Thiotepa and antithymocyte globulin-based conditioning prior to haploidentical transplantation with posttransplant cyclophosphamide in high-risk hematological malignancies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-31

AUTHORS

Zinaida Peric, Razan Mohty, Juliana Bastos, Eolia Brissot, Giorgia Battipaglia, Ramdane Belhocine, Simona Sestili, Federica Giannotti, Anne Vekhoff, Tounes Ledraa, Ollivier Legrand, Simona Lapusan, Francoise Isnard, Myriam Labopin, Agnes Bonnin, Clemence Mediavilla, Marie-Thérèse Rubio, Annalisa Ruggeri, Rémy Duléry, Florent Malard, Mohamad Mohty

ABSTRACT

We report results of a thiotepa-based conditioning in haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-CY) and antithymocyte globulin (ATG), for unmanipulated peripheral blood stem cell (PBSC) transplants, in 80 patients with hematological malignancies. Patients in complete remission (CR) received a thiotepa–busulfan–fludarabine (TBF) regimen, while patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of thiotepa–etoposide–cyclophosphamide (TEC) and reduced-intensity conditioning (RIC). The median age was 52 (range, 17–72) years, 44% patients had R/R disease at transplant, and the median follow-up was 417 (range, 180–1595) days. The median days to neutrophil engraftment was 17 (range, 12–34). The cumulative incidences (CI) of acute graft-versus-host disease (GVHD) grade III to IV, severe chronic GVHD, nonrelapse mortality (NRM), and relapse were 16%, 16%, 26, and 26%, respectively. The 2-year overall survival (OS) and disease-free survival (DFS) were 53% and 47%, respectively. There were no significant differences between the patients in CR and R/R patients in terms of engraftment, GVHD, NRM, relapse, OS, or DFS. We conclude that thiotepa-based regimen with PT-CY can be modified with PBSC and ATG, still providing low toxicity, protection against GVHD, and low relapse incidence. Particularly encouraging are the results with the modification to sequential regimen in R/R patients. More... »

PAGES

763-772

References to SciGraph publications

  • 2015-08-17. Safety and feasibility of romiplostim treatment for patients with persistent thrombocytopenia after allogeneic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2002-02-01. Allogeneic transplantation from HLA-matched sibling or partially HLA-mismatched related donors for primary refractory acute leukemia in BONE MARROW TRANSPLANTATION
  • 2016-09-19. Safety and efficacy of thiotepa-based conditioning for allogeneic transplantation in AML: a survey from the ALWP of the EBMT in BONE MARROW TRANSPLANTATION
  • 2019-05-14. Prospective phase II study of prophylactic low-dose azacitidine and donor lymphocyte infusions following allogeneic hematopoietic stem cell transplantation for high-risk acute myeloid leukemia and myelodysplastic syndrome in BONE MARROW TRANSPLANTATION
  • 2015-06-03. Haploidentical, G-CSF-primed, unmanipulated bone marrow transplantation for patients with high-risk hematological malignancies: an update in BONE MARROW TRANSPLANTATION
  • 2015-06-03. Unmanipulated haploidentical bone marrow transplantation and post-transplant cyclophosphamide for hematologic malignanices following a myeloablative conditioning: an update in BONE MARROW TRANSPLANTATION
  • 2005-09-29. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT) in LEUKEMIA
  • 2010-09-30. Antithymocyte globulins and chronic graft-vs-host disease after myeloablative allogeneic stem cell transplantation from HLA-matched unrelated donors: a report from the Sociéte Française de Greffe de Moelle et de Thérapie Cellulaire in LEUKEMIA
  • 2014-09-15. Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas in BONE MARROW TRANSPLANTATION
  • 2016-10-24. Inhibition of FLT3 in AML: a focus on sorafenib in BONE MARROW TRANSPLANTATION
  • 2007-10-15. Lymphocyte subsets recovery following allogeneic bone marrow transplantation (BMT): CD4+ cell count and transplant-related mortality in BONE MARROW TRANSPLANTATION
  • 2013-11-04. Unmanipulated haploidentical BMT following non-myeloablative conditioning and post-transplantation CY for advanced Hodgkin’s lymphoma in BONE MARROW TRANSPLANTATION
  • 2005-10-31. Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up in BONE MARROW TRANSPLANTATION
  • 2015-04-17. Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia in LEUKEMIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7

    DOI

    http://dx.doi.org/10.1038/s41409-019-0726-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122202387

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31673080


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antilymphocyte Serum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclophosphamide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft vs Host Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematologic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thiotepa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Haploidentical", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peric", 
