Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the “dark side” of addiction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Qian Peng, Chris Bizon, Ian R. Gizer, Kirk C. Wilhelmsen, Cindy L. Ehlers

ABSTRACT

A limited number of genetic variants have been identified in traditional GWAS as risk or protective factors for alcohol use disorders (AUD) and related phenotypes. We herein report whole-genome association and rare-variant analyses on AUD traits in American Indians (AI) and European Americans (EA). We evaluated 742 AIs and 1711 EAs using low-coverage whole-genome sequencing. Phenotypes included: (1) a metric based on the occurrence of 36 alcohol-related life events that reflect AUD severity; (2) two alcohol-induced affective symptoms that accompany severe AUDs. We identified two new loci for alcohol-related life events with converging evidence from both cohorts: rare variants of K2P channel gene KCNK2, and rare missense and splice-site variants in pro-inflammatory mediator gene PDE4C. A NAF1-FSTL5 intergenic variant and an FSTL5 variant were respectively associated with alcohol-related life events in AI and EA. PRKG2 of serine/threonine protein kinase family, and rare variants in interleukin subunit gene EBI3 (IL-27B) were uniquely associated with alcohol-induced affective symptoms in AI. LncRNA LINC02347 on 12q24.32 was uniquely associated with alcohol-induced depression in EA. The top GWAS findings were primarily rare/low-frequency variants in AI, and common variants in EA. Adrenal gland was the most enriched in tissue-specific gene expression analysis for alcohol-related life events, and nucleus accumbens was the most enriched for alcohol-induced affective states in AI. Prefrontal cortex was the most enriched in EA for both traits. These studies suggest that whole-genome sequencing can identify novel, especially uncommon, variants associated with severe AUD phenotypes although the findings may be population specific. More... »

PAGES

71

References to SciGraph publications

  • 2014-01. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci in MOLECULAR PSYCHIATRY
  • 2005-11. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction in NATURE NEUROSCIENCE
  • 2016-12. Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits in SCIENTIFIC REPORTS
  • 2013. Neuroimmune Genes and Alcohol Drinking Behavior in NEURAL-IMMUNE INTERACTIONS IN BRAIN FUNCTION AND ALCOHOL RELATED DISORDERS
  • 2013-09. A Genome-Wide Association Study of Behavioral Disinhibition in BEHAVIOR GENETICS
  • 2014-12. Variant calling in low-coverage whole genome sequencing of a Native American population sample in BMC GENOMICS
  • 2017-09. Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study in MOLECULAR PSYCHIATRY
  • 2013-08. Genetics and alcoholism in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2010-07. Conserved role of intragenic DNA methylation in regulating alternative promoters in NATURE
  • 2012-09. Replication and meta-analysis of TMEM132D gene variants in panic disorder in TRANSLATIONAL PSYCHIATRY
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2009-04. Human genetic variation and its contribution to complex traits in NATURE REVIEWS GENETICS
  • 2013-11. A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53 in MOLECULAR PSYCHIATRY
  • 2008-06. Whole-genome association study of bipolar disorder in MOLECULAR PSYCHIATRY
  • 2017-10. Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) in MOLECULAR PSYCHIATRY
  • 2006-09. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype in NATURE NEUROSCIENCE
  • 2010-04. A method and server for predicting damaging missense mutations in NATURE METHODS
  • 2017-04-26. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits in NATURE COMMUNICATIONS
  • 2011-12. Chromosome 12q24.31-q24.33 deletion causes multiple dysmorphic features and developmental delay: First mosaic patient and overview of the phenotype related to 12q24qter defects in MOLECULAR CYTOGENETICS
  • 2007-04. The neuronal background K2P channels: focus on TREK1 in NATURE REVIEWS NEUROSCIENCE
  • 2014-10. Genetic variability in the regulation of gene expression in ten regions of the human brain in NATURE NEUROSCIENCE
  • 2010-04. Variance component model to account for sample structure in genome-wide association studies in NATURE GENETICS
  • 2015-10. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index in NATURE GENETICS
  • 2014-04. Hypermethylation in the ZBTB20 gene is associated with major depressive disorder in GENOME BIOLOGY
  • 2017-02. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41398-019-0397-6

    DOI

    http://dx.doi.org/10.1038/s41398-019-0397-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111906767

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30718457


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Scripps Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "Department of Neuroscience, The Scripps Research Institute, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Qian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Renaissance Computing Institute, University of North Carolina, 27517, Chapel Hill, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bizon", 
            "givenName": "Chris", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Department of Psychological Sciences, University of Missouri-Columbia, 65211, Columbia, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gizer", 
            "givenName": "Ian R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Renaissance Computing Institute, University of North Carolina, 27517, Chapel Hill, NC, USA", 
                "Department of Genetics and Neurology, University of North Carolina, 27599, Chapel Hill, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilhelmsen", 
            "givenName": "Kirk C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Scripps Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "Department of Neuroscience, The Scripps Research Institute, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ehlers", 
