Daratumumab, lenalidomide, and dexamethasone in East Asian patients with relapsed or refractory multiple myeloma: subgroup analyses of the phase 3 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04

AUTHORS

Kenshi Suzuki, Meletios A. Dimopoulos, Naoki Takezako, Shinichiro Okamoto, Atsushi Shinagawa, Morio Matsumoto, Hiroshi Kosugi, Sung-Soo Yoon, Shang-Yi Huang, Xiang Qin, Ming Qi, Shinsuke Iida

ABSTRACT

In the phase 3 POLLUX study, daratumumab plus lenalidomide and dexamethasone (DRd) significantly reduced the risk of progression/death and induced deeper responses vs. lenalidomide and dexamethasone alone (Rd) in patients with relapsed/refractory multiple myeloma (RRMM). We report a subgroup analysis of East Asian (Japanese, Korean, and Taiwanese) patients from POLLUX based on a longer follow-up of 24.7 months. Median progression-free survival was not reached (NR) for DRd vs. 13.8 months for Rd (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.23-0.76), and overall response rates were higher for DRd vs. Rd (90.2 vs. 72.1%). DRd extended the median duration of response vs. Rd (NR vs. 20.2 months), and minimal residual disease-negative rates at the 10-5 sensitivity threshold were 21.2 vs. 9.1% for DRd vs. Rd. No new safety signals were observed. Similar efficacy and safety were observed in the smaller subgroup of Japanese patients treated with DRd vs. Rd. These results demonstrate favorable efficacy and safety of DRd vs. Rd in East Asian patients and also in the Japanese-only patient subgroup that are consistent with findings in the overall patient population of POLLUX. More... »

PAGES

41

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41408-018-0071-x

DOI

http://dx.doi.org/10.1038/s41408-018-0071-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103640953

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29712896


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lenalidomide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Myeloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retreatment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Japanese Red Cross Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414929.3", 
          "name": [
            "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Kenshi", 
        "id": "sg:person.014724732234.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014724732234.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dimopoulos", 
        "givenName": "Meletios A.", 
        "id": "sg:person.01046642035.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046642035.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Hematology, National Hospital Organization Disaster Medical Center of Japan, Tachikawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takezako", 
        "givenName": "Naoki", 
        "id": "sg:person.01255632675.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255632675.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412096.8", 
          "name": [
            "Keio University Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamoto", 
        "givenName": "Shinichiro", 
        "id": "sg:person.0715264147.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hitachi General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414178.f", 
          "name": [
            "Hitachi General Hospital, Hitachi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinagawa", 
        "givenName": "Atsushi", 
        "id": "sg:person.01107405655.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107405655.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Hematology, National Hospital Organization Shibukawa Medical Center, Shibukawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Morio", 
        "id": "sg:person.010131465352.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010131465352.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ogaki Municipal Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416762.0", 
          "name": [
            "Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kosugi", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0716070516.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716070516.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Sung-Soo", 
        "id": "sg:person.01340117230.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340117230.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "National Taiwan University Hospital, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Shang-Yi", 
        "id": "sg:person.016600345354.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016600345354.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.497530.c", 
          "name": [
            "Janssen Research & Development, LLC, Spring House, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qin", 
        "givenName": "Xiang", 
        "id": "sg:person.0666422125.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666422125.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.497530.c", 
          "name": [
            "Janssen Research & Development, LLC, Spring House, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Ming", 
        "id": "sg:person.0620306725.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620306725.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iida", 
        "givenName": "Shinsuke", 
        "id": "sg:person.010211623302.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010211623302.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1506348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002559520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)01120-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009614699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1606038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010220122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-12-687749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019394202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1607751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026669052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-10-299487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029457945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033553106", 
          "https://doi.org/10.1038/sj.leu.2404284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033553106", 
          "https://doi.org/10.1038/sj.leu.2404284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cas.12826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040449203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.36.2236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041387125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30206-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042996950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imr.12389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047504372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1003032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051064690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/19420862.2015.1007813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058413271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1501351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079287282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bcj.2017.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084127674", 
          "https://doi.org/10.1038/bcj.2017.18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hon.2439_153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085909565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-017-2281-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086126618", 
          "https://doi.org/10.1007/s12185-017-2281-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-017-2281-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086126618", 
          "https://doi.org/10.1007/s12185-017-2281-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2017-05-785246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086132764"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04", 
    "datePublishedReg": "2018-04-01", 
    "description": "In the phase 3 POLLUX study, daratumumab plus lenalidomide and dexamethasone (DRd) significantly reduced the risk of progression/death and induced deeper responses vs. lenalidomide and dexamethasone alone (Rd) in patients with relapsed/refractory multiple myeloma (RRMM). We report a subgroup analysis of East Asian (Japanese, Korean, and Taiwanese) patients from POLLUX based on a longer follow-up of 24.7 months. Median progression-free survival was not reached (NR) for DRd vs. 13.8 months for Rd (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.23-0.76), and overall response rates were higher for DRd vs. Rd (90.2 vs. 72.1%). DRd extended the median duration of response vs. Rd (NR vs. 20.2 months), and minimal residual disease-negative rates at the 10-5 sensitivity threshold were 21.2 vs. 9.1% for DRd vs. Rd. No new safety signals were observed. Similar efficacy and safety were observed in the smaller subgroup of Japanese patients treated with DRd vs. Rd. These results demonstrate favorable efficacy and safety of DRd vs. Rd in East Asian patients and also in the Japanese-only patient subgroup that are consistent with findings in the overall patient population of POLLUX.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41408-018-0071-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045682", 
        "issn": [
          "2044-5385"
        ], 
        "name": "Blood Cancer Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Daratumumab, lenalidomide, and dexamethasone in East Asian patients with relapsed or refractory multiple myeloma: subgroup analyses of the phase 3 POLLUX study", 
    "pagination": "41", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "88ce922e94ba6031cd8d28e1832ae447ff0d3d60a12fea3f647099c5305cf03c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29712896"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101568469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41408-018-0071-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103640953"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41408-018-0071-x", 
      "https://app.dimensions.ai/details/publication/pub.1103640953"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72868_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41408-018-0071-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41408-018-0071-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41408-018-0071-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41408-018-0071-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41408-018-0071-x'


