Unit selection for umbilical cord blood transplantation for adults with acute myeloid leukemia in complete remission: a Japanese experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05-08

AUTHORS

Masamitsu Yanada, Takaaki Konuma, Yachiyo Kuwatsuka, Tadakazu Kondo, Takahito Kawata, Satoshi Takahashi, Naoyuki Uchida, Shigesaburo Miyakoshi, Masatsugu Tanaka, Yukiyasu Ozawa, Masashi Sawa, Hirohisa Nakamae, Nobuyuki Aotsuka, Junya Kanda, Minoko Takanashi, Yoshinobu Kanda, Yoshiko Atsuta, Shingo Yano

ABSTRACT

To investigate optimal unit selection for umbilical cord blood transplantation (UCBT), we conducted a registry-based study of 1355 adults with acute myeloid leukemia in first or second complete remission who underwent single-unit UCBT. To be eligible for analysis, UCB units had to contain a total nucleated cell (TNC) dose of 2.0 × 107/kg or higher and present at least a 4/6-match for HLA-A, -B, and -DR antigens in line with clinical practice in Japan, both of which are less stringent criteria than those used in Western countries. Neither TNC dose nor the degree of HLA matching affected survival (P = 0.138 and P = 0.696, respectively). As for HLA-A, -B antigens and -DRB1 allele, better HLA matching was associated with lower non-relapse mortality (P = 0.011) but higher relapse (P = 0.046), resulting in no improvement in survival (P = 0.680). Taking the allele level for each HLA-A, -B, and -DRB1 into consideration was less useful for predicting non-relapse mortality (P = 0.198). These findings suggest that the less stringent criteria for UCB unit selection are acceptable for Japanese patient population and perhaps even more beneficial in terms of providing a better chance to find a suitable UCB unit. More... »

PAGES

1789-1798

References to SciGraph publications

  • 2015-11-20. Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2015-03-11. HLA-DRB1 mismatch is associated with a decreased relapse in adult acute myeloid leukemia after single-unit myeloablative cord blood transplantation in ANNALS OF HEMATOLOGY
  • 2015-11-07. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data) in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2007-10-01. Unification of Hematopoietic Stem Cell Transplantation Registries in Japan and Establishment of the TRUMP System in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2010-05-03. Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries in BONE MARROW TRANSPLANTATION
  • 2016-10-17. Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation in LEUKEMIA
  • 2015-09-14. A prospective investigation of cell dose in single-unit umbilical cord blood transplantation for adults with high-risk hematologic malignancies in BONE MARROW TRANSPLANTATION
  • 2014-09-12. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia during first complete remission: a clinical perspective in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2005-10-10. High-resolution HLA typing by sequencing for HLA-A, -B, -C, -DR, -DQ in 122 unrelated cord blood/patient pair transplants hardly improves long-term clinical outcome in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41409-019-0539-8

    DOI

    http://dx.doi.org/10.1038/s41409-019-0539-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113958970

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31068659


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