Stopping tyrosine kinase inhibitors started after allogeneic HCT in patients with Philadelphia chromosome-positive leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-08

AUTHORS

Hideki Nakasone, Shinichi Kako, Takehiko Mori, Satoshi Takahashi, Makoto Onizuka, Shin-ichiro Fujiwara, Toru Sakura, Emiko Sakaida, Akira Yokota, Nobuyuki Aotsuka, Maki Hagihara, Nobuhiro Tsukada, Yoshihiro Hatta, Kensuke Usuki, Reiko Watanabe, Moritaka Gotoh, Shin Fujisawa, Shingo Yano, Heiwa Kanamori, Shinichiro Okamoto, Yoshinobu Kanda

ABSTRACT

For patients with Philadelphia chromosome (Ph)-positive leukemia, there is no consensus regarding how long tyrosine kinase inhibitors (TKI) should be given or whether TKI could be stopped if TKI is administrated after allogeneic hematopoietic cell transplantation (allo-HCT). We analyzed relapse-free survival (RFS) in 92 allo-HCT patients who received TKI for >3 months after allo-HCT, and aimed to develop a novel indicator, called as current TKI- & relapse-free (cTRFree) achievement. TKI after allo-HCT was started as planned in 39 patients, based on measurable residual disease (MRD) in 53 at a median of 152 days after allo-HCT. There was no difference in post-TKI RFS between the planned and MRD-based starting groups (P = 0.69). Second-generation TKIs were associated with superior RFS in Ph-positive acute leukemia (HR 2.71, P = 0.031). TKI was stopped before relapse in 48 patients. Stopping TKI as a time-dependent covariate was not associated with subsequent hematological relapse (HR 1.18, P = 0.72). In the TKI-stop group, TKI administration for >6 months tended to be associated with superior RFS (HR = 0.30, P = 0.08). As an indicator of transplant success, cTRFree was 35% 5 years after starting TKI. TKI could be stopped for recipients with sustained undetectable MRD. However, further prospective studies will be required to establish clinical recommendations. More... »

PAGES

1402-1412

References to SciGraph publications

  • 2012-06-08. Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphobla stic leukemia in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2011-03-28. Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS in BONE MARROW TRANSPLANTATION
  • 2002-03-01. Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia in LEUKEMIA
  • 2010-04-29. Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia in LEUKEMIA
  • 2019-01-24. Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 2018-04-24. Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph+ALL in ANNALS OF HEMATOLOGY
  • 2015-11-17. Allogeneic transplantation for CML in the TKI era: striking the right balance in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2012-12-05. Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR–ABL1-positive acute lymphoblastic leukemia in LEUKEMIA
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2011-10-11. Estimation of current cumulative incidence of leukaemia-free patients and current leukaemia-free survival in chronic myeloid leukaemia in the era of modern pharmacotherapy in BMC MEDICAL RESEARCH METHODOLOGY
  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    6

    VOLUME

    56

    Author Affiliations

  • Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
  • Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  • Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
  • Department of Hematology, Chiba University Hospital, Chiba, Japan
  • Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Division of Hematology and Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
  • Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
  • Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
  • Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
  • Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
  • Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  • Department of Hematology, Tokyo Medical University, Tokyo, Japan
  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-01206-5

    DOI

    http://dx.doi.org/10.1038/s41409-020-01206-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1134422797