            "givenName": "Cindy L.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nn1749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001189003", 
              "https://doi.org/10.1038/nn1749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001189003", 
              "https://doi.org/10.1038/nn1749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001620489", 
              "https://doi.org/10.1038/ng.3390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2013.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001757600", 
              "https://doi.org/10.1038/nrgastro.2013.86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1611243113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001844056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10519-013-9606-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001957205", 
              "https://doi.org/10.1007/s10519-013-9606-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000141821.06062.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002519667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000141821.06062.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002519667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/acer.12792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003257504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2014-15-4-r56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007141732", 
              "https://doi.org/10.1186/gb-2014-15-4-r56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1105-1442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007251662", 
              "https://doi.org/10.1038/nn1105-1442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1105-1442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007251662", 
              "https://doi.org/10.1038/nn1105-1442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010056536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10550880802324754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011262941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011407465", 
              "https://doi.org/10.1038/nrg2554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011407465", 
              "https://doi.org/10.1038/nrg2554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011836248", 
              "https://doi.org/10.1038/mp.2013.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011836248", 
              "https://doi.org/10.1038/mp.2013.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2012.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012212268", 
              "https://doi.org/10.1038/mp.2012.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2013.01.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013520284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.31218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015335553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000107200.88229.57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015697806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000107200.88229.57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015697806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016055940", 
              "https://doi.org/10.1038/ng.548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016055940", 
              "https://doi.org/10.1038/ng.548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0042646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016242074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2215-0366(16)00104-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017872270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2012.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018233810", 
              "https://doi.org/10.1038/tp.2012.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019242813", 
              "https://doi.org/10.1038/nature09165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019242813", 
              "https://doi.org/10.1038/nature09165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021971381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.64.5.566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023558656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15476286.2016.1207036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024015104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1017288108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024216511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1521-0391.2009.00021.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024594680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1521-0391.2009.00021.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024594680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archgenpsychiatry.2009.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026660094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027398186", 
              "https://doi.org/10.1038/ng.3749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m212083200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027555130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep32894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028757889", 
              "https://doi.org/10.1038/srep32894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1755-8166-4-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029633109", 
              "https://doi.org/10.1186/1755-8166-4-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.30346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029663085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamapsychiatry.2015.0584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030024258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1530-0277.2012.01845.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030407047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.110.001776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031127210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4614-4729-0_13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031309928", 
