Haploidentical transplantation and posttransplant cyclophosphamide for treating aplastic anemia patients: a report from the EBMT Severe Aplastic Anemia Working Party View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12-16

AUTHORS

Pedro H. Prata, Dirk-Jan Eikema, Boris Afansyev, Paul Bosman, Frans Smiers, José L. Diez-Martin, Celso Arrais-Rodrigues, Yener Koc, Xavier Poiré, Anne Sirvent, Nicolaus Kröger, Fulvio Porta, Wolfgang Holter, Adrian Bloor, Charlotte Jubert, Arnold Ganser, Alina Tanase, Anne-Lise Ménard, Pietro Pioltelli, José A. Pérez-Simón, Aloysius Ho, Mahmoud Aljurf, Nigel Russell, Helene Labussiere-Wallet, Tessa Kerre, Vanderson Rocha, Gérard Socié, Antonio Risitano, Carlo Dufour, Régis Peffault de Latour

ABSTRACT

In the absence of an HLA-matched donor, the best treatment for acquired aplastic anemia patients refractory to immunosuppression is unclear. We collected and analyzed data from all acquired aplastic anemia patients who underwent a haploidentical transplantation with posttransplant cyclophosphamide in Europe from 2011 to 2017 (n = 33). The cumulative incidence of neutrophil engraftment was 67% (CI95%: 51–83%) at D +28 and was unaffected by age group, stem cell source, ATG use, or Baltimore conditioning regimen. The cumulative incidence of grades II–III acute GvHD was 23% at D +100, and limited chronic GvHD was 10% (0–20) at 2 years, without cases of grade IV acute or extensive chronic GvHD. Two-year overall survival was 78% (64–93), and 2-year graft-versus-host disease-free survival was 63% (46–81). In univariate analysis, the 2-year OS was higher among patients who received the Baltimore conditioning regimen (93% (81–100) versus 64% (41–87), p = 0.03), whereas age group, stem cell source, and ATG use had no effect. Our results using unmanipulated haploidentical transplantation and posttransplant cyclophosphamide for treating refractory AA patients are encouraging, but warrant confirmation in a prospective study with a larger number of patients and longer follow-up. More... »

PAGES

1050-1058

Journal

TITLE

Bone Marrow Transplantation

ISSUE

6

VOLUME

55

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-019-0773-0

DOI

http://dx.doi.org/10.1038/s41409-019-0773-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123431971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31844137


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