Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05-31

AUTHORS

Shingo Yano, Hiroki Yokoyama, Masamitsu Yanada, Jinichi Mori, Jun Aoki, Kazuteru Ohashi, Heiwa Kanomori, Yuichiro Ozawa, Masashi Sawa, Hiroshisa Nakamae, Tetsuya Eto, Shuichi Ohta, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Akiyoshi Takami

ABSTRACT

Allogeneic hematopoietic stem cell transplantation (HCT) offers the most effective prevention of relapse and has significant overall survival (OS) benefits for patients with acute myeloid leukemia (AML) in first complete remission (CR1). We conducted a retrospective analysis of a cohort of patients with intermediate- or poor-risk AML. The purpose of the present study was to investigate the role of alternative donors for AML in CR1. We analyzed 1561 patients who underwent HCT from an HLA-matched related donor (MRD), HLA 8/8-matched unrelated donor (MUD), or umbilical cord blood (UCB). The results of a multivariate analysis showed that HCT from UCB (HR = 1.28, 95% CI: 1.07–1.52), age ≥50 years (HR = 1.36, 95% CI: 1.14–1.62), male (HR = 1.42, 95% CI: 1.21–1.66), PS > 1 (HR = 1.68, 95% CI: 1.17–2.42), and poor-risk cytogenetics (HR = 1.53, 95% CI: 1.29–1.81) had an inferior prognostic impact on OS. We conclude that an MUD is the best alternative to an HLA identical MRD for patients with AML in CR1. UCB is an alternative option if neither MRD nor MUD are available, or when patients need to receive urgent HCT for poor-risk AML in CR1. More... »

PAGES

2004-2012

Journal

TITLE

Bone Marrow Transplantation

ISSUE

12

VOLUME

54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-019-0571-8

DOI

http://dx.doi.org/10.1038/s41409-019-0571-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1116067650

