A high CD34+ cell dose is associated with better disease-free survival in patients with low-risk diseases undergoing peripheral blood stem ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-02-10

AUTHORS

Yasuhisa Yokoyama, Koichiro Maie, Takahiro Fukuda, Naoyuki Uchida, Junichi Mukae, Masashi Sawa, Kohmei Kubo, Mineo Kurokawa, Hirohisa Nakamae, Tatsuo Ichinohe, Yoshiko Atsuta, Shigeru Chiba

ABSTRACT

To elucidate the impact of infused CD34+ cell doses on transplant outcome, we retrospectively analyzed 851 adult patients who received peripheral blood stem cell transplantation (PBSCT) from human leukocyte antigen (HLA)-matched related donors. The patients were divided into high- and low-CD34 groups at the cutoff value of 4.5 × 106/kg. Overall, the high CD34 group showed early neutrophil and platelet recovery. Stratification of disease risks demonstrated that among the patients with low-risk diseases, the high-CD34 group showed better disease-free survival (DFS) (64.9% vs. 55.5%, P = 0.0415) than did the low-CD34 group, without any increase in graft-versus-host disease (GVHD). Meanwhile, a higher CD34+ cell dose had no impacts on the outcomes of patients with high-risk diseases. Multivariate analyses for the patients with low-risk diseases revealed that a high CD34+ cell dose (hazard ratio [HR] 0.72, P = 0.048) and development of grade III-to-IV acute GVHD (HR 1.64, P = 0.018) were significantly associated with DFS. An excessive dose of CD34+ cells (>8.0 × 106/kg) led to an increase in acute GVHD. By stratification of disease risk, a CD34+ cell dose between 4.5 and 8.0 × 106/kg can be suggested for patients with low-risk diseases who undergo PBSCT from HLA-matched related donors. More... »

PAGES

1726-1735

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-020-0817-5

DOI

http://dx.doi.org/10.1038/s41409-020-0817-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1124773742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32042104


