The genomics of major psychiatric disorders in a large pedigree from Northern Sweden View Full Text


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Article Info

DATE

2019-12

AUTHORS

Jin Szatkiewicz, James J. Crowley, Annelie Nordin Adolfsson, Karolina A. Åberg, Maaike Alaerts, Giulio Genovese, Steven McCarroll, Jurgen Del-Favero, Rolf Adolfsson, Patrick F. Sullivan

ABSTRACT

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls. More... »

PAGES

60

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41398-019-0414-9

    DOI

    http://dx.doi.org/10.1038/s41398-019-0414-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111908257

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30718465


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