            "givenName": "Zinaida", 
            "id": "sg:person.01214745331.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214745331.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohty", 
            "givenName": "Razan", 
            "id": "sg:person.010654236227.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010654236227.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bastos", 
            "givenName": "Juliana", 
            "id": "sg:person.014110025401.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110025401.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brissot", 
            "givenName": "Eolia", 
            "id": "sg:person.01037550106.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037550106.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Battipaglia", 
            "givenName": "Giorgia", 
            "id": "sg:person.01222046703.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222046703.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belhocine", 
            "givenName": "Ramdane", 
            "id": "sg:person.0714167344.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714167344.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sestili", 
            "givenName": "Simona", 
            "id": "sg:person.011632436534.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011632436534.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giannotti", 
            "givenName": "Federica", 
            "id": "sg:person.0725453530.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725453530.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vekhoff", 
            "givenName": "Anne", 
            "id": "sg:person.01362131264.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362131264.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ledraa", 
            "givenName": "Tounes", 
            "id": "sg:person.01111461403.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111461403.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Legrand", 
            "givenName": "Ollivier", 
            "id": "sg:person.0752753564.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lapusan", 
            "givenName": "Simona", 
            "id": "sg:person.01025216261.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025216261.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Isnard", 
            "givenName": "Francoise", 
            "id": "sg:person.010506014074.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010506014074.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labopin", 
            "givenName": "Myriam", 
            "id": "sg:person.0762572112.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762572112.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonnin", 
            "givenName": "Agnes", 
            "id": "sg:person.016332521016.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016332521016.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mediavilla", 
            "givenName": "Clemence", 
            "id": "sg:person.012376072024.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012376072024.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rubio", 
            "givenName": "Marie-Th\u00e9r\u00e8se", 
            "id": "sg:person.01244324152.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244324152.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruggeri", 
            "givenName": "Annalisa", 
            "id": "sg:person.0773443476.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773443476.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dul\u00e9ry", 
            "givenName": "R\u00e9my", 
            "id": "sg:person.01250665275.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250665275.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malard", 
            "givenName": "Florent", 
            "id": "sg:person.0751372141.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751372141.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France", 
                "UMRS 938, Inserm, Paris, France", 
                "Universit\u00e9 Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohty", 
            "givenName": "Mohamad", 
            "id": "sg:person.0644135047.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135047.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41409-019-0536-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114225724", 
              "https://doi.org/10.1038/s41409-019-0536-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2016.251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043106990", 
              "https://doi.org/10.1038/bmt.2016.251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2013.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004741171", 
              "https://doi.org/10.1038/bmt.2013.166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042851300", 