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33420396


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Philadelphia Chromosome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Homologous", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakasone", 
            "givenName": "Hideki", 
            "id": "sg:person.01157322255.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157322255.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kako", 
            "givenName": "Shinichi", 
            "id": "sg:person.0675760325.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Takehiko", 
            "id": "sg:person.015512754302.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Satoshi", 
            "id": "sg:person.0721047700.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onizuka", 
            "givenName": "Makoto", 
            "id": "sg:person.01046262603.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiwara", 
            "givenName": "Shin-ichiro", 
            "id": "sg:person.01073536015.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416616.2", 
              "name": [
                "Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakura", 
            "givenName": "Toru", 
            "id": "sg:person.0620232746.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620232746.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba University Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411321.4", 
              "name": [
                "Department of Hematology, Chiba University Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakaida", 
            "givenName": "Emiko", 
            "id": "sg:person.0775302360.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459433.c", 
              "name": [
                "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokota", 
            "givenName": "Akira", 
            "id": "sg:person.01317232725.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232725.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459661.9", 
              "name": [
                "Division of Hematology and Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aotsuka", 
            "givenName": "Nobuyuki", 
            "id": "sg:person.0577376767.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.268441.d", 
              "name": [
                "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hagihara", 
            "givenName": "Maki", 
            "id": "sg:person.0663130331.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663130331.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414929.3", 
              "name": [
                "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsukada", 
            "givenName": "Nobuhiro", 
            "id": "sg:person.0766244401.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766244401.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatta", 
            "givenName": "Yoshihiro", 
            "id": "sg:person.01010357272.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010357272.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414992.3", 
              "name": [
                "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Usuki", 
            "givenName": "Kensuke", 
            "id": "sg:person.0724116206.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Reiko", 
            "id": "sg:person.012637131732.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Tokyo Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "Department of Hematology, Tokyo Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gotoh", 
            "givenName": "Moritaka", 
            "id": "sg:person.01256303666.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256303666.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujisawa", 
            "givenName": "Shin", 
            "id": "sg:person.01145377314.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yano", 
            "givenName": "Shingo", 
            "id": "sg:person.01265010246.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanamori", 
            "givenName": "Heiwa", 
            "id": "sg:person.01060176576.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamoto", 
            "givenName": "Shinichiro", 
            "id": "sg:person.0715264147.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.0617055140.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.leu.2402392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007721716", 
              "https://doi.org/10.1038/sj.leu.2402392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052594326", 
              "https://doi.org/10.1038/bmt.2011.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2288-11-140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000178141", 
              "https://doi.org/10.1186/1471-2288-11-140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037699787", 
