Three-dimensional alteration of neurites in schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ryuta Mizutani, Rino Saiga, Akihisa Takeuchi, Kentaro Uesugi, Yasuko Terada, Yoshio Suzuki, Vincent De Andrade, Francesco De Carlo, Susumu Takekoshi, Chie Inomoto, Naoya Nakamura, Itaru Kushima, Shuji Iritani, Norio Ozaki, Soichiro Ide, Kazutaka Ikeda, Kenichi Oshima, Masanari Itokawa, Makoto Arai

ABSTRACT

Psychiatric symptoms of schizophrenia suggest alteration of cerebral neurons. However, the physical basis of the schizophrenia symptoms has not been delineated at the cellular level. Here, we report nanometer-scale three-dimensional analysis of brain tissues of schizophrenia and control cases. Structures of cerebral tissues of the anterior cingulate cortex were visualized with synchrotron radiation nanotomography. Tissue constituents visualized in the three-dimensional images were traced to build Cartesian coordinate models of tissue constituents, such as neurons and blood vessels. The obtained Cartesian coordinates were used for calculating curvature and torsion of neurites in order to analyze their geometry. Results of the geometric analyses indicated that the curvature of neurites is significantly different between schizophrenia and control cases. The mean curvature of distal neurites of the schizophrenia cases was ~1.5 times higher than that of the controls. The schizophrenia case with the highest neurite curvature carried a frame shift mutation in the GLO1 gene, suggesting that oxidative stress due to the GLO1 mutation caused the structural alteration of the neurites. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. It has been shown that the anterior cingulate cortex analyzed in this study has emotional and cognitive functions. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia. More... »

PAGES

85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41398-019-0427-4

DOI

http://dx.doi.org/10.1038/s41398-019-0427-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112069956

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30755587


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Applied Biochemistry, Tokai University, 259-1292, Hiratsuka, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizutani", 
        "givenName": "Ryuta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Applied Biochemistry, Tokai University, 259-1292, Hiratsuka, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saiga", 
        "givenName": "Rino", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Synchrotron Radiation Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.410592.b", 
          "name": [
            "Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 679-5198, Sayo, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeuchi", 
        "givenName": "Akihisa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Synchrotron Radiation Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.410592.b", 
          "name": [
            "Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 679-5198, Sayo, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uesugi", 
        "givenName": "Kentaro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Synchrotron Radiation Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.410592.b", 
          "name": [
            "Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 679-5198, Sayo, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terada", 
        "givenName": "Yasuko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Graduate School of Frontier Sciences, University of Tokyo, 277-8561, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Yoshio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Argonne National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.187073.a", 
          "name": [
            "Advanced Photon Source, Argonne National Laboratory, 60439, Lemont, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Andrade", 
        "givenName": "Vincent", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Argonne National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.187073.a", 
          "name": [
            "Advanced Photon Source, Argonne National Laboratory, 60439, Lemont, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Carlo", 
        "givenName": "Francesco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Tokai University School of Medicine, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takekoshi", 
        "givenName": "Susumu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Tokai University School of Medicine, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inomoto", 
        "givenName": "Chie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Tokai University School of Medicine, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Naoya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Graduate School of Medicine, Nagoya University, 466-8550, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kushima", 
        "givenName": "Itaru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Graduate School of Medicine, Nagoya University, 466-8550, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iritani", 
        "givenName": "Shuji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Graduate School of Medicine, Nagoya University, 466-8550, Nagoya, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozaki", 
        "givenName": "Norio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ide", 
        "givenName": "Soichiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeda", 
        "givenName": "Kazutaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oshima", 
        "givenName": "Kenichi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itokawa", 
        "givenName": "Masanari", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Makoto", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0802615105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003162424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.chi.0000132812.44664.2d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003582454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.chi.0000132812.44664.2d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003582454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.chi.0000132812.44664.2d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003582454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003598753", 
          "https://doi.org/10.1038/nmeth.2476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nima.2010.03.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006655059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3355-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006785407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.57.1.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008952361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2008.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009843758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012798279", 
          "https://doi.org/10.1038/nature09818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pcn.12216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013611595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199403103301006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015022542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2011.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015476451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micron.2014.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016186477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2010.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019138889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2010.01231.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019470309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2010.01231.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019470309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/neuro.01.1.1.010.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019480186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020357656", 
          "https://doi.org/10.1038/46035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020357656", 
          "https://doi.org/10.1038/46035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0909049507009004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023351294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35104061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023675797", 
