Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Stephen P. Robinson, Ariane Boumendil, Herve Finel, Karl S. Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger

ABSTRACT

Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%. Non-relapse mortality (NRM) was 10% at 100 days and 24% at 1 year and was lower for patients receiving anti-thymocyte globulin (ATG)/ALG (RR 0.59, p = 0.046). After a median follow-up of 72 months (range 3-159), 118 patients relapsed at a median of 8 months post RIST (range 1-117). The cumulative incidence of relapse was 25% and 40% at 1 and 5 years, respectively, and was associated with chemorefractory disease (HR 0.49, p = 0.01) and the use of CAMPATH (HR 2.59, p = 0.0002). The 4-year progression-free survival rate and overall survival rate was 31 and 40%, respectively. RIST results in long-term disease-free survival in about 30% of the patients, including those patients relapsing after a prior autoSCT. More... »

PAGES

617-624

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41409-017-0067-3

DOI

http://dx.doi.org/10.1038/s41409-017-0067-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100275561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29335632


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "University Hospitals Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robinson", 
        "givenName": "Stephen P.", 
        "id": "sg:person.01051376755.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051376755.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Society for Blood and Marrow Transplantation", 
          "id": "https://www.grid.ac/institutes/grid.492743.f", 
          "name": [
            "Lymphoma Working Party EBMT, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boumendil", 
        "givenName": "Ariane", 
        "id": "sg:person.0747051674.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747051674.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Society for Blood and Marrow Transplantation", 
          "id": "https://www.grid.ac/institutes/grid.492743.f", 
          "name": [
            "Lymphoma Working Party EBMT, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finel", 
        "givenName": "Herve", 
        "id": "sg:person.01015165074.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015165074.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.439749.4", 
          "name": [
            "University College London Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peggs", 
        "givenName": "Karl S.", 
        "id": "sg:person.0630024242.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630024242.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nantes", 
          "id": "https://www.grid.ac/institutes/grid.277151.7", 
          "name": [
            "CHU, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chevallier", 
        "givenName": "Patrice", 
        "id": "sg:person.0671734306.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671734306.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Sant Pau", 
          "id": "https://www.grid.ac/institutes/grid.413396.a", 
          "name": [
            "Hospital Santa Creu i Sant Pau, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sierra", 
        "givenName": "Jorge", 
        "id": "sg:person.01056413664.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056413664.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "University of Freiburg, Freiburg im Breisgau, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finke", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.01341317720.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341317720.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Cliniques Universitaires St. Luc, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poir\u00e9", 
        "givenName": "Xavier", 
        "id": "sg:person.01237362707.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362707.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Poitiers", 
          "id": "https://www.grid.ac/institutes/grid.411162.1", 
          "name": [
            "H\u00f4pital La Miletrie, Poitiers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maillard", 
        "givenName": "Natacha", 
        "id": "sg:person.01067470361.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067470361.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "CHU Bordeaux, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milpied", 
        "givenName": "No\u00ebl", 
        "id": "sg:person.01074165145.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074165145.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Claude Huriez", 
          "id": "https://www.grid.ac/institutes/grid.413875.c", 
          "name": [
            "H\u00f4pital Huriez, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yakoub-Agha", 
        "givenName": "Ibrahim", 
        "id": "sg:person.0631077726.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631077726.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St George's, University of London", 
          "id": "https://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "St. George\u2019s Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "Mickey", 
        "id": "sg:person.012431116622.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012431116622.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "University Hospital Eppendorf, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00f6ger", 
        "givenName": "Nicolaus", 