              "https://doi.org/10.1038/bmt.2015.182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023301181", 
              "https://doi.org/10.1038/sj.leu.2403967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010838302", 
              "https://doi.org/10.1038/leu.2010.200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1703373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007055481", 
              "https://doi.org/10.1038/sj.bmt.1703373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2015.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044650418", 
              "https://doi.org/10.1038/leu.2015.98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2016.239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012081555", 
              "https://doi.org/10.1038/bmt.2016.239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026148482", 
              "https://doi.org/10.1038/sj.bmt.1705207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016258171", 
              "https://doi.org/10.1038/bmt.2015.91"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2014.197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044023524", 
              "https://doi.org/10.1038/bmt.2014.197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045259163", 
              "https://doi.org/10.1038/sj.bmt.1705870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036456897", 
              "https://doi.org/10.1038/bmt.2015.93"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-10-31", 
        "datePublishedReg": "2019-10-31", 
        "description": "We report results of a thiotepa-based conditioning in haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-CY) and antithymocyte globulin (ATG), for unmanipulated peripheral blood stem cell (PBSC) transplants, in 80 patients with hematological malignancies. Patients in complete remission (CR) received a thiotepa\u2013busulfan\u2013fludarabine (TBF) regimen, while patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of thiotepa\u2013etoposide\u2013cyclophosphamide (TEC) and reduced-intensity conditioning (RIC). The median age was 52 (range, 17\u201372) years, 44% patients had R/R disease at transplant, and the median follow-up was 417 (range, 180\u20131595) days. The median days to neutrophil engraftment was 17 (range, 12\u201334). The cumulative incidences (CI) of acute graft-versus-host disease (GVHD) grade III to IV, severe chronic GVHD, nonrelapse mortality (NRM), and relapse were 16%, 16%, 26, and 26%, respectively. The 2-year overall survival (OS) and disease-free survival (DFS) were 53% and 47%, respectively. There were no significant differences between the patients in CR and R/R patients in terms of engraftment, GVHD, NRM, relapse, OS, or DFS. We conclude that thiotepa-based regimen with PT-CY can be modified with PBSC and ATG, still providing low toxicity, protection against GVHD, and low relapse incidence. Particularly encouraging are the results with the modification to sequential regimen in R/R patients.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41409-019-0726-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "55"
          }
        ], 
        "keywords": [
          "disease-free survival", 
          "reduced-intensity conditioning", 
          "antithymocyte globulin", 
          "nonrelapse mortality", 
          "complete remission", 
          "overall survival", 
          "posttransplant cyclophosphamide", 
          "sequential regimen", 
          "cumulative incidence", 
          "R patients", 
          "hematological malignancies", 
          "peripheral blood stem cell transplant", 
          "host disease (GVHD) grade III", 
          "high-risk hematological malignancies", 
          "haploidentical stem cell transplantation", 
          "blood stem cell transplant", 
          "severe chronic GVHD", 
          "terms of engraftment", 
          "lower relapse incidence", 
          "stem cell transplant", 
          "stem cell transplantation", 
          "fludarabine regimen", 
          "R disease", 
          "acute graft", 
          "chronic GVHD", 
          "PT-Cy", 
          "neutrophil engraftment", 
          "relapse incidence", 
          "haploidentical transplantation", 
          "median age", 
          "cell transplant", 
          "refractory malignancies", 
          "cell transplantation", 
          "grade III", 
          "median days", 
          "patients", 
          "regimen", 
          "GVHD", 
          "cyclophosphamide", 
          "malignancy", 
          "relapse", 
          "significant differences", 
          "transplantation", 
          "thiotepa", 
          "transplant", 
          "engraftment", 
          "incidence", 
          "survival", 
          "days", 
          "remission", 
          "low toxicity", 
          "PBSC", 
          "graft", 
          "mortality", 
          "disease", 
          "globulin", 
          "age", 
