Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Mary Mufford, Josh Cheung, Neda Jahanshad, Celia van der Merwe, Linda Ding, Nynke Groenewold, Nastassja Koen, Emile R. Chimusa, Shareefa Dalvie, Raj Ramesar, , James A. Knowles, Christine Lochner, Derrek P. Hibar, Peristera Paschou, Odile A. van den Heuvel, Sarah E. Medland, Jeremiah M. Scharf, Carol A. Mathews, Paul M. Thompson, Dan J. Stein

ABSTRACT

There have been considerable recent advances in understanding the genetic architecture of Tourette syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS-and its main symptom dimensions-influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated in TS. We obtained summary statistics for the most recent TS genome-wide association study (GWAS) from the TS Psychiatric Genomics Consortium Working Group (4644 cases and 8695 controls) and GWAS of subcortical volumes from the ENIGMA consortium (30,717 individuals). We also undertook analyses using GWAS summary statistics of key symptom factors in TS, namely social disinhibition and symmetry behaviour. SNP effect concordance analysis (SECA) was used to examine genetic pleiotropy-the same SNP affecting two traits-and concordance-the agreement in single nucelotide polymorphism (SNP) effect directions across these two traits. In addition, a conditional false discovery rate (FDR) analysis was performed, conditioning the TS risk variants on each of the seven subcortical and the intracranial brain volume GWAS. Linkage disequilibrium score regression (LDSR) was used as validation of the SECA method. SECA revealed significant pleiotropy between TS and putamen (p = 2 × 10-4) and caudate (p = 4 × 10-4) volumes, independent of direction of effect, and significant concordance between TS and lower thalamic volume (p = 1 × 10-3). LDSR lent additional support for the association between TS and thalamus volume (p = 5.85 × 10-2). Furthermore, SECA revealed significant evidence of concordance between the social disinhibition symptom dimension and lower thalamus volume (p = 1 × 10-3), as well as concordance between symmetry behaviour and greater putamen volume (p = 7 × 10-4). Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10-7) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively. These data indicate concordance for genetic variation involved in disorder risk and subcortical brain volumes in TS. Further work with larger samples is needed to fully delineate the genetic architecture of these disorders and their underlying neurocircuitry. More... »

PAGES

120

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41398-019-0452-3

DOI

http://dx.doi.org/10.1038/s41398-019-0452-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112949219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30902966


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mufford", 
        "givenName": "Mary", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "Josh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jahanshad", 
        "givenName": "Neda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Merwe", 
        "givenName": "Celia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Linda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groenewold", 
        "givenName": "Nynke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Groote Schuur Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413335.3", 
          "name": [
            "Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa", 
            "Groote Schuur Hospital, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koen", 
        "givenName": "Nastassja", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chimusa", 
        "givenName": "Emile R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Groote Schuur Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413335.3", 
          "name": [
            "Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa", 
            "Groote Schuur Hospital, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalvie", 
        "givenName": "Shareefa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cape Town", 
          "id": "https://www.grid.ac/institutes/grid.7836.a", 
          "name": [
            "Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramesar", 
        "givenName": "Raj", 
        "type": "Person"
      }, 
      {}, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Department of Psychiatry and the Behavioural Sciences, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knowles", 
        "givenName": "James A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stellenbosch University", 
          "id": "https://www.grid.ac/institutes/grid.11956.3a", 
          "name": [
            "Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lochner", 
        "givenName": "Christine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibar", 
        "givenName": "Derrek P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Purdue University", 
          "id": "https://www.grid.ac/institutes/grid.169077.e", 
          "name": [
            "Department of Biological Sciences, Purdue University, West Lafayette, IN USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paschou", 
        "givenName": "Peristera", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amsterdam Neuroscience", 
          "id": "https://www.grid.ac/institutes/grid.484519.5", 
          "name": [
            "Department of Psychiatry, Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Heuvel", 
        "givenName": "Odile A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "QIMR Berghofer Medical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.1049.c", 
          "name": [