        "id": "sg:person.01232367165.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232367165.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagler", 
        "givenName": "Arnon", 
        "id": "sg:person.0644252102.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644252102.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Park Hospitals, Antalya, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koc", 
        "givenName": "Yener", 
        "id": "sg:person.01111720055.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111720055.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dietrich", 
        "givenName": "Sascha", 
        "id": "sg:person.01267120746.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267120746.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "St. Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montoto", 
        "givenName": "Silvia", 
        "id": "sg:person.01372123443.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372123443.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dreger", 
        "givenName": "Peter", 
        "id": "sg:person.01002205325.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002205325.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/bjh.12046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001169896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-03-635326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003507853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-05-286856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006139174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.49.2454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007168174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-03-147025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014062347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-09-370320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016737424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-10-184200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020592930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-08-2476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025513720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-06-2275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026296709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2010.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026718337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-10-673145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034166673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00739-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034609184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.22.2554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034769929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2012.09174.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034788790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1306220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035996659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1306220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035996659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-09-2687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037068927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037425350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00667-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037749972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039799830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-10-3883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040043539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2013.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046337821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.14241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047995563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2001-11-0107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049524566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.12.3803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083360507"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%. Non-relapse mortality (NRM) was 10% at 100 days and 24% at 1 year and was lower for patients receiving anti-thymocyte globulin (ATG)/ALG (RR 0.59, p\u2009=\u20090.046). After a median follow-up of 72 months (range 3-159), 118 patients relapsed at a median of 8 months post RIST (range 1-117). The cumulative incidence of relapse was 25% and 40% at 1 and 5 years, respectively, and was associated with chemorefractory disease (HR 0.49, p\u2009=\u20090.01) and the use of CAMPATH (HR 2.59, p\u2009=\u20090.0002). The 4-year progression-free survival rate and overall survival rate was 31 and 40%, respectively. RIST results in long-term disease-free survival in about 30% of the patients, including those patients relapsing after a prior autoSCT.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41409-017-0067-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "53"
      }
    ], 
    "name": "Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party", 
    "pagination": "617-624", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dffc0698385d80d151f6883a126c3f43032886a937ae7d78604bb55e8ec8f70a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29335632"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41409-017-0067-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100275561"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41409-017-0067-3", 