          "conditioning", 
          "toxicity", 
          "years", 
          "differences", 
          "protection", 
          "results", 
          "modification", 
          "terms"
        ], 
        "name": "Thiotepa and antithymocyte globulin-based conditioning prior to haploidentical transplantation with posttransplant cyclophosphamide in high-risk hematological malignancies", 
        "pagination": "763-772", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1122202387"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41409-019-0726-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31673080"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41409-019-0726-7", 
          "https://app.dimensions.ai/details/publication/pub.1122202387"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T22:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_814.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41409-019-0726-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    372 TRIPLES      22 PREDICATES      116 URIs      94 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41409-019-0726-7 schema:about N0f907b1c09444647aeddb50068ce6eec
    2 N211ccfd6a2f34d2e8ffb9cf75350358e
    3 N24d905a9937645f9bf4525e043ac22a7
    4 N477e1709db2242978df2c45a92f5502f
    5 N78f2a80277e24a9abeb69a5d2982aa6f
    6 N8419c500510949b1a5185fa2a5809ad1
    7 N8a7ba303c9024aeb93e053b442d6ae9d
    8 N8eb801fb7ed1490197a1aa123fd4f81e
    9 Nb1580d05f0ec4301af7d9e88aa6162d5
    10 Nce57312e49704dd589fc6e065e69bd3e
    11 Ne1bb8a0ade3d4779a4ab91c1df7a404e
    12 anzsrc-for:11
    13 anzsrc-for:1102
    14 schema:author Nd3c8d8aa358e418bb193c06f43cb3045
    15 schema:citation sg:pub.10.1038/bmt.2013.166
    16 sg:pub.10.1038/bmt.2014.197
    17 sg:pub.10.1038/bmt.2015.182
    18 sg:pub.10.1038/bmt.2015.91
    19 sg:pub.10.1038/bmt.2015.93
    20 sg:pub.10.1038/bmt.2016.239
    21 sg:pub.10.1038/bmt.2016.251
    22 sg:pub.10.1038/leu.2010.200
    23 sg:pub.10.1038/leu.2015.98
    24 sg:pub.10.1038/s41409-019-0536-y
    25 sg:pub.10.1038/sj.bmt.1703373
    26 sg:pub.10.1038/sj.bmt.1705207
    27 sg:pub.10.1038/sj.bmt.1705870
    28 sg:pub.10.1038/sj.leu.2403967
    29 schema:datePublished 2019-10-31
    30 schema:datePublishedReg 2019-10-31
    31 schema:description We report results of a thiotepa-based conditioning in haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-CY) and antithymocyte globulin (ATG), for unmanipulated peripheral blood stem cell (PBSC) transplants, in 80 patients with hematological malignancies. Patients in complete remission (CR) received a thiotepa–busulfan–fludarabine (TBF) regimen, while patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of thiotepa–etoposide–cyclophosphamide (TEC) and reduced-intensity conditioning (RIC). The median age was 52 (range, 17–72) years, 44% patients had R/R disease at transplant, and the median follow-up was 417 (range, 180–1595) days. The median days to neutrophil engraftment was 17 (range, 12–34). The cumulative incidences (CI) of acute graft-versus-host disease (GVHD) grade III to IV, severe chronic GVHD, nonrelapse mortality (NRM), and relapse were 16%, 16%, 26, and 26%, respectively. The 2-year overall survival (OS) and disease-free survival (DFS) were 53% and 47%, respectively. There were no significant differences between the patients in CR and R/R patients in terms of engraftment, GVHD, NRM, relapse, OS, or DFS. We conclude that thiotepa-based regimen with PT-CY can be modified with PBSC and ATG, still providing low toxicity, protection against GVHD, and low relapse incidence. Particularly encouraging are the results with the modification to sequential regimen in R/R patients.
    32 schema:genre article
    33 schema:inLanguage en
    34 schema:isAccessibleForFree false
    35 schema:isPartOf N88b0a16cfaef479f926ed8198045d5b6
    36 N9e971922a0d04f3eab91c0c932ef3e9a
    37 sg:journal.1096890
    38 schema:keywords GVHD
    39 PBSC
    40 PT-Cy
    41 R disease
    42 R patients
    43 acute graft
    44 age
    45 antithymocyte globulin
    46 blood stem cell transplant
    47 cell transplant
    48 cell transplantation
    49 chronic GVHD
    50 complete remission
    51 conditioning
    52 cumulative incidence
    53 cyclophosphamide
    54 days
    55 differences
    56 disease
    57 disease-free survival
    58 engraftment
    59 fludarabine regimen
    60 globulin
    61 grade III
    62 graft
    63 haploidentical stem cell transplantation
    64 haploidentical transplantation
    65 hematological malignancies
    66 high-risk hematological malignancies
    67 host disease (GVHD) grade III
    68 incidence
    69 low toxicity
    70 lower relapse incidence
    71 malignancy
    72 median age
    73 median days
    74 modification
    75 mortality
    76 neutrophil engraftment
    77 nonrelapse mortality
    78 overall survival
    79 patients
    80 peripheral blood stem cell transplant
    81 posttransplant cyclophosphamide
