Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-09

AUTHORS

Satoko Morishima, Takahiro Fukuda, Noriko Doki, Takehiko Mori, Makoto Onizuka, Toshihiro Kawakita, Chiaki Kato, Yukiyasu Ozawa, Masatsugu Tanaka, Mineo Kurokawa, Tomohiko Kamimura, Masami Inoue, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Yasuo Morishima

ABSTRACT

In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87; P < 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes. More... »

PAGES

646-654

Journal

TITLE

Bone Marrow Transplantation

ISSUE

3

VOLUME

56

Author Affiliations

  • Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology, Meitetsu Hospital, Nagoya, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Department of Hematology, Harasanshin Hospital, Fukuoka, Japan
  • Department of Hematology/Oncology, Osaka Women’s and Children’s Hospital, Izumi, Japan
  • Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-020-01070-3

    DOI

    http://dx.doi.org/10.1038/s41409-020-01070-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131541024

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33037403


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    16 schema:description In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87; P < 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.
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