Transplant outcomes for patients with therapy-related acute myeloid leukemia with prior lymphoid malignancy: an ALWP of EBMT study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-09-16

AUTHORS

Katie S. Gatwood, Myriam Labopin, Bipin N. Savani, Jürgen Finke, Gerard Socie, Dietrich Beelen, Ibrahim Yakoub-Agha, Patrice Chevallier, Arnold Ganser, Didier Blaise, Noel Milpied, Lioure Bruno, Audrey Mailhol, Mohamad Mohty, Arnon Nagler

ABSTRACT

Allogeneic hematopoietic cell transplant (HCT) is a curative therapy for patients with secondary acute myeloid leukemia (sAML), though the impact of conditioning regimens on HCT outcomes for patients with antecedent lymphoid malignancy is largely unknown. This multicenter, retrospective registry study of the ALWP of the EBMT assessed HCT outcomes in this population. In all, 549 patients ≥18 years with sAML following an antecedent lymphoid malignancy treated with first allograft between 2000–2016 were included. Myeloablative (MAC) and reduced intensity conditioning (RIC) was given in 258 (47%) and 291 (53%), respectively. At 2 years, leukemia-free survival (LFS) was 31.7% (95% CI, 27.5–35.9), overall survival (OS) was 37.4% (95% CI, 33–41.8), nonrelapse mortality (NRM) was 28.9% (95% CI, 25–33), and GVHD-free, relapse-free survival (GRFS) was 22.8% (95% CI, 19–26.6). In multivariate analysis, patients receiving RIC regimens had lower risk of NRM (HR: 0.58, CI: 0.40–0.83, p = 0.003), and improved LFS (HR: 0.67, CI: 0.52–0.85, p = 0.001). Patients with prior autologous HCT had inferior LFS (HR: 1.30, CI: 1.01–1.67, p = 0.01). This study demonstrates that sAML patients following prior lymphoid malignancy treated with RIC regimens have a lower risk of NRM and improved LFS, OS, and GFRS. Other variables associated with inferior outcomes include older age, active disease, adverse cytogenetics, and prior auto-HCT. More... »

PAGES

224-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-019-0673-3

DOI

http://dx.doi.org/10.1038/s41409-019-0673-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121010086

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31527819


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53 malignancy
54 mortality
55 multicenter
56 multivariate analysis
57 myeloablative
58 myeloid leukemia
59 nonrelapse mortality
60 older age
61 outcomes
62 overall survival
63 patients
64 population
65 regimens
66 registry study
67 relapse-free survival
68 retrospective registry study
69 risk
70 sAML patients
71 secondary acute myeloid leukemia
72 study
73 survival
74 therapy
75 therapy-related acute myeloid leukemia
76 transplant
77 transplant outcomes
78 variables
79 years
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