Ontology type: schema:ScholarlyArticle
2019-10-31
AUTHORSZinaida Peric, Razan Mohty, Juliana Bastos, Eolia Brissot, Giorgia Battipaglia, Ramdane Belhocine, Simona Sestili, Federica Giannotti, Anne Vekhoff, Tounes Ledraa, Ollivier Legrand, Simona Lapusan, Francoise Isnard, Myriam Labopin, Agnes Bonnin, Clemence Mediavilla, Marie-Thérèse Rubio, Annalisa Ruggeri, Rémy Duléry, Florent Malard, Mohamad Mohty
ABSTRACTWe report results of a thiotepa-based conditioning in haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-CY) and antithymocyte globulin (ATG), for unmanipulated peripheral blood stem cell (PBSC) transplants, in 80 patients with hematological malignancies. Patients in complete remission (CR) received a thiotepa–busulfan–fludarabine (TBF) regimen, while patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of thiotepa–etoposide–cyclophosphamide (TEC) and reduced-intensity conditioning (RIC). The median age was 52 (range, 17–72) years, 44% patients had R/R disease at transplant, and the median follow-up was 417 (range, 180–1595) days. The median days to neutrophil engraftment was 17 (range, 12–34). The cumulative incidences (CI) of acute graft-versus-host disease (GVHD) grade III to IV, severe chronic GVHD, nonrelapse mortality (NRM), and relapse were 16%, 16%, 26, and 26%, respectively. The 2-year overall survival (OS) and disease-free survival (DFS) were 53% and 47%, respectively. There were no significant differences between the patients in CR and R/R patients in terms of engraftment, GVHD, NRM, relapse, OS, or DFS. We conclude that thiotepa-based regimen with PT-CY can be modified with PBSC and ATG, still providing low toxicity, protection against GVHD, and low relapse incidence. Particularly encouraging are the results with the modification to sequential regimen in R/R patients. More... »
PAGES763-772
http://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7
DOIhttp://dx.doi.org/10.1038/s41409-019-0726-7
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/31673080
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"description": "We report results of a thiotepa-based conditioning in haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-CY) and antithymocyte globulin (ATG), for unmanipulated peripheral blood stem cell (PBSC) transplants, in 80 patients with hematological malignancies. Patients in complete remission (CR) received a thiotepa\u2013busulfan\u2013fludarabine (TBF) regimen, while patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of thiotepa\u2013etoposide\u2013cyclophosphamide (TEC) and reduced-intensity conditioning (RIC). The median age was 52 (range, 17\u201372) years, 44% patients had R/R disease at transplant, and the median follow-up was 417 (range, 180\u20131595) days. The median days to neutrophil engraftment was 17 (range, 12\u201334). The cumulative incidences (CI) of acute graft-versus-host disease (GVHD) grade III to IV, severe chronic GVHD, nonrelapse mortality (NRM), and relapse were 16%, 16%, 26, and 26%, respectively. The 2-year overall survival (OS) and disease-free survival (DFS) were 53% and 47%, respectively. There were no significant differences between the patients in CR and R/R patients in terms of engraftment, GVHD, NRM, relapse, OS, or DFS. We conclude that thiotepa-based regimen with PT-CY can be modified with PBSC and ATG, still providing low toxicity, protection against GVHD, and low relapse incidence. Particularly encouraging are the results with the modification to sequential regimen in R/R patients.",
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0726-7'
This table displays all metadata directly associated to this object as RDF triples.
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