Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-07-31

AUTHORS

Shohei Mizuno, Masamitsu Yanada, Koji Kawamura, Masayoshi Masuko, Naoyuki Uchida, Yukiyasu Ozawa, Koji Iwato, Kazuteru Ohashi, Kazuhiro Ikegame, Sung-Won Kim, Masatsugu Tanaka, Tetsuya Eto, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Shingo Yano, Akiyoshi Takami

ABSTRACT

Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) confers a dismal prognosis when treated with chemotherapy alone. Data on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes are limited. We retrospectively analyzed 4649 AML patients who received allo-HCT and were in complete remission. Outcomes of Ph+ AML (n = 30), intermediate-risk, and poor-risk AML patients were compared. The 3-year overall survival after allo-HCT was similar in intermediate-risk (62.7%; 95% CI: 61.0–64.3%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.42); however, it differed significantly between the poor-risk (49.7%; 95% CI: 45.9–53.4%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.049). Disease-free survival in Ph+ AML patients was comparable to that in intermediate-risk patients but better than that in poor-risk patients. Relapse rates were significantly lower in Ph+ AML patients than in other groups. Non-relapse mortality (NRM) rates were similar among groups. Multivariate analysis showed that Ph+ AML was not a significant predictor of poor prognosis in terms of overall survival, disease-free survival, relapse, and NRM. Our data showed better post-transplant outcomes for Ph+ AML patients than for those with poor-risk AML. Hence, allo-HCT could be a feasible treatment option for Ph+ AML patients. More... »

PAGES

232-242

Journal

TITLE

Bone Marrow Transplantation

ISSUE

1

VOLUME

56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-020-01011-0

DOI

http://dx.doi.org/10.1038/s41409-020-01011-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129778468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32737447


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19 schema:description Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) confers a dismal prognosis when treated with chemotherapy alone. Data on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes are limited. We retrospectively analyzed 4649 AML patients who received allo-HCT and were in complete remission. Outcomes of Ph+ AML (n = 30), intermediate-risk, and poor-risk AML patients were compared. The 3-year overall survival after allo-HCT was similar in intermediate-risk (62.7%; 95% CI: 61.0–64.3%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.42); however, it differed significantly between the poor-risk (49.7%; 95% CI: 45.9–53.4%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.049). Disease-free survival in Ph+ AML patients was comparable to that in intermediate-risk patients but better than that in poor-risk patients. Relapse rates were significantly lower in Ph+ AML patients than in other groups. Non-relapse mortality (NRM) rates were similar among groups. Multivariate analysis showed that Ph+ AML was not a significant predictor of poor prognosis in terms of overall survival, disease-free survival, relapse, and NRM. Our data showed better post-transplant outcomes for Ph+ AML patients than for those with poor-risk AML. Hence, allo-HCT could be a feasible treatment option for Ph+ AML patients.
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26 AML group
27 AML patients
28 NRM
29 Philadelphia chromosome-positive acute myeloid leukemia
30 acute myeloid leukemia
31 allo-HCT
32 allogeneic hematopoietic cell transplantation outcomes
33 analysis
34 better post-transplant outcomes
35 cell transplantation efficacy
36 cell transplantation outcomes
37 chemotherapy
38 complete remission
39 data
40 disease-free survival
41 dismal prognosis
42 efficacy
43 feasible treatment option
44 group
45 hematopoietic cell transplantation outcomes
46 intermediate-risk patients
47 leukemia
48 mortality rate
49 multivariate analysis
50 myeloid leukemia
51 non-relapse mortality rate
52 options
53 outcomes
54 overall survival
55 patients
56 poor prognosis
57 poor risk AML patients
58 poor-risk AML
59 poor-risk patients
60 post-transplant outcomes
61 predictors
62 prognosis
63 rate
64 relapse
65 relapse rate
66 remission
67 significant predictors
68 survival
69 terms
70 transplantation efficacy
71 transplantation outcomes
72 treatment options
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