              "https://doi.org/10.1007/978-1-4614-4729-0_13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.alcohol.2015.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034610009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0116815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037409868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037491398", 
              "https://doi.org/10.1038/sj.mp.4002151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1601-183x.2012.00803.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038034010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drugalcdep.2010.07.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038245349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2008.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038826763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2008.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038826763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039987283", 
              "https://doi.org/10.1038/nprot.2008.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/ajad.12290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040515981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1360-0443.2006.01592.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040565116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2016.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040707550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2016.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040707550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajhb.22521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042606496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10550490252801594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043053887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10826080500391803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044092353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044482013", 
              "https://doi.org/10.1038/nrn2117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000142261.32980.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046779312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000142261.32980.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046779312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2014.00129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047668679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047887176", 
              "https://doi.org/10.1186/1471-2164-15-85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000057122.36127.c2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050773092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.alc.0000057122.36127.c2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050773092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.32272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051838603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052242395", 
              "https://doi.org/10.1038/nn.3801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/383251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058674529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e32832cbe61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e32832cbe61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e32832cbe61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e32832cbe61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.150.5.786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063482350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.154.7.948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063485150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.161.7.1204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063496029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.2012.12010113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063499649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.2012.12020237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063499674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2013-1053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2005-0035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15288/qjsa.1946.7.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067705642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15288/jsa.1995.56.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067707932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15288/jsa.2001.62.158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067708578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15288/jsad.2008.69.834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067709407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m116.762021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084153120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085060523", 
              "https://doi.org/10.1038/ncomms14977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085075998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085075998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2017.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085215230", 
              "https://doi.org/10.1038/mp.2017.101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2017.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090891255", 