            "QIMR Berghofer Medical Research Institute, Brisbane, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Medland", 
        "givenName": "Sarah E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Boston, MA USA", 
            "Department of Psychiatry, Massachusetts General Hospital, Boston, MA USA", 
            "Department of Neurology, Massachusetts General Hospital, Boston, MA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scharf", 
        "givenName": "Jeremiah M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathews", 
        "givenName": "Carol A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Paul M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Groote Schuur Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413335.3", 
          "name": [
            "Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa", 
            "Groote Schuur Hospital, Cape Town, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stein", 
        "givenName": "Dan J.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000434226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001779993", 
          "https://doi.org/10.1038/nature14101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001779993", 
          "https://doi.org/10.1038/nature14101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpedi.160.1.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002197383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003060895", 
          "https://doi.org/10.1038/nn.4228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003060895", 
          "https://doi.org/10.1038/nn.4228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2016.164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004025535", 
          "https://doi.org/10.1038/mp.2016.164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2013.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004236657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181b2163c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005108247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181b2163c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005108247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181b2163c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005108247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2004.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005225106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2015.10.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005388210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.105.008813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005980881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2010.225029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009297588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2010.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009497006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10615-013-0445-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010720084", 
          "https://doi.org/10.1007/s10615-013-0445-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011521286", 
          "https://doi.org/10.1038/nrg2760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011521286", 
          "https://doi.org/10.1038/nrg2760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.107.039909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011832006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tics.2004.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012008594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013672904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3401-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015213654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2016.194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015246396", 
          "https://doi.org/10.1038/mp.2016.194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2016.194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015246396", 
          "https://doi.org/10.1038/mp.2016.194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.58.5.427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015875509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016337581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016405801", 
          "https://doi.org/10.1038/ng.3406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnr.0b013e328302c873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019337120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnr.0b013e328302c873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019337120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ypg.0000000000000084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020572531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ypg.0000000000000084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020572531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ypg.0000000000000084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020572531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022282347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7610.2006.01639.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022577156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awn267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024786743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1092852912000703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025332128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaac.2010.