Decrease in voriconazole concentration-to-dose ratio after letermovir initiation: a retrospective, observational study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-25

AUTHORS

Shinichi Hikasa, Shota Shimabukuro, Yuko Osugi, Kazuhiro Ikegame, Katsuji Kaida, Keiko Fukunaga, Tomoko Higami, Masami Tada, Kuniyoshi Tanaka, Mina Yanai, Takeshi Kimura

ABSTRACT

Letermovir is used to prevent cytomegalovirus infection in hematopoietic stem cell transplantation (HSCT) recipients. Although this agent decreases voriconazole exposure in healthy individuals, the effect of coadministration of letermovir and voriconazole in HSCT recipients is unknown. This retrospective, observational, single-center study was conducted between January 2016 and July 2019 to examine the voriconazole concentration-to-dose ratio over three periods: (A) (days −7 to −1 [day 0: day of HCST]), (B) (days 4–10), and (C) (days 11–17). Forty-two HSCT recipients administered voriconazole were divided into the following two groups based on letermovir coadministration: letermovir (n = 15) and control (n = 27). The percent change (−33.2%, p < 0.05) in the voriconazole concentration-to-dose ratio from periods A to C in the letermovir group was significantly lower than that in the control group. Therefore, frequent therapeutic drug monitoring of voriconazole concentrations and subsequent dose adjustments should be performed regularly in HSCT recipients. More... »

PAGES

949-951

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-020-01093-w

DOI

http://dx.doi.org/10.1038/s41409-020-01093-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132039483

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33100323


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Voriconazole", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hikasa", 
        "givenName": "Shinichi", 
        "id": "sg:person.011425346455.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425346455.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimabukuro", 
        "givenName": "Shota", 
        "id": "sg:person.011444204507.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011444204507.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osugi", 
        "givenName": "Yuko", 
        "id": "sg:person.014707713047.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014707713047.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikegame", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01126146426.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126146426.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaida", 
        "givenName": "Katsuji", 
        "id": "sg:person.01154445343.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154445343.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukunaga", 
        "givenName": "Keiko", 
        "id": "sg:person.013443512417.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443512417.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higami", 
        "givenName": "Tomoko", 
        "id": "sg:person.011016610265.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011016610265.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tada", 
        "givenName": "Masami", 
        "id": "sg:person.011614170665.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011614170665.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Kuniyoshi", 
        "id": "sg:person.013460377060.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013460377060.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanai", 
        "givenName": "Mina", 
        "id": "sg:person.015142021551.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015142021551.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Takeshi", 
        "id": "sg:person.012173163322.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012173163322.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00277-017-3196-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099701204", 
          "https://doi.org/10.1007/s00277-017-3196-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645070-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037510163", 
          "https://doi.org/10.2165/00003088-200645070-00002"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-10-25", 
    "datePublishedReg": "2020-10-25", 
    "description": "Letermovir is used to prevent cytomegalovirus infection in hematopoietic stem cell transplantation (HSCT) recipients. Although this agent decreases voriconazole exposure in healthy individuals, the effect of coadministration of letermovir and voriconazole in HSCT recipients is unknown. This retrospective, observational, single-center study was conducted between January 2016 and July 2019 to examine the voriconazole concentration-to-dose ratio over three periods: (A) (days \u22127 to \u22121 [day 0: day of HCST]), (B) (days 4\u201310), and (C) (days 11\u201317). Forty-two HSCT recipients administered voriconazole were divided into the following two groups based on letermovir coadministration: letermovir (n\u2009=\u200915) and control (n\u2009=\u200927). The percent change (\u221233.2%, p\u2009<\u20090.05) in the voriconazole concentration-to-dose ratio from periods A to C in the letermovir group was significantly lower than that in the control group. Therefore, frequent therapeutic drug monitoring of voriconazole concentrations and subsequent dose adjustments should be performed regularly in HSCT recipients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41409-020-01093-w", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "keywords": [
      "voriconazole concentrations", 
      "HSCT recipients", 
      "dose ratio", 
      "hematopoietic stem cell transplantation recipients", 
      "frequent therapeutic drug monitoring", 
      "stem cell transplantation recipients", 
      "single-center study", 
      "subsequent dose adjustment", 
      "cell transplantation recipients", 
      "effect of coadministration", 
      "therapeutic drug monitoring", 
      "voriconazole exposure", 
      "letermovir group", 
      "letermovir initiation", 
      "cytomegalovirus infection", 
      "transplantation recipients", 
      "dose adjustment", 
      "observational study", 
      "healthy individuals", 
      "control group", 
      "percent change", 
      "drug monitoring", 
      "letermovir", 
      "recipients", 
      "coadministration", 
      "voriconazole", 
      "group", 
      "infection", 
      "period", 
      "study", 
      "concentration", 
      "exposure", 
      "initiation", 
      "agents", 
      "individuals", 
      "adjustment", 
      "ratio", 
      "control", 
      "effect", 
      "changes", 
      "monitoring"
    ], 
    "name": "Decrease in voriconazole concentration-to-dose ratio after letermovir initiation: a retrospective, observational study", 
    "pagination": "949-951", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132039483"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41409-020-01093-w"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33100323"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41409-020-01093-w", 
      "https://app.dimensions.ai/details/publication/pub.1132039483"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_868.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41409-020-01093-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01093-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01093-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01093-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01093-w'