              "https://doi.org/10.1038/mp.2017.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/acer.13480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091219740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/232330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099653286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/232330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099653286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/232330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099653286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/275917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101408512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/275917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101408512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/275917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101408512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.24238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105140107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.24238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105140107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.24238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105140107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.24238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105140107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hbm.24238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105140107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/add.14431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106382579"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "A limited number of genetic variants have been identified in traditional GWAS as risk or protective factors for alcohol use disorders (AUD) and related phenotypes. We herein report whole-genome association and rare-variant analyses on AUD traits in American Indians (AI) and European Americans (EA). We evaluated 742 AIs and 1711 EAs using low-coverage whole-genome sequencing. Phenotypes included: (1) a metric based on the occurrence of 36 alcohol-related life events that reflect AUD severity; (2) two alcohol-induced affective symptoms that accompany severe AUDs. We identified two new loci for alcohol-related life events with converging evidence from both cohorts: rare variants of K2P channel gene KCNK2, and rare missense and splice-site variants in pro-inflammatory mediator gene PDE4C. A NAF1-FSTL5 intergenic variant and an FSTL5 variant were respectively associated with alcohol-related life events in AI and EA. PRKG2 of serine/threonine protein kinase family, and rare variants in interleukin subunit gene EBI3 (IL-27B) were uniquely associated with alcohol-induced affective symptoms in AI. LncRNA LINC02347 on 12q24.32 was uniquely associated with alcohol-induced depression in EA. The top GWAS findings were primarily rare/low-frequency variants in AI, and common variants in EA. Adrenal gland was the most enriched in tissue-specific gene expression analysis for alcohol-related life events, and nucleus accumbens was the most enriched for alcohol-induced affective states in AI. Prefrontal cortex was the most enriched in EA for both traits. These studies suggest that whole-genome sequencing can identify novel, especially uncommon, variants associated with severe AUD phenotypes although the findings may be population specific.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41398-019-0397-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2633390", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2487034", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5504042", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2443184", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045271", 
            "issn": [
              "2158-3188"
            ], 
            "name": "Translational Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the \u201cdark side\u201d of addiction", 
        "pagination": "71", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41398-019-0397-6"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "08458ac44e7f98d4a5f77b65a96118b5d9a5fcee6686aab0422bbfc685114a11"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111906767"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101562664"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30718457"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41398-019-0397-6", 
          "https://app.dimensions.ai/details/publication/pub.1111906767"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91447_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41398-019-0397-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0397-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0397-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0397-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0397-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    379 TRIPLES      21 PREDICATES      111 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41398-019-0397-6 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Neec8b1b86d3e44acafd3a70c6875b4c1
    4 schema:citation sg:pub.10.1007/978-1-4614-4729-0_13
    5 sg:pub.10.1007/s10519-013-9606-x
    6 sg:pub.10.1038/mp.2012.143
    7 sg:pub.10.1038/mp.2013.145
    8 sg:pub.10.1038/mp.2017.101
    9 sg:pub.10.1038/mp.2017.153
    10 sg:pub.10.1038/nature09165
    11 sg:pub.10.1038/ncomms14977
    12 sg:pub.10.1038/ng.3390
    13 sg:pub.10.1038/ng.3749
    14 sg:pub.10.1038/ng.548
    15 sg:pub.10.1038/nmeth0410-248
    16 sg:pub.10.1038/nn.3801
    17 sg:pub.10.1038/nn1105-1442
    18 sg:pub.10.1038/nn1749
    19 sg:pub.10.1038/nprot.2008.211
    20 sg:pub.10.1038/nrg2554
    21 sg:pub.10.1038/nrgastro.2013.86
    22 sg:pub.10.1038/nrn2117
    23 sg:pub.10.1038/sj.mp.4002151
    24 sg:pub.10.1038/srep32894
    25 sg:pub.10.1038/tp.2012.85
    26 sg:pub.10.1186/1471-2164-15-85
    27 sg:pub.10.1186/1755-8166-4-9
    28 sg:pub.10.1186/gb-2014-15-4-r56
    29 https://doi.org/10.1001/archgenpsychiatry.2009.83
    30 https://doi.org/10.1001/archpsyc.64.5.566
    31 https://doi.org/10.1001/jamapsychiatry.2015.0584
    32 https://doi.org/10.1002/ajhb.22521
    33 https://doi.org/10.1002/ajmg.b.30346
    34 https://doi.org/10.1002/ajmg.b.31218
    35 https://doi.org/10.1002/ajmg.b.32272
    36 https://doi.org/10.1002/hbm.24238
    37 https://doi.org/10.1016/j.ajhg.2008.06.024
    38 https://doi.org/10.1016/j.ajhg.2016.11.007
    39 https://doi.org/10.1016/j.alcohol.2015.03.007
    40 https://doi.org/10.1016/j.conb.2013.01.024
    41 https://doi.org/10.1016/j.drugalcdep.2010.07.017
    42 https://doi.org/10.1016/s2215-0366(16)00104-8
    43 https://doi.org/10.1073/pnas.1017288108
    44 https://doi.org/10.1073/pnas.1611243113
    45 https://doi.org/10.1074/jbc.m116.762021
    46 https://doi.org/10.1074/jbc.m212083200
    47 https://doi.org/10.1080/10550490252801594