              "https://doi.org/10.1038/leu.2010.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-018-3323-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103623153", 
              "https://doi.org/10.1007/s00277-018-3323-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2015.193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031502952", 
              "https://doi.org/10.1038/nrclinonc.2015.193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11864-019-0603-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111626118", 
              "https://doi.org/10.1007/s11864-019-0603-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021091201", 
              "https://doi.org/10.1038/leu.2012.352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8722-5-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042061405", 
              "https://doi.org/10.1186/1756-8722-5-29"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-01-08", 
        "datePublishedReg": "2021-01-08", 
        "description": "For patients with Philadelphia chromosome (Ph)-positive leukemia, there is no consensus regarding how long tyrosine kinase inhibitors (TKI) should be given or whether TKI could be stopped if TKI is administrated after allogeneic hematopoietic cell transplantation (allo-HCT). We analyzed relapse-free survival (RFS) in 92 allo-HCT patients who received TKI for >3 months after allo-HCT, and aimed to develop a novel indicator, called as current TKI- & relapse-free (cTRFree) achievement. TKI after allo-HCT was started as planned in 39 patients, based on measurable residual disease (MRD) in 53 at a median of 152 days after allo-HCT. There was no difference in post-TKI RFS between the planned and MRD-based starting groups (P\u2009=\u20090.69). Second-generation TKIs were associated with superior RFS in Ph-positive acute leukemia (HR 2.71, P\u2009=\u20090.031). TKI was stopped before relapse in 48 patients. Stopping TKI as a time-dependent covariate was not associated with subsequent hematological relapse (HR 1.18, P\u2009=\u20090.72). In the TKI-stop group, TKI administration for >6 months tended to be associated with superior RFS (HR\u2009=\u20090.30, P\u2009=\u20090.08). As an indicator of transplant success, cTRFree was 35% 5 years after starting TKI. TKI could be stopped for recipients with sustained undetectable MRD. However, further prospective studies will be required to establish clinical recommendations.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41409-020-01206-5", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "56"
          }
        ], 
        "keywords": [
          "relapse-free survival", 
          "measurable residual disease", 
          "tyrosine kinase inhibitors", 
          "superior relapse-free survival", 
          "allo-HCT", 
          "second-generation tyrosine kinase inhibitors", 
          "current tyrosine kinase inhibitors", 
          "Ph-positive acute leukemia", 
          "undetectable measurable residual disease", 
          "allogeneic hematopoietic cell transplantation", 
          "kinase inhibitors", 
          "allo-HCT patients", 
          "Philadelphia chromosome-positive leukemia", 
          "hematopoietic cell transplantation", 
          "Further prospective studies", 
          "TKI administration", 
          "allogeneic HCT", 
          "time-dependent covariates", 
          "hematological relapse", 
          "prospective study", 
          "cell transplantation", 
          "residual disease", 
          "acute leukemia", 
          "clinical recommendations", 
          "patients", 
          "Philadelphia chromosome", 
          "positive leukemia", 
          "leukemia", 
          "transplant success", 
          "relapse", 
          "months", 
          "inhibitors", 
          "novel indicator", 
          "transplantation", 
          "group", 
          "disease", 
          "administration", 
          "Hct", 
          "recipients", 
          "median", 
          "survival", 
          "covariates", 
          "days", 
          "years", 
          "indicators", 
          "recommendations", 
          "differences", 
          "consensus", 
          "study", 
          "success", 
          "chromosomes", 
          "achievement"
        ], 
        "name": "Stopping tyrosine kinase inhibitors started after allogeneic HCT in patients with Philadelphia chromosome-positive leukemia", 
        "pagination": "1402-1412", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1134422797"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41409-020-01206-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33420396"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41409-020-01206-5", 
          "https://app.dimensions.ai/details/publication/pub.1134422797"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:31", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_909.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41409-020-01206-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01206-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01206-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01206-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01206-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    377 TRIPLES      22 PREDICATES      96 URIs      78 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41409-020-01206-5 schema:about N29a079e892784ea0b4142660fe5efee1
