Ontology type: schema:ScholarlyArticle
2020-08-14
AUTHORSMasamitsu Yanada, Takaaki Konuma, Shohei Mizuno, Masuho Saburi, Akihito Shinohara, Masatsugu Tanaka, Atsushi Marumo, Masashi Sawa, Naoyuki Uchida, Yukiyasu Ozawa, Makoto Onizuka, Satoshi Yoshioka, Hirohisa Nakamae, Tadakazu Kondo, Takafumi Kimura, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Hideki Nakasone, Shingo Yano
ABSTRACTThe aim of this study was to develop a comprehensive system for predicting non-relapse mortality after allogeneic hematopoietic cell transplantation (HCT) during first complete remission (CR) of acute myeloid leukemia (AML). After dividing 2344 eligible patients randomly into a training set and a validation set, we first identified and scored five parameters, that is, age, sex, performance status, HCT-comorbidity index (HCT-CI), and donor type, on the basis of their impact on non-relapse mortality for patients in the training set. The non-relapse mortality-J (NRM-J) index using the sum of these scores was then applied to patients in the validation set, resulting in a clear differentiation of non-relapse mortality, with expected 2-year rates of 11%, 16%, 27%, and 33%, respectively (P < 0.001). The estimated c-statistic was 0.67, which was significantly higher than that of the European Society for Blood and Marrow Transplantation score (0.60, P = 0.002) and the HCT-CI (0.57, P < 0.001). The NRM-J index showed a significant association with overall survival, but not with relapse. Our findings demonstrate that the NRM-J index is useful for predicting post-transplant non-relapse mortality for patients with AML in first CR, for whom the decision of whether to perform allogeneic HCT is critical. More... »
PAGES387-394
http://scigraph.springernature.com/pub.10.1038/s41409-020-01032-9
DOIhttp://dx.doi.org/10.1038/s41409-020-01032-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1130099020
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32796950
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recurrence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Conditioning",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation, Homologous",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Aichi Cancer Center, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.410800.d",
"name": [
"Aichi Cancer Center, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Yanada",
"givenName": "Masamitsu",
"id": "sg:person.01024604275.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Institute of Medical Science, The University of Tokyo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Konuma",
"givenName": "Takaaki",
"id": "sg:person.01350075427.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350075427.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aichi Medical University, Nagakute, Japan",
"id": "http://www.grid.ac/institutes/grid.411234.1",
"name": [
"Aichi Medical University, Nagakute, Japan"
],
"type": "Organization"
},
"familyName": "Mizuno",
"givenName": "Shohei",
"id": "sg:person.0677731025.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677731025.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Oita Prefectural Hospital, Oita, Japan",
"id": "http://www.grid.ac/institutes/grid.416794.9",
"name": [
"Oita Prefectural Hospital, Oita, Japan"
],
"type": "Organization"
},
"familyName": "Saburi",
"givenName": "Masuho",
"id": "sg:person.01175423317.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175423317.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Women\u2019s Medical University, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410818.4",
"name": [
"Tokyo Women\u2019s Medical University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Shinohara",
"givenName": "Akihito",
"id": "sg:person.01362244512.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362244512.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kanagawa Cancer Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.414944.8",
"name": [
"Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Masatsugu",
"id": "sg:person.01171141246.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.415479.a",
"name": [
"Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Marumo",
"givenName": "Atsushi",
"id": "sg:person.01010653757.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010653757.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Anjo Kosei Hospital, Anjo, Japan",
"id": "http://www.grid.ac/institutes/grid.413779.f",
"name": [
"Anjo Kosei Hospital, Anjo, Japan"
],
"type": "Organization"
},
"familyName": "Sawa",
"givenName": "Masashi",
"id": "sg:person.0635043607.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Toranomon Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410813.f",
"name": [
"Toranomon Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Uchida",
"givenName": "Naoyuki",
"id": "sg:person.01243564276.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japanese Red Cross Nagoya First Hospital, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.414932.9",
"name": [
"Japanese Red Cross Nagoya First Hospital, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Ozawa",
"givenName": "Yukiyasu",
"id": "sg:person.01165712107.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Onizuka",
"givenName": "Makoto",
"id": "sg:person.01046262603.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kobe City Medical Center General Hospital, Kobe, Japan",
"id": "http://www.grid.ac/institutes/grid.410843.a",
"name": [
"Kobe City Medical Center General Hospital, Kobe, Japan"
],
"type": "Organization"
},
"familyName": "Yoshioka",
"givenName": "Satoshi",
"id": "sg:person.0741323336.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741323336.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate School of Medicine, Osaka City University, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Graduate School of Medicine, Osaka City University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Nakamae",
"givenName": "Hirohisa",
"id": "sg:person.01014223462.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate School of Medicine, Kyoto University, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.258799.8",
"name": [
"Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "Tadakazu",
"id": "sg:person.0666225507.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japanese Red Cross Kinki Block Blood Center, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.410775.0",
"name": [
"Japanese Red Cross Kinki Block Blood Center, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Takafumi",
"id": "sg:person.013702352722.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013702352722.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate School of Medicine, Kyoto University, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.258799.8",
"name": [
"Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kanda",
"givenName": "Junya",
"id": "sg:person.01100640630.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cancer Center Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.272242.3",
"name": [
"National Cancer Center Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Fukuda",
"givenName": "Takahiro",