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD34", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft vs Host Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Blood Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Yasuhisa", 
        "id": "sg:person.01130015361.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130015361.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maie", 
        "givenName": "Koichiro", 
        "id": "sg:person.0737713220.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737713220.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuda", 
        "givenName": "Takahiro", 
        "id": "sg:person.016452523632.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410813.f", 
          "name": [
            "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Naoyuki", 
        "id": "sg:person.01243564276.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Junichi", 
        "id": "sg:person.016270257233.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016270257233.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413779.f", 
          "name": [
            "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sawa", 
        "givenName": "Masashi", 
        "id": "sg:person.0635043607.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Aomori Prefectural Central Hospital, Aomori, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413825.9", 
          "name": [
            "Department of Hematology, Aomori Prefectural Central Hospital, Aomori, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubo", 
        "givenName": "Kohmei", 
        "id": "sg:person.07565420012.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07565420012.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412708.8", 
          "name": [
            "Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurokawa", 
        "givenName": "Mineo", 
        "id": "sg:person.01124305446.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124305446.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "Hirohisa", 
        "id": "sg:person.01014223462.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichinohe", 
        "givenName": "Tatsuo", 
        "id": "sg:person.0623252373.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
            "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01146754030.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiba", 
        "givenName": "Shigeru", 
        "id": "sg:person.0671177613.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671177613.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bmt.2012.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006774435", 
          "https://doi.org/10.1038/bmt.2012.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024785620", 
          "https://doi.org/10.1038/sj.bmt.1704042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045786347", 
          "https://doi.org/10.1038/sj.leu.2402909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2014.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005577754", 
          "https://doi.org/10.1038/bmt.2014.94"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-02-10", 
    "datePublishedReg": "2020-02-10", 
    "description": "To elucidate the impact of infused CD34+ cell doses on transplant outcome, we retrospectively analyzed 851 adult patients who received peripheral blood stem cell transplantation (PBSCT) from human leukocyte antigen (HLA)-matched related donors. The patients were divided into high- and low-CD34 groups at the cutoff value of 4.5\u2009\u00d7\u2009106/kg. Overall, the high CD34 group showed early neutrophil and platelet recovery. Stratification of disease risks demonstrated that among the patients with low-risk diseases, the high-CD34 group showed better disease-free survival (DFS) (64.9% vs. 55.5%, P\u2009=\u20090.0415) than did the low-CD34 group, without any increase in graft-versus-host disease (GVHD). Meanwhile, a higher CD34+ cell dose had no impacts on the outcomes of patients with high-risk diseases. Multivariate analyses for the patients with low-risk\u00a0diseases revealed that a high CD34+ cell dose (hazard ratio [HR] 0.72, P\u2009=\u20090.048) and development of grade III-to-IV acute GVHD (HR 1.64, P\u2009=\u20090.018) were significantly associated with DFS. An excessive dose of CD34+ cells (>8.0\u2009\u00d7\u2009106/kg) led to an increase in acute GVHD. By stratification of disease risk, a CD34+ cell dose between 4.5 and 8.0\u2009\u00d7\u2009106/kg can be suggested for patients with low-risk diseases who undergo PBSCT from HLA-matched related donors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41409-020-0817-5", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "peripheral blood stem cell transplantation", 
      "disease-free survival", 
      "low-risk disease", 
      "blood stem cell transplantation", 
      "better disease-free survival", 
      "stem cell transplantation", 