    2 N940f48fe4cc344f79304d055edf2917e
    3 N98ec2cfdeebf407a957cf7e6831c407a
    4 Na4ef5aa1292f4f10acdf0c85c18ac96e
    5 Na7a0cb795cb14de8b1c8c9f5275e8d99
    6 Nabc2c0675be24cc2ad0cae2070d208eb
    7 Nf2dc13d3c4d246ab8aa740f9ccaf3044
    8 Nf2f2610d86cc4404a376734078576a4b
    9 anzsrc-for:11
    10 anzsrc-for:1112
    11 schema:author Ndeb7afb1f25a4151a4f7a9a5499aba19
    12 schema:citation sg:pub.10.1007/s00277-018-3323-8
    13 sg:pub.10.1007/s11864-019-0603-z
    14 sg:pub.10.1038/bmt.2011.69
    15 sg:pub.10.1038/bmt.2012.244
    16 sg:pub.10.1038/leu.2010.83
    17 sg:pub.10.1038/leu.2012.352
    18 sg:pub.10.1038/nrclinonc.2015.193
    19 sg:pub.10.1038/sj.leu.2402392
    20 sg:pub.10.1186/1471-2288-11-140
    21 sg:pub.10.1186/1756-8722-5-29
    22 schema:datePublished 2021-01-08
    23 schema:datePublishedReg 2021-01-08
    24 schema:description For patients with Philadelphia chromosome (Ph)-positive leukemia, there is no consensus regarding how long tyrosine kinase inhibitors (TKI) should be given or whether TKI could be stopped if TKI is administrated after allogeneic hematopoietic cell transplantation (allo-HCT). We analyzed relapse-free survival (RFS) in 92 allo-HCT patients who received TKI for >3 months after allo-HCT, and aimed to develop a novel indicator, called as current TKI- & relapse-free (cTRFree) achievement. TKI after allo-HCT was started as planned in 39 patients, based on measurable residual disease (MRD) in 53 at a median of 152 days after allo-HCT. There was no difference in post-TKI RFS between the planned and MRD-based starting groups (P = 0.69). Second-generation TKIs were associated with superior RFS in Ph-positive acute leukemia (HR 2.71, P = 0.031). TKI was stopped before relapse in 48 patients. Stopping TKI as a time-dependent covariate was not associated with subsequent hematological relapse (HR 1.18, P = 0.72). In the TKI-stop group, TKI administration for >6 months tended to be associated with superior RFS (HR = 0.30, P = 0.08). As an indicator of transplant success, cTRFree was 35% 5 years after starting TKI. TKI could be stopped for recipients with sustained undetectable MRD. However, further prospective studies will be required to establish clinical recommendations.
    25 schema:genre article
    26 schema:inLanguage en
    27 schema:isAccessibleForFree false
    28 schema:isPartOf N615f3fbd2a014d9096a7b97796754636
    29 Nfcf47f1fc7e14f8e905072fb0aa56516
    30 sg:journal.1096890
    31 schema:keywords Further prospective studies
    32 Hct
    33 Ph-positive acute leukemia
    34 Philadelphia chromosome
    35 Philadelphia chromosome-positive leukemia
    36 TKI administration
    37 achievement
    38 acute leukemia
    39 administration
    40 allo-HCT
    41 allo-HCT patients
    42 allogeneic HCT
    43 allogeneic hematopoietic cell transplantation
    44 cell transplantation
    45 chromosomes
    46 clinical recommendations
    47 consensus
    48 covariates
    49 current tyrosine kinase inhibitors
    50 days
    51 differences
    52 disease
    53 group
    54 hematological relapse
    55 hematopoietic cell transplantation
    56 indicators
    57 inhibitors
    58 kinase inhibitors
    59 leukemia
    60 measurable residual disease
    61 median
    62 months
    63 novel indicator
    64 patients
    65 positive leukemia
    66 prospective study
    67 recipients
    68 recommendations
    69 relapse
    70 relapse-free survival
    71 residual disease
    72 second-generation tyrosine kinase inhibitors
    73 study
    74 success
    75 superior relapse-free survival
    76 survival
    77 time-dependent covariates
    78 transplant success
    79 transplantation
    80 tyrosine kinase inhibitors
    81 undetectable measurable residual disease
    82 years
    83 schema:name Stopping tyrosine kinase inhibitors started after allogeneic HCT in patients with Philadelphia chromosome-positive leukemia
    84 schema:pagination 1402-1412
    85 schema:productId N6a34027e07b440cc8e54183af85a1e09
    86 N6ea6270334c24a6380b75d863cc45ca2
    87 Ncdd2ca34fce243a18104017daabc5882
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1134422797
    89 https://doi.org/10.1038/s41409-020-01206-5
    90 schema:sdDatePublished 2022-05-10T10:31
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nb49ce2d02fd349cc94c4e1f27ed9e661
    93 schema:url https://doi.org/10.1038/s41409-020-01206-5
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N1ac214b997814db0bc821360b81ddecc rdf:first sg:person.0663130331.38
    98 rdf:rest N38927ca7f8254509b59211dc3ecc4e64
    99 N29a079e892784ea0b4142660fe5efee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Hematopoietic Stem Cell Transplantation