          "https://doi.org/10.1038/35104061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35104061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023675797", 
          "https://doi.org/10.1038/35104061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(98)00281-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025910886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1742-6596/186/1/012018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026559270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jmi.12315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027403331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2015.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030182119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbs076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030693840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2006.04.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032261765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2012.04.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033688355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1742-6596/186/1/012020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033904944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(99)00083-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038768255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2013.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040203517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040555314", 
          "https://doi.org/10.1038/nrn1885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040555314", 
          "https://doi.org/10.1038/nrn1885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1364-6613(00)01483-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041179616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1001961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041944399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.2011.03549.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042875616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/11.6.558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043669543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhp237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043814456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/321969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043832960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2008.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044123684", 
          "https://doi.org/10.1038/npp.2008.67"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/2.1201604.006461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045506495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbs118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046696596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbn025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046809423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micron.2009.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049007741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2014.11.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nbdi.1998.0206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051189304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fonc.2014.00366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053125681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053196326", 
          "https://doi.org/10.1038/nn.4135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.125225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057689346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.1501451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057713339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.1515385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057715085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.2857476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057878873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199707000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199707000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199707000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/83.661186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061239714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/titb.2002.1006304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061656220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.157.1.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063485920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.162.6.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063496705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004010100392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074895157", 
          "https://doi.org/10.1007/s004010100392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btw794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085373110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085428344", 
          "https://doi.org/10.1038/nature22356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085428344", 
          "https://doi.org/10.1038/nature22356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.201703482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091738759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.4937507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1096148593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13041-017-0339-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099598016", 
          "https://doi.org/10.1186/s13041-017-0339-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-04477-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104478411", 
          "https://doi.org/10.1038/s41467-018-04477-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Psychiatric symptoms of schizophrenia suggest alteration of cerebral neurons. However, the physical basis of the schizophrenia symptoms has not been delineated at the cellular level. Here, we report nanometer-scale three-dimensional analysis of brain tissues of schizophrenia and control cases. Structures of cerebral tissues of the anterior cingulate cortex were visualized with synchrotron radiation nanotomography. Tissue constituents visualized in the three-dimensional images were traced to build Cartesian coordinate models of tissue constituents, such as neurons and blood vessels. The obtained Cartesian coordinates were used for calculating curvature and torsion of neurites in order to analyze their geometry. Results of the geometric analyses indicated that the curvature of neurites is significantly different between schizophrenia and control cases. The mean curvature of distal neurites of the schizophrenia cases was ~1.5 times higher than that of the controls. The schizophrenia case with the highest neurite curvature carried a frame shift mutation in the GLO1 gene, suggesting that oxidative stress due to the GLO1 mutation caused the structural alteration of the neurites. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. It has been shown that the anterior cingulate cortex analyzed in this study has emotional and cognitive functions. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41398-019-0427-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6109045", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6019728", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6126109", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045271", 
        "issn": [
          "2158-3188"
        ], 
        "name": "Translational Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Three-dimensional alteration of neurites in schizophrenia", 
    "pagination": "85", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b0900abd17e23df8f4993f9f9edbfd22ae1664f34f7f2522ba0d29b022413303"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30755587"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101562664"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41398-019-0427-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112069956"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41398-019-0427-4", 
      "https://app.dimensions.ai/details/publication/pub.1112069956"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47975_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41398-019-0427-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0427-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0427-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0427-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0427-4'


 

This table displays all metadata directly associated to this object as RDF triples.

