel has a more intense disease control potential and Flu + ivBu is less toxic than the other. Both RIC regimens provide similar survival outcomes and are effective and useful regimens for patients with AML who received allo-HCT.
    28 schema:genre article
    29 schema:isAccessibleForFree false
    30 schema:isPartOf N4a85c31dcff3404b8d2a90cc5308ec36
    31 N4b72828740c741239807a9a38b704a6c
    32 sg:journal.1096890
    33 schema:keywords FM
    34 Mel
    35 RIC regimens
    36 acute myeloid leukemia
    37 adult patients
    38 allo-HCT
    39 allogeneic hematopoietic cell transplantation
    40 analysis
    41 better leukemia-free survival
    42 busulfan
    43 cell transplantation
    44 clinical outcomes
    45 conditioning
    46 control potential
    47 cumulative incidence
    48 differences
    49 disease control potential
    50 doses
    51 first allo-HCT
    52 flu
    53 fludarabine
    54 group
    55 hematopoietic cell transplantation
    56 higher non-relapse mortality
    57 incidence
    58 intravenous busulfan
    59 ivBu
    60 leukemia
    61 leukemia-free survival
    62 lower risk
    63 melphalan
    64 mortality
    65 multivariate analysis
    66 myeloablative conditioning
    67 myeloid leukemia
    68 nationwide retrospective study
    69 non-relapse mortality
    70 outcomes
    71 overall survival
    72 patients
    73 potential
    74 reduced doses
    75 reduced-intensity conditioning
    76 reduced-intensity stem cell transplantation
    77 regimens
    78 relapse
    79 results
    80 retrospective study
    81 risk
    82 significant differences
    83 similar survival outcomes
    84 stem cell transplantation
    85 study
    86 survival
    87 survival outcomes
    88 transplantation
    89 useful regimens
    90 schema:name Reduced-intensity stem cell transplantation for acute myeloid leukemia with fludarabine-based conditioning with intravenous busulfan versus melphalan
    91 schema:pagination 1955-1965
    92 schema:productId N3d60ad2fbac44fd98fc3fa0abb38d383
    93 Nb3d728243d9942d08c74fb48e00c0871
    94 Nd6a3a3b980ee495f972edb1167ccf88f
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125556029
    96 https://doi.org/10.1038/s41409-020-0856-y
    97 schema:sdDatePublished 2022-08-04T17:09
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher Nde33c9977fe645c7a4a9cfbd6370dfbf
    100 schema:url https://doi.org/10.1038/s41409-020-0856-y
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N2c48abe0f1d6404186ba274a10b0a3ef rdf:first sg:person.0577702220.98
    105 rdf:rest Nd5cbbe0385534407b0f287dd884845e4
    106 N3d60ad2fbac44fd98fc3fa0abb38d383 schema:name doi
    107 schema:value 10.1038/s41409-020-0856-y
    108 rdf:type schema:PropertyValue
    109 N49661bd1c4dc4a8dbc7669d26cda3679 rdf:first sg:person.01100640630.10
    110 rdf:rest N92a2efd312ab4f95b247c8d0d83c3647
    111 N4a85c31dcff3404b8d2a90cc5308ec36 schema:volumeNumber 55
    112 rdf:type schema:PublicationVolume
    113 N4b72828740c741239807a9a38b704a6c schema:issueNumber 10
    114 rdf:type schema:PublicationIssue
    115 N5b36bbfb92d142d6b5b4a431dfe4aeb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Hematopoietic Stem Cell Transplantation
    117 rdf:type schema:DefinedTerm
    118 N6340aad2df6949d3b39b5be2da59ffc0 rdf:first sg:person.016452523632.46
    119 rdf:rest Nb3feb0f6e566418bad72077bd6c261c5
    120 N70c28681515b4d6e8b682f52749722df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Leukemia, Myeloid, Acute
    122 rdf:type schema:DefinedTerm
    123 N81faedcd3ee54a47a0e928fcdb23cfa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Transplantation Conditioning
    125 rdf:type schema:DefinedTerm
    126 N86d139d20991479592aa21182b87def2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Retrospective Studies
    128 rdf:type schema:DefinedTerm
    129 N87b28bdf22df480fbb60de933bfeb3c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Melphalan
    131 rdf:type schema:DefinedTerm
    132 N882320be0cbb4507bc8b8a9cf3cae07a rdf:first sg:person.01276656114.09
    133 rdf:rest N2c48abe0f1d6404186ba274a10b0a3ef
    134 N92a2efd312ab4f95b247c8d0d83c3647 rdf:first sg:person.01146754030.08
    135 rdf:rest Na8fd9160f25d49c8bd66bedeb3bce48b
    136 N9809087f94834b15ba78b7b85e5a66f8 rdf:first sg:person.01071077443.23
    137 rdf:rest N49661bd1c4dc4a8dbc7669d26cda3679
    138 N9cf2434dc2814e55aa26db71a7fb78cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Humans
    140 rdf:type schema:DefinedTerm
    141 Na4f3916d6cea406d907ba5c6dae87724 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Busulfan
    143 rdf:type schema:DefinedTerm
    144 Na8fd9160f25d49c8bd66bedeb3bce48b rdf:first sg:person.01265010246.42
    145 rdf:rest rdf:nil
    146 Nafdc785b103043ca88fad8378da560aa rdf:first sg:person.011176077202.18
    147 rdf:rest Ndc95dfbc800741b883dc7aa40884a10e
    148 Nb3d728243d9942d08c74fb48e00c0871 schema:name pubmed_id
    149 schema:value 32203256
    150 rdf:type schema:PropertyValue
    151 Nb3feb0f6e566418bad72077bd6c261c5 rdf:first sg:person.0720274373.65
    152 rdf:rest Ne51200bbabca47f6a94e555a529951a9
