Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Chris Baeken, Guo-Rong Wu, Kees van Heeringen

ABSTRACT

The application of repetitive transcranial magnetic stimulation has been shown to rapidly decrease suicidal ideation in major depressive disorder (MDD). However, the neural working mechanisms behind this prompt attenuation of suicidal thoughts remains to be determined. Here, we examined how placebo-accelerated intermittent theta burst stimulation (aiTBS) may influence brain perfusion and suicidal thoughts using arterial spin labeling (ASL). In a randomized double-blind sham-controlled crossover trial, 45 MDD patients received aiTBS applied to the left dorsolateral prefrontal cortex (Trial registration: http://clinicaltrials.gov/show/NCT01832805 ). With each ASL scan measurement, suicidal ideation was assessed with the Beck Scale for Suicidal Ideation (BSI) and depression severity with the Beck Depression Inventory (BDI). Compared with active stimulation, the attenuation of suicidal ideation after 4 days of placebo aiTBS was related to significant frontopolar prefrontal perfusion decreases. These findings were unrelated to changes in depression severity scores. Although both active and sham aiTBS resulted in prompt decreases in suicidal ideation, specifically sham aiTBS significantly attenuated frontopolar perfusion in relation to reductions in BSI scores. Our findings show that in accelerated neurostimulation paradigms, placebo responses are related to perfusion decreases in brain areas associated with higher cognitive processes, resulting in suicidal ideation attenuation. More... »

PAGES

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41398-019-0377-x

DOI

http://dx.doi.org/10.1038/s41398-019-0377-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111747607

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30696807


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium", 
            "Department of Psychiatry, University Hospital (UZBrussel), Brussels, Belgium", 
            "Ghent Experimental Psychiatry (GHEP) lab, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baeken", 
        "givenName": "Chris", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southwest University", 
          "id": "https://www.grid.ac/institutes/grid.263906.8", 
          "name": [
            "Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Guo-Rong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Heeringen", 
        "givenName": "Kees", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1523/jneurosci.2324-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000151181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4679(198807)44:4<499::aid-jclp2270440404>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005043186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brs.2014.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005170376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00124509-200103000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005681054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00124509-200103000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005681054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2015.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007608187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2014.05.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007969099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2010.0398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009830621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinph.2014.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010293217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/818456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011925755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08039480802421182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015262494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhq239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016418930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00169-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018020307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00169-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018020307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2016.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019313579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2016.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019313579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/da.20731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020401836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/da.20731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020401836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2015.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020506205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00029157.2014.976785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020593846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnhum.2016.00480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023144669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-014-0809-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026530925", 
          "https://doi.org/10.1007/s00429-014-0809-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-014-0809-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026530925", 
          "https://doi.org/10.1007/s00429-014-0809-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2016.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029748953", 
          "https://doi.org/10.1038/tp.2016.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13811118.2013.801813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030033955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.114.009423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030186365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamapsychiatry.2016.3644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032338396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2013.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034977333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(03)00088-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036836627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(03)00088-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036836627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2215-0366(14)70220-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038487203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2016.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038519002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040236803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2009.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2007.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040942635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2017.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041935864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2017.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041935864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1961.01710120031004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042708087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnhum.2014.00824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042784408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2010.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044933687", 
          "https://doi.org/10.1038/npp.2010.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e32832d9505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051440846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e32832d9505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051440846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e32832d9505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051440846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2005.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052885450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2016.12.077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053402771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2016.12.077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053402771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2016.12.077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053402771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2016.12.077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053402771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291715001890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053819117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpsc.2017.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054017218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpsc.2017.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054017218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.159.5.728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063494619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/jnp.2009.21.4.430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063512734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.neuropsych.21.4.430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078021534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083371524", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-clinpsy-021815-093015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084512016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15622975.2017.1355472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091108588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2017.09.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091903090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn.2017.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091928736", 
          "https://doi.org/10.1038/nrn.2017.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2017.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092413080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-15926-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092669234", 
          "https://doi.org/10.1038/s41598-017-15926-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2017.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093137640"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "The application of repetitive transcranial magnetic stimulation has been shown to rapidly decrease suicidal ideation in major depressive disorder (MDD). However, the neural working mechanisms behind this prompt attenuation of suicidal thoughts remains to be determined. Here, we examined how placebo-accelerated intermittent theta burst stimulation (aiTBS) may influence brain perfusion and suicidal thoughts using arterial spin labeling (ASL). In a randomized double-blind sham-controlled crossover trial, 45 MDD patients received aiTBS applied to the left dorsolateral prefrontal cortex (Trial registration: http://clinicaltrials.gov/show/NCT01832805 ). With each ASL scan measurement, suicidal ideation was assessed with the Beck Scale for Suicidal Ideation (BSI) and depression severity with the Beck Depression Inventory (BDI). Compared with active stimulation, the attenuation of suicidal ideation after 4 days of placebo aiTBS was related to significant frontopolar prefrontal perfusion decreases. These findings were unrelated to changes in depression severity scores. Although both active and sham aiTBS resulted in prompt decreases in suicidal ideation, specifically sham aiTBS significantly attenuated frontopolar perfusion in relation to reductions in BSI scores. Our findings show that in accelerated neurostimulation paradigms, placebo responses are related to perfusion decreases in brain areas associated with higher cognitive processes, resulting in suicidal ideation attenuation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41398-019-0377-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045271", 
        "issn": [
          "2158-3188"
        ], 
        "name": "Translational Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression", 
    "pagination": "38", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d92ef38ab6c3d18391e28de052196c884d2b05c5d60df1c96a1ebc128901e020"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30696807"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101562664"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41398-019-0377-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111747607"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41398-019-0377-x", 
      "https://app.dimensions.ai/details/publication/pub.1111747607"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68474_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41398-019-0377-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0377-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0377-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0377-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41398-019-0377-x'


