Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSMasamitsu Yanada, Masayoshi Masuko, Jinichi Mori, Jun Aoki, Shohei Mizuno, Takahiro Fukuda, Kazuhiko Kakihana, Yukiyasu Ozawa, Shuichi Ota, Heiwa Kanamori, Takehiko Mori, Hirohisa Nakamae, Tetsuya Eto, Souichi Shiratori, Tetsuo Maeda, Koji Iwato, Tatsuo Ichinohe, Yoshinobu Kanda, Junji Tanaka, Yoshiko Atsuta, Shingo Yano
ABSTRACTIt remains unclear how specific innovations in allogeneic hematopoietic cell transplantation (HCT) attained over the past decades have contributed to improvement in transplantation outcomes. To address this question, we conducted a registry-based study of adults with acute myeloid leukemia in first or second complete remission who underwent allogeneic HCT between 1994 and 2013 from a sibling (N = 1600) or unrelated (N = 2113) donor matched at the antigen level for HLA-A, -B, and -DR. Preliminary analysis led us to focus on comparisons between the 1994-2006 and 2007-2013 periods. Significant improvement in survival was observed in the later cohort compared to the earlier cohort for unrelated HCT (P = 0.004), but not for related HCT (P = 0.767). The improvement in unrelated HCT was solely due to diminished non-relapse mortality (P = 0.001), while incidence of relapse did not change over time (P = 0.934). The percentage of patients receiving transplants from 8/8-matched unrelated donors was significantly higher in the later cohort (P < 0.001), and their survival was significantly better than that of those undergoing mismatched unrelated HCT (P = 0.022). These findings suggest that advances in HLA-typing technology have been vital for improvement in transplantation outcomes. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1038/s41409-018-0301-7
DOIhttp://dx.doi.org/10.1038/s41409-018-0301-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1106149902
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30108330
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Fujita Health University",
"id": "https://www.grid.ac/institutes/grid.256115.4",
"name": [
"Aichi Cancer Center, Nagoya, Japan",
"Fujita Health University School of Medicine, Toyoake, Japan"
],
"type": "Organization"
},
"familyName": "Yanada",
"givenName": "Masamitsu",
"id": "sg:person.01024604275.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Niigata University Medical and Dental Hospital",
"id": "https://www.grid.ac/institutes/grid.412181.f",
"name": [
"Niigata University Medical and Dental Hospital, Niigata, Japan"
],
"type": "Organization"
},
"familyName": "Masuko",
"givenName": "Masayoshi",
"id": "sg:person.01274407522.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274407522.85"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Jyoban Hospital Tokiwa Foundation, Fukushima, Japan"
],
"type": "Organization"
},
"familyName": "Mori",
"givenName": "Jinichi",
"id": "sg:person.0765070735.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765070735.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University Medical Center",
"id": "https://www.grid.ac/institutes/grid.413045.7",
"name": [
"Yokohama City University Medical Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Aoki",
"givenName": "Jun",
"id": "sg:person.01264262573.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264262573.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aichi Medical University",
"id": "https://www.grid.ac/institutes/grid.411234.1",
"name": [
"Aichi Medical University, Nagakute, Japan"
],
"type": "Organization"
},
"familyName": "Mizuno",
"givenName": "Shohei",
"id": "sg:person.0677731025.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677731025.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.272242.3",
"name": [
"National Cancer Center Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Fukuda",
"givenName": "Takahiro",
"id": "sg:person.016452523632.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Metropolitan Komagome Hospital",
"id": "https://www.grid.ac/institutes/grid.415479.a",
"name": [
"Tokyo Metropolitan Komagome Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kakihana",
"givenName": "Kazuhiko",
"id": "sg:person.0677710136.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677710136.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japanese Red Cross Nagoya Daiichi Hospital",
"id": "https://www.grid.ac/institutes/grid.414932.9",
"name": [
"Japanese Red Cross Nagoya First Hospital, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Ozawa",
"givenName": "Yukiyasu",
"id": "sg:person.01165712107.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165712107.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sapporo Hokuyu Hospital",
"id": "https://www.grid.ac/institutes/grid.415262.6",
"name": [
"Sapporo Hokuyu Hospital, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Ota",
"givenName": "Shuichi",
"id": "sg:person.011176077202.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kanagawa Prefectural Hospital",
"id": "https://www.grid.ac/institutes/grid.414944.8",
"name": [
"Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Kanamori",
"givenName": "Heiwa",
"id": "sg:person.01060176576.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Keio University",
"id": "https://www.grid.ac/institutes/grid.26091.3c",
"name": [
"Keio University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Mori",
"givenName": "Takehiko",
"id": "sg:person.015512754302.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka City University",
"id": "https://www.grid.ac/institutes/grid.261445.0",
"name": [
"Graduate School of Medicine, Osaka City University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Nakamae",
"givenName": "Hirohisa",
"id": "sg:person.01014223462.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hamanomachi Hospital",
"id": "https://www.grid.ac/institutes/grid.413617.6",
"name": [
"Hamanomachi Hospital, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Eto",
"givenName": "Tetsuya",
"id": "sg:person.0720274373.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hokkaido University",
"id": "https://www.grid.ac/institutes/grid.39158.36",
"name": [
"Hokkaido University Faculty of Medicine, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Shiratori",
"givenName": "Souichi",
"id": "sg:person.0653535643.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Maeda",
"givenName": "Tetsuo",
"id": "sg:person.01227433131.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227433131.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital",
"id": "https://www.grid.ac/institutes/grid.414175.2",
"name": [
"Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Iwato",
"givenName": "Koji",
"id": "sg:person.01045601306.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045601306.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University Hospital",
"id": "https://www.grid.ac/institutes/grid.470097.d",
"name": [
"Hiroshima University Hospital, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ichinohe",
"givenName": "Tatsuo",
"id": "sg:person.0623252373.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jichi Medical University",
"id": "https://www.grid.ac/institutes/grid.410804.9",
"name": [
"Jichi Medical University, Shimotsuke, Japan"
],
"type": "Organization"
},
"familyName": "Kanda",
"givenName": "Yoshinobu",
"id": "sg:person.0617055140.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Women's Medical University",
"id": "https://www.grid.ac/institutes/grid.410818.4",
