Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-24

AUTHORS

Shuhei Kurosawa, Shohei Mizuno, Yasuyuki Arai, Masayoshi Masuko, Junya Kanda, Kentaro Kohno, Daishi Onai, Takahiro Fukuda, Yukiyasu Ozawa, Yuta Katayama, Masatsugu Tanaka, Kazuhiro Ikegame, Naoyuki Uchida, Tetsuya Eto, Shuichi Ota, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada

ABSTRACT

The present study evaluated outcomes and prognostic factors in adult patients with acute myeloid leukemia (AML) after syngeneic hematopoietic stem cell transplantation (HSCT). Among patients in first complete remission (CR1), outcomes of syngeneic HSCT (Syn) were compared with those of autologous HSCT (Auto), allogeneic HSCT from human leukocyte antigen (HLA)-matched sibling donor (MSD), or allogeneic HSCT from HLA-matched unrelated donor (MUD). Among 11,866 patients receiving first HSCT, 26 in the Syn group were analyzed. The 5-year overall survival (OS) rate, the cumulative incidence of relapse, and the cumulative incidence of non-relapse mortality (NRM) were 47.8%, 59.6%, and 4.6%, respectively. The OS was significantly better in patients in CR1 (n = 13) than in patients in non-CR1 (P = 0.012). Furthermore, 39 patients in CR1 each were assigned to the Auto, MSD, and MUD groups using propensity score matching. The 5-year OS in the Syn (68.4%) was not significantly different from those in the Auto (55.9%, P = 0.265), MSD (62.4%, P = 0.419), or MUD (63.7%, P = 0.409) groups. A higher relapse in the Syn than in the MSD and MUD groups was offset by lower NRM. In summary, syngeneic HSCT might be an alternative option for AML patients in CR1. More... »

PAGES

159

References to SciGraph publications

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  • Journal

    TITLE

    Blood Cancer Journal

    ISSUE

    9

    VOLUME

    11

    Author Affiliations

  • Division of Stem Cell and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
  • Department of Hematology, Kyoto University Hospital, Kyoto, Japan
  • Division of Stem Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Hematology and Oncology, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Kitakyushu, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Higashi-Hiroshima, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41408-021-00553-w

    DOI

    http://dx.doi.org/10.1038/s41408-021-00553-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141358818

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34561419


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