      "https://app.dimensions.ai/details/publication/pub.1100275561"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41409-017-0067-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41409-017-0067-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41409-017-0067-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41409-017-0067-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41409-017-0067-3'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      53 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41409-017-0067-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nfc679f716f4246aa9428db3faa5e6a82
4 schema:citation https://doi.org/10.1016/j.bbmt.2010.04.006
5 https://doi.org/10.1016/j.bbmt.2013.01.009
6 https://doi.org/10.1016/s0140-6736(15)00667-4
7 https://doi.org/10.1016/s0140-6736(16)00739-x
8 https://doi.org/10.1056/nejmoa1306220
9 https://doi.org/10.1093/annonc/mds054
10 https://doi.org/10.1093/annonc/mds643
11 https://doi.org/10.1111/bjh.12046
12 https://doi.org/10.1111/bjh.14241
13 https://doi.org/10.1111/j.1365-2141.2012.09174.x
14 https://doi.org/10.1182/blood-2001-11-0107
15 https://doi.org/10.1182/blood-2002-08-2476
16 https://doi.org/10.1182/blood-2002-09-2687
17 https://doi.org/10.1182/blood-2004-06-2275
18 https://doi.org/10.1182/blood-2004-10-3883
19 https://doi.org/10.1182/blood-2008-03-147025
20 https://doi.org/10.1182/blood-2008-10-184200
21 https://doi.org/10.1182/blood-2010-05-286856
22 https://doi.org/10.1182/blood-2011-09-370320
23 https://doi.org/10.1182/blood-2015-03-635326
24 https://doi.org/10.1182/blood-2015-10-673145
25 https://doi.org/10.1200/jco.1998.16.12.3803
26 https://doi.org/10.1200/jco.2009.22.2554
27 https://doi.org/10.1200/jco.2013.49.2454
28 schema:datePublished 2018-05
29 schema:datePublishedReg 2018-05-01
30 schema:description Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%. Non-relapse mortality (NRM) was 10% at 100 days and 24% at 1 year and was lower for patients receiving anti-thymocyte globulin (ATG)/ALG (RR 0.59, p = 0.046). After a median follow-up of 72 months (range 3-159), 118 patients relapsed at a median of 8 months post RIST (range 1-117). The cumulative incidence of relapse was 25% and 40% at 1 and 5 years, respectively, and was associated with chemorefractory disease (HR 0.49, p = 0.01) and the use of CAMPATH (HR 2.59, p = 0.0002). The 4-year progression-free survival rate and overall survival rate was 31 and 40%, respectively. RIST results in long-term disease-free survival in about 30% of the patients, including those patients relapsing after a prior autoSCT.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N6c741dbdb03f4bdeb5dc6fcaf827c9e7
35 N8b71ca0811924fbcaca5dfd551bc8155
36 sg:journal.1096890
37 schema:name Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party
38 schema:pagination 617-624
39 schema:productId N031c568a92ba4588af7e789a4ec7cbec
40 N599a0ffa13714035927a0f90e63cc02e
41 N5ca4b1c0bbaa45d1a623ff3dc6682f05
42 Ncabf1f3d01604a6695d43f26ac87f076
43 Nd8cf69d3b6d24e0790604c59202d9759
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100275561
45 https://doi.org/10.1038/s41409-017-0067-3
46 schema:sdDatePublished 2019-04-10T20:43
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher Nf1a4acff5d3b44e6aad9a32dfdb97980
49 schema:url https://www.nature.com/articles/s41409-017-0067-3
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N031c568a92ba4588af7e789a4ec7cbec schema:name readcube_id
54 schema:value dffc0698385d80d151f6883a126c3f43032886a937ae7d78604bb55e8ec8f70a
55 rdf:type schema:PropertyValue
56 N2f28be483d47466b99cc14a2b108fc33 schema:name Medical Park Hospitals, Antalya, Turkey
57 rdf:type schema:Organization
58 N30c05535b7dd4bb5ba59db71ad601f43 rdf:first sg:person.0630024242.03
59 rdf:rest N70c54be61163433885c14489cc9bc80b
60 N387740ff11014cc29beabb217e600e15 rdf:first sg:person.01111720055.15
61 rdf:rest N43fa6018b02b4770ad29637ffaade6d1
62 N43fa6018b02b4770ad29637ffaade6d1 rdf:first sg:person.01267120746.12
63 rdf:rest Ne36d8a859851458ab8a9c08e9c50e751
64 N57c1354ef3864e3b979082ccb9982e3e rdf:first sg:person.01232367165.72
65 rdf:rest Nd5cc2a77f92a47e5bf6e36fc83f57039
66 N599a0ffa13714035927a0f90e63cc02e schema:name pubmed_id
67 schema:value 29335632
68 rdf:type schema:PropertyValue
69 N5ca4b1c0bbaa45d1a623ff3dc6682f05 schema:name dimensions_id
70 schema:value pub.1100275561
71 rdf:type schema:PropertyValue
72 N6c741dbdb03f4bdeb5dc6fcaf827c9e7 schema:issueNumber 5
73 rdf:type schema:PublicationIssue
74 N70c54be61163433885c14489cc9bc80b rdf:first sg:person.0671734306.06
75 rdf:rest Nc3adc0444ad3440db7811914d7fc1540
76 N809bfcaa5e1c40358ca0a68c803b9754 rdf:first sg:person.01002205325.01
77 rdf:rest rdf:nil
78 N877a3b82d3674e5890dcd5cb9c384c28 rdf:first sg:person.0631077726.87
79 rdf:rest N9eb4ff87b9074698a85d7a2f88d8e621
80 N8b71ca0811924fbcaca5dfd551bc8155 schema:volumeNumber 53
81 rdf:type schema:PublicationVolume
82 N9dc6a8cef2a648239c7703ce08ef3d28 rdf:first sg:person.01341317720.21
83 rdf:rest Nac1a73f8c38043d9b30942c4682bed5f
84 N9eb4ff87b9074698a85d7a2f88d8e621 rdf:first sg:person.012431116622.55
85 rdf:rest N57c1354ef3864e3b979082ccb9982e3e
86 Nac1a73f8c38043d9b30942c4682bed5f rdf:first sg:person.01237362707.22
87 rdf:rest Nc3279a1670c44650961c1e5668a54693
88 Nc3279a1670c44650961c1e5668a54693 rdf:first sg:person.01067470361.59
89 rdf:rest Ne0f41fdf2a624076b3c29ad9f65746c5
90 Nc3adc0444ad3440db7811914d7fc1540 rdf:first sg:person.01056413664.96
91 rdf:rest N9dc6a8cef2a648239c7703ce08ef3d28
92 Nc52bfef36292463cbe7e7cbcf99dad45 rdf:first sg:person.01015165074.81
93 rdf:rest N30c05535b7dd4bb5ba59db71ad601f43
