Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant Complications Working Group of Japan ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-07

AUTHORS

Shigeo Fuji, Kumi Oshima, Kazuteru Ohashi, Masashi Sawa, Takeshi Saito, Tetsuya Eto, Masatsugu Tanaka, Makoto Onizuka, Hirohisa Nakamae, Souichi Shiratori, Yukiyasu Ozawa, Michihiro Hidaka, Tokiko Nagamura-Inoue, Hidenori Tanaka, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Masao Ogata

ABSTRACT

Graft failure (GF) remains a major complication of cord blood transplantation (CBT). Although the presence of pretransplant, donor-specific anti-HLA antibodies (DSA) was reported to be associated with an increased risk of GF after CBT, data are still limited. Thus, we conducted a retrospective analysis of recipients of single-unit CBT with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation (JSHCT). Data for recipients of single-unit CBT with pretransplant anti-HLA antibodies from 2010 to 2014 were obtained. In total, 343 patients who received CBT and who had detailed information about anti-HLA antibodies were included. The median age was 51 years (range, 0–71). Regarding DSA, 25 patients had a mean fluorescence intensity (MFI) ≥ 1000 (DSA-positive group) and 318 patients had a MFI <1000 (DSA-negative group). The cumulative incidence of neutrophil engraftment at 60 days after CBT was 75.7% (95% CI, 70.6–80.1) in the DSA-negative group and 56.0% (95% CI, 34.1–73.1) in the DSA-positive group (P = 0.03). In conclusion, pretransplant DSA with a MFI ≥ 1000 was associated with an increased risk of GF in single-unit CBT. More... »

PAGES

722-728

References to SciGraph publications

  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    4

    VOLUME

    55

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-019-0712-0

    DOI

    http://dx.doi.org/10.1038/s41409-019-0712-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1121528681

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31591450


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    19 schema:description Graft failure (GF) remains a major complication of cord blood transplantation (CBT). Although the presence of pretransplant, donor-specific anti-HLA antibodies (DSA) was reported to be associated with an increased risk of GF after CBT, data are still limited. Thus, we conducted a retrospective analysis of recipients of single-unit CBT with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation (JSHCT). Data for recipients of single-unit CBT with pretransplant anti-HLA antibodies from 2010 to 2014 were obtained. In total, 343 patients who received CBT and who had detailed information about anti-HLA antibodies were included. The median age was 51 years (range, 0–71). Regarding DSA, 25 patients had a mean fluorescence intensity (MFI) ≥ 1000 (DSA-positive group) and 318 patients had a MFI <1000 (DSA-negative group). The cumulative incidence of neutrophil engraftment at 60 days after CBT was 75.7% (95% CI, 70.6–80.1) in the DSA-negative group and 56.0% (95% CI, 34.1–73.1) in the DSA-positive group (P = 0.03). In conclusion, pretransplant DSA with a MFI ≥ 1000 was associated with an increased risk of GF in single-unit CBT.
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