388 TRIPLES      21 PREDICATES      89 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41398-019-0427-4 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N98e6e9af34214be6b89285a01535bc9a
4 schema:citation sg:pub.10.1007/s004010100392
5 sg:pub.10.1038/35104061
6 sg:pub.10.1038/46035
7 sg:pub.10.1038/nature09818
8 sg:pub.10.1038/nature22356
9 sg:pub.10.1038/nmeth.2476
10 sg:pub.10.1038/nn.4135
11 sg:pub.10.1038/npp.2008.67
12 sg:pub.10.1038/nrn1885
13 sg:pub.10.1038/s41467-018-04477-1
14 sg:pub.10.1186/s13041-017-0339-2
15 https://doi.org/10.1001/archgenpsychiatry.2010.62
16 https://doi.org/10.1001/archpsyc.57.1.65
17 https://doi.org/10.1002/adma.201703482
18 https://doi.org/10.1006/nbdi.1998.0206
19 https://doi.org/10.1016/j.biopsych.2011.01.032
20 https://doi.org/10.1016/j.brainres.2008.01.029
21 https://doi.org/10.1016/j.jsb.2013.08.012
22 https://doi.org/10.1016/j.micron.2009.09.001
23 https://doi.org/10.1016/j.micron.2014.01.009
24 https://doi.org/10.1016/j.neulet.2014.11.042
25 https://doi.org/10.1016/j.neuroscience.2006.04.084
26 https://doi.org/10.1016/j.neuroscience.2012.04.044
27 https://doi.org/10.1016/j.neuroscience.2015.06.028
28 https://doi.org/10.1016/j.nima.2010.03.111
29 https://doi.org/10.1016/s0006-3223(98)00281-9
30 https://doi.org/10.1016/s0006-3223(99)00083-9
31 https://doi.org/10.1016/s1364-6613(00)01483-2
32 https://doi.org/10.1056/nejm199403103301006
33 https://doi.org/10.1063/1.125225
34 https://doi.org/10.1063/1.1501451
35 https://doi.org/10.1063/1.1515385
36 https://doi.org/10.1063/1.2857476
37 https://doi.org/10.1063/1.4937507
38 https://doi.org/10.1073/pnas.0802615105
39 https://doi.org/10.1086/321969
40 https://doi.org/10.1088/1742-6596/186/1/012018
41 https://doi.org/10.1088/1742-6596/186/1/012020
42 https://doi.org/10.1093/bioinformatics/btw794
43 https://doi.org/10.1093/cercor/11.6.558
44 https://doi.org/10.1093/cercor/bhp237
45 https://doi.org/10.1093/schbul/sbn025
46 https://doi.org/10.1093/schbul/sbs076
47 https://doi.org/10.1093/schbul/sbs118
48 https://doi.org/10.1097/00004728-199707000-00006
49 https://doi.org/10.1097/01.chi.0000132812.44664.2d
50 https://doi.org/10.1107/s0909049507009004
51 https://doi.org/10.1109/83.661186
52 https://doi.org/10.1109/titb.2002.1006304
53 https://doi.org/10.1111/j.1365-2818.2011.03549.x
54 https://doi.org/10.1111/j.1469-7580.2010.01231.x
55 https://doi.org/10.1111/jmi.12315
56 https://doi.org/10.1111/pcn.12216
57 https://doi.org/10.1117/2.1201604.006461
58 https://doi.org/10.1176/ajp.157.1.16
59 https://doi.org/10.1176/appi.ajp.162.6.1200
60 https://doi.org/10.1371/journal.pmed.1001961
61 https://doi.org/10.1523/jneurosci.3355-09.2009
62 https://doi.org/10.3389/fonc.2014.00366
63 https://doi.org/10.3389/neuro.01.1.1.010.2007
64 schema:datePublished 2019-12
65 schema:datePublishedReg 2019-12-01
66 schema:description Psychiatric symptoms of schizophrenia suggest alteration of cerebral neurons. However, the physical basis of the schizophrenia symptoms has not been delineated at the cellular level. Here, we report nanometer-scale three-dimensional analysis of brain tissues of schizophrenia and control cases. Structures of cerebral tissues of the anterior cingulate cortex were visualized with synchrotron radiation nanotomography. Tissue constituents visualized in the three-dimensional images were traced to build Cartesian coordinate models of tissue constituents, such as neurons and blood vessels. The obtained Cartesian coordinates were used for calculating curvature and torsion of neurites in order to analyze their geometry. Results of the geometric analyses indicated that the curvature of neurites is significantly different between schizophrenia and control cases. The mean curvature of distal neurites of the schizophrenia cases was ~1.5 times higher than that of the controls. The schizophrenia case with the highest neurite curvature carried a frame shift mutation in the GLO1 gene, suggesting that oxidative stress due to the GLO1 mutation caused the structural alteration of the neurites. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. It has been shown that the anterior cingulate cortex analyzed in this study has emotional and cognitive functions. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf Na961a60c71254d1ca78671f84d1937ba
71 Ndb9f522b88104cc7b4df63f52e9ec7bd
72 sg:journal.1045271
73 schema:name Three-dimensional alteration of neurites in schizophrenia