    153 Nbd2b3c45a5554172a4827bf9a6e0e002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Adult
    155 rdf:type schema:DefinedTerm
    156 Nc5697957568147ecb29bc7abc5d85f4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Vidarabine
    158 rdf:type schema:DefinedTerm
    159 Nd097c60d62c643cb840250fd2f6c0cfa rdf:first sg:person.01137533644.09
    160 rdf:rest Ne5131febb5c541cdb0949d6328780d86
    161 Nd5cbbe0385534407b0f287dd884845e4 rdf:first sg:person.01243564276.76
    162 rdf:rest N6340aad2df6949d3b39b5be2da59ffc0
    163 Nd6a3a3b980ee495f972edb1167ccf88f schema:name dimensions_id
    164 schema:value pub.1125556029
    165 rdf:type schema:PropertyValue
    166 Ndc95dfbc800741b883dc7aa40884a10e rdf:first sg:person.0647415353.43
    167 rdf:rest Nd097c60d62c643cb840250fd2f6c0cfa
    168 Nde33c9977fe645c7a4a9cfbd6370dfbf schema:name Springer Nature - SN SciGraph project
    169 rdf:type schema:Organization
    170 Ne51200bbabca47f6a94e555a529951a9 rdf:first sg:person.0653535643.01
    171 rdf:rest Nafdc785b103043ca88fad8378da560aa
    172 Ne5131febb5c541cdb0949d6328780d86 rdf:first sg:person.0666225507.36
    173 rdf:rest N9809087f94834b15ba78b7b85e5a66f8
    174 Ne6ef7f203cac4ed9b16e899d7e817060 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Graft vs Host Disease
    176 rdf:type schema:DefinedTerm
    177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Medical and Health Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Cardiorespiratory Medicine and Haematology
    182 rdf:type schema:DefinedTerm
    183 sg:grant.7535173 http://pending.schema.org/fundedItem sg:pub.10.1038/s41409-020-0856-y
    184 rdf:type schema:MonetaryGrant
    185 sg:journal.1096890 schema:issn 0268-3369
    186 1476-5365
    187 schema:name Bone Marrow Transplantation
    188 schema:publisher Springer Nature
    189 rdf:type schema:Periodical
    190 sg:person.01071077443.23 schema:affiliation grid-institutes:grid.415538.e
    191 schema:familyName Hidaka
    192 schema:givenName Michihiro
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071077443.23
    194 rdf:type schema:Person
    195 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.258799.8
    196 schema:familyName Kanda
    197 schema:givenName Junya
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
    199 rdf:type schema:Person
    200 sg:person.011176077202.18 schema:affiliation grid-institutes:grid.415262.6
    201 schema:familyName Ota
    202 schema:givenName Shuichi
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18
    204 rdf:type schema:Person
    205 sg:person.01137533644.09 schema:affiliation grid-institutes:grid.417092.9
    206 schema:familyName Miyakoshi
    207 schema:givenName Shigesaburo
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137533644.09
    209 rdf:type schema:Person
    210 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
    211 schema:familyName Atsuta
    212 schema:givenName Yoshiko
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
    214 rdf:type schema:Person
    215 sg:person.01243564276.76 schema:affiliation grid-institutes:grid.410813.f
    216 schema:familyName Uchida
    217 schema:givenName Naoyuki
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76
    219 rdf:type schema:Person
    220 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
    221 schema:familyName Yano
    222 schema:givenName Shingo
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
    224 rdf:type schema:Person
    225 sg:person.01276656114.09 schema:affiliation grid-institutes:grid.430395.8
    226 schema:familyName Yamashita
    227 schema:givenName Takuya
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656114.09
    229 rdf:type schema:Person
    230 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    231 schema:familyName Fukuda
    232 schema:givenName Takahiro
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    234 rdf:type schema:Person
    235 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.510308.f
    236 schema:familyName Takami
    237 schema:givenName Akiyoshi
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
    239 rdf:type schema:Person
    240 sg:person.0647415353.43 schema:affiliation grid-institutes:grid.416952.d
    241 schema:familyName Akasaka
    242 schema:givenName Takashi
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647415353.43
    244 rdf:type schema:Person
    245 sg:person.0653535643.01 schema:affiliation grid-institutes:grid.412167.7
    246 schema:familyName Shiratori
    247 schema:givenName Souichi
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01
    249 rdf:type schema:Person
    250 sg:person.0666225507.36 schema:affiliation grid-institutes:grid.411217.0
    251 schema:familyName Kondo
    252 schema:givenName Tadakazu
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36
    254 rdf:type schema:Person
    255 sg:person.0720274373.65 schema:affiliation grid-institutes:grid.413617.6
    256 schema:familyName Eto
    257 schema:givenName Tetsuya
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65
    259 rdf:type schema:Person