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026048920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.24215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026342115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026593218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000180957.98702.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028647384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000180957.98702.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028647384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.23199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033756951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.23199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033756951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2215-0366(14)00132-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034347997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1369-703x(00)00062-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037607453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038392860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2010.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039321165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.60.4.415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039732545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2010.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040229077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-003-1102-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041304440", 
          "https://doi.org/10.1007/s00415-003-1102-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2012.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043010958", 
          "https://doi.org/10.1038/mp.2012.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(01)00428-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044014838", 
          "https://doi.org/10.1016/s0893-133x(01)00428-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044231071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044444076", 
          "https://doi.org/10.1038/ng.3211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7610.2010.02324.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044888283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamapsychiatry.2015.0627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047583379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.64.11.1281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051540943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0150-11.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052918273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropsychologia.2006.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053212722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.161.11.2028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063495630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2014.13101306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063500245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2016.16020240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063500885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd809b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd809b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd809b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078148400", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083087711", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2016.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083404612", 
          "https://doi.org/10.1038/nrdp.2016.97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2215-0366(17)30049-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083851513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2215-0366(17)30049-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083851513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2215-0366(17)30049-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083851513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.books.9780890425596.744053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088628321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-017-0496-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093026639", 
          "https://doi.org/10.1186/s13073-017-0496-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-017-0496-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093026639", 
          "https://doi.org/10.1186/s13073-017-0496-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2985301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101981261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2985301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101981261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2018.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103902029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.2018.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105155779"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "There have been considerable recent advances in understanding the genetic architecture of Tourette syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS-and its main symptom dimensions-influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated in TS. We obtained summary statistics for the most recent TS genome-wide association study (GWAS) from the TS Psychiatric Genomics Consortium Working Group (4644 cases and 8695 controls) and GWAS of subcortical volumes from the ENIGMA consortium (30,717 individuals). We also undertook analyses using GWAS summary statistics of key symptom factors in TS, namely social disinhibition and symmetry behaviour. SNP effect concordance analysis (SECA) was used to examine genetic pleiotropy-the same SNP affecting two