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31152148


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yano", 
        "givenName": "Shingo", 
        "id": "sg:person.01265010246.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Hiroki", 
        "id": "sg:person.01015104665.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015104665.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanada", 
        "givenName": "Masamitsu", 
        "id": "sg:person.01024604275.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Jyoban Hospital Tokiwa Foundation, Fukushima, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Hematology, Jyoban Hospital Tokiwa Foundation, Fukushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Jinichi", 
        "id": "sg:person.0765070735.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765070735.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Jun", 
        "id": "sg:person.01264262573.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264262573.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "Kazuteru", 
        "id": "sg:person.012430503152.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414944.8", 
          "name": [
            "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanomori", 
        "givenName": "Heiwa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414932.9", 
          "name": [
            "Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Yuichiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413779.f", 
          "name": [
            "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sawa", 
        "givenName": "Masashi", 
        "id": "sg:person.0635043607.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Osaka City University Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.470114.7", 
          "name": [
            "Department of Hematology, Osaka City University Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "Hiroshisa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413617.6", 
          "name": [
            "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eto", 
        "givenName": "Tetsuya", 
        "id": "sg:person.0720274373.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415262.6", 
          "name": [
            "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohta", 
        "givenName": "Shuichi", 
        "id": "sg:person.012351566121.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351566121.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Hematology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Junji", 
        "id": "sg:person.0714107337.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichinohe", 
        "givenName": "Tatsuo", 
        "id": "sg:person.0623252373.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
            "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01146754030.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takami", 
        "givenName": "Akiyoshi", 
        "id": "sg:person.0577702220.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.leu.2403967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023301181", 
          "https://doi.org/10.1038/sj.leu.2403967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-015-1894-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036307316", 
          "https://doi.org/10.1007/s12185-015-1894-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2011.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052594326", 
          "https://doi.org/10.1038/bmt.2011.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1532/ijh97.06239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054504897", 
          "https://doi.org/10.1532/ijh97.06239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2015.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013678032", 
          "https://doi.org/10.1038/bmt.2015.121"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-05-31", 
    "datePublishedReg": "2019-05-31", 
    "description": "Allogeneic hematopoietic stem cell transplantation (HCT) offers the most effective prevention of relapse and has significant overall survival (OS) benefits for patients with acute myeloid leukemia (AML) in first complete remission (CR1). We conducted a retrospective analysis of a cohort of patients with intermediate- or poor-risk AML. The purpose of the present study was to investigate the role of alternative donors for AML in CR1. We analyzed 1561 patients who underwent HCT from an HLA-matched related donor (MRD), HLA 8/8-matched unrelated donor (MUD), or umbilical cord blood (UCB). The results of a multivariate analysis showed that HCT from UCB (HR\u2009=\u20091.28, 95% CI: 1.07\u20131.52), age \u226550 years (HR\u2009=\u20091.36, 95% CI: 1.14\u20131.62), male (HR\u2009=\u20091.42, 95% CI: 1.21\u20131.66), PS\u2009>\u20091 (HR\u2009=\u20091.68, 95% CI: 1.17\u20132.42), and poor-risk cytogenetics (HR\u2009=\u20091.53, 95% CI: 1.29\u20131.81) had an inferior prognostic impact on OS. We conclude that an MUD is the best alternative to an HLA identical MRD for patients with AML in CR1. UCB is an alternative option if neither MRD nor MUD are available, or when patients need to receive urgent HCT for poor-risk AML in CR1.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41409-019-0571-8", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7535173", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "54"
      }
    ], 
    "keywords": [
      "hematopoietic stem cell transplantation", 
      "poor-risk acute myeloid leukemia", 
      "acute myeloid leukemia", 
      "umbilical cord blood", 
      "first complete remission", 
      "stem cell transplantation", 
      "complete remission", 
      "cell transplantation", 
      "myeloid leukemia", 
      "donor allogeneic hematopoietic stem cell transplantation", 
      "allogeneic hematopoietic stem cell transplantation", 
      "significant overall survival benefit", 