    260 sg:pub.10.1038/bmt.2008.372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026589975
    261 https://doi.org/10.1038/bmt.2008.372
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/bmt.2011.167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044929323
    264 https://doi.org/10.1038/bmt.2011.167
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    267 https://doi.org/10.1038/bmt.2012.244
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/bmt.2017.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085413197
    270 https://doi.org/10.1038/bmt.2017.83
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/sj.bmt.1702351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023445788
    273 https://doi.org/10.1038/sj.bmt.1702351
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/sj.bmt.1703215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044695461
    276 https://doi.org/10.1038/sj.bmt.1703215
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/sj.bmt.1705801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051994531
    279 https://doi.org/10.1038/sj.bmt.1705801
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/sj.leu.2404335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038554232
    282 https://doi.org/10.1038/sj.leu.2404335
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/sj.leu.2404886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052335578
    285 https://doi.org/10.1038/sj.leu.2404886
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1532/ijh97.06199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040472130
    288 https://doi.org/10.1532/ijh97.06199
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1532/ijh97.06239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054504897
    291 https://doi.org/10.1532/ijh97.06239
    292 rdf:type schema:CreativeWork
    293 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    294 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    295 rdf:type schema:Organization
    296 grid-institutes:grid.272242.3 schema:alternateName Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    297 schema:name Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    298 rdf:type schema:Organization
    299 grid-institutes:grid.27476.30 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
    300 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
    301 Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    302 rdf:type schema:Organization
    303 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    304 schema:name Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    305 rdf:type schema:Organization
    306 grid-institutes:grid.411217.0 schema:alternateName Department of Hematology, Kyoto University Hospital, Kyoto, Japan
    307 schema:name Department of Hematology, Kyoto University Hospital, Kyoto, Japan
    308 rdf:type schema:Organization
    309 grid-institutes:grid.411898.d schema:alternateName Department of Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
    310 schema:name Department of Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
    311 rdf:type schema:Organization
    312 grid-institutes:grid.412167.7 schema:alternateName Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    313 schema:name Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    314 rdf:type schema:Organization
    315 grid-institutes:grid.413617.6 schema:alternateName Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    316 schema:name Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    317 rdf:type schema:Organization
    318 grid-institutes:grid.415262.6 schema:alternateName Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    319 schema:name Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    320 rdf:type schema:Organization
    321 grid-institutes:grid.415538.e schema:alternateName Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
    322 schema:name Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
    323 rdf:type schema:Organization
    324 grid-institutes:grid.416952.d schema:alternateName Department of Hematology, Tenri Hospital, Tenri, Japan
    325 schema:name Department of Hematology, Tenri Hospital, Tenri, Japan
    326 rdf:type schema:Organization
    327 grid-institutes:grid.417092.9 schema:alternateName Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    328 schema:name Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    329 rdf:type schema:Organization
    330 grid-institutes:grid.430395.8 schema:alternateName Department of Hematology, St. Luke’s International Hospital, Tokyo, Japan
    331 schema:name Department of Hematology, St. Luke’s International Hospital, Tokyo, Japan
    332 rdf:type schema:Organization
    333 grid-institutes:grid.510308.f schema:alternateName Division of Hematology, Department of Internal Medicine, Aichi Medical University Hospital, Aichi, Japan
    334 schema:name Division of Hematology, Department of Internal Medicine, Aichi Medical University Hospital, Aichi, Japan
    335 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...