"id": "sg:person.016452523632.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University Graduate School of Medicine, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan",
"Nagoya University Graduate School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Atsuta",
"givenName": "Yoshiko",
"id": "sg:person.01146754030.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jichi Medical University Saitama Medical Center, Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.415020.2",
"name": [
"Jichi Medical University Saitama Medical Center, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Nakasone",
"givenName": "Hideki",
"id": "sg:person.01157322255.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157322255.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Jikei University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"The Jikei University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yano",
"givenName": "Shingo",
"id": "sg:person.01265010246.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s13045-016-0347-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008861458",
"https://doi.org/10.1186/s13045-016-0347-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005426871",
"https://doi.org/10.1038/bmt.2012.236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2012.150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021737859",
"https://doi.org/10.1038/nrclinonc.2012.150"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.319",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045367684",
"https://doi.org/10.1038/leu.2014.319"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-019-0571-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1116067650",
"https://doi.org/10.1038/s41409-019-0571-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1894-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036307316",
"https://doi.org/10.1007/s12185-015-1894-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-020-04051-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1127340057",
"https://doi.org/10.1007/s00277-020-04051-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020254406",
"https://doi.org/10.1038/leu.2014.164"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-014-1657-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031936200",
"https://doi.org/10.1007/s12185-014-1657-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-020-0856-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125556029",
"https://doi.org/10.1038/s41409-020-0856-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023301181",
"https://doi.org/10.1038/sj.leu.2403967"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2015.121",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013678032",
"https://doi.org/10.1038/bmt.2015.121"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2011.69",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052594326",
"https://doi.org/10.1038/bmt.2011.69"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2016.358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074201971",
"https://doi.org/10.1038/bmt.2016.358"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-020-0868-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125759940",
"https://doi.org/10.1038/s41409-020-0868-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-018-0344-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107223668",
"https://doi.org/10.1038/s41409-018-0344-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-019-0539-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113958970",
"https://doi.org/10.1038/s41409-019-0539-8"
],
"type": "CreativeWork"
}
],
"datePublished": "2020-08-14",
"datePublishedReg": "2020-08-14",
"description": "The aim of this study was to develop a comprehensive system for predicting non-relapse mortality after allogeneic hematopoietic cell transplantation (HCT) during first complete remission (CR) of acute myeloid leukemia (AML). After dividing 2344 eligible patients randomly into a training set and a validation set, we first identified and scored five parameters, that is, age, sex, performance status, HCT-comorbidity index (HCT-CI), and donor type, on the basis of their impact on non-relapse mortality for patients in the training set. The non-relapse mortality-J (NRM-J) index using the sum of these scores was then applied to patients in the validation set, resulting in a clear differentiation of non-relapse mortality, with expected 2-year rates of 11%, 16%, 27%, and 33%, respectively (P\u2009<\u20090.001). The estimated c-statistic was 0.67, which was significantly higher than that of the European Society for Blood and Marrow Transplantation score (0.60, P\u2009=\u20090.002) and the HCT-CI (0.57, P\u2009<\u20090.001). The NRM-J index showed a significant association with overall survival, but not with relapse. Our findings demonstrate that the NRM-J index is useful for predicting post-transplant non-relapse mortality for patients with AML in first CR, for whom the decision of whether to perform allogeneic HCT is critical.",
"genre": "article",
"id": "sg:pub.10.1038/s41409-020-01032-9",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.9199736",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1096890",
"issn": [
"0268-3369",
"1476-5365"
],
"name": "Bone Marrow Transplantation",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "56"
}
],
"keywords": [
"allogeneic hematopoietic cell transplantation",
"non-relapse mortality",
"hematopoietic cell transplantation",
"acute myeloid leukemia",
"HCT comorbidity index",
"first complete remission",
"complete remission",
"cell transplantation",
"myeloid leukemia",
"Marrow Transplantation score",
"eligible patients",
"first remission",
"performance status",
"overall survival",
"C-statistic",
"donor type",
"patients",
"significant association",
"mortality",
"validation set",
"European Society",
"remission",
"transplantation",
"leukemia",
"scores",
"relapse",
"index",
"blood",
"survival",
"age",
"sex",
"association",
"status",
"aim",
"findings",
"clear differentiation",
"differentiation",
"study",
"rate",
"comprehensive system",
"training set",
"types",
"impact",
"decisions",
"basis",
"society",
"parameters",
"system",
"sum",
"set"
],
"name": "Predicting non-relapse mortality following allogeneic hematopoietic cell transplantation during first remission of acute myeloid leukemia",
"pagination": "387-394",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1130099020"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41409-020-01032-9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"32796950"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41409-020-01032-9",
"https://app.dimensions.ai/details/publication/pub.1130099020"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_839.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41409-020-01032-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01032-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01032-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01032-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-020-01032-9'
This table displays all metadata directly associated to this object as RDF triples.
397 TRIPLES
21 PREDICATES
99 URIs
74 LITERALS
14 BLANK NODES