FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Janine Diehl-Schmid, Abigail Licata, Oliver Goldhardt, Hans Förstl, Igor Yakushew, Markus Otto, Sarah Anderl-Straub, Ambros Beer, Albert Christian Ludolph, Georg Bernhard Landwehrmeyer, Johannes Levin, Adrian Danek, Klaus Fliessbach, Annika Spottke, Klaus Fassbender, Epameinondas Lyros, Johannes Prudlo, Bernd Joachim Krause, Alexander Volk, Dieter Edbauer, Matthias Leopold Schroeter, Alexander Drzezga, Johannes Kornhuber, Martin Lauer, , Timo Grimmer

ABSTRACT

C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, 18F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Thalamic metabolism did not correlate with disease severity, duration of disease, or the presence of psychotic symptoms. Against our expectations we could not demonstrate a cerebellar hypometabolism in carriers or non-carriers. Future imaging and neuropathological studies in large patient cohorts are required to further elucidate the central role of the thalamus in C9FTLD. More... »

PAGES

54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41398-019-0381-1

DOI

http://dx.doi.org/10.1038/s41398-019-0381-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111776604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30705258


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