 

This table displays all metadata directly associated to this object as RDF triples.

294 TRIPLES      21 PREDICATES      63 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41408-018-0071-x schema:about N05bfd3586ba04bc8b07d2c023455b74f
2 N0b7c59968c8349a990f5a4df31242406
3 N10faaf4938f34ba0a2eb3a1ff82eb7d5
4 N1697c677bd284849be613b264ab2a3f8
5 N1d08ea2b6b954d88af4a9808cae359b1
6 N2046596bb15040bbbf4d2b7b6618050a
7 N335d6b1920b442bea0fcad007e134137
8 N36524eb4a99349c8a3dfc52d32d87bd8
9 N3c59549a53404a17b4bb75e35bd077f0
10 N45a621a1927e4245be2d68b2189ede28
11 Naa9a5de166d541cfaf3139fa745184c6
12 Nb8746ad3e31d4151a3d9c1afe2f29878
13 Nca081f5cb1784c5a897eabf4ed4132dd
14 Ncb9b1de21dc24154bf30807e37d97b58
15 Nd230f47243cb413ca45244f769220bb9
16 Nebcf3c0dfb5d447b8e92243d2090b895
17 anzsrc-for:11
18 anzsrc-for:1117
19 schema:author N9ee26bac64db4e61969f71e2e4c8d9b8
20 schema:citation sg:pub.10.1007/s12185-017-2281-6
21 sg:pub.10.1038/bcj.2017.18
22 sg:pub.10.1038/sj.leu.2404284
23 https://doi.org/10.1002/hon.2439_153
24 https://doi.org/10.1016/s0140-6736(15)01120-4
25 https://doi.org/10.1016/s1470-2045(16)30206-6
26 https://doi.org/10.1056/nejmoa1506348
27 https://doi.org/10.1056/nejmoa1606038
28 https://doi.org/10.1056/nejmoa1607751
29 https://doi.org/10.1080/19420862.2015.1007813
30 https://doi.org/10.1111/cas.12826
31 https://doi.org/10.1111/imr.12389
32 https://doi.org/10.1182/blood-2010-10-299487
33 https://doi.org/10.1182/blood-2015-12-687749
34 https://doi.org/10.1182/blood-2017-05-785246
35 https://doi.org/10.1200/jco.2011.36.2236
36 https://doi.org/10.4049/jimmunol.1003032
37 https://doi.org/10.4049/jimmunol.1501351
38 schema:datePublished 2018-04
39 schema:datePublishedReg 2018-04-01
40 schema:description In the phase 3 POLLUX study, daratumumab plus lenalidomide and dexamethasone (DRd) significantly reduced the risk of progression/death and induced deeper responses vs. lenalidomide and dexamethasone alone (Rd) in patients with relapsed/refractory multiple myeloma (RRMM). We report a subgroup analysis of East Asian (Japanese, Korean, and Taiwanese) patients from POLLUX based on a longer follow-up of 24.7 months. Median progression-free survival was not reached (NR) for DRd vs. 13.8 months for Rd (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.23-0.76), and overall response rates were higher for DRd vs. Rd (90.2 vs. 72.1%). DRd extended the median duration of response vs. Rd (NR vs. 20.2 months), and minimal residual disease-negative rates at the 10<sup>-5</sup> sensitivity threshold were 21.2 vs. 9.1% for DRd vs. Rd. No new safety signals were observed. Similar efficacy and safety were observed in the smaller subgroup of Japanese patients treated with DRd vs. Rd. These results demonstrate favorable efficacy and safety of DRd vs. Rd in East Asian patients and also in the Japanese-only patient subgroup that are consistent with findings in the overall patient population of POLLUX.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N3bd67293275244f3a2c848251b80e192
45 N50fc0926f6dd4470ac69e58a1cf39bf9
46 sg:journal.1045682
47 schema:name Daratumumab, lenalidomide, and dexamethasone in East Asian patients with relapsed or refractory multiple myeloma: subgroup analyses of the phase 3 POLLUX study
48 schema:pagination 41
49 schema:productId N2e2a3aee8d244d38a42d700d8c783549
50 N6f5371d107c242178195f98318501e7b
51 N8ef2181794fc49528c5079fa7e97f0fe
52 Nac8f79ef852e4b6c9c8666024a1636cf
53 Nbadc0c6852f74219973a2b4347d462c0
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103640953
55 https://doi.org/10.1038/s41408-018-0071-x
56 schema:sdDatePublished 2019-04-11T12:55
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher Nca61cd3de4d94455b4306a8c68b4c540
59 schema:url https://www.nature.com/articles/s41408-018-0071-x
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N05bfd3586ba04bc8b07d2c023455b74f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Middle Aged