traits-and concordance-the agreement in single nucelotide polymorphism (SNP) effect directions across these two traits. In addition, a conditional false discovery rate (FDR) analysis was performed, conditioning the TS risk variants on each of the seven subcortical and the intracranial brain volume GWAS. Linkage disequilibrium score regression (LDSR) was used as validation of the SECA method. SECA revealed significant pleiotropy between TS and putamen (p\u2009=\u20092\u2009\u00d7\u200910-4) and caudate (p\u2009=\u20094\u2009\u00d7\u200910-4) volumes, independent of direction of effect, and significant concordance between TS and lower thalamic volume (p\u2009=\u20091\u2009\u00d7\u200910-3). LDSR lent additional support for the association between TS and thalamus volume (p\u2009=\u20095.85\u2009\u00d7\u200910-2). Furthermore, SECA revealed significant evidence of concordance between the social disinhibition symptom dimension and lower thalamus volume (p\u2009=\u20091\u2009\u00d7\u200910-3), as well as concordance between symmetry behaviour and greater putamen volume (p\u2009=\u20097\u2009\u00d7\u200910-4). Conditional FDR analysis further revealed novel variants significantly associated with TS (p\u2009<\u20098\u2009\u00d7\u200910-7) when conditioning on intracranial (rs2708146, q\u2009=\u20090.046; and rs72853320, q\u2009=\u20090.035) and hippocampal (rs1922786, q\u2009=\u20090.001) volumes, respectively. These data indicate concordance for genetic variation involved in disorder risk and subcortical brain volumes in TS. Further work with larger samples is needed to fully delineate the genetic architecture of these disorders and their underlying neurocircuitry.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41398-019-0452-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045271", 
        "issn": [
          "2158-3188"
        ], 
        "name": "Translational Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry", 
    "pagination": "120", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6e419880628337cf8fe3b3b4dc8a0402c36b06d872892187c8de5f78a83c4b2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30902966"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101562664"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41398-019-0452-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112949219"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41398-019-0452-3", 
      "https://app.dimensions.ai/details/publication/pub.1112949219"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130801_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41398-019-0452-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0452-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0452-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0452-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0452-3'


 

This table displays all metadata directly associated to this object as RDF triples.

415 TRIPLES      21 PREDICATES      93 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41398-019-0452-3 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N64325d3819524a92a3f47230441ec549
4 schema:citation sg:pub.10.1007/s00415-003-1102-4
5 sg:pub.10.1007/s10615-013-0445-2
6 sg:pub.10.1016/s0893-133x(01)00428-6
7 sg:pub.10.1038/mp.2012.69
8 sg:pub.10.1038/mp.2016.164
9 sg:pub.10.1038/mp.2016.194
10 sg:pub.10.1038/nature14101
11 sg:pub.10.1038/ng.3211
12 sg:pub.10.1038/ng.3406
13 sg:pub.10.1038/nn.4228
14 sg:pub.10.1038/nrdp.2016.97
15 sg:pub.10.1038/nrg2760
16 sg:pub.10.1186/s13073-017-0496-z
17 https://app.dimensions.ai/details/publication/pub.1078148400
18 https://app.dimensions.ai/details/publication/pub.1083087711
19 https://doi.org/10.1001/archgenpsychiatry.2010.102
20 https://doi.org/10.1001/archgenpsychiatry.2010.70
21 https://doi.org/10.1001/archpedi.160.1.65
22 https://doi.org/10.1001/archpsyc.58.5.427
23 https://doi.org/10.1001/archpsyc.60.4.415
24 https://doi.org/10.1001/archpsyc.64.11.1281
25 https://doi.org/10.1001/jamapsychiatry.2015.0627
26 https://doi.org/10.1002/ana.24215
27 https://doi.org/10.1002/mds.21599
28 https://doi.org/10.1002/mds.22264
29 https://doi.org/10.1002/mds.23199
30 https://doi.org/10.1016/j.ajhg.2010.11.011
31 https://doi.org/10.1016/j.ajhg.2013.01.001
32 https://doi.org/10.1016/j.ajhg.2018.03.021
33 https://doi.org/10.1016/j.biopsych.2008.01.019
34 https://doi.org/10.1016/j.cell.2016.10.042
35 https://doi.org/10.1016/j.jaac.2010.08.016
36 https://doi.org/10.1016/j.jad.2015.10.061
37 https://doi.org/10.1016/j.neuroimage.2004.12.005
38 https://doi.org/10.1016/j.neuropsychologia.2006.03.018
39 https://doi.org/10.1016/j.tics.2004.03.004
40 https://doi.org/10.1016/s1369-703x(00)00062-0
41 https://doi.org/10.1016/s2215-0366(14)00132-1
42 https://doi.org/10.1016/s2215-0366(17)30049-4
43 https://doi.org/10.1017/s1092852912000703
44 https://doi.org/10.1086/519795
45 https://doi.org/10.1093/bioinformatics/btu171
46 https://doi.org/10.1093/brain/awn267
47 https://doi.org/10.1097/chi.0b013e3181b2163c
48 https://doi.org/10.1097/wnr.0b013e328302c873
49 https://doi.org/10.1097/ypg.0000000000000084
50 https://doi.org/10.1111/j.1469-7610.2006.01639.x
51 https://doi.org/10.1111/j.1469-7610.2010.02324.x
52 https://doi.org/10.1136/jnnp.2010.225029
53 https://doi.org/10.1176/appi.ajp.161.11.2028
54 https://doi.org/10.1176/appi.ajp.2014.13101306
55 https://doi.org/10.1176/appi.ajp.2016.16020240
56 https://doi.org/10.1176/appi.books.9780890425596.744053
57 https://doi.org/10.1192/bjp.2018.62
58 https://doi.org/10.1192/bjp.bp.105.008813
59 https://doi.org/10.1192/bjp.bp.107.039909
60 https://doi.org/10.1212/01.wnl.0000180957.98702.69
61 https://doi.org/10.1212/wnl.0000000000002910