    101 rdf:type schema:DefinedTerm
    102 N2a6f6ed194b04580ac41488b283d684f rdf:first sg:person.01265010246.42
    103 rdf:rest Nd5e89b3b1cd64d85b49c57d192d9505c
    104 N388ef24cfd124a30b41785c61a930c81 rdf:first sg:person.0724116206.23
    105 rdf:rest Nd38affaa1a46483f93a24c655ee34272
    106 N38927ca7f8254509b59211dc3ecc4e64 rdf:first sg:person.0766244401.31
    107 rdf:rest N3b911434c7b141d695d7f247cfe564e1
    108 N3b911434c7b141d695d7f247cfe564e1 rdf:first sg:person.01010357272.28
    109 rdf:rest N388ef24cfd124a30b41785c61a930c81
    110 N410d8ed2aa51478d9847e25a06e40a24 rdf:first sg:person.01046262603.08
    111 rdf:rest Ndb6bd8a5da1f431e89a1768157998200
    112 N615f3fbd2a014d9096a7b97796754636 schema:issueNumber 6
    113 rdf:type schema:PublicationIssue
    114 N6a34027e07b440cc8e54183af85a1e09 schema:name pubmed_id
    115 schema:value 33420396
    116 rdf:type schema:PropertyValue
    117 N6ea6270334c24a6380b75d863cc45ca2 schema:name doi
    118 schema:value 10.1038/s41409-020-01206-5
    119 rdf:type schema:PropertyValue
    120 N777f4cb1ff23424d8c2c782c666dffd4 rdf:first sg:person.01145377314.06
    121 rdf:rest N2a6f6ed194b04580ac41488b283d684f
    122 N8b6ab55177ee42628fd23b0f6cdc41d7 rdf:first sg:person.0675760325.07
    123 rdf:rest Nd6eef22de3e34725af055f8499c7df37
    124 N8bc436320e0e4e65aef95c5fd51ce00e rdf:first sg:person.0617055140.49
    125 rdf:rest rdf:nil
    126 N90c8b02217a0403a97a694865a73f9f0 rdf:first sg:person.0620232746.38
    127 rdf:rest Nd15e1e0d163e418fbe25605855cad594
    128 N940f48fe4cc344f79304d055edf2917e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Retrospective Studies
    130 rdf:type schema:DefinedTerm
    131 N98ec2cfdeebf407a957cf7e6831c407a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Transplantation, Homologous
    133 rdf:type schema:DefinedTerm
    134 Na4ef5aa1292f4f10acdf0c85c18ac96e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Protein Kinase Inhibitors
    136 rdf:type schema:DefinedTerm
    137 Na7a0cb795cb14de8b1c8c9f5275e8d99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Humans
    139 rdf:type schema:DefinedTerm
    140 Naa8b6fd610f9407cab8809faf2739b03 rdf:first sg:person.0721047700.17
    141 rdf:rest N410d8ed2aa51478d9847e25a06e40a24
    142 Nabc2c0675be24cc2ad0cae2070d208eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Philadelphia Chromosome
    144 rdf:type schema:DefinedTerm
    145 Nb2dd5aa27c654f6296d588ba9298a354 rdf:first sg:person.01317232725.31
    146 rdf:rest Ndd0b34aa64dc4220ba6d8cc2e4fb42ec
    147 Nb49ce2d02fd349cc94c4e1f27ed9e661 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 Nc8a927c1540c427f8ced54a76f013670 rdf:first sg:person.0715264147.87
    150 rdf:rest N8bc436320e0e4e65aef95c5fd51ce00e
    151 Ncdd2ca34fce243a18104017daabc5882 schema:name dimensions_id
    152 schema:value pub.1134422797
    153 rdf:type schema:PropertyValue
    154 Nd15e1e0d163e418fbe25605855cad594 rdf:first sg:person.0775302360.96
    155 rdf:rest Nb2dd5aa27c654f6296d588ba9298a354
    156 Nd38affaa1a46483f93a24c655ee34272 rdf:first sg:person.012637131732.19
    157 rdf:rest Nd57d732118e84118903363cdb939867c
    158 Nd57d732118e84118903363cdb939867c rdf:first sg:person.01256303666.11
    159 rdf:rest N777f4cb1ff23424d8c2c782c666dffd4
    160 Nd5e89b3b1cd64d85b49c57d192d9505c rdf:first sg:person.01060176576.11
    161 rdf:rest Nc8a927c1540c427f8ced54a76f013670
    162 Nd6eef22de3e34725af055f8499c7df37 rdf:first sg:person.015512754302.32
    163 rdf:rest Naa8b6fd610f9407cab8809faf2739b03
    164 Ndb6bd8a5da1f431e89a1768157998200 rdf:first sg:person.01073536015.79
    165 rdf:rest N90c8b02217a0403a97a694865a73f9f0
    166 Ndd0b34aa64dc4220ba6d8cc2e4fb42ec rdf:first sg:person.0577376767.42
    167 rdf:rest N1ac214b997814db0bc821360b81ddecc
    168 Ndeb7afb1f25a4151a4f7a9a5499aba19 rdf:first sg:person.01157322255.50
    169 rdf:rest N8b6ab55177ee42628fd23b0f6cdc41d7
    170 Nf2dc13d3c4d246ab8aa740f9ccaf3044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
    172 rdf:type schema:DefinedTerm
    173 Nf2f2610d86cc4404a376734078576a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Prospective Studies
    175 rdf:type schema:DefinedTerm
    176 Nfcf47f1fc7e14f8e905072fb0aa56516 schema:volumeNumber 56
    177 rdf:type schema:PublicationVolume
    178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical and Health Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Oncology and Carcinogenesis
    183 rdf:type schema:DefinedTerm
    184 sg:journal.1096890 schema:issn 0268-3369
    185 1476-5365
    186 schema:name Bone Marrow Transplantation
    187 schema:publisher Springer Nature
    188 rdf:type schema:Periodical
    189 sg:person.01010357272.28 schema:affiliation grid-institutes:grid.260969.2
    190 schema:familyName Hatta
    191 schema:givenName Yoshihiro
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010357272.28
    193 rdf:type schema:Person
    194 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