65 rdf:type schema:DefinedTerm
66 N0b7c59968c8349a990f5a4df31242406 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Antineoplastic Combined Chemotherapy Protocols
68 rdf:type schema:DefinedTerm
69 N10faaf4938f34ba0a2eb3a1ff82eb7d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Aged, 80 and over
71 rdf:type schema:DefinedTerm
72 N1697c677bd284849be613b264ab2a3f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Drug Resistance, Neoplasm
74 rdf:type schema:DefinedTerm
75 N1d08ea2b6b954d88af4a9808cae359b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Female
77 rdf:type schema:DefinedTerm
78 N2046596bb15040bbbf4d2b7b6618050a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Aged
80 rdf:type schema:DefinedTerm
81 N20a9997e17f94cbeb67c156363704cac rdf:first sg:person.01340117230.25
82 rdf:rest N748f7733e49648f1b9c3b2cff6472830
83 N225654a5ca6f4abeab37358501b42fc6 rdf:first sg:person.010211623302.76
84 rdf:rest rdf:nil
85 N2e2a3aee8d244d38a42d700d8c783549 schema:name dimensions_id
86 schema:value pub.1103640953
87 rdf:type schema:PropertyValue
88 N2f3dc3e1ef2644cc91d6aee914e6d960 rdf:first sg:person.01107405655.54
89 rdf:rest N9e5ba1fd0f86478bb0c5a6860ff66c31
90 N302d45c0cd95498ea4bf9012ca854d18 rdf:first sg:person.0715264147.87
91 rdf:rest N2f3dc3e1ef2644cc91d6aee914e6d960
92 N335d6b1920b442bea0fcad007e134137 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N36524eb4a99349c8a3dfc52d32d87bd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Adult
97 rdf:type schema:DefinedTerm
98 N3bd67293275244f3a2c848251b80e192 schema:volumeNumber 8
99 rdf:type schema:PublicationVolume
100 N3c59549a53404a17b4bb75e35bd077f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Multiple Myeloma
102 rdf:type schema:DefinedTerm
103 N3d1de99d253440ec8be57f6866f79e53 schema:name Department of Hematology, National Hospital Organization Disaster Medical Center of Japan, Tachikawa, Japan
104 rdf:type schema:Organization
105 N45a621a1927e4245be2d68b2189ede28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Recurrence
107 rdf:type schema:DefinedTerm
108 N478e7f9411424d2c91da3ad3fe9f4480 rdf:first sg:person.0716070516.48
109 rdf:rest N20a9997e17f94cbeb67c156363704cac
110 N50fc0926f6dd4470ac69e58a1cf39bf9 schema:issueNumber 4
111 rdf:type schema:PublicationIssue
112 N6f5371d107c242178195f98318501e7b schema:name pubmed_id
113 schema:value 29712896
114 rdf:type schema:PropertyValue
115 N748f7733e49648f1b9c3b2cff6472830 rdf:first sg:person.016600345354.31
116 rdf:rest Nd475b13b52ce4376a8766c8dbf677d97
117 N8ef2181794fc49528c5079fa7e97f0fe schema:name doi
118 schema:value 10.1038/s41408-018-0071-x
119 rdf:type schema:PropertyValue
120 N9e5ba1fd0f86478bb0c5a6860ff66c31 rdf:first sg:person.010131465352.91
121 rdf:rest N478e7f9411424d2c91da3ad3fe9f4480
122 N9ee26bac64db4e61969f71e2e4c8d9b8 rdf:first sg:person.014724732234.38
123 rdf:rest Nf9f5918fc5ed4458a918bb207f097fc7
124 Na9916ecf9b454fa29141a8d1ddf3286c rdf:first sg:person.01255632675.62
125 rdf:rest N302d45c0cd95498ea4bf9012ca854d18
126 Naa9a5de166d541cfaf3139fa745184c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Retreatment
128 rdf:type schema:DefinedTerm
129 Nac8f79ef852e4b6c9c8666024a1636cf schema:name readcube_id
130 schema:value 88ce922e94ba6031cd8d28e1832ae447ff0d3d60a12fea3f647099c5305cf03c
131 rdf:type schema:PropertyValue
132 Nb28f0977d891494c885b59feef2d4180 schema:name Department of Hematology, National Hospital Organization Shibukawa Medical Center, Shibukawa, Japan
133 rdf:type schema:Organization
134 Nb3447d3e0bd7496aa56bc1fe9291b5f9 rdf:first sg:person.0620306725.09
135 rdf:rest N225654a5ca6f4abeab37358501b42fc6
136 Nb8746ad3e31d4151a3d9c1afe2f29878 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Dexamethasone
138 rdf:type schema:DefinedTerm
139 Nbadc0c6852f74219973a2b4347d462c0 schema:name nlm_unique_id
140 schema:value 101568469