62 https://doi.org/10.1212/wnl.0b013e3181bd809b
63 https://doi.org/10.1371/journal.pgen.1003455
64 https://doi.org/10.1371/journal.pgen.1003864
65 https://doi.org/10.1523/jneurosci.0150-11.2011
66 https://doi.org/10.1523/jneurosci.3401-04.2005
67 https://doi.org/10.2307/2985301
68 schema:datePublished 2019-12
69 schema:datePublishedReg 2019-12-01
70 schema:description There have been considerable recent advances in understanding the genetic architecture of Tourette syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS-and its main symptom dimensions-influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated in TS. We obtained summary statistics for the most recent TS genome-wide association study (GWAS) from the TS Psychiatric Genomics Consortium Working Group (4644 cases and 8695 controls) and GWAS of subcortical volumes from the ENIGMA consortium (30,717 individuals). We also undertook analyses using GWAS summary statistics of key symptom factors in TS, namely social disinhibition and symmetry behaviour. SNP effect concordance analysis (SECA) was used to examine genetic pleiotropy-the same SNP affecting two traits-and concordance-the agreement in single nucelotide polymorphism (SNP) effect directions across these two traits. In addition, a conditional false discovery rate (FDR) analysis was performed, conditioning the TS risk variants on each of the seven subcortical and the intracranial brain volume GWAS. Linkage disequilibrium score regression (LDSR) was used as validation of the SECA method. SECA revealed significant pleiotropy between TS and putamen (p = 2 × 10<sup>-4</sup>) and caudate (p = 4 × 10<sup>-4</sup>) volumes, independent of direction of effect, and significant concordance between TS and lower thalamic volume (p = 1 × 10<sup>-3</sup>). LDSR lent additional support for the association between TS and thalamus volume (p = 5.85 × 10<sup>-2</sup>). Furthermore, SECA revealed significant evidence of concordance between the social disinhibition symptom dimension and lower thalamus volume (p = 1 × 10<sup>-3</sup>), as well as concordance between symmetry behaviour and greater putamen volume (p = 7 × 10<sup>-4</sup>). Conditional FDR analysis further revealed novel variants significantly associated with TS (p &lt; 8 × 10<sup>-7</sup>) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively. These data indicate concordance for genetic variation involved in disorder risk and subcortical brain volumes in TS. Further work with larger samples is needed to fully delineate the genetic architecture of these disorders and their underlying neurocircuitry.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N597204fcc99f4dba9c5824815c20edbc
75 Nc818283ff52547089e2d21b72cef40cb
76 sg:journal.1045271
77 schema:name Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry
78 schema:pagination 120
79 schema:productId N339fe7a4ec804759982ae6e5d52cc8e0
80 N359cb4aae3e64bf1aaa6987116c0b605
81 Nc5cbdbcbb38c4a6eaded9da9d7fa2867
82 Nd696eaf8b89447679567aab007d5f039
83 Ne57ead3c4dbb42e38acbb0d0e99bc06e
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112949219
85 https://doi.org/10.1038/s41398-019-0452-3
86 schema:sdDatePublished 2019-04-11T13:52
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N8869f445f57544038c375ed78b379cd1
89 schema:url https://www.nature.com/articles/s41398-019-0452-3
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0c559479431c4b49af77d48d3961b734 rdf:first Ne76962d7d63345b1b888a3343f164044
94 rdf:rest N8a258566264041158558cabc564e5a87
95 N16471c8c4eb148748b8a7764d7e7da32 schema:affiliation https://www.grid.ac/institutes/grid.7836.a
96 schema:familyName van der Merwe
97 schema:givenName Celia
98 rdf:type schema:Person
99 N1a20ae2eec71424a8b50c77daeb1a84f schema:affiliation https://www.grid.ac/institutes/grid.42505.36
100 schema:familyName Thompson
101 schema:givenName Paul M.
102 rdf:type schema:Person
103 N1c45c56d01804ee5a54a0c4e2209c4cc rdf:first N24f03ff6647044fab3c678c5d5d3992e
104 rdf:rest rdf:nil
105 N1fe65865e3c84f439b3956ed8a4df67c rdf:first N437de1cb298940d299455046a098a3da
106 rdf:rest N4b29b97d067b4e7c81a382af10014ce6
107 N21e26196cb78454eb41af7732c3d2a7f rdf:first Nbb62f638ad2b4c9cb903ad2b580f225d
108 rdf:rest Neea8fe96d738474bbc2d166dbb9192d7
109 N24f03ff6647044fab3c678c5d5d3992e schema:affiliation https://www.grid.ac/institutes/grid.413335.3
110 schema:familyName Stein
111 schema:givenName Dan J.
112 rdf:type schema:Person
113 N29aa5f5eb45e4a129711cd20652e9dde rdf:first N79c7dbf8e57b479ab1c426e6a8dc1b75
114 rdf:rest N47dbffbcbaca422ba0a630f770af2ab2
115 N320c3a9714d94cbdbeef01210a7e10b9 rdf:first Nf2991561044f4df0b54daf7cb877f37d
116 rdf:rest Nef60aae69a1445fea98044ab5c697396
117 N339fe7a4ec804759982ae6e5d52cc8e0 schema:name doi
118 schema:value 10.1038/s41398-019-0452-3
119 rdf:type schema:PropertyValue
120 N359cb4aae3e64bf1aaa6987116c0b605 schema:name dimensions_id
121 schema:value pub.1112949219
122 rdf:type schema:PropertyValue
123 N437de1cb298940d299455046a098a3da schema:affiliation https://www.grid.ac/institutes/grid.413335.3
124 schema:familyName Dalvie
125 schema:givenName Shareefa
126 rdf:type schema:Person
127 N47dbffbcbaca422ba0a630f770af2ab2 rdf:first N65d3a8a4fa6b4fcca5fe16066845bdab
128 rdf:rest N320c3a9714d94cbdbeef01210a7e10b9
129 N4b29b97d067b4e7c81a382af10014ce6 rdf:first N97c396201cb24c9aa57d1b76f3f69d05
130 rdf:rest N29aa5f5eb45e4a129711cd20652e9dde
131 N4f026ef4254d46248e3057c40991ebf8 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
132 schema:familyName Cheung
133 schema:givenName Josh
134 rdf:type schema:Person
135 N526209761d994ec6a1d8b3775b974334 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
136 schema:familyName Scharf
137 schema:givenName Jeremiah M.
