Improved trends in survival and engraftment after single cord blood transplantation for adult acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-25

AUTHORS

Takaaki Konuma, Shohei Mizuno, Tadakazu Kondo, Yasuyuki Arai, Naoyuki Uchida, Satoshi Takahashi, Masatsugu Tanaka, Takuro Kuriyama, Shigesaburo Miyakoshi, Makoto Onizuka, Shuichi Ota, Yasuhiro Sugio, Yasushi Kouzai, Toshiro Kawakita, Hikaru Kobayashi, Yukiyasu Ozawa, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada

ABSTRACT

Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell transplantation (HCT) but lack an HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes for unselected adult AML. To investigate the trends of survival and engraftment after CBT over the past 22 years, we retrospectively evaluated the data of patients with AML in Japan according to the time period of CBT (1998–2007 vs 2008–2013 vs 2014–2019). A total of 5504 patients who received single-unit CBT as first allogeneic HCT for AML were included. Overall survival (OS) at 2 years significantly improved over time. The improved OS among patients in ≥ complete remission (CR)3 and active disease at CBT was mainly due to a reduction of relapse-related mortality, whereas among patients in first or second CR at CBT, this was due mainly to a reduction of non-relapse mortality. The trends of neutrophil engraftment also improved over time. This experience demonstrated that the survival and engraftment rate after CBT for this group has improved over the past 22 years. More... »

PAGES

81

References to SciGraph publications

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  • Journal

    TITLE

    Blood Cancer Journal

    ISSUE

    5

    VOLUME

    12

    Author Affiliations

  • Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Hematology, Toranomon Hospital, Tokyo, Japan
  • Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Department of Internal Medicine, Kitakyushu City Hospital Organization, Kitakyushu Municipal Medical Center, Kitakyushu, Japan
  • Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
  • Department of Hematology, National Hospital Organisation Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
  • Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41408-022-00678-6

    DOI

    http://dx.doi.org/10.1038/s41408-022-00678-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148148205

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35614057


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