 

This table displays all metadata directly associated to this object as RDF triples.

210 TRIPLES      21 PREDICATES      75 URIs      65 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41409-020-01093-w schema:about N0537c5032075451280945bdd8713090d
2 N0c48c3c38c944e448e112c9f8bf339e1
3 N686985810aac443b86b82d33e8d19340
4 N71ee2232af9f4738bd4cabb62e224821
5 N8456059778ea4507b69d8b9eaeffeaec
6 Nc09cda00b8db4122ab1687c0601c6dcc
7 Nf97e4cc0a88a412f9baea907e82a879b
8 anzsrc-for:11
9 anzsrc-for:1117
10 schema:author N3ad2be95dcaa4e208e2f1cdc10c1b83e
11 schema:citation sg:pub.10.1007/s00277-017-3196-2
12 sg:pub.10.2165/00003088-200645070-00002
13 schema:datePublished 2020-10-25
14 schema:datePublishedReg 2020-10-25
15 schema:description Letermovir is used to prevent cytomegalovirus infection in hematopoietic stem cell transplantation (HSCT) recipients. Although this agent decreases voriconazole exposure in healthy individuals, the effect of coadministration of letermovir and voriconazole in HSCT recipients is unknown. This retrospective, observational, single-center study was conducted between January 2016 and July 2019 to examine the voriconazole concentration-to-dose ratio over three periods: (A) (days −7 to −1 [day 0: day of HCST]), (B) (days 4–10), and (C) (days 11–17). Forty-two HSCT recipients administered voriconazole were divided into the following two groups based on letermovir coadministration: letermovir (n = 15) and control (n = 27). The percent change (−33.2%, p < 0.05) in the voriconazole concentration-to-dose ratio from periods A to C in the letermovir group was significantly lower than that in the control group. Therefore, frequent therapeutic drug monitoring of voriconazole concentrations and subsequent dose adjustments should be performed regularly in HSCT recipients.
16 schema:genre article
17 schema:isAccessibleForFree false
18 schema:isPartOf N7c311ec0ae1c4755ad7a2e928b02205e
19 Ne1beceb4de5f493c86e1378dc314131d
20 sg:journal.1096890
21 schema:keywords HSCT recipients
22 adjustment
23 agents
24 cell transplantation recipients
25 changes
26 coadministration
27 concentration
28 control
29 control group
30 cytomegalovirus infection
31 dose adjustment
32 dose ratio
33 drug monitoring
34 effect
35 effect of coadministration
36 exposure
37 frequent therapeutic drug monitoring
38 group
39 healthy individuals
40 hematopoietic stem cell transplantation recipients
41 individuals
42 infection
43 initiation
44 letermovir
45 letermovir group
46 letermovir initiation
47 monitoring
48 observational study
49 percent change
50 period
51 ratio
52 recipients
53 single-center study
54 stem cell transplantation recipients
55 study
56 subsequent dose adjustment
57 therapeutic drug monitoring
58 transplantation recipients
59 voriconazole
60 voriconazole concentrations
61 voriconazole exposure
62 schema:name Decrease in voriconazole concentration-to-dose ratio after letermovir initiation: a retrospective, observational study
63 schema:pagination 949-951
64 schema:productId N1895fd128ffb4eb89736afc1ccc15190
65 N30e8727756d04eae9e4231b2cee3cc7d
66 N48514b3d203f40f7899b6194177ffa4e
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132039483
68 https://doi.org/10.1038/s41409-020-01093-w
69 schema:sdDatePublished 2022-10-01T06:47
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N06ce498d2d9b456781ad7aa8513ae4ae
