Prognostic impact of cytogenetic abnormalities in adult patients with Philadelphia chromosome-negative ALL who underwent an allogeneic transplant View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06-11

AUTHORS

Hiroaki Shimizu, Noriko Doki, Heiwa Kanamori, Toru Sakura, Takehiko Mori, Shinichiro Machida, Satoshi Takahashi, Chikako Ohwada, Shin Fujisawa, Shingo Yano, Maki Hagihara, Yoshinobu Kanda, Masahiro Onoda, Moritaka Gotoh, Shinichi Kako, Jun Taguchi, Kensuke Usuki, Nobutaka Kawai, Nobuyuki Aotsuka, Shinichiro Okamoto

ABSTRACT

Although cytogenetic abnormalities at diagnosis are recognized as an important prognostic factor in patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL), the prognostic impact has not been evaluated in allogeneic stem cell transplant (allo-SCT) recipients. Thus, we assessed 373 Ph-negative ALL patients who underwent allo-SCT. The high-risk (HR) group included those with t(4;11), t(8;14), low hypodiploidy, and complex karyotype, and the standard risk (SR) group included all other karyotypes. Among the 204 patients who underwent a transplant during the first remission (167 in the SR group and 37 in the HR group), the overall survival (OS) rates were similar between these groups (64.1% vs. 80.0% at 5 years, respectively; p = 0.12). Conversely, among the 106 patients who underwent a transplant while not in remission (84 in the SR group and 22 in the HR group), patients in the SR group showed a significantly superior OS rate compared to the HR group (15.4% vs. 4.5% at 5 years, respectively; p = 0.022). These results suggested that treatment outcomes of Ph-negative ALL patients with HR cytogenetic abnormalities may improve following allo-SCT, especially in the first remission. Innovative transplant approaches are warranted in patients who are not in remission. More... »

PAGES

2020-2026

Journal

TITLE

Bone Marrow Transplantation

ISSUE

12

VOLUME

54

Author Affiliations

  • Department of Hematology, Gunma University, Gunma, Japan
  • Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Leukemia Research Center, Saiseikai Maebashi Hospital, Gunma, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Kanagawa, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Hematology, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
  • Department of Hematology and Clinical Immunology, Yokohama City University Hospital, Yokohama, Japan
  • Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  • Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Department of Hematology, Tokyo Medical University, Tokyo, Japan
  • Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  • Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan
  • Division of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
  • Department of Hematology, International Medical Center, Saitama Medical University, Saitama, Japan
  • Department of Hematology, Narita Red Cross Hospital, Narita, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-019-0585-2

    DOI

    http://dx.doi.org/10.1038/s41409-019-0585-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1117048435

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31186516


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    355 grid-institutes:grid.470126.6 schema:alternateName Department of Hematology and Clinical Immunology, Yokohama City University Hospital, Yokohama, Japan
    356 schema:name Department of Hematology and Clinical Immunology, Yokohama City University Hospital, Yokohama, Japan
    357 rdf:type schema:Organization
     




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