Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Daisuke Tomizawa, Masanori Yoshida, Tadakazu Kondo, Takako Miyamura, Takashi Taga, Souichi Adachi, Katsuyoshi Koh, Maiko Noguchi, Harumi Kakuda, Kenichiro Watanabe, Yuko Cho, Takahiro Fukuda, Motohiro Kato, Norio Shiba, Hiroaki Goto, Keiko Okada, Masami Inoue, Yoshiko Hashii, Yoshiko Atsuta, Hiroyuki Ishida

ABSTRACT

Allocating patients with acute myeloid leukemia and high-risk cytogenetic abnormalities (HR-AML) for allogeneic hematopoietic stem cell transplantation (allo-HSCT) is part of the standard treatment protocol; however, whether allo-HSCT truly improves the outcomes in these patients is debatable. Data on 169 children and adolescents with HR-AML who received their first allo-HSCT in first or second remission between 2000 and 2015 were extracted from a nationwide, Japanese HSCT registry. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 55.2% (95% CI, 46.8-62.9%) and 69.6% (61.4-76.3%), respectively, for all the HR-AML patients. In univariate analysis, the cytogenetic subgroup had a significant impact on both the DFS (P = 0.011) and OS (P < 0.001) rates. In particular, 14 patients with t(16;21) showed an extremely poor outcome. Additionally, older age at allo-HSCT (10-19 years old, P = 0.025), myeloablative conditioning with total-body irradiation (P = 0.019), and grade II-IV acute graft-versus-host disease (GVHD, P = 0.049) were associated with inferior OS. The donor type and occurrence of chronic GVHD did not affect the outcome. Multivariate analysis revealed t(16;21) to be associated with increased overall mortality (hazard ratio = 4.416, P < 0.001). Because the outcome of patients with certain HR-AML subgroups, such as t(16;21)-positive cases, is extremely poor even with allo-HSCT in remission, a novel therapy is urgently required. More... »

PAGES

393-401

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-018-0273-7

DOI

http://dx.doi.org/10.1038/s41409-018-0273-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105215134

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29959436


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0273-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0273-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0273-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-018-0273-7'


 

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301 https://www.grid.ac/institutes/grid.414947.b schema:alternateName Kanagawa Children's Medical Center
302 schema:name Division of Hemato/Oncology and Regenerative Medicine, Kanagawa Children’s Medical Center, Yokohama, Japan
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304 https://www.grid.ac/institutes/grid.415597.b schema:alternateName Kyoto City Hospital
305 schema:name Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan
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307 https://www.grid.ac/institutes/grid.415613.4 schema:alternateName National Kyushu Medical Center
308 schema:name Department of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan
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310 https://www.grid.ac/institutes/grid.415798.6 schema:alternateName Shizuoka Children's Hospital
311 schema:name Department of Hematology and Oncology, Shizuoka Children’s Hospital, Shizuoka, Japan
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313 https://www.grid.ac/institutes/grid.416697.b schema:alternateName Saitama Children's Medical Center
314 schema:name Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Japan
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316 https://www.grid.ac/institutes/grid.416948.6 schema:alternateName Osaka City General Hospital
317 schema:name Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
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319 https://www.grid.ac/institutes/grid.470126.6 schema:alternateName Yokohama City University Hospital
320 schema:name Department of Pediatrics, Yokohama City University Hospital, Yokohama, Japan
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322 https://www.grid.ac/institutes/grid.63906.3a schema:alternateName National Center For Child Health and Development
323 schema:name Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
324 Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan
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