    48 https://doi.org/10.1080/10550880802324754
    49 https://doi.org/10.1080/10826080500391803
    50 https://doi.org/10.1080/15476286.2016.1207036
    51 https://doi.org/10.1086/383251
    52 https://doi.org/10.1093/nar/gkq537
    53 https://doi.org/10.1093/nar/gkv1070
    54 https://doi.org/10.1097/01.alc.0000057122.36127.c2
    55 https://doi.org/10.1097/01.alc.0000107200.88229.57
    56 https://doi.org/10.1097/01.alc.0000141821.06062.20
    57 https://doi.org/10.1097/01.alc.0000142261.32980.64
    58 https://doi.org/10.1097/fpc.0000000000000250
    59 https://doi.org/10.1097/fpc.0b013e32832cbe61
    60 https://doi.org/10.1101/232330
    61 https://doi.org/10.1101/275917
    62 https://doi.org/10.1111/acer.12792
    63 https://doi.org/10.1111/acer.13480
    64 https://doi.org/10.1111/add.14431
    65 https://doi.org/10.1111/ajad.12290
    66 https://doi.org/10.1111/j.1360-0443.2006.01592.x
    67 https://doi.org/10.1111/j.1521-0391.2009.00021.x
    68 https://doi.org/10.1111/j.1530-0277.2012.01845.x
    69 https://doi.org/10.1111/j.1601-183x.2012.00803.x
    70 https://doi.org/10.1176/ajp.150.5.786
    71 https://doi.org/10.1176/ajp.154.7.948
    72 https://doi.org/10.1176/appi.ajp.161.7.1204
    73 https://doi.org/10.1176/appi.ajp.2012.12010113
    74 https://doi.org/10.1176/appi.ajp.2012.12020237
    75 https://doi.org/10.1210/er.2013-1053
    76 https://doi.org/10.1210/jc.2005-0035
    77 https://doi.org/10.1371/journal.pgen.1006528
    78 https://doi.org/10.1371/journal.pone.0042646
    79 https://doi.org/10.1371/journal.pone.0116815
    80 https://doi.org/10.15288/jsa.1995.56.218
    81 https://doi.org/10.15288/jsa.2001.62.158
    82 https://doi.org/10.15288/jsad.2008.69.834
    83 https://doi.org/10.15288/qjsa.1946.7.1
    84 https://doi.org/10.3389/fnins.2014.00129
    85 https://doi.org/10.3945/ajcn.110.001776
    86 schema:datePublished 2019-12
    87 schema:datePublishedReg 2019-12-01
    88 schema:description A limited number of genetic variants have been identified in traditional GWAS as risk or protective factors for alcohol use disorders (AUD) and related phenotypes. We herein report whole-genome association and rare-variant analyses on AUD traits in American Indians (AI) and European Americans (EA). We evaluated 742 AIs and 1711 EAs using low-coverage whole-genome sequencing. Phenotypes included: (1) a metric based on the occurrence of 36 alcohol-related life events that reflect AUD severity; (2) two alcohol-induced affective symptoms that accompany severe AUDs. We identified two new loci for alcohol-related life events with converging evidence from both cohorts: rare variants of K<sub>2P</sub> channel gene KCNK2, and rare missense and splice-site variants in pro-inflammatory mediator gene PDE4C. A NAF1-FSTL5 intergenic variant and an FSTL5 variant were respectively associated with alcohol-related life events in AI and EA. PRKG2 of serine/threonine protein kinase family, and rare variants in interleukin subunit gene EBI3 (IL-27B) were uniquely associated with alcohol-induced affective symptoms in AI. LncRNA LINC02347 on 12q24.32 was uniquely associated with alcohol-induced depression in EA. The top GWAS findings were primarily rare/low-frequency variants in AI, and common variants in EA. Adrenal gland was the most enriched in tissue-specific gene expression analysis for alcohol-related life events, and nucleus accumbens was the most enriched for alcohol-induced affective states in AI. Prefrontal cortex was the most enriched in EA for both traits. These studies suggest that whole-genome sequencing can identify novel, especially uncommon, variants associated with severe AUD phenotypes although the findings may be population specific.
    89 schema:genre research_article
    90 schema:inLanguage en
    91 schema:isAccessibleForFree true
    92 schema:isPartOf N2e143c4b3fe547ca962637da1322450e
    93 Nebb7e657014c4c76a90afd6271bec865
    94 sg:journal.1045271
    95 schema:name Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the “dark side” of addiction
    96 schema:pagination 71
    97 schema:productId N2efb1af57a4f4911bd856a2c982f81fe
    98 N318e076ed28346298d7a894cd5a72270
    99 N69c51f94c77e4736a3487313019c9386
    100 N7a2dfb2132034a8f9883b6a212537734
    101 Nb36d03581d374c358de8a2f1bd57bb37
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111906767
    103 https://doi.org/10.1038/s41398-019-0397-6
    104 schema:sdDatePublished 2019-04-15T09:01
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher Ncc1282e19d0648eab5238c5bd096d531
    107 schema:url https://www.nature.com/articles/s41398-019-0397-6
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N0437e0c038c64e2db65145993e380cd4 rdf:first N76f5c611680b40c6b8f1b46ff9c05d20
    112 rdf:rest rdf:nil
    113 N152f00d666a242cd96493713cbf67e8d schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    114 schema:familyName Gizer
    115 schema:givenName Ian R.
    116 rdf:type schema:Person
    117 N2e143c4b3fe547ca962637da1322450e schema:issueNumber 1
    118 rdf:type schema:PublicationIssue
    119 N2efb1af57a4f4911bd856a2c982f81fe schema:name nlm_unique_id
    120 schema:value 101562664
    121 rdf:type schema:PropertyValue
    122 N318e076ed28346298d7a894cd5a72270 schema:name doi
    123 schema:value 10.1038/s41398-019-0397-6
    124 rdf:type schema:PropertyValue
    125 N485b2923734e4468a2fcaa260498edd2 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
    126 schema:familyName Peng
    127 schema:givenName Qian
    128 rdf:type schema:Person
    129 N4902c902553a4febba551d3b3497de70 rdf:first Nb4843119f61c410bbe974190b39f1260
    130 rdf:rest Na5e8b20ae29b494a80d55250d4999fd9
    131 N49fd543837c54e53b34634f7484cc1a3 schema:name Renaissance Computing Institute, University of North Carolina, 27517, Chapel Hill, NC, USA
    132 rdf:type schema:Organization
    133 N69c51f94c77e4736a3487313019c9386 schema:name dimensions_id
    134 schema:value pub.1111906767
    135 rdf:type schema:PropertyValue
    136 N76f5c611680b40c6b8f1b46ff9c05d20 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
    137 schema:familyName Ehlers
    138 schema:givenName Cindy L.