      "cell dose", 
      "related donors", 
      "higher CD34", 
      "CD34 group", 
      "acute GVHD", 
      "cell transplantation", 
      "disease risk", 
      "outcomes of patients", 
      "high-risk disease", 
      "human leukocyte antigen", 
      "early neutrophil", 
      "transplant outcomes", 
      "host disease", 
      "adult patients", 
      "infused CD34", 
      "leukocyte antigen", 
      "grade III", 
      "platelet recovery", 
      "cell doses", 
      "patients", 
      "cutoff value", 
      "multivariate analysis", 
      "excessive dose", 
      "CD34", 
      "disease", 
      "dose", 
      "GVHD", 
      "transplantation", 
      "HLA", 
      "survival", 
      "outcomes", 
      "risk", 
      "group", 
      "donors", 
      "neutrophils", 
      "graft", 
      "stratification", 
      "antigen", 
      "doses", 
      "increase", 
      "cells", 
      "recovery", 
      "impact", 
      "development", 
      "analysis", 
      "values"
    ], 
    "name": "A high CD34+ cell dose is associated with better disease-free survival in patients with low-risk diseases undergoing peripheral blood stem cell transplantation from HLA-matched related donors", 
    "pagination": "1726-1735", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1124773742"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41409-020-0817-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32042104"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41409-020-0817-5", 
      "https://app.dimensions.ai/details/publication/pub.1124773742"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_870.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41409-020-0817-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0817-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0817-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0817-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-0817-5'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      92 URIs      79 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41409-020-0817-5 schema:about N0edb07da64bd479295febf1baf754cfe
2 N249513a4c8744e23a29e15615012555b
3 N283a74e5bbfb4139968fe9810b9b46cd
4 N34afa06ca2c64c88b1d4930137c55651
5 N3b73d46981f34f319ff425a707f892e8
6 N43bf330bcd5b48429275c66745c21bca
7 N582f7746606c4c3b81ae7f8e5a191362
8 N7d7d6c5fc98f456f9641204d0860d149
9 Nec951ac81dd8480cb2753fcc14435ca5
10 Nf94f69037fc049c589b4131408861762
11 anzsrc-for:11
12 anzsrc-for:1102
13 schema:author N3cf253d9467046ff9666fdc166181f05
14 schema:citation sg:pub.10.1038/bmt.2012.244
15 sg:pub.10.1038/bmt.2012.75
16 sg:pub.10.1038/bmt.2014.94
17 sg:pub.10.1038/sj.bmt.1704042
18 sg:pub.10.1038/sj.leu.2402909
19 schema:datePublished 2020-02-10
20 schema:datePublishedReg 2020-02-10
21 schema:description To elucidate the impact of infused CD34+ cell doses on transplant outcome, we retrospectively analyzed 851 adult patients who received peripheral blood stem cell transplantation (PBSCT) from human leukocyte antigen (HLA)-matched related donors. The patients were divided into high- and low-CD34 groups at the cutoff value of 4.5 × 106/kg. Overall, the high CD34 group showed early neutrophil and platelet recovery. Stratification of disease risks demonstrated that among the patients with low-risk diseases, the high-CD34 group showed better disease-free survival (DFS) (64.9% vs. 55.5%, P = 0.0415) than did the low-CD34 group, without any increase in graft-versus-host disease (GVHD). Meanwhile, a higher CD34+ cell dose had no impacts on the outcomes of patients with high-risk diseases. Multivariate analyses for the patients with low-risk diseases revealed that a high CD34+ cell dose (hazard ratio [HR] 0.72, P = 0.048) and development of grade III-to-IV acute GVHD (HR 1.64, P = 0.018) were significantly associated with DFS. An excessive dose of CD34+ cells (>8.0 × 106/kg) led to an increase in acute GVHD. By stratification of disease risk, a CD34+ cell dose between 4.5 and 8.0 × 106/kg can be suggested for patients with low-risk diseases who undergo PBSCT from HLA-matched related donors.
22 schema:genre article
23 schema:isAccessibleForFree false
24 schema:isPartOf N17252fe5b4d043588de040b83239b1a2
25 N736f6e1c30264a3f89ab3116883f2569
26 sg:journal.1096890
27 schema:keywords CD34
28 CD34 group
29 GVHD
30 HLA
31 acute GVHD
32 adult patients
33 analysis
34 antigen
35 better disease-free survival
36 blood stem cell transplantation
37 cell dose
38 cell doses
39 cell transplantation
40 cells
41 cutoff value
42 development
43 disease
44 disease risk
45 disease-free survival
46 donors
47 dose
48 doses
49 early neutrophil
50 excessive dose
51 grade III
52 graft
53 group
54 high-risk disease
55 higher CD34
56 host disease
57 human leukocyte antigen
58 impact
59 increase
60 infused CD34
61 leukocyte antigen
62 low-risk disease
63 multivariate analysis
64 neutrophils
65 outcomes
66 outcomes of patients
67 patients
68 peripheral blood stem cell transplantation
69 platelet recovery
70 recovery