74 schema:pagination 85
75 schema:productId N2d46531e46ec4f73b1ad4dba1522fea4
76 N3688427f524a46f8b0f773945a7bf70f
77 N96b28d50b4ac4c2cb1bbd35e6bb5539d
78 Na5a2bb0b20bd4facaa43a3048aa02f38
79 Nbeaaebd7e3ca486b826ca475d0634733
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112069956
81 https://doi.org/10.1038/s41398-019-0427-4
82 schema:sdDatePublished 2019-04-11T09:11
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N3121173514674ebc8914677a238bb45a
85 schema:url https://www.nature.com/articles/s41398-019-0427-4
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0200f8b4065d4a05a810777030af1f0c schema:affiliation https://www.grid.ac/institutes/grid.410592.b
90 schema:familyName Uesugi
91 schema:givenName Kentaro
92 rdf:type schema:Person
93 N026ef09bf6164227b05aea47a5b55a92 rdf:first N277dc9003b0440d3a1c8b213c0619c5c
94 rdf:rest N79029ec473a149ea92d28b247a561225
95 N182a9c6a89274d1ba467b5f49e9067a9 rdf:first N2fd7690d6fb748c298574993d19a49d1
96 rdf:rest N614dc55e13ce49fcaa25b7ff0b46602f
97 N277dc9003b0440d3a1c8b213c0619c5c schema:affiliation https://www.grid.ac/institutes/grid.272456.0
98 schema:familyName Itokawa
99 schema:givenName Masanari
100 rdf:type schema:Person
101 N2d46531e46ec4f73b1ad4dba1522fea4 schema:name nlm_unique_id
102 schema:value 101562664
103 rdf:type schema:PropertyValue
104 N2fd7690d6fb748c298574993d19a49d1 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
105 schema:familyName Saiga
106 schema:givenName Rino
107 rdf:type schema:Person
108 N3121173514674ebc8914677a238bb45a schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N34168cefca124aea8f9407633b099290 schema:affiliation https://www.grid.ac/institutes/grid.187073.a
111 schema:familyName De Carlo
112 schema:givenName Francesco
113 rdf:type schema:Person
114 N3688427f524a46f8b0f773945a7bf70f schema:name pubmed_id
115 schema:value 30755587
116 rdf:type schema:PropertyValue
117 N3ae1d4ac911f4c149c94701c83694884 rdf:first Nf57a851821c347d4a22529e603ae7900
118 rdf:rest Ne9761a2b244143a79e7823bad16dddf4
119 N4ccb9a3b892a4a58b1a63d6403af0640 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
120 schema:familyName Arai
121 schema:givenName Makoto
122 rdf:type schema:Person
123 N5894d2f844af4c00b5eb5873b21c451d schema:affiliation https://www.grid.ac/institutes/grid.410592.b
124 schema:familyName Takeuchi
125 schema:givenName Akihisa
126 rdf:type schema:Person
127 N5f1a2e5f0f58470c8729f003ed89b51e schema:affiliation https://www.grid.ac/institutes/grid.272456.0
128 schema:familyName Oshima
129 schema:givenName Kenichi
130 rdf:type schema:Person
131 N5f78e1f927b04a4296837a06a57d5c63 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
132 schema:familyName Takekoshi
133 schema:givenName Susumu
134 rdf:type schema:Person
135 N614dc55e13ce49fcaa25b7ff0b46602f rdf:first N5894d2f844af4c00b5eb5873b21c451d
136 rdf:rest Ne848e6068ec0439093781135712f9747
137 N647fde9acc404d24991b05ff1841b3da schema:affiliation https://www.grid.ac/institutes/grid.265061.6
138 schema:familyName Inomoto
139 schema:givenName Chie
140 rdf:type schema:Person
141 N6d35cd5fc4084bd6ba3546f683ce9ead rdf:first N90acad33e62f418ba89f28c035b99ef4
142 rdf:rest Nfb08ead3e4f04991b2ed4c9db20e36c8
143 N71ed012be3a048669037d824263c5769 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
144 schema:familyName Ozaki
145 schema:givenName Norio
146 rdf:type schema:Person
147 N79029ec473a149ea92d28b247a561225 rdf:first N4ccb9a3b892a4a58b1a63d6403af0640
148 rdf:rest rdf:nil
149 N90acad33e62f418ba89f28c035b99ef4 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
150 schema:familyName Ide
151 schema:givenName Soichiro
152 rdf:type schema:Person
153 N9309ee6cea7b42e8890f59a8746d62fa rdf:first Nbbd5eaa4f57c43f88727e292ba430040
154 rdf:rest Nfdc47264a27c4c42bcf9b2855c05f95b
155 N96b28d50b4ac4c2cb1bbd35e6bb5539d schema:name doi
156 schema:value 10.1038/s41398-019-0427-4
157 rdf:type schema:PropertyValue
158 N98e6e9af34214be6b89285a01535bc9a rdf:first Ne4b7f58140db4ef1af80ab5573f28d66
159 rdf:rest N182a9c6a89274d1ba467b5f49e9067a9
160 N9fcfb55103d3428cbecacf8bce57f43b schema:affiliation https://www.grid.ac/institutes/grid.27476.30
161 schema:familyName Kushima
162 schema:givenName Itaru
163 rdf:type schema:Person
164 Na5a2bb0b20bd4facaa43a3048aa02f38 schema:name dimensions_id
165 schema:value pub.1112069956
166 rdf:type schema:PropertyValue
167 Na73ee62e174d47cdb9228174c11b3231 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