    82 protection
    83 reduced-intensity conditioning
    84 refractory malignancies
    85 regimen
    86 relapse
    87 relapse incidence
    88 remission
    89 results
    90 sequential regimen
    91 severe chronic GVHD
    92 significant differences
    93 stem cell transplant
    94 stem cell transplantation
    95 survival
    96 terms
    97 terms of engraftment
    98 thiotepa
    99 toxicity
    100 transplant
    101 transplantation
    102 years
    103 schema:name Thiotepa and antithymocyte globulin-based conditioning prior to haploidentical transplantation with posttransplant cyclophosphamide in high-risk hematological malignancies
    104 schema:pagination 763-772
    105 schema:productId N1b0dafd5d43b47b58de33ac16c7ce2ce
    106 N9a430ef5411c4e8a952408282a3fea22
    107 Nb2a259a58dfd41e3b0b5dd265d245372
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1122202387
    109 https://doi.org/10.1038/s41409-019-0726-7
    110 schema:sdDatePublished 2022-06-01T22:19
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher Nbe20ed45c3af4b7e8dc2ef6890153398
    113 schema:url https://doi.org/10.1038/s41409-019-0726-7
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N0f907b1c09444647aeddb50068ce6eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Neoplasm Recurrence, Local
    119 rdf:type schema:DefinedTerm
    120 N1a0691327c8643468ce0fb3b36d28dfd rdf:first sg:person.010654236227.21
    121 rdf:rest N278ffc5d153143508b9da6a98ed4d99c
    122 N1b0dafd5d43b47b58de33ac16c7ce2ce schema:name dimensions_id
    123 schema:value pub.1122202387
    124 rdf:type schema:PropertyValue
    125 N211ccfd6a2f34d2e8ffb9cf75350358e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Cyclophosphamide
    127 rdf:type schema:DefinedTerm
    128 N24d905a9937645f9bf4525e043ac22a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Hematologic Neoplasms
    130 rdf:type schema:DefinedTerm
    131 N278ffc5d153143508b9da6a98ed4d99c rdf:first sg:person.014110025401.76
    132 rdf:rest Nbfac10cccc1445d08a5b1373b5d69ca4
    133 N316f6ca3b4f94ea8a8bc4e5844077dab rdf:first sg:person.01250665275.99
    134 rdf:rest N83e14b7c8d7444cfb392046c7159d281
    135 N42fd08dfa2b3484b90320f4ce7a701e4 rdf:first sg:person.0725453530.98
    136 rdf:rest Nef078606cd164d2b97c571f2749625e7
    137 N477e1709db2242978df2c45a92f5502f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Thiotepa
    139 rdf:type schema:DefinedTerm
    140 N57ecbd40ce2649718c0220e81b7a5291 rdf:first sg:person.012376072024.24
    141 rdf:rest N863bd633fc024785a17177dcd96564be
    142 N57ffb4345af7428ebcb2902d5dc737ba rdf:first sg:person.01111461403.25
    143 rdf:rest N70066e3fe5ab42848cc8e71af13753c3
    144 N70066e3fe5ab42848cc8e71af13753c3 rdf:first sg:person.0752753564.08
    145 rdf:rest Ne8fc69c5730b49df86b2052c2fbc4c12
    146 N78f2a80277e24a9abeb69a5d2982aa6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Transplantation, Haploidentical
    148 rdf:type schema:DefinedTerm
    149 N7c07fdb976c64466a5abc4e054b6700c rdf:first sg:person.01222046703.79
    150 rdf:rest Nad88191880ab408b8a826c767cfd5f4e
    151 N83e14b7c8d7444cfb392046c7159d281 rdf:first sg:person.0751372141.23
    152 rdf:rest Nfef3bca210ff415daa981bc3271f3d74
    153 N8419c500510949b1a5185fa2a5809ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Hematopoietic Stem Cell Transplantation
    155 rdf:type schema:DefinedTerm
    156 N863bd633fc024785a17177dcd96564be rdf:first sg:person.01244324152.40
    157 rdf:rest Naeab2e5b066b493d829941e73e06ae27
    158 N88b0a16cfaef479f926ed8198045d5b6 schema:issueNumber 4
    159 rdf:type schema:PublicationIssue
    160 N8a7ba303c9024aeb93e053b442d6ae9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Transplantation Conditioning
    162 rdf:type schema:DefinedTerm
    163 N8eb801fb7ed1490197a1aa123fd4f81e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Middle Aged
    165 rdf:type schema:DefinedTerm
    166 N94fbc486a5814c44b0ddaa1cd313517e rdf:first sg:person.011632436534.55
    167 rdf:rest N42fd08dfa2b3484b90320f4ce7a701e4
    168 N9a430ef5411c4e8a952408282a3fea22 schema:name pubmed_id
    169 schema:value 31673080
    170 rdf:type schema:PropertyValue
    171 N9c1110903e6b4c768c299c53c8bdc39b rdf:first sg:person.0762572112.39
    172 rdf:rest Nd4f31e67f767464eb9f5634193824a1c
    173 N9e971922a0d04f3eab91c0c932ef3e9a schema:volumeNumber 55
    174 rdf:type schema:PublicationVolume
    175 Nad88191880ab408b8a826c767cfd5f4e rdf:first sg:person.0714167344.64
    176 rdf:rest N94fbc486a5814c44b0ddaa1cd313517e
    177 Naeab2e5b066b493d829941e73e06ae27 rdf:first sg:person.0773443476.03
    178 rdf:rest N316f6ca3b4f94ea8a8bc4e5844077dab
    179 Nb1580d05f0ec4301af7d9e88aa6162d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Antilymphocyte Serum
    181 rdf:type schema:DefinedTerm
    182 Nb2a259a58dfd41e3b0b5dd265d245372 schema:name doi
    183 schema:value 10.1038/s41409-019-0726-7
    184 rdf:type schema:PropertyValue