    195 schema:familyName Onizuka
    196 schema:givenName Makoto
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
    198 rdf:type schema:Person
    199 sg:person.01060176576.11 schema:affiliation grid-institutes:grid.414944.8
    200 schema:familyName Kanamori
    201 schema:givenName Heiwa
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11
    203 rdf:type schema:Person
    204 sg:person.01073536015.79 schema:affiliation grid-institutes:grid.410804.9
    205 schema:familyName Fujiwara
    206 schema:givenName Shin-ichiro
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79
    208 rdf:type schema:Person
    209 sg:person.01145377314.06 schema:affiliation grid-institutes:grid.413045.7
    210 schema:familyName Fujisawa
    211 schema:givenName Shin
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06
    213 rdf:type schema:Person
    214 sg:person.01157322255.50 schema:affiliation grid-institutes:grid.415020.2
    215 schema:familyName Nakasone
    216 schema:givenName Hideki
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157322255.50
    218 rdf:type schema:Person
    219 sg:person.01256303666.11 schema:affiliation grid-institutes:grid.410793.8
    220 schema:familyName Gotoh
    221 schema:givenName Moritaka
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256303666.11
    223 rdf:type schema:Person
    224 sg:person.012637131732.19 schema:affiliation grid-institutes:None
    225 schema:familyName Watanabe
    226 schema:givenName Reiko
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19
    228 rdf:type schema:Person
    229 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
    230 schema:familyName Yano
    231 schema:givenName Shingo
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
    233 rdf:type schema:Person
    234 sg:person.01317232725.31 schema:affiliation grid-institutes:grid.459433.c
    235 schema:familyName Yokota
    236 schema:givenName Akira
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232725.31
    238 rdf:type schema:Person
    239 sg:person.015512754302.32 schema:affiliation grid-institutes:grid.26091.3c
    240 schema:familyName Mori
    241 schema:givenName Takehiko
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32
    243 rdf:type schema:Person
    244 sg:person.0577376767.42 schema:affiliation grid-institutes:grid.459661.9
    245 schema:familyName Aotsuka
    246 schema:givenName Nobuyuki
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42
    248 rdf:type schema:Person
    249 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.415020.2
    250 schema:familyName Kanda
    251 schema:givenName Yoshinobu
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
    253 rdf:type schema:Person
    254 sg:person.0620232746.38 schema:affiliation grid-institutes:grid.416616.2
    255 schema:familyName Sakura
    256 schema:givenName Toru
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620232746.38
    258 rdf:type schema:Person
    259 sg:person.0663130331.38 schema:affiliation grid-institutes:grid.268441.d
    260 schema:familyName Hagihara
    261 schema:givenName Maki
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663130331.38
    263 rdf:type schema:Person
    264 sg:person.0675760325.07 schema:affiliation grid-institutes:grid.415020.2
    265 schema:familyName Kako
    266 schema:givenName Shinichi
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07
    268 rdf:type schema:Person
    269 sg:person.0715264147.87 schema:affiliation grid-institutes:grid.26091.3c
    270 schema:familyName Okamoto
    271 schema:givenName Shinichiro
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87
    273 rdf:type schema:Person
    274 sg:person.0721047700.17 schema:affiliation grid-institutes:grid.26999.3d
    275 schema:familyName Takahashi
    276 schema:givenName Satoshi
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17
    278 rdf:type schema:Person
    279 sg:person.0724116206.23 schema:affiliation grid-institutes:grid.414992.3
    280 schema:familyName Usuki
    281 schema:givenName Kensuke
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23
    283 rdf:type schema:Person
    284 sg:person.0766244401.31 schema:affiliation grid-institutes:grid.414929.3
    285 schema:familyName Tsukada
    286 schema:givenName Nobuhiro
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766244401.31
    288 rdf:type schema:Person
    289 sg:person.0775302360.96 schema:affiliation grid-institutes:grid.411321.4
    290 schema:familyName Sakaida
    291 schema:givenName Emiko
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96
    293 rdf:type schema:Person
    294 sg:pub.10.1007/s00277-018-3323-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103623153
    295 https://doi.org/10.1007/s00277-018-3323-8
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s11864-019-0603-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1111626118
    298 https://doi.org/10.1007/s11864-019-0603-z
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/bmt.2011.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052594326
