Efficacy and safety of autologous stem cell transplantation in patients aged ≥ 65 years with multiple myeloma in the era ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-19

AUTHORS

Shohei Mizuno, Koji Kawamura, Ichiro Hanamura, Kazutaka Sunami, Takehiko Mori, Fumihiko Nakamura, Shinsuke Iida, Hideyuki Nakazawa, Masanori Makita, Shinichi Kako, Masashi Sawa, Yasunori Ueda, Hiroyuki Takahashi, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Hiroyuki Takamatsu, Akiyoshi Takami

ABSTRACT

Clinical trials evaluating the role of autologous hematopoietic stem cell transplantation (auto-HCT) in multiple myeloma have mostly included patients aged <65 years. Therefore, this study was aimed to evaluate the efficacy and safety of auto-HCT in elderly patients with multiple myeloma in the era of novel agents. We retrospectively analyzed 2056 patients with multiple myeloma, who underwent auto-HCT in 2007–2014 (287 were aged ≥65 years). We evaluated the 100-day treatment-related mortality (TRM) and overall survival (OS) in two groups; elderly patients ( ≥65 years) who underwent auto-HCT compared with younger patients ( <65 years). In the propensity score–matched-pair analysis used to adjust for possible selection bias, the incidence of 100-day TRM between patients aged <65 (0.4%; 95% confidence interval [CI]: 0.0–2.0%) and ≥65 years (1.2%; 95% CI: 0.3–3.1%) showed no statistically significant difference (p = 0.31). The probability of the 5-year OS after transplantation in those aged <65 (62.5%; 95% CI: 58.6–66.1%) and ≥65 (63.5%; 95% CI: 52.2–72.7%) years was also not significantly different (p = 0.56). This study showed that the safety and efficacy of auto-HCT in elderly patients with multiple myeloma in the era of novel agents compared with younger patients were similar. More... »

PAGES

1595-1604

Journal

TITLE

Bone Marrow Transplantation

ISSUE

10

VOLUME

54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-019-0478-4

DOI

http://dx.doi.org/10.1038/s41409-019-0478-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112222491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30783208


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20 schema:description Clinical trials evaluating the role of autologous hematopoietic stem cell transplantation (auto-HCT) in multiple myeloma have mostly included patients aged <65 years. Therefore, this study was aimed to evaluate the efficacy and safety of auto-HCT in elderly patients with multiple myeloma in the era of novel agents. We retrospectively analyzed 2056 patients with multiple myeloma, who underwent auto-HCT in 2007–2014 (287 were aged ≥65 years). We evaluated the 100-day treatment-related mortality (TRM) and overall survival (OS) in two groups; elderly patients ( ≥65 years) who underwent auto-HCT compared with younger patients ( <65 years). In the propensity score–matched-pair analysis used to adjust for possible selection bias, the incidence of 100-day TRM between patients aged <65 (0.4%; 95% confidence interval [CI]: 0.0–2.0%) and ≥65 years (1.2%; 95% CI: 0.3–3.1%) showed no statistically significant difference (p = 0.31). The probability of the 5-year OS after transplantation in those aged <65 (62.5%; 95% CI: 58.6–66.1%) and ≥65 (63.5%; 95% CI: 52.2–72.7%) years was also not significantly different (p = 0.56). This study showed that the safety and efficacy of auto-HCT in elderly patients with multiple myeloma in the era of novel agents compared with younger patients were similar.
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28 autologous hematopoietic stem cell transplantation
29 autologous stem cell transplantation
30 bias
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32 clinical trials
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35 elderly patients
36 era
37 group
38 hematopoietic stem cell transplantation
39 incidence
40 mortality
41 multiple myeloma
42 myeloma
43 novel agents
44 overall survival
45 pair analysis
46 patients
47 possible selection bias
48 probability
49 propensity
50 role
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52 selection bias
53 significant differences
54 stem cell transplantation
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