168 schema:familyName Iritani
169 schema:givenName Shuji
170 rdf:type schema:Person
171 Na961a60c71254d1ca78671f84d1937ba schema:volumeNumber 9
172 rdf:type schema:PublicationVolume
173 Nbbd5eaa4f57c43f88727e292ba430040 schema:affiliation https://www.grid.ac/institutes/grid.410592.b
174 schema:familyName Terada
175 schema:givenName Yasuko
176 rdf:type schema:Person
177 Nbe7d827a0c224efa90d1ed9f947d4644 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
178 schema:familyName Suzuki
179 schema:givenName Yoshio
180 rdf:type schema:Person
181 Nbeaaebd7e3ca486b826ca475d0634733 schema:name readcube_id
182 schema:value b0900abd17e23df8f4993f9f9edbfd22ae1664f34f7f2522ba0d29b022413303
183 rdf:type schema:PropertyValue
184 Nbffd9eeadfad4521bf8f12759b1ee053 rdf:first N71ed012be3a048669037d824263c5769
185 rdf:rest N6d35cd5fc4084bd6ba3546f683ce9ead
186 Ndb9f522b88104cc7b4df63f52e9ec7bd schema:issueNumber 1
187 rdf:type schema:PublicationIssue
188 Ndd3344dd1ced439ca1614ef3f1e17b2c rdf:first Na73ee62e174d47cdb9228174c11b3231
189 rdf:rest Nbffd9eeadfad4521bf8f12759b1ee053
190 Ne4b7f58140db4ef1af80ab5573f28d66 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
191 schema:familyName Mizutani
192 schema:givenName Ryuta
193 rdf:type schema:Person
194 Ne75d30df05d84c18bbfae5770762f57c schema:affiliation https://www.grid.ac/institutes/grid.272456.0
195 schema:familyName Ikeda
196 schema:givenName Kazutaka
197 rdf:type schema:Person
198 Ne848e6068ec0439093781135712f9747 rdf:first N0200f8b4065d4a05a810777030af1f0c
199 rdf:rest N9309ee6cea7b42e8890f59a8746d62fa
200 Ne9761a2b244143a79e7823bad16dddf4 rdf:first N34168cefca124aea8f9407633b099290
201 rdf:rest Nff41d28a27a5455c8acfd25b79df0124
202 Nf013268c39954823b3aeea42f86bf8ad schema:affiliation https://www.grid.ac/institutes/grid.265061.6
203 schema:familyName Nakamura
204 schema:givenName Naoya
205 rdf:type schema:Person
206 Nf2b3d9dd84374a3cafef827fb8d31553 rdf:first Nf013268c39954823b3aeea42f86bf8ad
207 rdf:rest Nf31917316b9440fbb9e8bebb1842e001
208 Nf31917316b9440fbb9e8bebb1842e001 rdf:first N9fcfb55103d3428cbecacf8bce57f43b
209 rdf:rest Ndd3344dd1ced439ca1614ef3f1e17b2c
210 Nf57a851821c347d4a22529e603ae7900 schema:affiliation https://www.grid.ac/institutes/grid.187073.a
211 schema:familyName De Andrade
212 schema:givenName Vincent
213 rdf:type schema:Person
214 Nfb06468eb1de448194ab6d62003db8ce rdf:first N647fde9acc404d24991b05ff1841b3da
215 rdf:rest Nf2b3d9dd84374a3cafef827fb8d31553
216 Nfb08ead3e4f04991b2ed4c9db20e36c8 rdf:first Ne75d30df05d84c18bbfae5770762f57c
217 rdf:rest Nff070b51162942208dae29d9e1136c52
218 Nfdc47264a27c4c42bcf9b2855c05f95b rdf:first Nbe7d827a0c224efa90d1ed9f947d4644
219 rdf:rest N3ae1d4ac911f4c149c94701c83694884
220 Nff070b51162942208dae29d9e1136c52 rdf:first N5f1a2e5f0f58470c8729f003ed89b51e
221 rdf:rest N026ef09bf6164227b05aea47a5b55a92
222 Nff41d28a27a5455c8acfd25b79df0124 rdf:first N5f78e1f927b04a4296837a06a57d5c63
223 rdf:rest Nfb06468eb1de448194ab6d62003db8ce
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
228 schema:name Neurosciences
229 rdf:type schema:DefinedTerm
230 sg:grant.6019728 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0427-4
231 rdf:type schema:MonetaryGrant
232 sg:grant.6109045 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0427-4
233 rdf:type schema:MonetaryGrant
234 sg:grant.6126109 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0427-4
235 rdf:type schema:MonetaryGrant
236 sg:journal.1045271 schema:issn 2158-3188
237 schema:name Translational Psychiatry
238 rdf:type schema:Periodical
239 sg:pub.10.1007/s004010100392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074895157
240 https://doi.org/10.1007/s004010100392
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/35104061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023675797
243 https://doi.org/10.1038/35104061
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/46035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020357656
246 https://doi.org/10.1038/46035
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nature09818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012798279
249 https://doi.org/10.1038/nature09818
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature22356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085428344
252 https://doi.org/10.1038/nature22356