"name": [
"Tokyo Women\u2019s Medical University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Junji",
"id": "sg:person.0714107337.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan",
"Nagoya University Graduate School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Atsuta",
"givenName": "Yoshiko",
"id": "sg:person.01146754030.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jikei University",
"id": "https://www.grid.ac/institutes/grid.411898.d",
"name": [
"Jikei University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yano",
"givenName": "Shingo",
"id": "sg:person.01265010246.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s1470-2045(15)00200-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000386302"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bmt.1705739",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001598063",
"https://doi.org/10.1038/sj.bmt.1705739"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood.v99.11.4200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002016765"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.46.6193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002554711"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.172",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002781387",
"https://doi.org/10.1038/bmt.2012.172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2010-10-265603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006662607"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/bjh.12279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011003962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2007.03.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011755009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2014.10.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019479158"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2009.07.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020437675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.32.5001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020508536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70349-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023928953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1445-5994.2010.02262.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029228371"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2015-07-604546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029594163"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-014-1657-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031936200",
"https://doi.org/10.1007/s12185-014-1657-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1894-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036307316",
"https://doi.org/10.1007/s12185-015-1894-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0719-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039606343",
"https://doi.org/10.1007/s00277-009-0719-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0719-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039606343",
"https://doi.org/10.1007/s00277-009-0719-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0719-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039606343",
"https://doi.org/10.1007/s00277-009-0719-5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2011.05.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042706123"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1907-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045343135",
"https://doi.org/10.1007/s12185-015-1907-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1004383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053729233"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1532/ijh97.06239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054504897",
"https://doi.org/10.1532/ijh97.06239"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2016.358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074201971",
"https://doi.org/10.1038/bmt.2016.358"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077752613",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082422699",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2016.70.7091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083825068"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2017.79",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084128346",
"https://doi.org/10.1038/leu.2017.79"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/10428194.2017.1357173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090917592"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "It remains unclear how specific innovations in allogeneic hematopoietic cell transplantation (HCT) attained over the past decades have contributed to improvement in transplantation outcomes. To address this question, we conducted a registry-based study of adults with acute myeloid leukemia in first or second complete remission who underwent allogeneic HCT between 1994 and 2013 from a sibling (N\u2009=\u20091600) or unrelated (N\u2009=\u20092113) donor matched at the antigen level for HLA-A, -B, and -DR. Preliminary analysis led us to focus on comparisons between the 1994-2006 and 2007-2013 periods. Significant improvement in survival was observed in the later cohort compared to the earlier cohort for unrelated HCT (P\u2009=\u20090.004), but not for related HCT (P\u2009=\u20090.767). The improvement in unrelated HCT was solely due to diminished non-relapse mortality (P\u2009=\u20090.001), while incidence of relapse did not change over time (P\u2009=\u20090.934). The percentage of patients receiving transplants from 8/8-matched unrelated donors was significantly higher in the later cohort (P\u2009<\u20090.001), and their survival was significantly better than that of those undergoing mismatched unrelated HCT (P\u2009=\u20090.022). These findings suggest that advances in HLA-typing technology have been vital for improvement in transplantation outcomes.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41409-018-0301-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1096890",
"issn": [
"0268-3369",
"1476-5365"
],
"name": "Bone Marrow Transplantation",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "54"
}
],
"name": "Patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: trends in survival during the past two decades",
"pagination": "1-9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8c813801912e59fbd528d5c14839b43afae89ff67f99f2f4d520e3a316b96409"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30108330"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8702459"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41409-018-0301-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1106149902"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41409-018-0301-7",
"https://app.dimensions.ai/details/publication/pub.1106149902"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130829_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41409-018-0301-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0301-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0301-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0301-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0301-7'
This table displays all metadata directly associated to this object as RDF triples.
358 TRIPLES
21 PREDICATES
56 URIs
21 LITERALS
9 BLANK NODES