138 rdf:type schema:Person
139 N597204fcc99f4dba9c5824815c20edbc schema:volumeNumber 9
140 rdf:type schema:PublicationVolume
141 N59b59329f8404e739ac49ec76474d069 rdf:first Nf609c4bb4f9542e78d8a41bd98996910
142 rdf:rest Na6de66222b9b40bba5d43563f120b80c
143 N61942c0d970e44e0a68cf5d8651f672b schema:affiliation https://www.grid.ac/institutes/grid.7836.a
144 schema:familyName Groenewold
145 schema:givenName Nynke
146 rdf:type schema:Person
147 N64325d3819524a92a3f47230441ec549 rdf:first Nd0643d97c805461b97bbb8b62fcaebae
148 rdf:rest Na0bd94653ecc44c981928c7159db18c0
149 N65d3a8a4fa6b4fcca5fe16066845bdab schema:affiliation https://www.grid.ac/institutes/grid.42505.36
150 schema:familyName Knowles
151 schema:givenName James A.
152 rdf:type schema:Person
153 N664579c46eb540a38a737270a08567e9 rdf:first Nf92f1271933e4e42a9a5d729e8056a75
154 rdf:rest N73cb0937a45942189da18396d094b1bb
155 N73cb0937a45942189da18396d094b1bb rdf:first N16471c8c4eb148748b8a7764d7e7da32
156 rdf:rest N21e26196cb78454eb41af7732c3d2a7f
157 N8263a29f25894148984311d23c996bcf schema:affiliation https://www.grid.ac/institutes/grid.484519.5
158 schema:familyName van den Heuvel
159 schema:givenName Odile A.
160 rdf:type schema:Person
161 N8869f445f57544038c375ed78b379cd1 schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 N8a258566264041158558cabc564e5a87 rdf:first N1a20ae2eec71424a8b50c77daeb1a84f
164 rdf:rest N1c45c56d01804ee5a54a0c4e2209c4cc
165 N92fcba5f15bf40e7a62478df11c95fca schema:affiliation https://www.grid.ac/institutes/grid.42505.36
166 schema:familyName Hibar
167 schema:givenName Derrek P.
168 rdf:type schema:Person
169 N9692e3212cc3466c9960a35440993d22 schema:affiliation https://www.grid.ac/institutes/grid.169077.e
170 schema:familyName Paschou
171 schema:givenName Peristera
172 rdf:type schema:Person
173 N97c396201cb24c9aa57d1b76f3f69d05 schema:affiliation https://www.grid.ac/institutes/grid.7836.a
174 schema:familyName Ramesar
175 schema:givenName Raj
176 rdf:type schema:Person
177 Na0bd94653ecc44c981928c7159db18c0 rdf:first N4f026ef4254d46248e3057c40991ebf8
178 rdf:rest N664579c46eb540a38a737270a08567e9
179 Na6de66222b9b40bba5d43563f120b80c rdf:first Ncb67cdc5b1de46209e29c237fcd65c8b
180 rdf:rest N1fe65865e3c84f439b3956ed8a4df67c
181 Na6e45c04f2974ced9d1b1b7a36de09a1 rdf:first N526209761d994ec6a1d8b3775b974334
182 rdf:rest N0c559479431c4b49af77d48d3961b734
183 Naefc74552e514c5caa33f64dab499f24 rdf:first Nf37a459b50014e46a3fd1db828ce0f80
184 rdf:rest Na6e45c04f2974ced9d1b1b7a36de09a1
185 Nbb62f638ad2b4c9cb903ad2b580f225d schema:affiliation https://www.grid.ac/institutes/grid.42505.36
186 schema:familyName Ding
187 schema:givenName Linda
188 rdf:type schema:Person
189 Nc5cbdbcbb38c4a6eaded9da9d7fa2867 schema:name readcube_id
190 schema:value e6e419880628337cf8fe3b3b4dc8a0402c36b06d872892187c8de5f78a83c4b2
191 rdf:type schema:PropertyValue
192 Nc818283ff52547089e2d21b72cef40cb schema:issueNumber 1
193 rdf:type schema:PublicationIssue
194 Ncb67cdc5b1de46209e29c237fcd65c8b schema:affiliation https://www.grid.ac/institutes/grid.7836.a
195 schema:familyName Chimusa
196 schema:givenName Emile R.