 

This table displays all metadata directly associated to this object as RDF triples.

235 TRIPLES      21 PREDICATES      78 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41398-019-0377-x schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N58f2dfc8682247a48e3e19db9fc63894
4 schema:citation sg:pub.10.1007/s00429-014-0809-6
5 sg:pub.10.1038/npp.2010.81
6 sg:pub.10.1038/nrn.2017.111
7 sg:pub.10.1038/s41598-017-15926-0
8 sg:pub.10.1038/tp.2016.110
9 https://app.dimensions.ai/details/publication/pub.1083371524
10 https://doi.org/10.1001/archpsyc.1961.01710120031004
11 https://doi.org/10.1001/jamapsychiatry.2016.3644
12 https://doi.org/10.1002/1097-4679(198807)44:4<499::aid-jclp2270440404>3.0.co;2-6
13 https://doi.org/10.1002/da.20731
14 https://doi.org/10.1016/j.bbi.2005.03.010
15 https://doi.org/10.1016/j.biopsych.2009.09.013
16 https://doi.org/10.1016/j.bpsc.2017.01.001
17 https://doi.org/10.1016/j.brs.2014.03.006
18 https://doi.org/10.1016/j.clinph.2014.05.021
19 https://doi.org/10.1016/j.jad.2013.07.008
20 https://doi.org/10.1016/j.jad.2014.05.036
21 https://doi.org/10.1016/j.jad.2016.04.015
22 https://doi.org/10.1016/j.jad.2017.01.013
23 https://doi.org/10.1016/j.jad.2017.09.021
24 https://doi.org/10.1016/j.jpsychires.2016.10.011
25 https://doi.org/10.1016/j.neuroimage.2016.12.077
26 https://doi.org/10.1016/j.neuroscience.2015.08.017
27 https://doi.org/10.1016/j.pneurobio.2007.01.005
28 https://doi.org/10.1016/j.pneurobio.2017.11.004
29 https://doi.org/10.1016/j.pnpbp.2015.05.001
30 https://doi.org/10.1016/j.pnpbp.2017.10.016
31 https://doi.org/10.1016/s0006-3223(03)00088-x
32 https://doi.org/10.1016/s1053-8119(03)00169-1
33 https://doi.org/10.1016/s2215-0366(14)70220-2
34 https://doi.org/10.1017/s0033291715001890
35 https://doi.org/10.1080/00029157.2014.976785
36 https://doi.org/10.1080/08039480802421182
37 https://doi.org/10.1080/13811118.2013.801813
38 https://doi.org/10.1080/15622975.2017.1355472
39 https://doi.org/10.1093/cercor/bhq239
40 https://doi.org/10.1097/00124509-200103000-00007
41 https://doi.org/10.1097/wco.0b013e32832d9505
42 https://doi.org/10.1098/rstb.2010.0398
43 https://doi.org/10.1124/pr.114.009423
44 https://doi.org/10.1146/annurev-clinpsy-021815-093015
45 https://doi.org/10.1155/2012/818456
46 https://doi.org/10.1176/appi.ajp.159.5.728
47 https://doi.org/10.1176/appi.neuropsych.21.4.430
48 https://doi.org/10.1176/jnp.2009.21.4.430
49 https://doi.org/10.1371/journal.pone.0004824
50 https://doi.org/10.1523/jneurosci.2324-08.2008
51 https://doi.org/10.3389/fnhum.2014.00824
52 https://doi.org/10.3389/fnhum.2016.00480
53 schema:datePublished 2019-12
54 schema:datePublishedReg 2019-12-01
55 schema:description The application of repetitive transcranial magnetic stimulation has been shown to rapidly decrease suicidal ideation in major depressive disorder (MDD). However, the neural working mechanisms behind this prompt attenuation of suicidal thoughts remains to be determined. Here, we examined how placebo-accelerated intermittent theta burst stimulation (aiTBS) may influence brain perfusion and suicidal thoughts using arterial spin labeling (ASL). In a randomized double-blind sham-controlled crossover trial, 45 MDD patients received aiTBS applied to the left dorsolateral prefrontal cortex (Trial registration: http://clinicaltrials.gov/show/NCT01832805 ). With each ASL scan measurement, suicidal ideation was assessed with the Beck Scale for Suicidal Ideation (BSI) and depression severity with the Beck Depression Inventory (BDI). Compared with active stimulation, the attenuation of suicidal ideation after 4 days of placebo aiTBS was related to significant frontopolar prefrontal perfusion decreases. These findings were unrelated to changes in depression severity scores. Although both active and sham aiTBS resulted in prompt decreases in suicidal ideation, specifically sham aiTBS significantly attenuated frontopolar perfusion in relation to reductions in BSI scores. Our findings show that in accelerated neurostimulation paradigms, placebo responses are related to perfusion decreases in brain areas associated with higher cognitive processes, resulting in suicidal ideation attenuation.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf Ndc5a9dbfa6814e99a33d81f4e33ba1f3
60 Ne6eaef20c8f34af49c156c27465bf63e
61 sg:journal.1045271
62 schema:name Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression
63 schema:pagination 38
64 schema:productId N6426f933a54d44b48d86be93c39305d2
65 N7533afa83671414aa907c7da49370b43
66 N78def6c1771946de9d05d4b6a21abc80
67 Nb715b49197f14517b010fc881c6d6a52
68 Ne91cdafe16c14d58bc83d968f67bd9b4
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111747607
70 https://doi.org/10.1038/s41398-019-0377-x
71 schema:sdDatePublished 2019-04-11T08:59