141 rdf:type schema:PropertyValue
142 Nca081f5cb1784c5a897eabf4ed4132dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Treatment Outcome
144 rdf:type schema:DefinedTerm
145 Nca61cd3de4d94455b4306a8c68b4c540 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Ncb9b1de21dc24154bf30807e37d97b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Nd230f47243cb413ca45244f769220bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Antibodies, Monoclonal
152 rdf:type schema:DefinedTerm
153 Nd475b13b52ce4376a8766c8dbf677d97 rdf:first sg:person.0666422125.50
154 rdf:rest Nb3447d3e0bd7496aa56bc1fe9291b5f9
155 Nebcf3c0dfb5d447b8e92243d2090b895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Lenalidomide
157 rdf:type schema:DefinedTerm
158 Nf9f5918fc5ed4458a918bb207f097fc7 rdf:first sg:person.01046642035.29
159 rdf:rest Na9916ecf9b454fa29141a8d1ddf3286c
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
164 schema:name Public Health and Health Services
165 rdf:type schema:DefinedTerm
166 sg:journal.1045682 schema:issn 2044-5385
167 schema:name Blood Cancer Journal
168 rdf:type schema:Periodical
169 sg:person.010131465352.91 schema:affiliation Nb28f0977d891494c885b59feef2d4180
170 schema:familyName Matsumoto
171 schema:givenName Morio
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010131465352.91
173 rdf:type schema:Person
174 sg:person.010211623302.76 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
175 schema:familyName Iida
176 schema:givenName Shinsuke
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010211623302.76
178 rdf:type schema:Person
179 sg:person.01046642035.29 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
180 schema:familyName Dimopoulos
181 schema:givenName Meletios A.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046642035.29
183 rdf:type schema:Person
184 sg:person.01107405655.54 schema:affiliation https://www.grid.ac/institutes/grid.414178.f
185 schema:familyName Shinagawa
186 schema:givenName Atsushi
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107405655.54
188 rdf:type schema:Person
189 sg:person.01255632675.62 schema:affiliation N3d1de99d253440ec8be57f6866f79e53
190 schema:familyName Takezako
191 schema:givenName Naoki
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255632675.62
193 rdf:type schema:Person
194 sg:person.01340117230.25 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
195 schema:familyName Yoon
196 schema:givenName Sung-Soo
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340117230.25
198 rdf:type schema:Person
199 sg:person.014724732234.38 schema:affiliation https://www.grid.ac/institutes/grid.414929.3
200 schema:familyName Suzuki
201 schema:givenName Kenshi
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014724732234.38
203 rdf:type schema:Person
204 sg:person.016600345354.31 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
205 schema:familyName Huang
206 schema:givenName Shang-Yi
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016600345354.31
208 rdf:type schema:Person
209 sg:person.0620306725.09 schema:affiliation https://www.grid.ac/institutes/grid.497530.c
210 schema:familyName Qi
211 schema:givenName Ming
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620306725.09
213 rdf:type schema:Person
214 sg:person.0666422125.50 schema:affiliation https://www.grid.ac/institutes/grid.497530.c
215 schema:familyName Qin
216 schema:givenName Xiang
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666422125.50
218 rdf:type schema:Person
219 sg:person.0715264147.87 schema:affiliation https://www.grid.ac/institutes/grid.412096.8
220 schema:familyName Okamoto
221 schema:givenName Shinichiro
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87
223 rdf:type schema:Person
224 sg:person.0716070516.48 schema:affiliation https://www.grid.ac/institutes/grid.416762.0
225 schema:familyName Kosugi
226 schema:givenName Hiroshi
