Ontology type: schema:ScholarlyArticle
2020-07-31
AUTHORSShohei Mizuno, Masamitsu Yanada, Koji Kawamura, Masayoshi Masuko, Naoyuki Uchida, Yukiyasu Ozawa, Koji Iwato, Kazuteru Ohashi, Kazuhiro Ikegame, Sung-Won Kim, Masatsugu Tanaka, Tetsuya Eto, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Shingo Yano, Akiyoshi Takami
ABSTRACTPhiladelphia chromosome-positive acute myeloid leukemia (Ph+ AML) confers a dismal prognosis when treated with chemotherapy alone. Data on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes are limited. We retrospectively analyzed 4649 AML patients who received allo-HCT and were in complete remission. Outcomes of Ph+ AML (n = 30), intermediate-risk, and poor-risk AML patients were compared. The 3-year overall survival after allo-HCT was similar in intermediate-risk (62.7%; 95% CI: 61.0–64.3%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.42); however, it differed significantly between the poor-risk (49.7%; 95% CI: 45.9–53.4%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.049). Disease-free survival in Ph+ AML patients was comparable to that in intermediate-risk patients but better than that in poor-risk patients. Relapse rates were significantly lower in Ph+ AML patients than in other groups. Non-relapse mortality (NRM) rates were similar among groups. Multivariate analysis showed that Ph+ AML was not a significant predictor of poor prognosis in terms of overall survival, disease-free survival, relapse, and NRM. Our data showed better post-transplant outcomes for Ph+ AML patients than for those with poor-risk AML. Hence, allo-HCT could be a feasible treatment option for Ph+ AML patients. More... »
PAGES232-242
http://scigraph.springernature.com/pub.10.1038/s41409-020-01011-0
DOIhttp://dx.doi.org/10.1038/s41409-020-01011-0
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