Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-12-02

AUTHORS

Masamitsu Yanada, Takaaki Konuma, Satoshi Yamasaki, Tadakazu Kondo, Takahiro Fukuda, Naoki Shingai, Masashi Sawa, Yukiyasu Ozawa, Masatsugu Tanaka, Naoyuki Uchida, Hirohisa Nakamae, Yuta Katayama, Ken-ichi Matsuoka, Takafumi Kimura, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano

ABSTRACT

Posttransplant relapse represents the greatest obstacle to the success of allogeneic hematopoietic cell transplantation (HCT) for patients with acute myeloid leukemia (AML). This study investigated clinical features and outcomes of posttransplant relapse of AML based on data for 1265 patients with AML suffering relapse after allogeneic HCT conducted during complete remission (CR). Relapse occurred at a median of 6.1 months. The incidence rate of relapse peaked at 29.0 per 100 patient-years during the first 3–6 months period post transplant, after which the rate declined over time, and after 3 years remained consistently at less than 1 per 100 patient-years. The probability of overall survival (OS) after posttransplant relapse was 19% at 2 years, with 68% of deaths being attributed to leukemia. The interval from transplantation to relapse was identified as the strongest indicator for OS. Donor lymphocyte infusion (DLI) and second allogeneic HCT (HCT2) were administered to 152 (12%) and 481 (38%) patients, respectively. Landmark analyses showed some signs of survival benefit when these procedures were performed during CR, but no benefit was gained when performed during non-CR. Our findings clarify clinical features of posttransplant relapse of AML, and indicate the urgent need for developing effective bridging to cellular therapies. More... »

PAGES

1126-1133

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-020-01163-z

DOI

http://dx.doi.org/10.1038/s41409-020-01163-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1133004510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33268829


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