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nmeth.2476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003598753
255 https://doi.org/10.1038/nmeth.2476
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nn.4135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053196326
258 https://doi.org/10.1038/nn.4135
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/npp.2008.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044123684
261 https://doi.org/10.1038/npp.2008.67
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nrn1885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040555314
264 https://doi.org/10.1038/nrn1885
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/s41467-018-04477-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104478411
267 https://doi.org/10.1038/s41467-018-04477-1
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/s13041-017-0339-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099598016
270 https://doi.org/10.1186/s13041-017-0339-2
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1001/archgenpsychiatry.2010.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019138889
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1001/archpsyc.57.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008952361
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/adma.201703482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091738759
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1006/nbdi.1998.0206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051189304
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.biopsych.2011.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015476451
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.brainres.2008.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009843758
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.jsb.2013.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040203517
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.micron.2009.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049007741
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.micron.2014.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016186477
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.neulet.2014.11.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638150
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.neuroscience.2006.04.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032261765
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.neuroscience.2012.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033688355
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.neuroscience.2015.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030182119
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.nima.2010.03.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006655059
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0006-3223(98)00281-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025910886
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0006-3223(99)00083-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038768255
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s1364-6613(00)01483-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041179616
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1056/nejm199403103301006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015022542
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1063/1.125225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057689346
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1063/1.1501451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057713339
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1063/1.1515385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057715085
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1063/1.2857476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057878873
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1063/1.4937507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1096148593
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1073/pnas.0802615105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003162424
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1086/321969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043832960
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1088/1742-6596/186/1/012018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026559270