197 rdf:type schema:Person
198 Ncea7a743a81443efa424e01a67fc5ff3 rdf:first N9692e3212cc3466c9960a35440993d22
199 rdf:rest Nde04688fba3145c7b05bb00f3ef76202
200 Nd0643d97c805461b97bbb8b62fcaebae schema:affiliation https://www.grid.ac/institutes/grid.7836.a
201 schema:familyName Mufford
202 schema:givenName Mary
203 rdf:type schema:Person
204 Nd696eaf8b89447679567aab007d5f039 schema:name pubmed_id
205 schema:value 30902966
206 rdf:type schema:PropertyValue
207 Nde04688fba3145c7b05bb00f3ef76202 rdf:first N8263a29f25894148984311d23c996bcf
208 rdf:rest Naefc74552e514c5caa33f64dab499f24
209 Ne57ead3c4dbb42e38acbb0d0e99bc06e schema:name nlm_unique_id
210 schema:value 101562664
211 rdf:type schema:PropertyValue
212 Ne76962d7d63345b1b888a3343f164044 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
213 schema:familyName Mathews
214 schema:givenName Carol A.
215 rdf:type schema:Person
216 Neea8fe96d738474bbc2d166dbb9192d7 rdf:first N61942c0d970e44e0a68cf5d8651f672b
217 rdf:rest N59b59329f8404e739ac49ec76474d069
218 Nef60aae69a1445fea98044ab5c697396 rdf:first N92fcba5f15bf40e7a62478df11c95fca
219 rdf:rest Ncea7a743a81443efa424e01a67fc5ff3
220 Nf2991561044f4df0b54daf7cb877f37d schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
221 schema:familyName Lochner
222 schema:givenName Christine
223 rdf:type schema:Person
224 Nf37a459b50014e46a3fd1db828ce0f80 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
225 schema:familyName Medland
226 schema:givenName Sarah E.
227 rdf:type schema:Person
228 Nf609c4bb4f9542e78d8a41bd98996910 schema:affiliation https://www.grid.ac/institutes/grid.413335.3
229 schema:familyName Koen
230 schema:givenName Nastassja
231 rdf:type schema:Person
232 Nf92f1271933e4e42a9a5d729e8056a75 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
233 schema:familyName Jahanshad
234 schema:givenName Neda
235 rdf:type schema:Person
236 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
237 schema:name Biological Sciences
238 rdf:type schema:DefinedTerm
239 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
240 schema:name Genetics
241 rdf:type schema:DefinedTerm
242 sg:journal.1045271 schema:issn 2158-3188
243 schema:name Translational Psychiatry
244 rdf:type schema:Periodical
245 sg:pub.10.1007/s00415-003-1102-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041304440
246 https://doi.org/10.1007/s00415-003-1102-4
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s10615-013-0445-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010720084
249 https://doi.org/10.1007/s10615-013-0445-2
250 rdf:type schema:CreativeWork
251 sg:pub.10.1016/s0893-133x(01)00428-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044014838
252 https://doi.org/10.1016/s0893-133x(01)00428-6
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/mp.2012.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043010958
255 https://doi.org/10.1038/mp.2012.69
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/mp.2016.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004025535
258 https://doi.org/10.1038/mp.2016.164
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/mp.2016.194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015246396
261 https://doi.org/10.1038/mp.2016.194
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nature14101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001779993
264 https://doi.org/10.1038/nature14101
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/ng.3211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044444076
267 https://doi.org/10.1038/ng.3211
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/ng.3406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016405801
270 https://doi.org/10.1038/ng.3406
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nn.4228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003060895
273 https://doi.org/10.1038/nn.4228
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrdp.2016.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083404612
276 https://doi.org/10.1038/nrdp.2016.97
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nrg2760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011521286
279 https://doi.org/10.1038/nrg2760
280 rdf:type schema:CreativeWork
281 sg:pub.10.1186/s13073-017-0496-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093026639
282 https://doi.org/10.1186/s13073-017-0496-z
283 rdf:type schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1078148400 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1083087711 schema:CreativeWork
286 https://doi.org/10.1001/archgenpsychiatry.2010.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040229077
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1001/archgenpsychiatry.2010.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039321165
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1001/archpedi.160.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002197383
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1001/archpsyc.58.5.427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015875509
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1001/archpsyc.60.4.415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039732545
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1001/archpsyc.64.11.1281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051540943
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1001/jamapsychiatry.2015.0627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047583379
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1002/ana.24215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026342115
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1002/mds.21599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013672904
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/mds.22264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038392860
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/mds.23199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033756951
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ajhg.2010.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497006
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ajhg.2013.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004236657
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.ajhg.2018.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103902029
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.biopsych.2008.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000434226