    139 rdf:type schema:Person
    140 N7a2dfb2132034a8f9883b6a212537734 schema:name pubmed_id
    141 schema:value 30718457
    142 rdf:type schema:PropertyValue
    143 Na5e8b20ae29b494a80d55250d4999fd9 rdf:first N152f00d666a242cd96493713cbf67e8d
    144 rdf:rest Nf319169cdc924f329dec1534c79579ad
    145 Nb36d03581d374c358de8a2f1bd57bb37 schema:name readcube_id
    146 schema:value 08458ac44e7f98d4a5f77b65a96118b5d9a5fcee6686aab0422bbfc685114a11
    147 rdf:type schema:PropertyValue
    148 Nb4843119f61c410bbe974190b39f1260 schema:affiliation N49fd543837c54e53b34634f7484cc1a3
    149 schema:familyName Bizon
    150 schema:givenName Chris
    151 rdf:type schema:Person
    152 Ncc1282e19d0648eab5238c5bd096d531 schema:name Springer Nature - SN SciGraph project
    153 rdf:type schema:Organization
    154 Nda77d119904341f69c74f36fede8f764 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    155 schema:familyName Wilhelmsen
    156 schema:givenName Kirk C.
    157 rdf:type schema:Person
    158 Nebb7e657014c4c76a90afd6271bec865 schema:volumeNumber 9
    159 rdf:type schema:PublicationVolume
    160 Neec8b1b86d3e44acafd3a70c6875b4c1 rdf:first N485b2923734e4468a2fcaa260498edd2
    161 rdf:rest N4902c902553a4febba551d3b3497de70
    162 Nf319169cdc924f329dec1534c79579ad rdf:first Nda77d119904341f69c74f36fede8f764
    163 rdf:rest N0437e0c038c64e2db65145993e380cd4
    164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biological Sciences
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Genetics
    169 rdf:type schema:DefinedTerm
    170 sg:grant.2443184 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0397-6
    171 rdf:type schema:MonetaryGrant
    172 sg:grant.2487034 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0397-6
    173 rdf:type schema:MonetaryGrant
    174 sg:grant.2633390 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0397-6
    175 rdf:type schema:MonetaryGrant
    176 sg:grant.5504042 http://pending.schema.org/fundedItem sg:pub.10.1038/s41398-019-0397-6
    177 rdf:type schema:MonetaryGrant
    178 sg:journal.1045271 schema:issn 2158-3188
    179 schema:name Translational Psychiatry
    180 rdf:type schema:Periodical
    181 sg:pub.10.1007/978-1-4614-4729-0_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031309928
    182 https://doi.org/10.1007/978-1-4614-4729-0_13
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s10519-013-9606-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001957205
    185 https://doi.org/10.1007/s10519-013-9606-x
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/mp.2012.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012212268
    188 https://doi.org/10.1038/mp.2012.143
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/mp.2013.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011836248
    191 https://doi.org/10.1038/mp.2013.145
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/mp.2017.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085215230
    194 https://doi.org/10.1038/mp.2017.101
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/mp.2017.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090891255
    197 https://doi.org/10.1038/mp.2017.153
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nature09165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019242813
    200 https://doi.org/10.1038/nature09165
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ncomms14977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085060523
    203 https://doi.org/10.1038/ncomms14977
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ng.3390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001620489
    206 https://doi.org/10.1038/ng.3390
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/ng.3749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027398186
    209 https://doi.org/10.1038/ng.3749
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/ng.548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016055940
    212 https://doi.org/10.1038/ng.548
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nmeth0410-248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007489634
    215 https://doi.org/10.1038/nmeth0410-248
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nn.3801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052242395
    218 https://doi.org/10.1038/nn.3801
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nn1105-1442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007251662
    221 https://doi.org/10.1038/nn1105-1442
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nn1749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001189003
    224 https://doi.org/10.1038/nn1749
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
    227 https://doi.org/10.1038/nprot.2008.211
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nrg2554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011407465
    230 https://doi.org/10.1038/nrg2554
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nrgastro.2013.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001757600
    233 https://doi.org/10.1038/nrgastro.2013.86
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nrn2117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044482013
    236 https://doi.org/10.1038/nrn2117
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/sj.mp.4002151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037491398
    239 https://doi.org/10.1038/sj.mp.4002151
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/srep32894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028757889
    242 https://doi.org/10.1038/srep32894
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/tp.2012.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018233810
    245 https://doi.org/10.1038/tp.2012.85
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1186/1471-2164-15-85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047887176
    248 https://doi.org/10.1186/1471-2164-15-85
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1186/1755-8166-4-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029633109
    251 https://doi.org/10.1186/1755-8166-4-9
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1186/gb-2014-15-4-r56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007141732
    254 https://doi.org/10.1186/gb-2014-15-4-r56
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1001/archgenpsychiatry.2009.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026660094
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1001/archpsyc.64.5.566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023558656
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1001/jamapsychiatry.2015.0584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030024258
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1002/ajhb.22521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042606496
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1002/ajmg.b.30346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029663085
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1002/ajmg.b.31218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015335553
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/ajmg.b.32272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051838603
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/hbm.24238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105140107