94 Ncabf1f3d01604a6695d43f26ac87f076 schema:name doi
95 schema:value 10.1038/s41409-017-0067-3
96 rdf:type schema:PropertyValue
97 Ncb0d214a7c5048debce0bdde7acb4e69 rdf:first sg:person.0747051674.24
98 rdf:rest Nc52bfef36292463cbe7e7cbcf99dad45
99 Nd5cc2a77f92a47e5bf6e36fc83f57039 rdf:first sg:person.0644252102.00
100 rdf:rest N387740ff11014cc29beabb217e600e15
101 Nd8cf69d3b6d24e0790604c59202d9759 schema:name nlm_unique_id
102 schema:value 8702459
103 rdf:type schema:PropertyValue
104 Ne0f41fdf2a624076b3c29ad9f65746c5 rdf:first sg:person.01074165145.75
105 rdf:rest N877a3b82d3674e5890dcd5cb9c384c28
106 Ne36d8a859851458ab8a9c08e9c50e751 rdf:first sg:person.01372123443.83
107 rdf:rest N809bfcaa5e1c40358ca0a68c803b9754
108 Nf1a4acff5d3b44e6aad9a32dfdb97980 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 Nfc679f716f4246aa9428db3faa5e6a82 rdf:first sg:person.01051376755.85
111 rdf:rest Ncb0d214a7c5048debce0bdde7acb4e69
112 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical and Health Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
116 schema:name Oncology and Carcinogenesis
117 rdf:type schema:DefinedTerm
118 sg:journal.1096890 schema:issn 0268-3369
119 1476-5365
120 schema:name Bone Marrow Transplantation
121 rdf:type schema:Periodical
122 sg:person.01002205325.01 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
123 schema:familyName Dreger
124 schema:givenName Peter
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002205325.01
126 rdf:type schema:Person
127 sg:person.01015165074.81 schema:affiliation https://www.grid.ac/institutes/grid.492743.f
128 schema:familyName Finel
129 schema:givenName Herve
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015165074.81
131 rdf:type schema:Person
132 sg:person.01051376755.85 schema:affiliation https://www.grid.ac/institutes/grid.410421.2
133 schema:familyName Robinson
134 schema:givenName Stephen P.
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051376755.85
136 rdf:type schema:Person
137 sg:person.01056413664.96 schema:affiliation https://www.grid.ac/institutes/grid.413396.a
138 schema:familyName Sierra
139 schema:givenName Jorge
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056413664.96
141 rdf:type schema:Person
142 sg:person.01067470361.59 schema:affiliation https://www.grid.ac/institutes/grid.411162.1
143 schema:familyName Maillard
144 schema:givenName Natacha
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067470361.59
146 rdf:type schema:Person
147 sg:person.01074165145.75 schema:affiliation https://www.grid.ac/institutes/grid.42399.35
148 schema:familyName Milpied
149 schema:givenName Noël
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074165145.75
151 rdf:type schema:Person
152 sg:person.01111720055.15 schema:affiliation N2f28be483d47466b99cc14a2b108fc33
153 schema:familyName Koc
154 schema:givenName Yener
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111720055.15
156 rdf:type schema:Person
157 sg:person.01232367165.72 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
158 schema:familyName Kröger
159 schema:givenName Nicolaus
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232367165.72
161 rdf:type schema:Person
162 sg:person.01237362707.22 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
163 schema:familyName Poiré
164 schema:givenName Xavier
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362707.22
166 rdf:type schema:Person
167 sg:person.012431116622.55 schema:affiliation https://www.grid.ac/institutes/grid.264200.2
168 schema:familyName Koh
169 schema:givenName Mickey
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012431116622.55
171 rdf:type schema:Person
172 sg:person.01267120746.12 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
173 schema:familyName Dietrich
174 schema:givenName Sascha
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267120746.12
176 rdf:type schema:Person
177 sg:person.01341317720.21 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
178 schema:familyName Finke
179 schema:givenName Jürgen
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341317720.21
181 rdf:type schema:Person
182 sg:person.01372123443.83 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
183 schema:familyName Montoto
184 schema:givenName Silvia
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372123443.83
186 rdf:type schema:Person
187 sg:person.0630024242.03 schema:affiliation https://www.grid.ac/institutes/grid.439749.4
188 schema:familyName Peggs
189 schema:givenName Karl S.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630024242.03
191 rdf:type schema:Person
192 sg:person.0631077726.87 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
193 schema:familyName Yakoub-Agha
194 schema:givenName Ibrahim
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631077726.87
196 rdf:type schema:Person
197 sg:person.0644252102.00 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
198 schema:familyName Nagler
199 schema:givenName Arnon
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644252102.00
201 rdf:type schema:Person
202 sg:person.0671734306.06 schema:affiliation https://www.grid.ac/institutes/grid.277151.7
203 schema:familyName Chevallier
204 schema:givenName Patrice
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671734306.06
206 rdf:type schema:Person
207 sg:person.0747051674.24 schema:affiliation https://www.grid.ac/institutes/grid.492743.f
208 schema:familyName Boumendil
209 schema:givenName Ariane
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747051674.24
211 rdf:type schema:Person
212 https://doi.org/10.1016/j.bbmt.2010.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026718337
