Ontology type: schema:ScholarlyArticle Open Access: True
2019-11-12
AUTHORSChristina Rautenberg, Ulrich Germing, Sabrina Pechtel, Marius Lamers, Carolin Fischermanns, Paul Jäger, Stefanie Geyh, Rainer Haas, Guido Kobbe, Thomas Schroeder
ABSTRACTFew reports suggested a prognostic impact of Wilms‘Tumor-1 (WT1)-mRNA overexpression in MDS, but translation into clinical routine was hampered by limited patients numbers, differing sample sources, non-standardized methods/cut-offs. To evaluate whether WT1-mRNA expression yields additional prognostic information, we measured peripheral blood (PB) WT1-mRNA expression in 94 MDS using a standardized assay offering a validated cut-off to discriminate between normal and WT1-mRNA overexpression. Overall, 54 patients (57%) showed WT1-mRNA overexpression, while 40 patients (43%) had normal WT1-mRNA expression. This enabled discrimination between MDS and both healthy controls and non-MDS cytopenias. Furthermore, WT1-mRNA expression correlated with WHO 2016 subcategories and IPSS-R as indicated by mean WT1-mRNA expression and frequency of WT1-mRNA overexpressing patients within respective subgroups. Regarding the entire group, PB WT1-mRNA expression was associated with prognosis, as those patients showing WT1-mRNA overexpression had higher risk for disease progression and AML transformation and accordingly shorter progression-free, leukemia-free and overall survival in univariate analysis. In multivariate analysis, prognostic impact of PB WT1-mRNA expression status was independent of IPSS-R and enabled more precise prediction of PFS, but not OS, within IPSS-R very low/low and intermediate risk groups. Overall, measuring PB WT1-mRNA appears valuable to support diagnostics and refine prognostication provided by the IPSS-R. More... »
PAGES86
http://scigraph.springernature.com/pub.10.1038/s41408-019-0248-y
DOIhttp://dx.doi.org/10.1038/s41408-019-0248-y
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/31719523
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