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.ajhg.2008.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038826763
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.ajhg.2016.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040707550
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.alcohol.2015.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034610009
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.conb.2013.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013520284
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.drugalcdep.2010.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038245349
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s2215-0366(16)00104-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017872270
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1073/pnas.1017288108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024216511
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1073/pnas.1611243113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001844056
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1074/jbc.m116.762021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084153120
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1074/jbc.m212083200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027555130
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1080/10550490252801594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043053887
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1080/10550880802324754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011262941
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1080/10826080500391803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044092353
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1080/15476286.2016.1207036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024015104
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1086/383251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058674529
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/nar/gkq537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021971381
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/nar/gkv1070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010056536
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1097/01.alc.0000057122.36127.c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050773092
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1097/01.alc.0000107200.88229.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015697806
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1097/01.alc.0000141821.06062.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002519667
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1097/01.alc.0000142261.32980.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046779312
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1097/fpc.0000000000000250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340437
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1097/fpc.0b013e32832cbe61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340720
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1101/232330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099653286
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1101/275917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101408512
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1111/acer.12792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003257504
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1111/acer.13480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091219740
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1111/add.14431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106382579
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1111/ajad.12290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040515981
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1111/j.1360-0443.2006.01592.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565116
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1111/j.1521-0391.2009.00021.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024594680
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1111/j.1530-0277.2012.01845.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407047
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1111/j.1601-183x.2012.00803.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038034010
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1176/ajp.150.5.786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063482350
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1176/ajp.154.7.948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485150
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1176/appi.ajp.161.7.1204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063496029
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1176/appi.ajp.2012.12010113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063499649
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1176/appi.ajp.2012.12020237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063499674
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1210/er.2013-1053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286057
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1210/jc.2005-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288283
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1371/journal.pgen.1006528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085075998
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1371/journal.pone.0042646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016242074
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1371/journal.pone.0116815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037409868
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.15288/jsa.1995.56.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067707932
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.15288/jsa.2001.62.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067708578
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.15288/jsad.2008.69.834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067709407
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.15288/qjsa.1946.7.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067705642
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.3389/fnins.2014.00129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047668679
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.3945/ajcn.110.001776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031127210
    369 rdf:type schema:CreativeWork
    370 https://www.grid.ac/institutes/grid.134936.a schema:alternateName University of Missouri
    371 schema:name Department of Psychological Sciences, University of Missouri-Columbia, 65211, Columbia, MO, USA
    372 rdf:type schema:Organization
    373 https://www.grid.ac/institutes/grid.214007.0 schema:alternateName Scripps Research Institute
    374 schema:name Department of Neuroscience, The Scripps Research Institute, 92037, La Jolla, CA, USA
    375 rdf:type schema:Organization
    376 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
    377 schema:name Department of Genetics and Neurology, University of North Carolina, 27599, Chapel Hill, NC, USA
    378 Renaissance Computing Institute, University of North Carolina, 27517, Chapel Hill, NC, USA
    379 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...