      "poor-risk cytogenetics", 
      "overall survival benefit", 
      "cohort of patients", 
      "HLA 8/8", 
      "survival benefit", 
      "related donors", 
      "prognostic impact", 
      "unrelated donors", 
      "cord blood", 
      "retrospective analysis", 
      "alternative donors", 
      "patients", 
      "multivariate analysis", 
      "effective prevention", 
      "remission", 
      "transplantation", 
      "leukemia", 
      "CR1", 
      "present study", 
      "MRD", 
      "alternative option", 
      "donors", 
      "relapse", 
      "HLA", 
      "cohort", 
      "blood", 
      "prevention", 
      "age", 
      "males", 
      "role", 
      "cytogenetics", 
      "OS", 
      "good alternative", 
      "options", 
      "years", 
      "study", 
      "benefits", 
      "analysis", 
      "purpose", 
      "alternative", 
      "impact", 
      "results", 
      "PS", 
      "mud"
    ], 
    "name": "Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first complete remission", 
    "pagination": "2004-2012", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1116067650"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41409-019-0571-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31152148"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41409-019-0571-8", 
      "https://app.dimensions.ai/details/publication/pub.1116067650"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_815.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41409-019-0571-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0571-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0571-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0571-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-019-0571-8'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      101 URIs      87 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41409-019-0571-8 schema:about N0b560a0439be4aeab56f2e692bb2846f
2 N124bdd6cdaca4c62adeb70f6c22fdad6
3 N41e19f700e9e4716a789129dc1960936
4 N4d82b439e4444a118503b77f069144e4
5 N64846399c6e742b8b6c3235573ef7ff5
6 N83fd1780de604e3ea41a216be27b0283
7 N9cb9d5216bdd46a68687a414d9b9e177
8 Nbcf764e45eb448009d4d35485c772299
9 Nbf3e515175fe46cd9a20f0c10f113c47
10 Nd0e01b1f1bac48b7997fda03fc179f28
11 Nd898a2e2e42c4516b85d29752be64e68
12 Ne55bf094955c4efb878da60cef31325d
13 Ne83cda5a181e400b8e26c0837053641b
14 Nfb1efbdb96bc44f8afef026b53c40278
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author Necdf64ebb4d64bd0a764fcc97e9ceb07
18 schema:citation sg:pub.10.1007/s12185-015-1894-x
19 sg:pub.10.1038/bmt.2011.69
20 sg:pub.10.1038/bmt.2012.244
21 sg:pub.10.1038/bmt.2015.121
22 sg:pub.10.1038/sj.leu.2403967
23 sg:pub.10.1532/ijh97.06239
24 schema:datePublished 2019-05-31
25 schema:datePublishedReg 2019-05-31
26 schema:description Allogeneic hematopoietic stem cell transplantation (HCT) offers the most effective prevention of relapse and has significant overall survival (OS) benefits for patients with acute myeloid leukemia (AML) in first complete remission (CR1). We conducted a retrospective analysis of a cohort of patients with intermediate- or poor-risk AML. The purpose of the present study was to investigate the role of alternative donors for AML in CR1. We analyzed 1561 patients who underwent HCT from an HLA-matched related donor (MRD), HLA 8/8-matched unrelated donor (MUD), or umbilical cord blood (UCB). The results of a multivariate analysis showed that HCT from UCB (HR = 1.28, 95% CI: 1.07–1.52), age ≥50 years (HR = 1.36, 95% CI: 1.14–1.62), male (HR = 1.42, 95% CI: 1.21–1.66), PS > 1 (HR = 1.68, 95% CI: 1.17–2.42), and poor-risk cytogenetics (HR = 1.53, 95% CI: 1.29–1.81) had an inferior prognostic impact on OS. We conclude that an MUD is the best alternative to an HLA identical MRD for patients with AML in CR1. UCB is an alternative option if neither MRD nor MUD are available, or when patients need to receive urgent HCT for poor-risk AML in CR1.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N2c594369fc0c40b7a783af4badf47621
30 N7b36c7e6b1704d9e891398aed7600136
31 sg:journal.1096890
32 schema:keywords CR1
33 HLA
34 HLA 8/8
35 MRD
36 OS
37 PS
38 acute myeloid leukemia
39 age
40 allogeneic hematopoietic stem cell transplantation
41 alternative
42 alternative donors
43 alternative option
44 analysis
45 benefits
46 blood
47 cell transplantation
48 cohort
49 cohort of patients
50 complete remission
51 cord blood
52 cytogenetics
53 donor allogeneic hematopoietic stem cell transplantation
54 donors
55 effective prevention
56 first complete remission
57 good alternative
58 hematopoietic stem cell transplantation
59 impact
60 leukemia
61 males
62 mud
63 multivariate analysis
64 myeloid leukemia
65 options
66 overall survival benefit
67 patients
68 poor-risk acute myeloid leukemia
69 poor-risk cytogenetics
70 present study
71 prevention
72 prognostic impact
73 purpose
74 relapse
75 related donors
76 remission
77 results
78 retrospective analysis
79 role
80 significant overall survival benefit
81 stem cell transplantation
82 study
83 survival benefit
84 transplantation
85 umbilical cord blood
86 unrelated donors
87 years
88 schema:name Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first complete remission
89 schema:pagination 2004-2012
90 schema:productId N097f069967244001890439b474ec0ed3
91 N96974e6b768a4a7f96ee27db42fc50a5
92 Ne95ffb7d02e2444fa96d1729b78389ea
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1116067650
94 https://doi.org/10.1038/s41409-019-0571-8
95 schema:sdDatePublished 2022-08-04T17:09
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Nb1fba8daf92441889a97800e7e5acea8
98 schema:url https://doi.org/10.1038/s41409-019-0571-8
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N050291d378a2447cb66d5be418cc55e5 schema:affiliation grid-institutes:grid.414944.8
103 schema:familyName Kanomori
104 schema:givenName Heiwa
105 rdf:type schema:Person
106 N097f069967244001890439b474ec0ed3 schema:name pubmed_id