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N58585b503f584d8aada4a9a2e7b2c15d
74 schema:url https://www.nature.com/articles/s41398-019-0377-x
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0f4ca35c8001447fb9d5dbbe3273d86a schema:affiliation https://www.grid.ac/institutes/grid.5342.0
79 schema:familyName van Heeringen
80 schema:givenName Kees
81 rdf:type schema:Person
82 N31512a57823a441c9eeb38ee6cba2607 rdf:first Nb9a1bed69e6543129cff9abc68078a81
83 rdf:rest Nffd1851af7ef442f872023f89ea63212
84 N58585b503f584d8aada4a9a2e7b2c15d schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N58f2dfc8682247a48e3e19db9fc63894 rdf:first Nb3ea471d33d045cdb058fcfa5408555d
87 rdf:rest N31512a57823a441c9eeb38ee6cba2607
88 N6426f933a54d44b48d86be93c39305d2 schema:name dimensions_id
89 schema:value pub.1111747607
90 rdf:type schema:PropertyValue
91 N7533afa83671414aa907c7da49370b43 schema:name pubmed_id
92 schema:value 30696807
93 rdf:type schema:PropertyValue
94 N78def6c1771946de9d05d4b6a21abc80 schema:name nlm_unique_id
95 schema:value 101562664
96 rdf:type schema:PropertyValue
97 Nb3ea471d33d045cdb058fcfa5408555d schema:affiliation https://www.grid.ac/institutes/grid.5342.0
98 schema:familyName Baeken
99 schema:givenName Chris
100 rdf:type schema:Person
101 Nb715b49197f14517b010fc881c6d6a52 schema:name readcube_id
102 schema:value d92ef38ab6c3d18391e28de052196c884d2b05c5d60df1c96a1ebc128901e020
103 rdf:type schema:PropertyValue
104 Nb9a1bed69e6543129cff9abc68078a81 schema:affiliation https://www.grid.ac/institutes/grid.263906.8
105 schema:familyName Wu
106 schema:givenName Guo-Rong
107 rdf:type schema:Person
108 Ndc5a9dbfa6814e99a33d81f4e33ba1f3 schema:issueNumber 1
109 rdf:type schema:PublicationIssue
110 Ne6eaef20c8f34af49c156c27465bf63e schema:volumeNumber 9
111 rdf:type schema:PublicationVolume
112 Ne91cdafe16c14d58bc83d968f67bd9b4 schema:name doi
113 schema:value 10.1038/s41398-019-0377-x
114 rdf:type schema:PropertyValue
115 Nffd1851af7ef442f872023f89ea63212 rdf:first N0f4ca35c8001447fb9d5dbbe3273d86a
116 rdf:rest rdf:nil
117 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
118 schema:name Medical and Health Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
121 schema:name Clinical Sciences
122 rdf:type schema:DefinedTerm
123 sg:journal.1045271 schema:issn 2158-3188
124 schema:name Translational Psychiatry
125 rdf:type schema:Periodical
126 sg:pub.10.1007/s00429-014-0809-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026530925
127 https://doi.org/10.1007/s00429-014-0809-6
128 rdf:type schema:CreativeWork
129 sg:pub.10.1038/npp.2010.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044933687
130 https://doi.org/10.1038/npp.2010.81
131 rdf:type schema:CreativeWork
132 sg:pub.10.1038/nrn.2017.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091928736
133 https://doi.org/10.1038/nrn.2017.111
134 rdf:type schema:CreativeWork
135 sg:pub.10.1038/s41598-017-15926-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092669234
136 https://doi.org/10.1038/s41598-017-15926-0
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/tp.2016.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029748953
139 https://doi.org/10.1038/tp.2016.110
140 rdf:type schema:CreativeWork
141 https://app.dimensions.ai/details/publication/pub.1083371524 schema:CreativeWork
142 https://doi.org/10.1001/archpsyc.1961.01710120031004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042708087
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1001/jamapsychiatry.2016.3644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032338396
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1002/1097-4679(198807)44:4<499::aid-jclp2270440404>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005043186
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1002/da.20731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020401836
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/j.bbi.2005.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052885450
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.biopsych.2009.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662786
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.bpsc.2017.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054017218
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.brs.2014.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005170376
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.clinph.2014.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010293217
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.jad.2013.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034977333
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.jad.2014.05.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007969099