    301 https://doi.org/10.1038/bmt.2011.69
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    304 https://doi.org/10.1038/bmt.2012.244
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/leu.2010.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037699787
    307 https://doi.org/10.1038/leu.2010.83
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/leu.2012.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021091201
    310 https://doi.org/10.1038/leu.2012.352
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nrclinonc.2015.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031502952
    313 https://doi.org/10.1038/nrclinonc.2015.193
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/sj.leu.2402392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007721716
    316 https://doi.org/10.1038/sj.leu.2402392
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1186/1471-2288-11-140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000178141
    319 https://doi.org/10.1186/1471-2288-11-140
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1186/1756-8722-5-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042061405
    322 https://doi.org/10.1186/1756-8722-5-29
    323 rdf:type schema:CreativeWork
    324 grid-institutes:None schema:alternateName Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    325 schema:name Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    326 rdf:type schema:Organization
    327 grid-institutes:grid.26091.3c schema:alternateName Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    328 schema:name Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    329 rdf:type schema:Organization
    330 grid-institutes:grid.260969.2 schema:alternateName Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
    331 schema:name Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
    332 rdf:type schema:Organization
    333 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    334 schema:name Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    335 rdf:type schema:Organization
    336 grid-institutes:grid.268441.d schema:alternateName Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    337 schema:name Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    338 rdf:type schema:Organization
    339 grid-institutes:grid.26999.3d schema:alternateName Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    340 schema:name Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    341 rdf:type schema:Organization
    342 grid-institutes:grid.410793.8 schema:alternateName Department of Hematology, Tokyo Medical University, Tokyo, Japan
    343 schema:name Department of Hematology, Tokyo Medical University, Tokyo, Japan
    344 rdf:type schema:Organization
    345 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    346 schema:name Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    347 rdf:type schema:Organization
    348 grid-institutes:grid.411321.4 schema:alternateName Department of Hematology, Chiba University Hospital, Chiba, Japan
    349 schema:name Department of Hematology, Chiba University Hospital, Chiba, Japan
    350 rdf:type schema:Organization
    351 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    352 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    353 rdf:type schema:Organization
    354 grid-institutes:grid.413045.7 schema:alternateName Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    355 schema:name Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    356 rdf:type schema:Organization
    357 grid-institutes:grid.414929.3 schema:alternateName Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    358 schema:name Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    359 rdf:type schema:Organization
    360 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
    361 schema:name Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
    362 rdf:type schema:Organization
    363 grid-institutes:grid.414992.3 schema:alternateName Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    364 schema:name Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    365 rdf:type schema:Organization
    366 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    367 schema:name Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    368 rdf:type schema:Organization
    369 grid-institutes:grid.416616.2 schema:alternateName Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
    370 schema:name Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.459433.c schema:alternateName Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    373 schema:name Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    374 rdf:type schema:Organization
    375 grid-institutes:grid.459661.9 schema:alternateName Division of Hematology and Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    376 schema:name Division of Hematology and Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    377 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...