107 schema:value 31152148
108 rdf:type schema:PropertyValue
109 N0b560a0439be4aeab56f2e692bb2846f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adolescent
111 rdf:type schema:DefinedTerm
112 N124bdd6cdaca4c62adeb70f6c22fdad6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Aged
114 rdf:type schema:DefinedTerm
115 N1c7afbb1e4434f5e914d77e8dc24f92a schema:affiliation grid-institutes:grid.470114.7
116 schema:familyName Nakamae
117 schema:givenName Hiroshisa
118 rdf:type schema:Person
119 N1ebc2f5b60844b448546a0e4fecedb4c rdf:first sg:person.0720274373.65
120 rdf:rest Nddb97635f4d342179eea2f1e9d71203c
121 N2c594369fc0c40b7a783af4badf47621 schema:issueNumber 12
122 rdf:type schema:PublicationIssue
123 N391e43b829f347a3a07847bc2da6d9e3 rdf:first sg:person.0635043607.22
124 rdf:rest N429a6e28429f48e6a686ad5a379f5cea
125 N41e19f700e9e4716a789129dc1960936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Prognosis
127 rdf:type schema:DefinedTerm
128 N429a6e28429f48e6a686ad5a379f5cea rdf:first N1c7afbb1e4434f5e914d77e8dc24f92a
129 rdf:rest N1ebc2f5b60844b448546a0e4fecedb4c
130 N43f8f31fbaa248cd8928d691395b9656 rdf:first sg:person.0623252373.33
131 rdf:rest N59460eb6b3da4df6b98ba434aabb7718
132 N4d82b439e4444a118503b77f069144e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Leukemia, Myeloid, Acute
134 rdf:type schema:DefinedTerm
135 N59460eb6b3da4df6b98ba434aabb7718 rdf:first sg:person.01146754030.08
136 rdf:rest Na7627c5f9544404885a7df57a2cd0ce0
137 N60183b1b605c4a7aa314e1c56b651040 rdf:first N050291d378a2447cb66d5be418cc55e5
138 rdf:rest Nd4529c3e3f5343f39a437da7ed72460a
139 N64846399c6e742b8b6c3235573ef7ff5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adult
141 rdf:type schema:DefinedTerm
142 N70d69040ddd64b05a895b4310a892c42 rdf:first sg:person.0765070735.66
143 rdf:rest Nd586ac596ea744b0a9879c2157bf7312
144 N7b36c7e6b1704d9e891398aed7600136 schema:volumeNumber 54
145 rdf:type schema:PublicationVolume
146 N83fd1780de604e3ea41a216be27b0283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N8b52d55ccc5b47579e9d84b74be84bd7 schema:affiliation grid-institutes:grid.414932.9
150 schema:familyName Ozawa
151 schema:givenName Yuichiro
152 rdf:type schema:Person
153 N96974e6b768a4a7f96ee27db42fc50a5 schema:name doi
154 schema:value 10.1038/s41409-019-0571-8
155 rdf:type schema:PropertyValue
156 N9cb9d5216bdd46a68687a414d9b9e177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Transplantation Conditioning
158 rdf:type schema:DefinedTerm
159 N9f01dd30451548bd9a67bb4c01e9bfca rdf:first sg:person.012430503152.76
160 rdf:rest N60183b1b605c4a7aa314e1c56b651040
161 Na7627c5f9544404885a7df57a2cd0ce0 rdf:first sg:person.0577702220.98
162 rdf:rest rdf:nil
163 Nb1fba8daf92441889a97800e7e5acea8 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nbcf764e45eb448009d4d35485c772299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Hematopoietic Stem Cell Transplantation
167 rdf:type schema:DefinedTerm
168 Nbf3e515175fe46cd9a20f0c10f113c47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Young Adult
170 rdf:type schema:DefinedTerm
171 Nd0e01b1f1bac48b7997fda03fc179f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Middle Aged
173 rdf:type schema:DefinedTerm
174 Nd4529c3e3f5343f39a437da7ed72460a rdf:first N8b52d55ccc5b47579e9d84b74be84bd7
175 rdf:rest N391e43b829f347a3a07847bc2da6d9e3
176 Nd586ac596ea744b0a9879c2157bf7312 rdf:first sg:person.01264262573.40
177 rdf:rest N9f01dd30451548bd9a67bb4c01e9bfca
178 Nd898a2e2e42c4516b85d29752be64e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transplantation, Homologous
180 rdf:type schema:DefinedTerm
181 Nddb97635f4d342179eea2f1e9d71203c rdf:first sg:person.012351566121.68
182 rdf:rest Nf2e2f93b6b8f48409888e5432c5a3c91
183 Ne55bf094955c4efb878da60cef31325d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Male
185 rdf:type schema:DefinedTerm
186 Ne5b10573ee6048d9a65424fb1c063e0b rdf:first sg:person.01015104665.33
187 rdf:rest Ned855271ac72444db0c67b8e30a4b176
188 Ne83cda5a181e400b8e26c0837053641b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Remission Induction
190 rdf:type schema:DefinedTerm
191 Ne95ffb7d02e2444fa96d1729b78389ea schema:name dimensions_id
192 schema:value pub.1116067650
193 rdf:type schema:PropertyValue
194 Necdf64ebb4d64bd0a764fcc97e9ceb07 rdf:first sg:person.01265010246.42
195 rdf:rest Ne5b10573ee6048d9a65424fb1c063e0b
196 Ned855271ac72444db0c67b8e30a4b176 rdf:first sg:person.01024604275.66
197 rdf:rest N70d69040ddd64b05a895b4310a892c42
198 Nf2e2f93b6b8f48409888e5432c5a3c91 rdf:first sg:person.0714107337.54
199 rdf:rest N43f8f31fbaa248cd8928d691395b9656
200 Nfb1efbdb96bc44f8afef026b53c40278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Humans
202 rdf:type schema:DefinedTerm
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
207 schema:name Cardiorespiratory Medicine and Haematology
208 rdf:type schema:DefinedTerm
209 sg:grant.7535173 http://pending.schema.org/fundedItem sg:pub.10.1038/s41409-019-0571-8
210 rdf:type schema:MonetaryGrant
211 sg:journal.1096890 schema:issn 0268-3369
212 1476-5365
213 schema:name Bone Marrow Transplantation
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01015104665.33 schema:affiliation grid-institutes:grid.411898.d
217 schema:familyName Yokoyama
218 schema:givenName Hiroki
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015104665.33
220 rdf:type schema:Person
221 sg:person.01024604275.66 schema:affiliation grid-institutes:grid.410800.d
222 schema:familyName Yanada
223 schema:givenName Masamitsu
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66
225 rdf:type schema:Person
226 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
227 schema:familyName Atsuta
228 schema:givenName Yoshiko
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
230 rdf:type schema:Person
231 sg:person.012351566121.68 schema:affiliation grid-institutes:grid.415262.6
232 schema:familyName Ohta
233 schema:givenName Shuichi