72 schema:url https://doi.org/10.1038/s41409-020-01093-w
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0537c5032075451280945bdd8713090d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Retrospective Studies
78 rdf:type schema:DefinedTerm
79 N06ce498d2d9b456781ad7aa8513ae4ae schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N0c48c3c38c944e448e112c9f8bf339e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Antiviral Agents
83 rdf:type schema:DefinedTerm
84 N1895fd128ffb4eb89736afc1ccc15190 schema:name doi
85 schema:value 10.1038/s41409-020-01093-w
86 rdf:type schema:PropertyValue
87 N30e8727756d04eae9e4231b2cee3cc7d schema:name dimensions_id
88 schema:value pub.1132039483
89 rdf:type schema:PropertyValue
90 N3ad2be95dcaa4e208e2f1cdc10c1b83e rdf:first sg:person.011425346455.71
91 rdf:rest Naaa5c71c66ea4ca4a54f0c5431682b59
92 N440e9a3b4c4e4eac8d43ccd56896b088 rdf:first sg:person.012173163322.36
93 rdf:rest rdf:nil
94 N48514b3d203f40f7899b6194177ffa4e schema:name pubmed_id
95 schema:value 33100323
96 rdf:type schema:PropertyValue
97 N4a5e9f0cb25f4414b36a0232618a32b2 rdf:first sg:person.011016610265.18
98 rdf:rest Nd3c3d999e1034a2da9d02f0f6f07e585
99 N686985810aac443b86b82d33e8d19340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Voriconazole
101 rdf:type schema:DefinedTerm
102 N71ee2232af9f4738bd4cabb62e224821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Quinazolines
104 rdf:type schema:DefinedTerm
105 N754fecd236db40ad8225d1b141896c96 rdf:first sg:person.013460377060.20
106 rdf:rest Naa64bd0d857d4e20990af3cccd4c2feb
107 N7c311ec0ae1c4755ad7a2e928b02205e schema:issueNumber 4
108 rdf:type schema:PublicationIssue
109 N8456059778ea4507b69d8b9eaeffeaec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hematopoietic Stem Cell Transplantation
111 rdf:type schema:DefinedTerm
112 Na5961dc77f024ba9ab45b71cfa72d6e8 rdf:first sg:person.01154445343.76
113 rdf:rest Nec4a6f164176402d864d835a421dbed5
114 Na677541210364647a886c57e2cbdb91e rdf:first sg:person.014707713047.00
115 rdf:rest Nf23e8117b0774983b85aa66eae11f521
116 Naa64bd0d857d4e20990af3cccd4c2feb rdf:first sg:person.015142021551.00
117 rdf:rest N440e9a3b4c4e4eac8d43ccd56896b088
118 Naaa5c71c66ea4ca4a54f0c5431682b59 rdf:first sg:person.011444204507.02
119 rdf:rest Na677541210364647a886c57e2cbdb91e
120 Nc09cda00b8db4122ab1687c0601c6dcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 Nd3c3d999e1034a2da9d02f0f6f07e585 rdf:first sg:person.011614170665.26
124 rdf:rest N754fecd236db40ad8225d1b141896c96
125 Ne1beceb4de5f493c86e1378dc314131d schema:volumeNumber 56
126 rdf:type schema:PublicationVolume
127 Nec4a6f164176402d864d835a421dbed5 rdf:first sg:person.013443512417.07
128 rdf:rest N4a5e9f0cb25f4414b36a0232618a32b2
129 Nf23e8117b0774983b85aa66eae11f521 rdf:first sg:person.01126146426.77
130 rdf:rest Na5961dc77f024ba9ab45b71cfa72d6e8
131 Nf97e4cc0a88a412f9baea907e82a879b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Acetates
133 rdf:type schema:DefinedTerm
134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical and Health Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
138 schema:name Public Health and Health Services
139 rdf:type schema:DefinedTerm
140 sg:journal.1096890 schema:issn 0268-3369
141 1476-5365
142 schema:name Bone Marrow Transplantation
143 schema:publisher Springer Nature