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.jad.2016.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019313579
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.jad.2017.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041935864
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.jad.2017.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091903090
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.jpsychires.2016.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038519002
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.neuroimage.2016.12.077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053402771
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.neuroscience.2015.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020506205
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.pneurobio.2007.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942635
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.pneurobio.2017.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093137640
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.pnpbp.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007608187
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.pnpbp.2017.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092413080
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0006-3223(03)00088-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036836627
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s1053-8119(03)00169-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018020307
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s2215-0366(14)70220-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038487203
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1017/s0033291715001890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053819117
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1080/00029157.2014.976785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020593846
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1080/08039480802421182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015262494
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1080/13811118.2013.801813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030033955
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1080/15622975.2017.1355472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091108588
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1093/cercor/bhq239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016418930
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00124509-200103000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005681054
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/wco.0b013e32832d9505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051440846
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1098/rstb.2010.0398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009830621
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1124/pr.114.009423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030186365
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1146/annurev-clinpsy-021815-093015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084512016
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1155/2012/818456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011925755
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1176/appi.ajp.159.5.728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063494619
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1176/appi.neuropsych.21.4.430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078021534
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1176/jnp.2009.21.4.430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063512734
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1371/journal.pone.0004824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040236803
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1523/jneurosci.2324-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000151181
223 rdf:type schema:CreativeWork
224 https://doi.org/10.3389/fnhum.2014.00824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042784408
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3389/fnhum.2016.00480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023144669
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.263906.8 schema:alternateName Southwest University
229 schema:name Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.5342.0 schema:alternateName Ghent University
232 schema:name Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
233 Department of Psychiatry, University Hospital (UZBrussel), Brussels, Belgium
234 Ghent Experimental Psychiatry (GHEP) lab, Ghent University, Ghent, Belgium
235 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...