71 related donors
72 risk
73 stem cell transplantation
74 stratification
75 survival
76 transplant outcomes
77 transplantation
78 values
79 schema:name A high CD34+ cell dose is associated with better disease-free survival in patients with low-risk diseases undergoing peripheral blood stem cell transplantation from HLA-matched related donors
80 schema:pagination 1726-1735
81 schema:productId N0ead055083734817a4445cd194d5a657
82 N18776945461f48b9a7728369b7187d4c
83 Nd95cea35955344fd94d6d2f5dae1cb1b
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124773742
85 https://doi.org/10.1038/s41409-020-0817-5
86 schema:sdDatePublished 2022-12-01T06:42
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N586e02578b92456f84548517726380fe
89 schema:url https://doi.org/10.1038/s41409-020-0817-5
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0ead055083734817a4445cd194d5a657 schema:name pubmed_id
94 schema:value 32042104
95 rdf:type schema:PropertyValue
96 N0edb07da64bd479295febf1baf754cfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Disease-Free Survival
98 rdf:type schema:DefinedTerm
99 N17252fe5b4d043588de040b83239b1a2 schema:volumeNumber 55
100 rdf:type schema:PublicationVolume
101 N18776945461f48b9a7728369b7187d4c schema:name doi
102 schema:value 10.1038/s41409-020-0817-5
103 rdf:type schema:PropertyValue
104 N249513a4c8744e23a29e15615012555b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Retrospective Studies
106 rdf:type schema:DefinedTerm
107 N283a74e5bbfb4139968fe9810b9b46cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Adult
109 rdf:type schema:DefinedTerm
110 N34afa06ca2c64c88b1d4930137c55651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Graft vs Host Disease
112 rdf:type schema:DefinedTerm
113 N39a97d17bd08426992edb73a41f64bb5 rdf:first sg:person.0623252373.33
114 rdf:rest N58a5b8ad3b4a42d8bf2e6b3497de1e79
115 N3b73d46981f34f319ff425a707f892e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Antigens, CD34
117 rdf:type schema:DefinedTerm
118 N3cf253d9467046ff9666fdc166181f05 rdf:first sg:person.01130015361.78
119 rdf:rest N70315267db2f4f2eb18f00891fb106ad
120 N43bf330bcd5b48429275c66745c21bca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N528dfd70a1dd4963b98ebf1ddc54dadf rdf:first sg:person.0671177613.83
124 rdf:rest rdf:nil
125 N582f7746606c4c3b81ae7f8e5a191362 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name HLA Antigens
127 rdf:type schema:DefinedTerm
128 N586e02578b92456f84548517726380fe schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N58a5b8ad3b4a42d8bf2e6b3497de1e79 rdf:first sg:person.01146754030.08
131 rdf:rest N528dfd70a1dd4963b98ebf1ddc54dadf
132 N5976680f11814e8199c6ea6e0843a371 rdf:first sg:person.01014223462.98
133 rdf:rest N39a97d17bd08426992edb73a41f64bb5
134 N5cedb02d61504ba481ff38c4bbe3ddc0 rdf:first sg:person.0635043607.22
135 rdf:rest Nc2b50b10d76d44cfb3ec9887e0e70310
136 N70315267db2f4f2eb18f00891fb106ad rdf:first sg:person.0737713220.33
137 rdf:rest N8bc78a331b0846fb8572a1f18c8f0900
138 N736f6e1c30264a3f89ab3116883f2569 schema:issueNumber 9
139 rdf:type schema:PublicationIssue
140 N7d7d6c5fc98f456f9641204d0860d149 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Transplantation, Homologous
142 rdf:type schema:DefinedTerm
143 N8bc78a331b0846fb8572a1f18c8f0900 rdf:first sg:person.016452523632.46
144 rdf:rest N91db09bbd4614bb496b6cae4a4627752
145 N8f1ec7c3e8594a409ee6bfbfecb1dd21 rdf:first sg:person.01124305446.95
146 rdf:rest N5976680f11814e8199c6ea6e0843a371
147 N91db09bbd4614bb496b6cae4a4627752 rdf:first sg:person.01243564276.76
148 rdf:rest Ne745eee5eeb1472b8a47dfd6b333e76c
149 Nc2b50b10d76d44cfb3ec9887e0e70310 rdf:first sg:person.07565420012.12
150 rdf:rest N8f1ec7c3e8594a409ee6bfbfecb1dd21
151 Nd95cea35955344fd94d6d2f5dae1cb1b schema:name dimensions_id
152 schema:value pub.1124773742
153 rdf:type schema:PropertyValue
154 Ne745eee5eeb1472b8a47dfd6b333e76c rdf:first sg:person.016270257233.06
155 rdf:rest N5cedb02d61504ba481ff38c4bbe3ddc0
156 Nec951ac81dd8480cb2753fcc14435ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Hematopoietic Stem Cell Transplantation
158 rdf:type schema:DefinedTerm
159 Nf94f69037fc049c589b4131408861762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Peripheral Blood Stem Cell Transplantation
161 rdf:type schema:DefinedTerm
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
166 schema:name Cardiorespiratory Medicine and Haematology
167 rdf:type schema:DefinedTerm
168 sg:journal.1096890 schema:issn 0268-3369
169 1476-5365
170 schema:name Bone Marrow Transplantation
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.261445.0
174 schema:familyName Nakamae
175 schema:givenName Hirohisa
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
177 rdf:type schema:Person
178 sg:person.01124305446.95 schema:affiliation grid-institutes:grid.412708.8
179 schema:familyName Kurokawa
180 schema:givenName Mineo
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124305446.95
182 rdf:type schema:Person