144 rdf:type schema:Periodical
145 sg:person.011016610265.18 schema:affiliation grid-institutes:grid.272264.7
146 schema:familyName Higami
147 schema:givenName Tomoko
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011016610265.18
149 rdf:type schema:Person
150 sg:person.01126146426.77 schema:affiliation grid-institutes:grid.272264.7
151 schema:familyName Ikegame
152 schema:givenName Kazuhiro
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126146426.77
154 rdf:type schema:Person
155 sg:person.011425346455.71 schema:affiliation grid-institutes:grid.272264.7
156 schema:familyName Hikasa
157 schema:givenName Shinichi
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425346455.71
159 rdf:type schema:Person
160 sg:person.011444204507.02 schema:affiliation grid-institutes:grid.272264.7
161 schema:familyName Shimabukuro
162 schema:givenName Shota
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011444204507.02
164 rdf:type schema:Person
165 sg:person.01154445343.76 schema:affiliation grid-institutes:grid.272264.7
166 schema:familyName Kaida
167 schema:givenName Katsuji
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154445343.76
169 rdf:type schema:Person
170 sg:person.011614170665.26 schema:affiliation grid-institutes:grid.272264.7
171 schema:familyName Tada
172 schema:givenName Masami
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011614170665.26
174 rdf:type schema:Person
175 sg:person.012173163322.36 schema:affiliation grid-institutes:grid.272264.7
176 schema:familyName Kimura
177 schema:givenName Takeshi
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012173163322.36
179 rdf:type schema:Person
180 sg:person.013443512417.07 schema:affiliation grid-institutes:grid.272264.7
181 schema:familyName Fukunaga
182 schema:givenName Keiko
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443512417.07
184 rdf:type schema:Person
185 sg:person.013460377060.20 schema:affiliation grid-institutes:grid.272264.7
186 schema:familyName Tanaka
187 schema:givenName Kuniyoshi
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013460377060.20
189 rdf:type schema:Person
190 sg:person.014707713047.00 schema:affiliation grid-institutes:grid.272264.7
191 schema:familyName Osugi
192 schema:givenName Yuko
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014707713047.00
194 rdf:type schema:Person
195 sg:person.015142021551.00 schema:affiliation grid-institutes:grid.272264.7
196 schema:familyName Yanai
197 schema:givenName Mina
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015142021551.00
199 rdf:type schema:Person
200 sg:pub.10.1007/s00277-017-3196-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099701204
201 https://doi.org/10.1007/s00277-017-3196-2
202 rdf:type schema:CreativeWork
203 sg:pub.10.2165/00003088-200645070-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037510163
204 https://doi.org/10.2165/00003088-200645070-00002
205 rdf:type schema:CreativeWork
206 grid-institutes:grid.272264.7 schema:alternateName Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan
207 Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan
208 schema:name Department of Pharmacy, Hyogo College of Medicine College Hospital, 663-8501, Hyogo, Japan
209 Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Hyogo, Japan
210 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...