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351566121.68
235 rdf:type schema:Person
236 sg:person.012430503152.76 schema:affiliation grid-institutes:grid.415479.a
237 schema:familyName Ohashi
238 schema:givenName Kazuteru
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76
240 rdf:type schema:Person
241 sg:person.01264262573.40 schema:affiliation grid-institutes:grid.413045.7
242 schema:familyName Aoki
243 schema:givenName Jun
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264262573.40
245 rdf:type schema:Person
246 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
247 schema:familyName Yano
248 schema:givenName Shingo
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
250 rdf:type schema:Person
251 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.411234.1
252 schema:familyName Takami
253 schema:givenName Akiyoshi
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
255 rdf:type schema:Person
256 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
257 schema:familyName Ichinohe
258 schema:givenName Tatsuo
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
260 rdf:type schema:Person
261 sg:person.0635043607.22 schema:affiliation grid-institutes:grid.413779.f
262 schema:familyName Sawa
263 schema:givenName Masashi
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22
265 rdf:type schema:Person
266 sg:person.0714107337.54 schema:affiliation grid-institutes:grid.410818.4
267 schema:familyName Tanaka
268 schema:givenName Junji
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54
270 rdf:type schema:Person
271 sg:person.0720274373.65 schema:affiliation grid-institutes:grid.413617.6
272 schema:familyName Eto
273 schema:givenName Tetsuya
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65
275 rdf:type schema:Person
276 sg:person.0765070735.66 schema:affiliation grid-institutes:None
277 schema:familyName Mori
278 schema:givenName Jinichi
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765070735.66
280 rdf:type schema:Person
281 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
282 https://doi.org/10.1007/s12185-015-1894-x
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/bmt.2011.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052594326
285 https://doi.org/10.1038/bmt.2011.69
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
288 https://doi.org/10.1038/bmt.2012.244
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/bmt.2015.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013678032
291 https://doi.org/10.1038/bmt.2015.121
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.leu.2403967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023301181
294 https://doi.org/10.1038/sj.leu.2403967
295 rdf:type schema:CreativeWork
296 sg:pub.10.1532/ijh97.06239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054504897
297 https://doi.org/10.1532/ijh97.06239
298 rdf:type schema:CreativeWork
299 grid-institutes:None schema:alternateName Division of Hematology, Jyoban Hospital Tokiwa Foundation, Fukushima, Japan
300 schema:name Division of Hematology, Jyoban Hospital Tokiwa Foundation, Fukushima, Japan
301 rdf:type schema:Organization
302 grid-institutes:grid.257022.0 schema:alternateName Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
303 schema:name Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
304 rdf:type schema:Organization
305 grid-institutes:grid.27476.30 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
306 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
307 Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
308 rdf:type schema:Organization
309 grid-institutes:grid.410800.d schema:alternateName Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan
310 schema:name Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan
311 rdf:type schema:Organization
312 grid-institutes:grid.410818.4 schema:alternateName Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
313 schema:name Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
314 rdf:type schema:Organization
315 grid-institutes:grid.411234.1 schema:alternateName Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan
316 schema:name Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan
317 rdf:type schema:Organization
318 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
319 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
320 rdf:type schema:Organization
321 grid-institutes:grid.413045.7 schema:alternateName Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
322 schema:name Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
323 rdf:type schema:Organization
324 grid-institutes:grid.413617.6 schema:alternateName Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
325 schema:name Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
326 rdf:type schema:Organization
327 grid-institutes:grid.413779.f schema:alternateName Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
328 schema:name Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
329 rdf:type schema:Organization
330 grid-institutes:grid.414932.9 schema:alternateName Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
331 schema:name Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
332 rdf:type schema:Organization
333 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
334 schema:name Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
335 rdf:type schema:Organization
336 grid-institutes:grid.415262.6 schema:alternateName Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
337 schema:name Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
338 rdf:type schema:Organization
339 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
340 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
341 rdf:type schema:Organization
342 grid-institutes:grid.470114.7 schema:alternateName Department of Hematology, Osaka City University Hospital, Osaka, Japan
343 schema:name Department of Hematology, Osaka City University Hospital, Osaka, Japan
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...