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716070516.48
228 rdf:type schema:Person
229 sg:pub.10.1007/s12185-017-2281-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086126618
230 https://doi.org/10.1007/s12185-017-2281-6
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/bcj.2017.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127674
233 https://doi.org/10.1038/bcj.2017.18
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.leu.2404284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033553106
236 https://doi.org/10.1038/sj.leu.2404284
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/hon.2439_153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085909565
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0140-6736(15)01120-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009614699
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s1470-2045(16)30206-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042996950
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejmoa1506348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002559520
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa1606038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010220122
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa1607751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026669052
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1080/19420862.2015.1007813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058413271
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/cas.12826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040449203
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/imr.12389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047504372
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1182/blood-2010-10-299487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029457945
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1182/blood-2015-12-687749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019394202
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1182/blood-2017-05-785246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086132764
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1200/jco.2011.36.2236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041387125
263 rdf:type schema:CreativeWork
264 https://doi.org/10.4049/jimmunol.1003032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051064690
265 rdf:type schema:CreativeWork
266 https://doi.org/10.4049/jimmunol.1501351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079287282
267 rdf:type schema:CreativeWork
268 https://www.grid.ac/institutes/grid.260433.0 schema:alternateName Nagoya City University
269 schema:name Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
272 schema:name National Taiwan University Hospital, Taipei, Taiwan
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.412096.8 schema:alternateName Keio University Hospital
275 schema:name Keio University Hospital, Tokyo, Japan
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
278 schema:name Seoul National University Hospital, Seoul, Korea
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.414178.f schema:alternateName Hitachi General Hospital
281 schema:name Hitachi General Hospital, Hitachi, Japan
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.414929.3 schema:alternateName Japanese Red Cross Medical Center
284 schema:name Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.416762.0 schema:alternateName Ogaki Municipal Hospital
287 schema:name Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.497530.c schema:alternateName Janssen (United States)
290 schema:name Janssen Research & Development, LLC, Spring House, PA, USA
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
293 schema:name National and Kapodistrian University of Athens, Athens, Greece
294 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...