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.cell.2016.10.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016337581
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.jaac.2010.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026048920
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.jad.2015.10.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005388210
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.neuroimage.2004.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005225106
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.neuropsychologia.2006.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053212722
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.tics.2004.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012008594
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s1369-703x(00)00062-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037607453
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/s2215-0366(14)00132-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034347997
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/s2215-0366(17)30049-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083851513
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1017/s1092852912000703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025332128
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/bioinformatics/btu171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044231071
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/brain/awn267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024786743
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1097/chi.0b013e3181b2163c schema:sameAs https://app.dimensions.ai/details/publication/pub.1005108247
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1097/wnr.0b013e328302c873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019337120
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/ypg.0000000000000084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020572531
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1469-7610.2006.01639.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022577156
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1469-7610.2010.02324.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044888283
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1136/jnnp.2010.225029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009297588
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1176/appi.ajp.161.11.2028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063495630
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1176/appi.ajp.2014.13101306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063500245
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1176/appi.ajp.2016.16020240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063500885
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1176/appi.books.9780890425596.744053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088628321
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1192/bjp.2018.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105155779
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1192/bjp.bp.105.008813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005980881
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1192/bjp.bp.107.039909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011832006
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1212/01.wnl.0000180957.98702.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028647384
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1212/wnl.0000000000002910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353686
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1212/wnl.0b013e3181bd809b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354739
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1371/journal.pgen.1003455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026593218
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1371/journal.pgen.1003864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022282347
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1523/jneurosci.0150-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052918273
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1523/jneurosci.3401-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015213654
381 rdf:type schema:CreativeWork
382 https://doi.org/10.2307/2985301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101981261
383 rdf:type schema:CreativeWork
384 https://www.grid.ac/institutes/grid.1049.c schema:alternateName QIMR Berghofer Medical Research Institute
385 schema:name QIMR Berghofer Medical Research Institute, Brisbane, Australia
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.11956.3a schema:alternateName Stellenbosch University
388 schema:name Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
391 schema:name Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL USA
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.169077.e schema:alternateName Purdue University
394 schema:name Department of Biological Sciences, Purdue University, West Lafayette, IN USA
395 rdf:type schema:Organization
396 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
397 schema:name Department of Neurology, Massachusetts General Hospital, Boston, MA USA
398 Department of Psychiatry, Massachusetts General Hospital, Boston, MA USA
399 Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Boston, MA USA
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.413335.3 schema:alternateName Groote Schuur Hospital
402 schema:name Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa
403 Groote Schuur Hospital, Cape Town, South Africa
404 rdf:type schema:Organization
405 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
406 schema:name Department of Psychiatry and the Behavioural Sciences, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA USA
407 Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.484519.5 schema:alternateName Amsterdam Neuroscience
410 schema:name Department of Psychiatry, Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, Netherlands
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.7836.a schema:alternateName University of Cape Town
413 schema:name Department of Psychiatry and MRC Unit on Risk & Resilience, University of Cape Town, Cape Town, South Africa
414 Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
415 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...