183 sg:person.01130015361.78 schema:affiliation grid-institutes:grid.20515.33
184 schema:familyName Yokoyama
185 schema:givenName Yasuhisa
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130015361.78
187 rdf:type schema:Person
188 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
189 schema:familyName Atsuta
190 schema:givenName Yoshiko
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
192 rdf:type schema:Person
193 sg:person.01243564276.76 schema:affiliation grid-institutes:grid.410813.f
194 schema:familyName Uchida
195 schema:givenName Naoyuki
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76
197 rdf:type schema:Person
198 sg:person.016270257233.06 schema:affiliation grid-institutes:grid.415479.a
199 schema:familyName Mukae
200 schema:givenName Junichi
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016270257233.06
202 rdf:type schema:Person
203 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
204 schema:familyName Fukuda
205 schema:givenName Takahiro
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
207 rdf:type schema:Person
208 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
209 schema:familyName Ichinohe
210 schema:givenName Tatsuo
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
212 rdf:type schema:Person
213 sg:person.0635043607.22 schema:affiliation grid-institutes:grid.413779.f
214 schema:familyName Sawa
215 schema:givenName Masashi
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22
217 rdf:type schema:Person
218 sg:person.0671177613.83 schema:affiliation grid-institutes:grid.20515.33
219 schema:familyName Chiba
220 schema:givenName Shigeru
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671177613.83
222 rdf:type schema:Person
223 sg:person.0737713220.33 schema:affiliation grid-institutes:grid.20515.33
224 schema:familyName Maie
225 schema:givenName Koichiro
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737713220.33
227 rdf:type schema:Person
228 sg:person.07565420012.12 schema:affiliation grid-institutes:grid.413825.9
229 schema:familyName Kubo
230 schema:givenName Kohmei
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07565420012.12
232 rdf:type schema:Person
233 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
234 https://doi.org/10.1038/bmt.2012.244
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/bmt.2012.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006774435
237 https://doi.org/10.1038/bmt.2012.75
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/bmt.2014.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005577754
240 https://doi.org/10.1038/bmt.2014.94
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/sj.bmt.1704042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024785620
243 https://doi.org/10.1038/sj.bmt.1704042
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.leu.2402909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045786347
246 https://doi.org/10.1038/sj.leu.2402909
247 rdf:type schema:CreativeWork
248 grid-institutes:grid.20515.33 schema:alternateName Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
249 schema:name Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
250 rdf:type schema:Organization
251 grid-institutes:grid.257022.0 schema:alternateName Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
252 schema:name Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
253 rdf:type schema:Organization
254 grid-institutes:grid.261445.0 schema:alternateName Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
255 schema:name Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
256 rdf:type schema:Organization
257 grid-institutes:grid.272242.3 schema:alternateName Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
258 schema:name Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
259 rdf:type schema:Organization
260 grid-institutes:grid.27476.30 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
261 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
262 Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
263 rdf:type schema:Organization
264 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
265 schema:name Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
266 rdf:type schema:Organization
267 grid-institutes:grid.412708.8 schema:alternateName Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan
268 schema:name Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan
269 rdf:type schema:Organization
270 grid-institutes:grid.413779.f schema:alternateName Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
271 schema:name Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
272 rdf:type schema:Organization
273 grid-institutes:grid.413825.9 schema:alternateName Department of Hematology, Aomori Prefectural Central Hospital, Aomori, Japan
274 schema:name Department of Hematology, Aomori Prefectural Central Hospital, Aomori, Japan
275 rdf:type schema:Organization
276 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
277 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...