Allogeneic stem cell transplantation in poor prognosis peripheral T-cell lymphoma: the impact of different donor type on outcome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-15

AUTHORS

Luca Castagna, Thomas Pagliardini, Stefania Bramanti, Jean Marc Schiano de Colella, Catalina Montes de Oca, Reda Bouabdallah, Jacopo Mariotti, Sabine Fürst, Angela Granata, Chiara De Philippis, Samia Harbi, Barbara Sarina, Faezeh Legrand, Valerio Maisano, Pierre Jean Weiller, Christian Chabannon, Carmelo Carlo-Stella, Armando Santoro, Didier Blaise, Raynier Devillier

ABSTRACT

We report the outcome of 68 patients with advanced peripheral T-cell lymphoma receiving transplantation from haploidentical or from conventional donors. The 4-year OS, PFS, 2-year cumulative incidence of relapse and 2-year GRFS was 75%, 70%, 21%, and 51%, respectively. Survival was not affected by donor type. The 2-year NRM was 9%, lower after related or haploidentical donor (21% vs 0% vs 7%; p = 0.06). Grade 2–4 aGVHD cumulative incidence was significantly different after transplantation from haploidentical vs matched sibling vs unrelated donor, and (24% vs 35% vs 58%, p = 0.024). The familial donor cohort was compared to the unrelated cohort. Familial donor induced less grade 2–4 aGVHD, with a trend to less grade 3–4 aGVHD or moderate-severe cGVHD. The OS and PFS were not different, while the relapse risk and NRM were reduced. Allo-SCT is highly effective in T-cell lymphoma, with low NRM and low relapse rate. The incidence of aGVHD was lower after haploidentical transplantation. Related donor may challenge unrelated transplant reducing the risk of relapse and NRM. More... »

PAGES

883-889

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-01133-5

    DOI

    http://dx.doi.org/10.1038/s41409-020-01133-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132646742

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33191403


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