Clinical course of autologous recovery with chromosomal abnormalities after allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12-09

AUTHORS

Motohiro Kato, Hideki Nakasone, Nobuaki Nakano, Shigeo Fuji, Akihito Shinohara, Hisayuki Yokoyama, Kazuo Sakashita, Tsukasa Hori, Satoshi Takahashi, Miho Nara, Yoshinobu Kanda, Takehiko Mori, Junko Takita, Hiroshi Kawaguchi, Toshiro Kawakita, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, Masao Ogata

ABSTRACT

After primary graft failure following allogeneic hematopoietic stem cell transplantation, some patients experience autologous recovery of hematopoiesis without salvage transplantation. However, clinicians occasionally encounter unusual chromosomal abnormalities in recipient cells, not related to the original underlying diseases. In this study, through a survey based on data from the nationwide registry at the Japan Society for Hematopoietic Cell Transplantation, 42 patients were identified as having chromosomal abnormalities after autologous recovery. The complex chromosomal abnormalities were not consistent and randomly changed at each testing. Of the 42 patients, seven experienced disappearance of chromosome abnormalities without any treatment, and the probability was estimated as 17.4% (95% CI: 7.5–30.7%) at the 5-year observation. On the other hand, two patients developed hematologic malignancy at 1447 and 6202 days. Ten patients were alive without relapse or development of hematologic disorders, even though chromosomal abnormalities were continuously detected at a median of 3192 (103–4710) days. In conclusion, chromosomal abnormalities can persist for more than 10 years, and may eventually contribute to hematologic malignancy development in a small fraction of cases. Although oncogenic effects of the chromosomal abnormalities are still unclear, these findings may provide supporting evidence for late occurrence of secondary malignant neoplasms after cancer treatment. More... »

PAGES

1023-1028

References to SciGraph publications

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  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    6

    VOLUME

    55

    Author Affiliations

  • Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan
  • Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
  • Department of Hematology, Imamura General Hospital, Kagoshima, Japan
  • Department of Hematology, Osaka International Cancer Center, Osaka, Japan
  • Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan
  • Department of Hematology/Oncology, Nagano Children’s Hospital, Nagano, Japan
  • Department of Pediatrics, Sapporo Medical University Hospital, Sapporo, Japan
  • Division of Molecular Therapy, the Advanced Clinical Research Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan
  • Division of Hematology, Nephrology and Rheumatology, Akita University Hospital, Akita, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Pediatrics, Kyoto University Hospital, Kyoto, Japan
  • Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima, Japan
  • Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology, Oita University Hospital, Oita, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-019-0765-0

    DOI

    http://dx.doi.org/10.1038/s41409-019-0765-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1123223191

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31819152


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