    185 Nb92e228b45d042bdbd65223c7cddf150 rdf:first sg:person.010506014074.64
    186 rdf:rest N9c1110903e6b4c768c299c53c8bdc39b
    187 Nbe20ed45c3af4b7e8dc2ef6890153398 schema:name Springer Nature - SN SciGraph project
    188 rdf:type schema:Organization
    189 Nbfac10cccc1445d08a5b1373b5d69ca4 rdf:first sg:person.01037550106.72
    190 rdf:rest N7c07fdb976c64466a5abc4e054b6700c
    191 Nce57312e49704dd589fc6e065e69bd3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Graft vs Host Disease
    193 rdf:type schema:DefinedTerm
    194 Nd3c8d8aa358e418bb193c06f43cb3045 rdf:first sg:person.01214745331.39
    195 rdf:rest N1a0691327c8643468ce0fb3b36d28dfd
    196 Nd4f31e67f767464eb9f5634193824a1c rdf:first sg:person.016332521016.91
    197 rdf:rest N57ecbd40ce2649718c0220e81b7a5291
    198 Ne1bb8a0ade3d4779a4ab91c1df7a404e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Humans
    200 rdf:type schema:DefinedTerm
    201 Ne8fc69c5730b49df86b2052c2fbc4c12 rdf:first sg:person.01025216261.91
    202 rdf:rest Nb92e228b45d042bdbd65223c7cddf150
    203 Nef078606cd164d2b97c571f2749625e7 rdf:first sg:person.01362131264.28
    204 rdf:rest N57ffb4345af7428ebcb2902d5dc737ba
    205 Nfef3bca210ff415daa981bc3271f3d74 rdf:first sg:person.0644135047.33
    206 rdf:rest rdf:nil
    207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Medical and Health Sciences
    209 rdf:type schema:DefinedTerm
    210 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Cardiorespiratory Medicine and Haematology
    212 rdf:type schema:DefinedTerm
    213 sg:journal.1096890 schema:issn 0268-3369
    214 1476-5365
    215 schema:name Bone Marrow Transplantation
    216 schema:publisher Springer Nature
    217 rdf:type schema:Periodical
    218 sg:person.01025216261.91 schema:affiliation grid-institutes:grid.412370.3
    219 schema:familyName Lapusan
    220 schema:givenName Simona
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025216261.91
    222 rdf:type schema:Person
    223 sg:person.01037550106.72 schema:affiliation grid-institutes:grid.462844.8
    224 schema:familyName Brissot
    225 schema:givenName Eolia
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037550106.72
    227 rdf:type schema:Person
    228 sg:person.010506014074.64 schema:affiliation grid-institutes:grid.412370.3
    229 schema:familyName Isnard
    230 schema:givenName Francoise
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010506014074.64
    232 rdf:type schema:Person
    233 sg:person.010654236227.21 schema:affiliation grid-institutes:grid.412370.3
    234 schema:familyName Mohty
    235 schema:givenName Razan
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010654236227.21
    237 rdf:type schema:Person
    238 sg:person.01111461403.25 schema:affiliation grid-institutes:grid.412370.3
    239 schema:familyName Ledraa
    240 schema:givenName Tounes
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111461403.25
    242 rdf:type schema:Person
    243 sg:person.011632436534.55 schema:affiliation grid-institutes:grid.412370.3
    244 schema:familyName Sestili
    245 schema:givenName Simona
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011632436534.55
    247 rdf:type schema:Person
    248 sg:person.01214745331.39 schema:affiliation grid-institutes:grid.412370.3
    249 schema:familyName Peric
    250 schema:givenName Zinaida
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214745331.39
    252 rdf:type schema:Person
    253 sg:person.01222046703.79 schema:affiliation grid-institutes:grid.462844.8
    254 schema:familyName Battipaglia
    255 schema:givenName Giorgia
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222046703.79
    257 rdf:type schema:Person
    258 sg:person.012376072024.24 schema:affiliation grid-institutes:grid.412370.3
    259 schema:familyName Mediavilla
    260 schema:givenName Clemence
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012376072024.24
    262 rdf:type schema:Person
    263 sg:person.01244324152.40 schema:affiliation grid-institutes:grid.412370.3
    264 schema:familyName Rubio
    265 schema:givenName Marie-Thérèse
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244324152.40
    267 rdf:type schema:Person
    268 sg:person.01250665275.99 schema:affiliation grid-institutes:grid.462844.8
    269 schema:familyName Duléry
    270 schema:givenName Rémy
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250665275.99
    272 rdf:type schema:Person
    273 sg:person.01362131264.28 schema:affiliation grid-institutes:grid.412370.3
    274 schema:familyName Vekhoff
    275 schema:givenName Anne
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362131264.28
    277 rdf:type schema:Person
    278 sg:person.014110025401.76 schema:affiliation grid-institutes:grid.412370.3
    279 schema:familyName Bastos
    280 schema:givenName Juliana
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110025401.76
    282 rdf:type schema:Person
    283 sg:person.016332521016.91 schema:affiliation grid-institutes:grid.412370.3