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1088/1742-6596/186/1/012020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033904944
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1093/bioinformatics/btw794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085373110
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1093/cercor/11.6.558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043669543
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/cercor/bhp237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043814456
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/schbul/sbn025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046809423
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/schbul/sbs076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030693840
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/schbul/sbs118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046696596
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1097/00004728-199707000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060189247
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/01.chi.0000132812.44664.2d schema:sameAs https://app.dimensions.ai/details/publication/pub.1003582454
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1107/s0909049507009004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023351294
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1109/83.661186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061239714
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1109/titb.2002.1006304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061656220
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1365-2818.2011.03549.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042875616
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1469-7580.2010.01231.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019470309
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1111/jmi.12315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027403331
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1111/pcn.12216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013611595
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1117/2.1201604.006461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045506495
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1176/ajp.157.1.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485920
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1176/appi.ajp.162.6.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063496705
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pmed.1001961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041944399
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1523/jneurosci.3355-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785407
365 rdf:type schema:CreativeWork
366 https://doi.org/10.3389/fonc.2014.00366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053125681
367 rdf:type schema:CreativeWork
368 https://doi.org/10.3389/neuro.01.1.1.010.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019480186
369 rdf:type schema:CreativeWork
370 https://www.grid.ac/institutes/grid.187073.a schema:alternateName Argonne National Laboratory
371 schema:name Advanced Photon Source, Argonne National Laboratory, 60439, Lemont, IL, USA
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.265061.6 schema:alternateName Tokai University
374 schema:name Department of Applied Biochemistry, Tokai University, 259-1292, Hiratsuka, Kanagawa, Japan
375 Tokai University School of Medicine, 259-1193, Isehara, Kanagawa, Japan
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
378 schema:name Graduate School of Frontier Sciences, University of Tokyo, 277-8561, Kashiwa, Chiba, Japan
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.272456.0 schema:alternateName Tokyo Metropolitan Institute of Medical Science
381 schema:name Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya, Tokyo, Japan
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
384 schema:name Graduate School of Medicine, Nagoya University, 466-8550, Nagoya, Aichi, Japan
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.410592.b schema:alternateName Japan Synchrotron Radiation Research Institute
387 schema:name Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 679-5198, Sayo, Hyogo, Japan
388 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...