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.bbmt.2013.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046337821
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0140-6736(15)00667-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037749972
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0140-6736(16)00739-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034609184
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1056/nejmoa1306220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035996659
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/annonc/mds054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039799830
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/annonc/mds643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037425350
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1111/bjh.12046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001169896
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/bjh.14241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047995563
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/j.1365-2141.2012.09174.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034788790
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1182/blood-2001-11-0107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049524566
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1182/blood-2002-08-2476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025513720
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1182/blood-2002-09-2687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037068927
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1182/blood-2004-06-2275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026296709
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1182/blood-2004-10-3883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040043539
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1182/blood-2008-03-147025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014062347
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1182/blood-2008-10-184200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020592930
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1182/blood-2010-05-286856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006139174
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1182/blood-2011-09-370320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016737424
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1182/blood-2015-03-635326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003507853
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1182/blood-2015-10-673145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034166673
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1200/jco.1998.16.12.3803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083360507
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1200/jco.2009.22.2554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034769929
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.2013.49.2454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007168174
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
261 schema:name University Hospital Eppendorf, Hamburg, Germany
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.264200.2 schema:alternateName St George's, University of London
264 schema:name St. George’s Hospital, London, UK
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.277151.7 schema:alternateName Centre Hospitalier Universitaire de Nantes
267 schema:name CHU, Nantes, France
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.410421.2 schema:alternateName University Hospitals Bristol NHS Foundation Trust
270 schema:name University Hospitals Bristol, Bristol, UK
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.411162.1 schema:alternateName Centre Hospitalier Universitaire de Poitiers
273 schema:name Hôpital La Miletrie, Poitiers, France
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.413396.a schema:alternateName Hospital de Sant Pau
276 schema:name Hospital Santa Creu i Sant Pau, Barcelona, Spain
277 rdf:type schema:Organization
278 https://www.grid.ac/institutes/grid.413795.d schema:alternateName Sheba Medical Center
279 schema:name Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.413875.c schema:alternateName Hôpital Claude Huriez
282 schema:name Hôpital Huriez, Lille, France
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.416353.6 schema:alternateName St Bartholomew's Hospital
285 schema:name St. Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.42399.35 schema:alternateName Centre Hospitalier Universitaire de Bordeaux
288 schema:name CHU Bordeaux, Bordeaux, France
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.439749.4 schema:alternateName University College Hospital
291 schema:name University College London Hospital, London, UK
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
294 schema:name Cliniques Universitaires St. Luc, Brussels, Belgium
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.492743.f schema:alternateName European Society for Blood and Marrow Transplantation
297 schema:name Lymphoma Working Party EBMT, Paris, France
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.5963.9 schema:alternateName University of Freiburg
300 schema:name University of Freiburg, Freiburg im Breisgau, Germany
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
303 schema:name University of Heidelberg, Heidelberg, Germany
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...