    284 schema:familyName Bonnin
    285 schema:givenName Agnes
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016332521016.91
    287 rdf:type schema:Person
    288 sg:person.0644135047.33 schema:affiliation grid-institutes:grid.462844.8
    289 schema:familyName Mohty
    290 schema:givenName Mohamad
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135047.33
    292 rdf:type schema:Person
    293 sg:person.0714167344.64 schema:affiliation grid-institutes:grid.412370.3
    294 schema:familyName Belhocine
    295 schema:givenName Ramdane
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714167344.64
    297 rdf:type schema:Person
    298 sg:person.0725453530.98 schema:affiliation grid-institutes:grid.412370.3
    299 schema:familyName Giannotti
    300 schema:givenName Federica
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725453530.98
    302 rdf:type schema:Person
    303 sg:person.0751372141.23 schema:affiliation grid-institutes:grid.462844.8
    304 schema:familyName Malard
    305 schema:givenName Florent
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751372141.23
    307 rdf:type schema:Person
    308 sg:person.0752753564.08 schema:affiliation grid-institutes:grid.462844.8
    309 schema:familyName Legrand
    310 schema:givenName Ollivier
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08
    312 rdf:type schema:Person
    313 sg:person.0762572112.39 schema:affiliation grid-institutes:grid.462844.8
    314 schema:familyName Labopin
    315 schema:givenName Myriam
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762572112.39
    317 rdf:type schema:Person
    318 sg:person.0773443476.03 schema:affiliation grid-institutes:grid.412370.3
    319 schema:familyName Ruggeri
    320 schema:givenName Annalisa
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773443476.03
    322 rdf:type schema:Person
    323 sg:pub.10.1038/bmt.2013.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004741171
    324 https://doi.org/10.1038/bmt.2013.166
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/bmt.2014.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044023524
    327 https://doi.org/10.1038/bmt.2014.197
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/bmt.2015.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042851300
    330 https://doi.org/10.1038/bmt.2015.182
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/bmt.2015.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016258171
    333 https://doi.org/10.1038/bmt.2015.91
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/bmt.2015.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036456897
    336 https://doi.org/10.1038/bmt.2015.93
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/bmt.2016.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012081555
    339 https://doi.org/10.1038/bmt.2016.239
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/bmt.2016.251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043106990
    342 https://doi.org/10.1038/bmt.2016.251
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/leu.2010.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010838302
    345 https://doi.org/10.1038/leu.2010.200
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/leu.2015.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044650418
    348 https://doi.org/10.1038/leu.2015.98
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/s41409-019-0536-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1114225724
    351 https://doi.org/10.1038/s41409-019-0536-y
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/sj.bmt.1703373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007055481
    354 https://doi.org/10.1038/sj.bmt.1703373
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/sj.bmt.1705207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026148482
    357 https://doi.org/10.1038/sj.bmt.1705207
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/sj.bmt.1705870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045259163
    360 https://doi.org/10.1038/sj.bmt.1705870
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/sj.leu.2403967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023301181
    363 https://doi.org/10.1038/sj.leu.2403967
    364 rdf:type schema:CreativeWork
    365 grid-institutes:grid.412370.3 schema:alternateName Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France
    366 schema:name Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France
    367 rdf:type schema:Organization
    368 grid-institutes:grid.462844.8 schema:alternateName Université Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France
    369 schema:name Department of Hematology and Cellular Therapy, Saint Antoine Hospital, AP-HP, Paris, France
    370 UMRS 938, Inserm, Paris, France
    371 Université Pierre et Marie Curie Paris VI, Sorbonne University, Paris, France
    372 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...